• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Complete mitochondrial genome of a natural triploid
Complete mitochondrial genome of a natural triploid

... Codon Usage program (http://www.entelechon.com). Most tRNA genes were identified by their proposed cloverleaf secondary structures using the web-based tRNAscan-SE v.1.21 software (http://lowelab.ucsc.edu/tRNAscan-SE/), which gave different cove score cut-off values to sequences (Lowe and Eddy, 1997) ...
TG - Science-with
TG - Science-with

... for every dihybrid cross that Mendel carried he got the 9:3:3:1 ratio (when he crossed the F1 generation). • this ratio is what is expected if the segregation of alleles for one gene had no influence on the segregation of alleles of another gene. Law of Independent Assortment • The two alleles of on ...
Patterns of Inheritance
Patterns of Inheritance

... • Refers to an allele which has more than one effect on the phenotype • Pleiotropic effects are difficult to predict, because a gene that affects one trait often performs other, unknown functions • This can be seen in human diseases such as cystic ...
DOCX 17 KB - Office of the Gene Technology Regulator
DOCX 17 KB - Office of the Gene Technology Regulator

... Our second choice is option 3. If a change to the GT Act is required to allow option 4 and that may not be possible currently, and a change to the GT Regulations can give us option 3 and that may be possible currently, then option 3 is a good compromise that gives us the ability to do our research. ...
Slide 1
Slide 1

... Summary of Basic Mendelian Genetics • We cannot predict with certainty the genotype or phenotype of any particular seed from the F2 generation of a dihybrid cross, but we can predict the probabilities that it will fit a specific genotype of phenotype. • Mendel’s experiments succeeded because he cou ...
Molecular and Cellular Biology, September 2000, p
Molecular and Cellular Biology, September 2000, p

... dependent activity of the histone H4 gene promoter (24, 43). All highly conserved nucleotide motifs in the consensus H4 site II sequence are absolutely conserved in the proximal promoter region of all known vertebrate H10 genes (Fig. 1B). These observations strongly suggest that at least in prolife ...
Probability
Probability

... the ability to roll the tongue. If a man who can roll his tongue and whose mother could not mates with a woman who cannot roll her tongue, what proportion of the children would be expected to be able to roll their tongues if they have a large number of children? What are the genotypes which are poss ...
Mystery of Heredity
Mystery of Heredity

... • Refers to an allele which has more than one effect on the phenotype • Pleiotropic effects are difficult to predict, because a gene that affects one trait often performs other, unknown functions • This can be seen in human diseases such as cystic ...
Ontologies (Susan McCouch) ()
Ontologies (Susan McCouch) ()

... Graham McLaren ...
Evolutionary biology looks at behavior genetics
Evolutionary biology looks at behavior genetics

... certain Class I and Class II major histocompatibility complex (MHC) genes, appear to work this way: All else equal, individuals may be better off when possessing a relatively rare form of immune defense, one that pathogens are not used to encountering. As a result of selection for alleles when they ...
Sex-Linked Problem Set
Sex-Linked Problem Set

... Alexis, was afflicted with the disease. Alexis and his four sisters are all thought to have been killed at the outbreak of the Revolution of 1917. Based on probability, what conclusions can be made regarding the children of Alexandria and Nicholas II? The situation is the same as in the previous que ...
Genetics - Mount Mansfield Union High School
Genetics - Mount Mansfield Union High School

... when an experiment is repeated an infinite number of times is the probability of the event. • Probabilities in genetics are often predicted based on certain hypotheses and then the predictions are used to test the hypothesis using real data. ...
Direct and indirect consequences of meiotic recombination
Direct and indirect consequences of meiotic recombination

... has also been discussed [20]. We refer to these processes as the direct effects of recombination (further details are presented in Box 1 and Figure 1). Although one of the advantages of the indirect effects of recombination is the efficient removal of deleterious alleles from a population, its direc ...
Bacterial Genetics
Bacterial Genetics

... g. Because the translational machinery recognized that this is the start of the mRNA molecule but the actual start of the gene starts here and it recognizes an ATG to translate the mRNA molecule to generate for example this alpha protein h. This is the promotor region which consists of -10 to -35 re ...
screening for genes involved in pathogenesis
screening for genes involved in pathogenesis

... attenuated in virulence on walnut (Figure 1) indicating that genes regulated by this locus are important in these phenotypes. Bacterial polymerases require the transient association of proteins called sigma factors for the initiation of transcription. Various sigma factors confer different specific ...
RNA Express Workflow - support.illumina.com
RNA Express Workflow - support.illumina.com

... converted to BAM files in real time with samtools2. There is no pre-treatment (trimming or filtering) of the FASTQ files. Instead a trim5’ and trim3’ option is passed to STAR, which does the trimming. In addition, STAR performs local alignment, allowing it to softclip read ends automatically (e.g. l ...
A Genetic Model for Colorectal Tumorigenesis Review
A Genetic Model for Colorectal Tumorigenesis Review

... seen in more than 75% of colorectal carcinomas (Vogelstein et al., 1988; Delattre et al., 1989) but such loss is relatively infrequent in adenomas of any stage (Figure 1). Moreover, in several patients the 17p allelic losses were found to be associated with the progression of individual tumors from ...
Ch 18
Ch 18

... Some viruses have envelopes that are not derived from plasma membrane.  The envelope of the herpesvirus is derived from the nuclear envelope of the host.  These double-stranded DNA viruses reproduce within the cell nucleus using viral and cellular enzymes to replicate and transcribe their DNA.  I ...
Gene duplications in prokaryotes can be
Gene duplications in prokaryotes can be

... GO was created as a tool to get a more unified and standard description of genes and their functions in eukaryotes and prokaryotes, in particular since it was found that a large fraction of genes specifying the core biological functions are shared among species. Gene products are described in terms ...
Document
Document

... Step 3A: Align Reads Using TopHat We will now align RNA-Seq reads to chr22 using mostly default parameters. Note: We are not providing gene information. TopHat will find splice junctions de novo. $ tophat –p 4 –o ctrl chr22 thrombin_control.txt # Run TopHAT using chr22 as reference and sequences in ...
Powerpoint for Bioinformatics course at CSULA
Powerpoint for Bioinformatics course at CSULA

... Bioinformatics isn’t going to replace lab work anytime soon Experimental proof is still the “Gold Standard”. ...
PDF sample
PDF sample

... swoop in to be paired up correctly with the lonely bases there. Adenines are connected to thymines; cytosines are paired with guanines. ...
7.L.2 - NHCS
7.L.2 - NHCS

... population. While this is sometimes true, it is not always the case. Physical traits are determined by specific segments of DNA called genes. Multiple genes are grouped toether to form chromosomes, which reside in the nucleus of the cell. Every cell (except eggs and sperm) in an individual’s body co ...
Depth-stratified functional and taxonomic niche
Depth-stratified functional and taxonomic niche

... to increase cyanophage fitness (Bragg and Chisholm, 2008), and commonly constitutes a large fraction of total psbA genes in marine microbial metagenomes (Sharon et al., 2007). Beyond elevating cyanophage fitness, these viral psbA gene copies alter the evolutionary trajectory of globally distributed ...
biology syllabus - prakashamarasooriya
biology syllabus - prakashamarasooriya

... 4.1 Chromosomes, genes, alleles and mutations ...
< 1 ... 281 282 283 284 285 286 287 288 289 ... 1288 >

Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
  • studyres.com © 2026
  • DMCA
  • Privacy
  • Terms
  • Report