Genetic Associations of Obesity: The Fat-Mass and Obesity
... rs9939609 and pancreatic cancer is independent of obesity. It is not clear if the risk associated with this FTO variant is relevant outside of East Asian populations; however, given the significant mortality of pancreatic cancer, this topic should be further studied. 4. Bariatric surgery. The use of ...
... rs9939609 and pancreatic cancer is independent of obesity. It is not clear if the risk associated with this FTO variant is relevant outside of East Asian populations; however, given the significant mortality of pancreatic cancer, this topic should be further studied. 4. Bariatric surgery. The use of ...
Cover Page The handle http://hdl.handle.net/41480 holds
... data that can be matched to a reference genome. Although NGS is comparatively expensive, and resource-intensive, it can identify single-nucleotide polymorphisms, splice-variants, and novel genes, and can also be used to profile expression in organisms for which little or no sequence information is a ...
... data that can be matched to a reference genome. Although NGS is comparatively expensive, and resource-intensive, it can identify single-nucleotide polymorphisms, splice-variants, and novel genes, and can also be used to profile expression in organisms for which little or no sequence information is a ...
Evolution of multicellularity and sexuality in the life cycles of
... in the major lineages of red, green, and brown plants. Completed genomic sequences are newly available (and more are rapidly becoming available) for representative unicellular and multicellular species from the major photosynthetic lineages. Therefore, it has now become possible to address the grand ...
... in the major lineages of red, green, and brown plants. Completed genomic sequences are newly available (and more are rapidly becoming available) for representative unicellular and multicellular species from the major photosynthetic lineages. Therefore, it has now become possible to address the grand ...
Symbiotic DNA in eukaryotic genomes
... cleaves itself into separate proteins. The transcripts are copied into DNA by reverse transcriptase, and integrases then insert these copies into the chromosomes (Fig. 1). Retroviruses differ from retrotrans- . posons in their capacity for extracellular transmission. In addition to the gene products ...
... cleaves itself into separate proteins. The transcripts are copied into DNA by reverse transcriptase, and integrases then insert these copies into the chromosomes (Fig. 1). Retroviruses differ from retrotrans- . posons in their capacity for extracellular transmission. In addition to the gene products ...
Gene Codon Composition Determines Differentiation
... By establishing mouse primary keratinocytes (KCs) in culture, we were able, for the first time, to express papillomavirus major capsid (L1) proteins by transient transfection of authentic or codon-modified L1 gene expression plasmids. We demonstrate in vitro and in vivo that gene codon composition i ...
... By establishing mouse primary keratinocytes (KCs) in culture, we were able, for the first time, to express papillomavirus major capsid (L1) proteins by transient transfection of authentic or codon-modified L1 gene expression plasmids. We demonstrate in vitro and in vivo that gene codon composition i ...
BIO 141 PTC DNA Fingerprint Analysis
... DNA’s structure resembles a twisted ladder called the double helix. DNA in all organisms consists of four bases called guanine, adenine, thymine, and cytosine. The unique order or sequence of these bases in an individual’s cells serves as the blueprint for that individual. Of the approximately 3.3 b ...
... DNA’s structure resembles a twisted ladder called the double helix. DNA in all organisms consists of four bases called guanine, adenine, thymine, and cytosine. The unique order or sequence of these bases in an individual’s cells serves as the blueprint for that individual. Of the approximately 3.3 b ...
W0=2, a stable aneuploid derivative of Candida
... albicans has been the subject of intensive studies over ...
... albicans has been the subject of intensive studies over ...
Characterisation of a Non-canonical Genetic Code in
... canonical CAA and CAG codons, and by TAA and TAG codons. This is only the fifth lineage of eukaryotes known to employ a non-canonical genetic code in the nuclear genome, but already the fourth lineage where this particular variant is found. The recurrent evolution of this variant code in nuclear gen ...
... canonical CAA and CAG codons, and by TAA and TAG codons. This is only the fifth lineage of eukaryotes known to employ a non-canonical genetic code in the nuclear genome, but already the fourth lineage where this particular variant is found. The recurrent evolution of this variant code in nuclear gen ...
