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Learning to Care for Those in Harm`s Way Uniformed Services
Learning to Care for Those in Harm`s Way Uniformed Services

... Bethesda, Maryland--Researchers at the Uniformed Services University of the Health Sciences (USU) Center for Prostate Disease Research (CPDR), in collaboration with investigators at the Armed Forces Institute of Pathology and Walter Reed Army Medical Center have developed a highly specific assay for ...
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Text for Slides on The Gravitational and Space Biology of Plants

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... Chemical Co.) was used to treat cultures for 24 h on d 6 of culture to further eliminate fibroblast contamination (Kufe et al., 1980). Cells were grown from d 7 to d 14 in 1% horse serum-containing medium (to limit proliferation of any surviving fibroblasts) and placed into serum-free medium on d 14 ...
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Single-Cell Transcription Site Activation Predicts Chemotherapy Response in Human Colorectal Tumors
Single-Cell Transcription Site Activation Predicts Chemotherapy Response in Human Colorectal Tumors

... expression profiles predictive of relative sensitivity to these drugs. The predictive value of this approach was better than other molecular markers that have been reported (12). Regardless of the method used to identify clinically useful markers of drug response, all approaches must eventually deal ...
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Amitosis

Amitosis (a- + mitosis) is absence of mitosis, the usual form of cell division in the cells of eukaryotes. There are several senses in which eukaryotic cells can be amitotic. One refers to capability for non-mitotic division and the other refers to lack of capability for division. In one sense of the word, which is now mostly obsolete, amitosis is cell division in eukaryotic cells that happens without the usual features of mitosis as seen on microscopy, namely, without nuclear envelope breakdown and without formation of mitotic spindle and condensed chromosomes as far as microscopy can detect. However, most examples of cell division formerly thought to belong to this supposedly ""non-mitotic"" class, such as the division of unicellular eukaryotes, are today recognized as belonging to a class of mitosis called closed mitosis. A spectrum of mitotic activity can be categorized as open, semi-closed, and closed mitosis, depending on the fate of the nuclear envelope. An exception is the division of ciliate macronucleus, which is not mitotic, and the reference to this process as amitosis may be the only legitimate use of the ""non-mitotic division"" sense of the term today. In animals and plants which normally have open mitosis, the microscopic picture described in the 19th century as amitosis most likely corresponded to apoptosis, a process of programmed cell death associated with fragmentation of the nucleus and cytoplasm. Relatedly, even in the late 19th century cytologists mentioned that in larger life forms, amitosis is a ""forerunner of degeneration"".Another sense of amitotic refers to cells of certain tissues that are usually no longer capable of mitosis once the organism has matured into adulthood. In humans this is true of various muscle and nerve tissue types; if the existing ones are damaged, they cannot be replaced with new ones of equal capability. For example, cardiac muscle destroyed by heart attack and nerves destroyed by piercing trauma usually cannot regenerate. In contrast, skin cells are capable of mitosis throughout adulthood; old skin cells that die and slough off are replaced with new ones. Human liver tissue also has a sort of dormant regenerative ability; it is usually not needed or expressed but can be elicited if needed.
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