chromosomes
... place on the chromosome where spindle fibers are attached during cell division. In general, if the centromere is near the middle, the chromosome is metacentric If the centromere is toward one end, the chromosome is acrocentric or submetacentric If the centromere is very near the end, the chromosome ...
... place on the chromosome where spindle fibers are attached during cell division. In general, if the centromere is near the middle, the chromosome is metacentric If the centromere is toward one end, the chromosome is acrocentric or submetacentric If the centromere is very near the end, the chromosome ...
The nucleotide sequence of Saccharomyces cerevisiae
... The sequence derived for chromosome IX is 439,886 nucleotides in length, and 71.6% codes for proteins or predicted proteins. There are 219 non-overlapping ORFs equal to or greater than 100 amino acids long, and a further two ORFs (YIL060W and YIL059C) that overlap; these are short, and both have a l ...
... The sequence derived for chromosome IX is 439,886 nucleotides in length, and 71.6% codes for proteins or predicted proteins. There are 219 non-overlapping ORFs equal to or greater than 100 amino acids long, and a further two ORFs (YIL060W and YIL059C) that overlap; these are short, and both have a l ...
Effects of OPRM1, ABCB1 and CYP2D6 single nucleotide
... OPRM1: Opioid receptor mu 1; ABCBl: ATP-binding cassette B1; CYP2D6: Cytochrome P450 consists of 28 exons 2D6; F: forward; R: reverse. [17, 18]. Cytochrome P450 2D6 (CYP2D6) is deemed as one of the most important enzymes related to the metabolism of xenobiotics in the body [19]. The CYP2D6 gene (sub ...
... OPRM1: Opioid receptor mu 1; ABCBl: ATP-binding cassette B1; CYP2D6: Cytochrome P450 consists of 28 exons 2D6; F: forward; R: reverse. [17, 18]. Cytochrome P450 2D6 (CYP2D6) is deemed as one of the most important enzymes related to the metabolism of xenobiotics in the body [19]. The CYP2D6 gene (sub ...
Identification and functional analysis of two ZIP metal Thlaspi caerulescens
... contains eight transmembrane domains (TMs) (Supplemental Fig. 1). The sequence has 86% DNA identity and 90% amino acid identity with AtZIP5 and was named TcZNT5-LC. There is a putative metal binding domain containing a series of repeated histidine residues (HVHAHGHAHG) between TM4 and TM5, and it al ...
... contains eight transmembrane domains (TMs) (Supplemental Fig. 1). The sequence has 86% DNA identity and 90% amino acid identity with AtZIP5 and was named TcZNT5-LC. There is a putative metal binding domain containing a series of repeated histidine residues (HVHAHGHAHG) between TM4 and TM5, and it al ...
A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system. PLoS Genetics 7: e1002087.
... and maintenance of body organs is a central goal of developmental biology, and understanding how these programs go awry in disease has important implications for medicine. Many such organogenesis genes have been identified, but most are early-acting ‘‘patterning genes’’ encoding signaling proteins a ...
... and maintenance of body organs is a central goal of developmental biology, and understanding how these programs go awry in disease has important implications for medicine. Many such organogenesis genes have been identified, but most are early-acting ‘‘patterning genes’’ encoding signaling proteins a ...
Development of an internally controlled real-time PCR
... difficult to validate a newly developed PCR against a poor reference standard. Although the positive pigeon samples were not tested against a recognised standard method, these samples were tested as highly suspected animal reservoirs. The detection of C. psittaci DNA in three of nine pigeons with a ...
... difficult to validate a newly developed PCR against a poor reference standard. Although the positive pigeon samples were not tested against a recognised standard method, these samples were tested as highly suspected animal reservoirs. The detection of C. psittaci DNA in three of nine pigeons with a ...
Information Extraction Using Hidden Markov Models
... Finding facts in English prose is a task that humans are good at and computers are bad at. However, humans cannot stand to spend more than a few minutes at a time occupied with such drudgery. In this respect, nding facts is unlike a host of the other jobs computers are currently hopeless at, like t ...
... Finding facts in English prose is a task that humans are good at and computers are bad at. However, humans cannot stand to spend more than a few minutes at a time occupied with such drudgery. In this respect, nding facts is unlike a host of the other jobs computers are currently hopeless at, like t ...
Nucleolar caspase-2: Protecting us from DNA damage
... damage. This may explain, in some part, the pathology of this disease. Importantly, the authors demonstrated that Npm1−/− mouse embryonic fibroblasts were also highly resistant to apoptosis induced by DNA-damaging agents, which would seem to contradict what is observed in AML. This may be a result o ...
... damage. This may explain, in some part, the pathology of this disease. Importantly, the authors demonstrated that Npm1−/− mouse embryonic fibroblasts were also highly resistant to apoptosis induced by DNA-damaging agents, which would seem to contradict what is observed in AML. This may be a result o ...
Anterior-posterior patterning within the
... germline (Wood, 1988). Anterior cells have short microvilli (Sulston and Horvitz, 1977), are associated with an expanded gut lumen and do not express the pho-1 acid phosphatase activity on their lumenal surface (Beh et al., 1991). We have previously described an example of anteriorposterior patterni ...
... germline (Wood, 1988). Anterior cells have short microvilli (Sulston and Horvitz, 1977), are associated with an expanded gut lumen and do not express the pho-1 acid phosphatase activity on their lumenal surface (Beh et al., 1991). We have previously described an example of anteriorposterior patterni ...
Heredity and Math - Computer Science
... Discuss eye color variations and the fact that dark is dominant and light is recessive. Assign a value from 1-10 for each student’s eye color, with 1 being very light and 10 being black. Create a frequency table, line plot or bar graph of the class results. Work in pairs to answer worksheet question ...
... Discuss eye color variations and the fact that dark is dominant and light is recessive. Assign a value from 1-10 for each student’s eye color, with 1 being very light and 10 being black. Create a frequency table, line plot or bar graph of the class results. Work in pairs to answer worksheet question ...
simple patterns of inheritance
... can come from the male gamete and the t allele from the female gamete, or vice versa. This accounts for the fact that the Tt genotype is produced twice as often as either TT or tt. The idea that the two copies of a gene segregate from each other during transmission from parent to offspring is known ...
... can come from the male gamete and the t allele from the female gamete, or vice versa. This accounts for the fact that the Tt genotype is produced twice as often as either TT or tt. The idea that the two copies of a gene segregate from each other during transmission from parent to offspring is known ...
Lesson Overview - mr. welling` s school page
... located on the X chromosome. In males, a defective allele for any of these genes results in colorblindness, an inability to distinguish certain colors. The most common form, red-green colorblindness, occurs in about 1 in 12 males. Among females, however, colorblindness affects only about 1 in 200. I ...
... located on the X chromosome. In males, a defective allele for any of these genes results in colorblindness, an inability to distinguish certain colors. The most common form, red-green colorblindness, occurs in about 1 in 12 males. Among females, however, colorblindness affects only about 1 in 200. I ...
Association Between Endothelial Nitric Oxide Synthase
... hyperlipidemia were independent risk factors for premature CAD in Taiwan. Neither reactive hyperemia nor NTG-mediated vasodilatation showed any difference between genetic polymorphs. In terms of impaired flow-mediated vasodilatation, hypertension was the independent factor (p=0.044), and hyperlipide ...
... hyperlipidemia were independent risk factors for premature CAD in Taiwan. Neither reactive hyperemia nor NTG-mediated vasodilatation showed any difference between genetic polymorphs. In terms of impaired flow-mediated vasodilatation, hypertension was the independent factor (p=0.044), and hyperlipide ...
operon
... • They are turned off allosterically, usually by an effector that is the end-product of the pathway © 2012 Pearson Education, Inc. ...
... • They are turned off allosterically, usually by an effector that is the end-product of the pathway © 2012 Pearson Education, Inc. ...
In-class assignment: Fukuda et al. (2016) paper
... knocked out, both transcript levels drop, suggesting that Oct4 is a positive regulator of expression of both genes. It is surprising for two genes with antagonistic functions to have the same positive regulator. Usually, the cell will express two antagonistic genes differentially, so the results are ...
... knocked out, both transcript levels drop, suggesting that Oct4 is a positive regulator of expression of both genes. It is surprising for two genes with antagonistic functions to have the same positive regulator. Usually, the cell will express two antagonistic genes differentially, so the results are ...
Sporadic Hypertrophic Cardiomyopathy Due to De Novo Myosin
... with familial hypertrophic cardiomyopathy frequently have multiple affected relatives, and must have one affected parent. Sporadic occurrence of hypertrophic cardiomyopathy is defined by similar anatomical and clinical features in an individual whose parents do not have the condition (6, 15). Estima ...
... with familial hypertrophic cardiomyopathy frequently have multiple affected relatives, and must have one affected parent. Sporadic occurrence of hypertrophic cardiomyopathy is defined by similar anatomical and clinical features in an individual whose parents do not have the condition (6, 15). Estima ...
The RNA world meets behavior: AfiI pre
... channels of the nervous system (Fig. 1), all of which are completely unedited in dADAR mutants. Unlike mouse ADAR2 knockouts, however, dADAR-mutant flies are not short-lived under ideal conditions. Because most known targets for specific Afi I RNA editing appear to be signaling components of vertebr ...
... channels of the nervous system (Fig. 1), all of which are completely unedited in dADAR mutants. Unlike mouse ADAR2 knockouts, however, dADAR-mutant flies are not short-lived under ideal conditions. Because most known targets for specific Afi I RNA editing appear to be signaling components of vertebr ...
Bioinformatics: Bringing it all together
... name on it') combined with frame-based systems, a way of representing data in computers as objects within a hierarchy. One frame, for example, could be called 'protein', with slots describing its relationships to other concepts, such as 'gene name', or 'post-translational modifications'. So when a u ...
... name on it') combined with frame-based systems, a way of representing data in computers as objects within a hierarchy. One frame, for example, could be called 'protein', with slots describing its relationships to other concepts, such as 'gene name', or 'post-translational modifications'. So when a u ...
Premature stop codons involved in muscular dystrophies
... CFTR gene. Similarly, a Hurler syndrome fibroblast cell line heterozygous for a stop mutation showed a significant increase in alpha-L-iduronidase when cultured in the presence of gentamicin.4,5 The strength of this approach was first demonstrated in vivo by the work of Barton-Davis and co-workers, ...
... CFTR gene. Similarly, a Hurler syndrome fibroblast cell line heterozygous for a stop mutation showed a significant increase in alpha-L-iduronidase when cultured in the presence of gentamicin.4,5 The strength of this approach was first demonstrated in vivo by the work of Barton-Davis and co-workers, ...
characterizing the genetic bases of autosomal recessive disorders
... Autosomal recessive disorders have devastating effects on patients and their families. Elucidating the genetic bases of such disorders is essential to improve their clinical outcome and for implementing effective prevention programs. In this dissertation, the genetic bases of seven autosomal recessi ...
... Autosomal recessive disorders have devastating effects on patients and their families. Elucidating the genetic bases of such disorders is essential to improve their clinical outcome and for implementing effective prevention programs. In this dissertation, the genetic bases of seven autosomal recessi ...
Parental Genome Separation and Elimination of Cells and
... Background and Aims The phenomenon of parental genome separation during the mitotic divisions of hybrid cells was proposed to occur under genetic control in intergeneric hybrids between cultivated Brassica species and Orychophragmus violaceus (2n = 24). To elucidate further the cytological and mol ...
... Background and Aims The phenomenon of parental genome separation during the mitotic divisions of hybrid cells was proposed to occur under genetic control in intergeneric hybrids between cultivated Brassica species and Orychophragmus violaceus (2n = 24). To elucidate further the cytological and mol ...
Genetics of Primary ciliary dyskinesia - HAL
... exons. So far, DNAH5 mutations have been found only in patients with partial or total loss of ODA associated or not with left-right asymmetry anomalies 34, 35. The DNAH5 mutation detection rate was shown to reach 49% in a subset of PCD families with documented ODA defects 35. A third candidate gene ...
... exons. So far, DNAH5 mutations have been found only in patients with partial or total loss of ODA associated or not with left-right asymmetry anomalies 34, 35. The DNAH5 mutation detection rate was shown to reach 49% in a subset of PCD families with documented ODA defects 35. A third candidate gene ...
Chromosomal Basis of Heredity
... 1. Mendelian inheritance has its physical basis in the behavior of chromosomes during sexual life cycles 2. Morgan traced a gene to a specific chromosome 3. Linked genes tend to be inherited together because they are located on the same chromosome 4. Independent assortment of chromosomes and crossin ...
... 1. Mendelian inheritance has its physical basis in the behavior of chromosomes during sexual life cycles 2. Morgan traced a gene to a specific chromosome 3. Linked genes tend to be inherited together because they are located on the same chromosome 4. Independent assortment of chromosomes and crossin ...
as Word 2000
... always successful unless the defending amoeba possesses Defense, Escape, or Armor. If the attack is successful unless the other amoeba possesses Defense, Escape, or Armor. If the attack is successful, the other amoeba is removed from the board. The attacker eats but does not excrete as normal. Inste ...
... always successful unless the defending amoeba possesses Defense, Escape, or Armor. If the attack is successful unless the other amoeba possesses Defense, Escape, or Armor. If the attack is successful, the other amoeba is removed from the board. The attacker eats but does not excrete as normal. Inste ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse