Chronic kidney disease: managing anaemia
... The guideline development group for this 2015 update considered the evidence in several areas that provide challenges for clinicians managing anaemia of CKD. Recombinant human erythropoietin (also called EPO, an erythropoietic stimulating agent or ESA) for treating anaemia of CKD is an important too ...
... The guideline development group for this 2015 update considered the evidence in several areas that provide challenges for clinicians managing anaemia of CKD. Recombinant human erythropoietin (also called EPO, an erythropoietic stimulating agent or ESA) for treating anaemia of CKD is an important too ...
Issue #9 June 2011 In This Issue Going Hog Wild Did You Know
... lead to an enhanced risk of cancer. Once marked for degradation by prolyl hydroxylases, another protein is necessary to direct the actual degradation of HIF1α. A genetic deficiency of this other protein leads to von HippelLindau syndrome, a strong cancer predisposition syndrome. The rationale for th ...
... lead to an enhanced risk of cancer. Once marked for degradation by prolyl hydroxylases, another protein is necessary to direct the actual degradation of HIF1α. A genetic deficiency of this other protein leads to von HippelLindau syndrome, a strong cancer predisposition syndrome. The rationale for th ...
1 Abnormal properties of red blood cells suggest a role in the
... Gaucher disease (GD) is a lysosomal storage disorder caused by glucocerebrosidase deficiency. It is notably characterized by splenomegaly, complex skeletal involvement, ischemic events of the spleen and bones, and the accumulation of Gaucher cells in several organs. We hypothesized that red blood ce ...
... Gaucher disease (GD) is a lysosomal storage disorder caused by glucocerebrosidase deficiency. It is notably characterized by splenomegaly, complex skeletal involvement, ischemic events of the spleen and bones, and the accumulation of Gaucher cells in several organs. We hypothesized that red blood ce ...
Neonatal haemophilia
... up to 72 hours. Some authors recommend it is given after birth in an attempt to prevent or decrease brain injury caused by ICH22. Although this idea seems attractive, there are concerns that this strategy may have adverse affects. Around 25-30% of haemophilia A patients develop FVIII inhibitors afte ...
... up to 72 hours. Some authors recommend it is given after birth in an attempt to prevent or decrease brain injury caused by ICH22. Although this idea seems attractive, there are concerns that this strategy may have adverse affects. Around 25-30% of haemophilia A patients develop FVIII inhibitors afte ...
The 2015 Canadian Hypertension Education Program
... Objective: To provide updated 2015 evidence-based recommendations for the prevention, diagnosis, assessment, and treatment of hypertension in adults. Methods: A medical librarian independently conducted a MEDLINE search current to August 2014. Reference lists were reviewed and experts were contacted ...
... Objective: To provide updated 2015 evidence-based recommendations for the prevention, diagnosis, assessment, and treatment of hypertension in adults. Methods: A medical librarian independently conducted a MEDLINE search current to August 2014. Reference lists were reviewed and experts were contacted ...
Mallinckrodt ECP for CTCL MSAC Protocol_FINAL
... Cutaneous T-cell lymphoma (CTCL) is a rare disease with a high burden of illness and an annual incidence of 0.23-0.75 per 100,000 in Australia [1]. CTCL involves malignant T-cell clones that accumulate in the skin, leading to plaques, patches, lesions, pruritus, tumours and lung and spleen damage [2 ...
... Cutaneous T-cell lymphoma (CTCL) is a rare disease with a high burden of illness and an annual incidence of 0.23-0.75 per 100,000 in Australia [1]. CTCL involves malignant T-cell clones that accumulate in the skin, leading to plaques, patches, lesions, pruritus, tumours and lung and spleen damage [2 ...
Hereditary spherocytosis
... the erythrocytes in this disorder is weakened vertical linkages between the membrane skeleton and the lipid bilayer with its integral proteins (table 1). Vertical linkages include spectrin, ankyrin-1, band-3, and protein-4.2 interactions; spectrin, protein-4.1R, glycophorin-C, and p55 interactions; ...
... the erythrocytes in this disorder is weakened vertical linkages between the membrane skeleton and the lipid bilayer with its integral proteins (table 1). Vertical linkages include spectrin, ankyrin-1, band-3, and protein-4.2 interactions; spectrin, protein-4.1R, glycophorin-C, and p55 interactions; ...
13 Recent trends and advances in hemophilia – its management
... individual may bleed spontaneously or for longer than a healthy person after injury or surgery. The blood coagulation mechanism is a process which transforms the blood from a liquid into a solid, and involves several different clotting factors. The mechanism generates fibrin when it is activated, wh ...
... individual may bleed spontaneously or for longer than a healthy person after injury or surgery. The blood coagulation mechanism is a process which transforms the blood from a liquid into a solid, and involves several different clotting factors. The mechanism generates fibrin when it is activated, wh ...
Benefits from Treatment and Control of Patients with Resistant
... Virtually no longitudinal study has addressed the particular prognosis of resistant hypertension. Relevant information may be extracted only from small clinical studies. Isakson and Ostergren studied 36 patients with resistant hypertension in Sweden for a 7-year follow-up period [47]. For each of th ...
