PINK1- and Parkin- mediated mitophagy at a glance
... al., 2010; Zhang et al., 2009a). Overexpression of Parkin has been found to induce the complete removal of mitochondria from cells by mitophagy when mitochondria lose their membrane potential (Narendra et al., 2008). As Parkin has also been found to selectively bind only to damaged mitochondria it h ...
... al., 2010; Zhang et al., 2009a). Overexpression of Parkin has been found to induce the complete removal of mitochondria from cells by mitophagy when mitochondria lose their membrane potential (Narendra et al., 2008). As Parkin has also been found to selectively bind only to damaged mitochondria it h ...
Assembly factors as a new class of disease
... analogous to those identified for complex IV in the yeast model organism (Fontanesi et al., 2006). Assembly factors aid assembly of a complex without being part of the final structure. Although the lack of complex I in yeast initially hampered their identification, pioneering work in the fungus Neur ...
... analogous to those identified for complex IV in the yeast model organism (Fontanesi et al., 2006). Assembly factors aid assembly of a complex without being part of the final structure. Although the lack of complex I in yeast initially hampered their identification, pioneering work in the fungus Neur ...
PDF
... observed (non-parametric Wilcoxon test, Z = -0.052, P = 0.95). However, significant differences between indel numbers and lengths per base or gene pair were observed (Wilcoxon test, P < 0.002), with more indels in first than non-first introns. This result indicates that the evolutionary pattern of i ...
... observed (non-parametric Wilcoxon test, Z = -0.052, P = 0.95). However, significant differences between indel numbers and lengths per base or gene pair were observed (Wilcoxon test, P < 0.002), with more indels in first than non-first introns. This result indicates that the evolutionary pattern of i ...
Work1
... Representation length – is a number of bits for each X in the phenotype (so the length of the genome is 3 times this number). Pm and Pc is the probabilities as defined in the genetic algorithms. Average fitness is the average fitness of the last generation. The phenotype presented as vector of 3 nu ...
... Representation length – is a number of bits for each X in the phenotype (so the length of the genome is 3 times this number). Pm and Pc is the probabilities as defined in the genetic algorithms. Average fitness is the average fitness of the last generation. The phenotype presented as vector of 3 nu ...
Visualization, description and analysis of the Drosophila melanogaster
... evolutionary process. On one hand, the molecule is intrinsically mutable, being this the origin of genetic variation. On the other hand, it allows the replication of old and new variants from one generation to another. The reproductive or survival advantage or disadvantage an individual has for carr ...
... evolutionary process. On one hand, the molecule is intrinsically mutable, being this the origin of genetic variation. On the other hand, it allows the replication of old and new variants from one generation to another. The reproductive or survival advantage or disadvantage an individual has for carr ...
Admixture Between Historically Isolated Mitochondrial Lineages in
... Our findings show that US zoo gorillas possess all of the major mitochondrial lineages found across the entire range of western gorillas. This includes the novel lineage C3, which has recently been identified in gorillas from Cameroon (Soto-Calderon, unpublished data). Our results indicate that the ...
... Our findings show that US zoo gorillas possess all of the major mitochondrial lineages found across the entire range of western gorillas. This includes the novel lineage C3, which has recently been identified in gorillas from Cameroon (Soto-Calderon, unpublished data). Our results indicate that the ...
the x chromosome in population genetics
... Mutation rates in males and females. The higher mutation rate in male mammals, including humans, is generally attributed to the larger number of mitoses that germline cells go through in males. Direct measurement of the difference in rates is difficult, however, as the absolute rates are low (~2 x 1 ...
... Mutation rates in males and females. The higher mutation rate in male mammals, including humans, is generally attributed to the larger number of mitoses that germline cells go through in males. Direct measurement of the difference in rates is difficult, however, as the absolute rates are low (~2 x 1 ...
Gene regulation in three dimensions
... Last, but not least I would like to thank Julie my fiancé who has supported me and been there for me when I needed it the most. K.T.W ...
... Last, but not least I would like to thank Julie my fiancé who has supported me and been there for me when I needed it the most. K.T.W ...
Characterization of chaperonin 10 (Cpn10)
... gaps, were excluded from the analysis, leaving a final dataset of 21 taxa and 69 amino acid positions. Bayesian searches of treespace were performed with the program MRBAYES (Huelsenbeck & Ronquist, 2001), using the JTT-f amino acid substitution matrix with four variable gamma rate corrections. Two ...
