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Transfusions in Surgery
Transfusions in Surgery

... • Hypothermia – slows activity of coagulation cascade, increases fibrinolysis and alters platelet function • Dilutional coagulopathy – exacerbated by initial volume contraction, fluid resuscitation and transfusion of factor and platelet-deficient PRBCs • Fibrinogen < 1.0 g/L when blood loss 142% • D ...
A 57-Year-Old Man Presents with Worsening Shortness of Breath
A 57-Year-Old Man Presents with Worsening Shortness of Breath

... A 57-year-old male presented to the emergency department and later was admitted to the hospital for evaluation of progressively worsening fatigue and shortness of breath. The patient was in his usual state of health until 10 days prior to admission when he experienced a mild sore throat and headache ...
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sickle cell anemia - Harlem Children Society
sickle cell anemia - Harlem Children Society

... dying of strokes and heart attacks dramatically increase. ...
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Researchers find link between blood clotting

... Moake said he and Turner are conducting follow-up research to measure more effectively the activation of C3 on VWF. They are also measuring whether the C3 activation stimulates the sequential cascade of reactions that leads to MAC formation. In particular, they are interested in studying how the con ...
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P-14

... Background: The tropical diabetic hand syndrome (TDHS) affects diabetes patients in the tropics, and encompasses a localized cellulitis with variable swelling and ulceration of the hands that may progress to fulminant sepsis and gangrene affecting the entire arm. Thus, we conducted a case-control st ...
Kidney PPT
Kidney PPT

...  Regulate the amount of WATER in the blood  Adjust the CONCENTRATION of other substances in ...
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Title of presentation (Arial bold 32 pt, default blue

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Heme/Onc Part 2 - LSU School of Medicine

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Week 9th and 10th DNA isolation and Amplification

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Action - Allnurses.com

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The kidney – structure and function

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On the basis of the clinical presentation, which disease entity/entities

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Chapter 14: Blood

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Opstel Biologie History of the microscope The most well

... physics and mathematics. During his life he married twice. First with Barbara de Meij. Later on whe she was death, he married with Cornelia Swalmius. With his first wife he got five children. At the age of 90 he died. He left his oldest daughter a heritage of 90.000 guilders after his death. ...
Sickle Cell Disease
Sickle Cell Disease

...  Hgb SC Disease  Sickle Beta-Thalassemia ...
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Platelets disorders

... Purpura associated with infections.(immune complex formation). ...
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Hemolytic-uremic syndrome



Hemolytic-uremic syndrome (or haemolytic-uraemic syndrome), abbreviated HUS, is a disease characterized by hemolytic anemia (anemia caused by destruction of red blood cells), acute kidney failure (uremia), and a low platelet count (thrombocytopenia). It predominantly, but not exclusively, affects children. Most cases are preceded by an episode of infectious, sometimes bloody, diarrhea acquired as a foodborne illness or from a contaminated water supply and caused by E. coli O157:H7, although Shigella, Campylobacter and a variety of viruses have also been implicated. It is now the most common cause of acquired acute renal failure in childhood. It is a medical emergency and carries a 5–10% mortality; of the remainder, the majority recover without major consequences but a small proportion develop chronic kidney disease and become reliant on renal replacement therapy.The primary target appears to be the vascular endothelial cell. This may explain the pathogenesis of HUS, in which a characteristic renal lesion is capillary microangiopathy.HUS was first defined as a syndrome in 1955. The more common form of the disease, Shiga-like toxin-producing E. coli HUS (STEC-HUS), is triggered by the infectious agent E. coli O157:H7. Certain Shiga toxin secreting strains of Shigella dysenteriae can also cause HUS. Approximately 5% of cases are classified as pneumococcal HUS, which results from infection by Streptococcus pneumoniae, the agent that causes traditional lobar pneumonia. There is also a rare, chronic, and severe form known as atypical hemolytic uremic syndrome (aHUS), which is caused by genetic defects resulting in chronic, uncontrolled complement activation. Both STEC-HUS and aHUS cause endothelial damage, leukocyte activation, platelet activation, and widespread inflammation and multiple thromboses in the small blood vessels, a condition known as systemic thrombotic microangiopathy (TMA), which leads to thrombotic events as well as organ damage/failure and death.
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