... Virtually no longitudinal study has addressed the particular prognosis of resistant hypertension. Relevant information may be extracted only from small clinical studies. Isakson and Ostergren studied 36 patients with resistant hypertension in Sweden for a 7-year follow-up period [47]. For each of th ...
Kassahun Tesfaye final2
... blood samples, which share the same antigenic identity, do not initiate an immune response, and hence are termed as compatible. The utility of these antigens is not only for blood transfusion or organ transplantation, but have also been utilized in genetic research, anthropology and tracing of ances ...
... blood samples, which share the same antigenic identity, do not initiate an immune response, and hence are termed as compatible. The utility of these antigens is not only for blood transfusion or organ transplantation, but have also been utilized in genetic research, anthropology and tracing of ances ...
Biyani`s Think Tank
... It is defined as reduction in the concentration of haemoglobin in the peripheral blood below the normal for the age and sex of the patient ...
... It is defined as reduction in the concentration of haemoglobin in the peripheral blood below the normal for the age and sex of the patient ...
Lenicek Krleza J.et al. - Capillary blood
... Capillary blood sampling is a medical procedure aimed at assisting in patient diagnosis, management and treatment, and is increasingly used worldwide, in part because of the increasing availability of point-of-care testing. It is also frequently used to obtain small blood volumes for laboratory test ...
... Capillary blood sampling is a medical procedure aimed at assisting in patient diagnosis, management and treatment, and is increasingly used worldwide, in part because of the increasing availability of point-of-care testing. It is also frequently used to obtain small blood volumes for laboratory test ...
Relationship between mean blood glucose and glycated
... calculated MBG and the measured HbA1c suggests that bloodglucose levels measured over a period of time by patients themselves can provide a reasonably accurate estimation of HbA1c. This finding is in agreement with previous results derived from Type 1 diabetic patients [14]. However, there are some ...
... calculated MBG and the measured HbA1c suggests that bloodglucose levels measured over a period of time by patients themselves can provide a reasonably accurate estimation of HbA1c. This finding is in agreement with previous results derived from Type 1 diabetic patients [14]. However, there are some ...
Resistant Hypertension
... that it is a relatively common clinical problem. The prevalence of resistant hypertension is projected to increase, owing to the aging population and increasing trends in obesity, sleep apnea, and chronic kidney disease. Management of resistant hypertension must begin with a careful evaluation of th ...
... that it is a relatively common clinical problem. The prevalence of resistant hypertension is projected to increase, owing to the aging population and increasing trends in obesity, sleep apnea, and chronic kidney disease. Management of resistant hypertension must begin with a careful evaluation of th ...
Cytosolic pH and the inflammatory
... infections and in abscesses, neutrophils are ineffective at killing bacteria and instead contribute to host tissue destruction. Both intracellular and extracellular factors might contribute to dysregulation of neutrophilic inflammation in such situations, although these are not well characterized. p ...
... infections and in abscesses, neutrophils are ineffective at killing bacteria and instead contribute to host tissue destruction. Both intracellular and extracellular factors might contribute to dysregulation of neutrophilic inflammation in such situations, although these are not well characterized. p ...
Full Text - Maastricht University Research Portal
... The most prevalent hereditary bleeding disorder is von Willebrand disease (vWD), which results from a deficiency of von Willebrand factor (vWF) and segregates as an autosomal dominant or recessive trait. Patients with vWD suffer mainly from mucosal bleeding. Because vWF has a role in platelet adhesi ...
... The most prevalent hereditary bleeding disorder is von Willebrand disease (vWD), which results from a deficiency of von Willebrand factor (vWF) and segregates as an autosomal dominant or recessive trait. Patients with vWD suffer mainly from mucosal bleeding. Because vWF has a role in platelet adhesi ...
Effect of whole blood viscosity and red cell mass on
... Exposure of activated or non-encrypted Tissue Factor (TF) is widely accepted as the first step in initiation of in vivo coagulation. TF is generally localized on cells not exposed to flowing blood under normal conditions, such as fibroblasts and smooth muscle cells. It can also be facultatively exp ...
... Exposure of activated or non-encrypted Tissue Factor (TF) is widely accepted as the first step in initiation of in vivo coagulation. TF is generally localized on cells not exposed to flowing blood under normal conditions, such as fibroblasts and smooth muscle cells. It can also be facultatively exp ...
ACE and ARB FAQ - South London Cardiac and Stroke Network
... Heart Failure: The only direct head-to-head study, ELITE-2 failed to show its primary end-point of reduced CV events in patients treated with losartan compared to captopril. This study was designed to show superiority of losartan over captopril and failed to do this. It was not powered to demonstrat ...
... Heart Failure: The only direct head-to-head study, ELITE-2 failed to show its primary end-point of reduced CV events in patients treated with losartan compared to captopril. This study was designed to show superiority of losartan over captopril and failed to do this. It was not powered to demonstrat ...
THE DIRECT CALCULATION OF THE VOLUME AND
... the volume of packed erythrocytes per unit of volume. These direct calculations of the volume and hemoglobin content of the erythrocyte are simple and clear as to their import. They afford a much clearer and more accurate conception of the physical state of the erythrocyte in health and the alterati ...
... the volume of packed erythrocytes per unit of volume. These direct calculations of the volume and hemoglobin content of the erythrocyte are simple and clear as to their import. They afford a much clearer and more accurate conception of the physical state of the erythrocyte in health and the alterati ...
Diagnosis and management of acute myeloid leukemia in adults
... leukemia (AML).1,2 These have been widely adopted in general practice, within clinical trials, and by regulatory agencies. During recent years, considerable progress has been made in deciphering the molecular genetic and epigenetic basis of AML and in defining new diagnostic and prognostic markers. ...
... leukemia (AML).1,2 These have been widely adopted in general practice, within clinical trials, and by regulatory agencies. During recent years, considerable progress has been made in deciphering the molecular genetic and epigenetic basis of AML and in defining new diagnostic and prognostic markers. ...
High BMI1 mRNA expression in peripheral whole
... blood from NSCLC patients and evaluating the impact of the expression level on treatment response and prognosis. Our results showed that BMI1 expression in whole blood of advanced NSCLC patients was decreased compared with the control group of patients. Consistent with this finding, we also found th ...
... blood from NSCLC patients and evaluating the impact of the expression level on treatment response and prognosis. Our results showed that BMI1 expression in whole blood of advanced NSCLC patients was decreased compared with the control group of patients. Consistent with this finding, we also found th ...
Diffusion capacity and haemodynamics in primary and chronic thromboembolic pulmonary hypertension
... ABSTRACT: The transfer factor of the lung for carbon monoxide (TL,CO) is decreased in patients with pulmonary hypertension. The pulmonary membrane diffusion capacity (Dm) and pulmonary capillary blood volume (Vc), were studied to establish: 1) the relative contribution of the components of the trans ...
... ABSTRACT: The transfer factor of the lung for carbon monoxide (TL,CO) is decreased in patients with pulmonary hypertension. The pulmonary membrane diffusion capacity (Dm) and pulmonary capillary blood volume (Vc), were studied to establish: 1) the relative contribution of the components of the trans ...
Molecular diagnosis of bloodstream infections with a new dual
... technology] and gives quicker results. The aim of the present study was to assess the clinical utility of this new technology to diagnose BSIs. ...
... technology] and gives quicker results. The aim of the present study was to assess the clinical utility of this new technology to diagnose BSIs. ...
Biofilm formation by Staphylococcus capitis strains isolated from
... platelet units. A ubiquitous constituent of the human skin microbiome (Kloos & Schleifer, 1975), S. capitis accounts for ~5 % of all clinical CoNS isolates (Oren & Merzbach, 1990). While S. capitis is typically apathogenic, it has occasionally been shown to cause illness such as skin infection, pneu ...
... platelet units. A ubiquitous constituent of the human skin microbiome (Kloos & Schleifer, 1975), S. capitis accounts for ~5 % of all clinical CoNS isolates (Oren & Merzbach, 1990). While S. capitis is typically apathogenic, it has occasionally been shown to cause illness such as skin infection, pneu ...
Hemolytic-uremic syndrome
Hemolytic-uremic syndrome (or haemolytic-uraemic syndrome), abbreviated HUS, is a disease characterized by hemolytic anemia (anemia caused by destruction of red blood cells), acute kidney failure (uremia), and a low platelet count (thrombocytopenia). It predominantly, but not exclusively, affects children. Most cases are preceded by an episode of infectious, sometimes bloody, diarrhea acquired as a foodborne illness or from a contaminated water supply and caused by E. coli O157:H7, although Shigella, Campylobacter and a variety of viruses have also been implicated. It is now the most common cause of acquired acute renal failure in childhood. It is a medical emergency and carries a 5–10% mortality; of the remainder, the majority recover without major consequences but a small proportion develop chronic kidney disease and become reliant on renal replacement therapy.The primary target appears to be the vascular endothelial cell. This may explain the pathogenesis of HUS, in which a characteristic renal lesion is capillary microangiopathy.HUS was first defined as a syndrome in 1955. The more common form of the disease, Shiga-like toxin-producing E. coli HUS (STEC-HUS), is triggered by the infectious agent E. coli O157:H7. Certain Shiga toxin secreting strains of Shigella dysenteriae can also cause HUS. Approximately 5% of cases are classified as pneumococcal HUS, which results from infection by Streptococcus pneumoniae, the agent that causes traditional lobar pneumonia. There is also a rare, chronic, and severe form known as atypical hemolytic uremic syndrome (aHUS), which is caused by genetic defects resulting in chronic, uncontrolled complement activation. Both STEC-HUS and aHUS cause endothelial damage, leukocyte activation, platelet activation, and widespread inflammation and multiple thromboses in the small blood vessels, a condition known as systemic thrombotic microangiopathy (TMA), which leads to thrombotic events as well as organ damage/failure and death.