... gaps, were excluded from the analysis, leaving a final dataset of 21 taxa and 69 amino acid positions. Bayesian searches of treespace were performed with the program MRBAYES (Huelsenbeck & Ronquist, 2001), using the JTT-f amino acid substitution matrix with four variable gamma rate corrections. Two ...
Analysis and nucleotide sequence of an origin of DNA replication in
... pWH1266 and transformants were scored on LB plates containing 100/~gAp/ml. Competency is observed from the early log phase to the stationary phase. A maximum of competency is found in the late log phase of growth with about 6 × l0 s transformants per 500 ng of plasmid DNA. This procedure is slightly ...
... pWH1266 and transformants were scored on LB plates containing 100/~gAp/ml. Competency is observed from the early log phase to the stationary phase. A maximum of competency is found in the late log phase of growth with about 6 × l0 s transformants per 500 ng of plasmid DNA. This procedure is slightly ...
The Mobile Genetic Element Alu in the Human Genome
... genome mapping and biomedical research. Only a small fraction of the human genome consists of functional, or protein-encoding, genes. If all the nucleotide information were translated, 10 9 amino acids, or approximately 3 million average-size proteins, would be encoded. Based on the fully sequenced ...
... genome mapping and biomedical research. Only a small fraction of the human genome consists of functional, or protein-encoding, genes. If all the nucleotide information were translated, 10 9 amino acids, or approximately 3 million average-size proteins, would be encoded. Based on the fully sequenced ...
Application of whole genome sequencing to fully characterise
... Campylobacter is the most common cause of acute bacterial gastroenteritis worldwide. In the UK alone it causes an estimated 500,000 infections each year. There have been two large studies of Infectious Intestinal Disease in the UK community (IID1 in the mid 1990s and IID2 in 2008-2009). In both stud ...
... Campylobacter is the most common cause of acute bacterial gastroenteritis worldwide. In the UK alone it causes an estimated 500,000 infections each year. There have been two large studies of Infectious Intestinal Disease in the UK community (IID1 in the mid 1990s and IID2 in 2008-2009). In both stud ...
Agilent Whole Human Genome Oligo Microarray Kit
... its whole genome microarray to represent the best possible view of the human genome as we know it today. The vast majority of highly-sensitive 60-mer oligo probes on this microarray have been empirically and experimentally validated to provide you with added confidence in its content. Moreover, thes ...
... its whole genome microarray to represent the best possible view of the human genome as we know it today. The vast majority of highly-sensitive 60-mer oligo probes on this microarray have been empirically and experimentally validated to provide you with added confidence in its content. Moreover, thes ...
Functional Annotation
... Bio-ontologies are used to capture biological information in a way that can be read by both humans and computers. necessary for high-throughput “omics” datasets allows data sharing across databases ...
... Bio-ontologies are used to capture biological information in a way that can be read by both humans and computers. necessary for high-throughput “omics” datasets allows data sharing across databases ...
transposon
... An insertion sequence is a transposon that codes for the enzyme(s) needed for transposition flanked by short inverted terminal repeats. The target site at which a transposon is inserted is duplicated during the insertion process to form two repeats in direct orientation at the ends of the transp ...
... An insertion sequence is a transposon that codes for the enzyme(s) needed for transposition flanked by short inverted terminal repeats. The target site at which a transposon is inserted is duplicated during the insertion process to form two repeats in direct orientation at the ends of the transp ...
Patterns of Segmental Duplication in the Human Genome
... ends of the alignment, while maintaining the requirement 90% sequence similarity during the extension process. Noting that some regions showed a higher density of duplication than others, we examined these regions for possible causes of duplication. Specifically, we divided each chromosome into no ...
... ends of the alignment, while maintaining the requirement 90% sequence similarity during the extension process. Noting that some regions showed a higher density of duplication than others, we examined these regions for possible causes of duplication. Specifically, we divided each chromosome into no ...
Probable presence of an ubiquitous cryptic mitochondrial gene on
... Background: Mitochondria mediate most of the energy production that occurs in the majority of eukaryotic organisms. These subcellular organelles contain a genome that differs from the nuclear genome and is referred to as mitochondrial DNA (mtDNA). Despite a disparity in gene content, all mtDNAs enco ...
... Background: Mitochondria mediate most of the energy production that occurs in the majority of eukaryotic organisms. These subcellular organelles contain a genome that differs from the nuclear genome and is referred to as mitochondrial DNA (mtDNA). Despite a disparity in gene content, all mtDNAs enco ...
The Maize Genome Poster
... occurred has been a puzzle for over a century. Geneticists are now convinced that humans living in the Balsas River region of Mexico were foraging teosinte seeds when they noticed rare aberrations—likely caused by random mutations— that increased spike size dramatically. Seeds were propagated from t ...
... occurred has been a puzzle for over a century. Geneticists are now convinced that humans living in the Balsas River region of Mexico were foraging teosinte seeds when they noticed rare aberrations—likely caused by random mutations— that increased spike size dramatically. Seeds were propagated from t ...
Why are most organelle genomes transmitted maternally?
... (chloroplasts) and mitochondria. The non-Mendelian inheritance of organelles is predominantly uniparental, usually maternal. Thus, organelle inheritance can be recognized as reciprocal difference in sexual crosses (Fig. 1). Other features of organelle inheritance include somatic segregation (sorting ...
... (chloroplasts) and mitochondria. The non-Mendelian inheritance of organelles is predominantly uniparental, usually maternal. Thus, organelle inheritance can be recognized as reciprocal difference in sexual crosses (Fig. 1). Other features of organelle inheritance include somatic segregation (sorting ...
PDF - Journal of Genomics
... biotypes of the soybean aphid have been identified in Midwest growing regions; biotypes are based on the ability to overcome host-plant resistance provided by one or more of these Rag genes. Biotype 2 can override the Rag1 gene (27), while biotype 3 can deride Rag2 resistance (28). Biotype 4 is capa ...
... biotypes of the soybean aphid have been identified in Midwest growing regions; biotypes are based on the ability to overcome host-plant resistance provided by one or more of these Rag genes. Biotype 2 can override the Rag1 gene (27), while biotype 3 can deride Rag2 resistance (28). Biotype 4 is capa ...
A novel arginine substitution mutation in 1A domain and a novel 27
... region have been reported.26–29 The proband of family B carries a novel duplication insertion of 27 nucleotides (1222ins27). This type of mutation is unique for a number of different reasons. Firstly, in-frame insertion or deletion mutations are extremely rare in keratin diseases (table 2), and this ...
... region have been reported.26–29 The proband of family B carries a novel duplication insertion of 27 nucleotides (1222ins27). This type of mutation is unique for a number of different reasons. Firstly, in-frame insertion or deletion mutations are extremely rare in keratin diseases (table 2), and this ...
Genome organization of Magnaporthe grisea
... Two sites of rearrangement identified in progeny isolates are indicated by black boxes on the affected chromosome segments ...
... Two sites of rearrangement identified in progeny isolates are indicated by black boxes on the affected chromosome segments ...
Evolution of a pseudo-control region in the mitochondrial genome of
... approach a 2.5 kb PCR fragment comprising the section between ND6 and 12s genes was isolated from Buteo buteo hureo,cloned and sequenced. The gene order corresponds to the novel arrangement described for Folco peregrinrrs by Mindell et al. (1998). The fragment includes a non coding section between t ...
... approach a 2.5 kb PCR fragment comprising the section between ND6 and 12s genes was isolated from Buteo buteo hureo,cloned and sequenced. The gene order corresponds to the novel arrangement described for Folco peregrinrrs by Mindell et al. (1998). The fragment includes a non coding section between t ...
The Drosophila Gene Disruption Project: Progress
... have been described (Thibault et al. 2004). These lines probably do not represent a completely random collection of insertions, because some lines disrupting major hotspots appear to have been culled by Exelixis. However, we found many cases where at least two lines bearing identical piggyBac insert ...
... have been described (Thibault et al. 2004). These lines probably do not represent a completely random collection of insertions, because some lines disrupting major hotspots appear to have been culled by Exelixis. However, we found many cases where at least two lines bearing identical piggyBac insert ...
Potential of promotion of alleles by genome editing for improving
... Operated by a traditional breeder (Bonus on basis of new lines released!!) ...
... Operated by a traditional breeder (Bonus on basis of new lines released!!) ...