DNA Duplication Associated with Charcot-Marie-Tooth Disease Type 1A. Lupski, et al., 1991 Cell, Vol. 66, 219-232, July 26, 1991,
... (Figure 2A) and Ashkenazic Jewish (Figure 2B) descent have three copies of the Dl7Sl22 locus, suggesting a duplication of this locus in CMTlA patients. Genotypes for RMI I-GT for all seven CMTl A pedigrees are shown in Figure 1 and demonstrate that three RMI lGT alleles are present only in affected ...
... (Figure 2A) and Ashkenazic Jewish (Figure 2B) descent have three copies of the Dl7Sl22 locus, suggesting a duplication of this locus in CMTlA patients. Genotypes for RMI I-GT for all seven CMTl A pedigrees are shown in Figure 1 and demonstrate that three RMI lGT alleles are present only in affected ...
Nucleic acids and protein synthesis
... bases is fixed, and successive regions are related to each other by sym metry, but there is no restriction on which pair of bases occurs at any point t as long as one of the allowed pairs is used ...
... bases is fixed, and successive regions are related to each other by sym metry, but there is no restriction on which pair of bases occurs at any point t as long as one of the allowed pairs is used ...
Item 6 - NHS England
... A new networked genetic laboratory and genomic medicine service infrastructure – consolidated genomic laboratory infrastructure for rare, and inherited diseases and cancer operating to a defined service model, and a transitional role for the existing Genomic Medicine Centres to establish comprehensi ...
... A new networked genetic laboratory and genomic medicine service infrastructure – consolidated genomic laboratory infrastructure for rare, and inherited diseases and cancer operating to a defined service model, and a transitional role for the existing Genomic Medicine Centres to establish comprehensi ...
Automation of genomic DNA isolation from formalin
... consecutive 10 m thick sections) and unstained slides (four consecutive 5 m thick sections) obtained from the paraffin blocks of the tumor tissues. The tissue rolls were collected in 1.5 ml micro-centrifuge tubes (USA Scientific, FL, USA), and the unstained sections from slides were scraped using a ...
... consecutive 10 m thick sections) and unstained slides (four consecutive 5 m thick sections) obtained from the paraffin blocks of the tumor tissues. The tissue rolls were collected in 1.5 ml micro-centrifuge tubes (USA Scientific, FL, USA), and the unstained sections from slides were scraped using a ...
CHAPTER 15
... Sturtevant used the testcross design to map the relative positions of three fruit fly genes: body color (b), wing size (vg), and eye color (cn). o Cinnabar (cn), one of many Drosophila genes affecting eye color, results in a bright red eye. o The recombination frequency between cn and b is 9%. o The ...
... Sturtevant used the testcross design to map the relative positions of three fruit fly genes: body color (b), wing size (vg), and eye color (cn). o Cinnabar (cn), one of many Drosophila genes affecting eye color, results in a bright red eye. o The recombination frequency between cn and b is 9%. o The ...
The Chromosomal Basis of Inheritance
... Sturtevant used the testcross design to map the relative positions of three fruit fly genes: body color (b), wing size (vg), and eye color (cn). o Cinnabar (cn), one of many Drosophila genes affecting eye color, results in a bright red eye. o The recombination frequency between cn and b is 9%. o The ...
... Sturtevant used the testcross design to map the relative positions of three fruit fly genes: body color (b), wing size (vg), and eye color (cn). o Cinnabar (cn), one of many Drosophila genes affecting eye color, results in a bright red eye. o The recombination frequency between cn and b is 9%. o The ...
Genetics: the Breeder`s Blueprint
... homozygous for the brindle gene (they have 2 genes for brindle and carry no gene for fawn) will produce 100% brindle pups. Admittedly the above examples are overly simplified when compared to multigenetically controlled traits. There are other types of genes which behave in different ways. In order ...
... homozygous for the brindle gene (they have 2 genes for brindle and carry no gene for fawn) will produce 100% brindle pups. Admittedly the above examples are overly simplified when compared to multigenetically controlled traits. There are other types of genes which behave in different ways. In order ...
15.13 Spm elements influence gene expression
... 15.5 Transposons cause rearrangement of DNA 15.6 Common intermediates for transposition 15.7 Replicative transposition proceeds through a cointegrate 15.8 Nonreplicative transposition proceeds by breakage and reunion 15.9 TnA transposition requires transposase and resolvase 15.10 Transposition of Tn ...
... 15.5 Transposons cause rearrangement of DNA 15.6 Common intermediates for transposition 15.7 Replicative transposition proceeds through a cointegrate 15.8 Nonreplicative transposition proceeds by breakage and reunion 15.9 TnA transposition requires transposase and resolvase 15.10 Transposition of Tn ...
Figure 15.6 Nonreplicative transposition allows a transposon to
... orientation in the same molecule of DNA; they are not necessarily adjacent. Inverted terminal repeats are the short related or identical sequences present in reverse orientation at the ends of some transposons. IS is an abbreviation for insertion sequence Transposase is the enzyme activity involved ...
... orientation in the same molecule of DNA; they are not necessarily adjacent. Inverted terminal repeats are the short related or identical sequences present in reverse orientation at the ends of some transposons. IS is an abbreviation for insertion sequence Transposase is the enzyme activity involved ...
and Flowers of Arabidopsis thaliana
... These simple sets of meristematic choices thus provide a tool kit for plant architecture, and the choice made at any time by each meristem sums to the total form of the plant. Little is known about the control of pattem formation in SAMs and their derivatives, but one thing is clear: It depends very ...
... These simple sets of meristematic choices thus provide a tool kit for plant architecture, and the choice made at any time by each meristem sums to the total form of the plant. Little is known about the control of pattem formation in SAMs and their derivatives, but one thing is clear: It depends very ...
Discriminate the Falsely Predicted Protein–Coding Genes in
... The detailed annotating information of A. pernix K1 genome was downloaded from RefSeq [35]. The G+C content among the 1700 annotated potential protein-coding genes ranges from 32.6% to 72.4%. Among the 1700 annotated genes, 727 have validated functions, 132 are marked as putative genes, and the rest ...
... The detailed annotating information of A. pernix K1 genome was downloaded from RefSeq [35]. The G+C content among the 1700 annotated potential protein-coding genes ranges from 32.6% to 72.4%. Among the 1700 annotated genes, 727 have validated functions, 132 are marked as putative genes, and the rest ...
General background text Pharmacogenetics
... activity of the TPMT enzyme. This involves measuring TPMT activity in red blood cells, which correlates well with TPMT activity in the thiopurine target organ (white blood cells). Individual enzyme activity established in phenotyping depends on both genetic and environmental factors. There is signif ...
... activity of the TPMT enzyme. This involves measuring TPMT activity in red blood cells, which correlates well with TPMT activity in the thiopurine target organ (white blood cells). Individual enzyme activity established in phenotyping depends on both genetic and environmental factors. There is signif ...
Gene mapping and medical genetics Human chromosome 8
... opposite transcriptional orientation, that is, head to Human LPL cDNA clones have been isolated head. from adipose tissue and the complete sequence The less frequent or variant 2pll and 22q12 determined.108 Analysis of the sequence indicates breakpoints involve those chromosome segments that LIPD co ...
... opposite transcriptional orientation, that is, head to Human LPL cDNA clones have been isolated head. from adipose tissue and the complete sequence The less frequent or variant 2pll and 22q12 determined.108 Analysis of the sequence indicates breakpoints involve those chromosome segments that LIPD co ...
Supplementary Tutorial - WashU Epigenome Browser
... Open the “Track management” tab in the control panel to access the track selection grid (Supplementary Figure 2). By default, rows of the grid correspond to sequencing experiment sample names, and columns correspond to the type of assay (epigenetic marks). Name with “/” icon means the marks can be c ...
... Open the “Track management” tab in the control panel to access the track selection grid (Supplementary Figure 2). By default, rows of the grid correspond to sequencing experiment sample names, and columns correspond to the type of assay (epigenetic marks). Name with “/” icon means the marks can be c ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse