
biology - LearnCOACH
... • Eat well • Sleep well • Do regular exercise and move around occasionally while studying It’s the basics that can make some of the biggest differences. ...
... • Eat well • Sleep well • Do regular exercise and move around occasionally while studying It’s the basics that can make some of the biggest differences. ...
Exceptionally high levels of recombination
... eukaryotes. The exceptionally high recombination rate is distributed genome-wide, but varies by two orders of magnitude. Analysis of chromosome, sequence, and gene parameters with respect to recombination showed that local recombination rate is associated with distance to the telomere, GC content, a ...
... eukaryotes. The exceptionally high recombination rate is distributed genome-wide, but varies by two orders of magnitude. Analysis of chromosome, sequence, and gene parameters with respect to recombination showed that local recombination rate is associated with distance to the telomere, GC content, a ...
1 Introduction
... predominantly in proliferating cells and is barely detectable in resting and differentiating cells, whereas topoisomerase IIβ is present in most if not all cells (Turley et al, 1997). ...
... predominantly in proliferating cells and is barely detectable in resting and differentiating cells, whereas topoisomerase IIβ is present in most if not all cells (Turley et al, 1997). ...
Polymorphisms of the bovine growth differentiation factor 9 gene
... optimal oocyte microenvironment, and synergistic action along with bone morphogenetic protein 15 through the regulation of several key granulosa cell enzymes that are essential for normal ovulation, fertilization, and female reproduction (Eppig et al., 1997; Yan et al., 2001; McNatty et al., 2005). ...
... optimal oocyte microenvironment, and synergistic action along with bone morphogenetic protein 15 through the regulation of several key granulosa cell enzymes that are essential for normal ovulation, fertilization, and female reproduction (Eppig et al., 1997; Yan et al., 2001; McNatty et al., 2005). ...
[PDF]
... 2400DLuc (Fig 1A). The tissue specific expression pattern of promoter deletion constructs was reported previously (Sun et al., 2000). The expression pattern for each construct was same among the founder lines. With the 234Luc transgene, low-level expression of luciferase was found only in the CNS, w ...
... 2400DLuc (Fig 1A). The tissue specific expression pattern of promoter deletion constructs was reported previously (Sun et al., 2000). The expression pattern for each construct was same among the founder lines. With the 234Luc transgene, low-level expression of luciferase was found only in the CNS, w ...
Chapter 11 - Chromosome Mutations
... allopolyploidy: some sets of chromosomes originate from different species nondisjunction: the failure of homologues (at meiosis) or sister chromatids (at mitosis) to separate properly to opposite poles monosomic: a cell or individual that is basically diploid but that has only one copy of one partic ...
... allopolyploidy: some sets of chromosomes originate from different species nondisjunction: the failure of homologues (at meiosis) or sister chromatids (at mitosis) to separate properly to opposite poles monosomic: a cell or individual that is basically diploid but that has only one copy of one partic ...
Worm research hits the fast lane
... we can map out what phenotype is observed when that gene is silenced,” says Yanik. The same methodology can also be used to perform drug and compound screens. He is also looking to extrapolate this technology to other model organisms, such as zebrafish and others that grow in liquid culture. “But we ...
... we can map out what phenotype is observed when that gene is silenced,” says Yanik. The same methodology can also be used to perform drug and compound screens. He is also looking to extrapolate this technology to other model organisms, such as zebrafish and others that grow in liquid culture. “But we ...
MicroRNA Analysis
... Argonaute collects latest information from both literature and other databases. In contrast to databases on miRNAs like miRBase::Sequences, NONCODE or RNAdb, Argonaute hosts additional information on the origin of an miRNA, i.e. in which host gene it is encoded, its expression in different tissues a ...
... Argonaute collects latest information from both literature and other databases. In contrast to databases on miRNAs like miRBase::Sequences, NONCODE or RNAdb, Argonaute hosts additional information on the origin of an miRNA, i.e. in which host gene it is encoded, its expression in different tissues a ...
Genetic Testing in Male Infertility
... infertility and idiopathic RSA as DNA damage in the sperm can be transmitted to the offspring and may potentially increase the risk for transgenerational infertility or other serious health problems such as congenital malformations and childhood cancer [4]. Genetic screening includes cytogenetic ana ...
... infertility and idiopathic RSA as DNA damage in the sperm can be transmitted to the offspring and may potentially increase the risk for transgenerational infertility or other serious health problems such as congenital malformations and childhood cancer [4]. Genetic screening includes cytogenetic ana ...
clinchem.org - Clinical Chemistry
... deletions or duplications and decreases costs because it does not require expensive fluorescent reagents. © 2006 American Association for Clinical Chemistry ...
... deletions or duplications and decreases costs because it does not require expensive fluorescent reagents. © 2006 American Association for Clinical Chemistry ...
CHAPTER 15 Non-Mendelian Inheritance
... 3. Yeast crosses between petite and wild-type cells (a X α crosses) determine the mechanism of inheritance for this phenotype. a. The zygote formed from mating is grown into a colony to check its phenotype, and when it sporulates by meiosis, the tetrad of ascospores can also be grown into colonies f ...
... 3. Yeast crosses between petite and wild-type cells (a X α crosses) determine the mechanism of inheritance for this phenotype. a. The zygote formed from mating is grown into a colony to check its phenotype, and when it sporulates by meiosis, the tetrad of ascospores can also be grown into colonies f ...
Slide 1
... • Genetic disorder of connective tissue • Due to mutation in one of several genes that encode different types of collagen proteins that are important ingredients of connective tissue of the eye, ear, cartilage, and other tissues. ...
... • Genetic disorder of connective tissue • Due to mutation in one of several genes that encode different types of collagen proteins that are important ingredients of connective tissue of the eye, ear, cartilage, and other tissues. ...
Recombination and clonal groupings within Helicobacter pylori from
... branches of a maximum parsimony phylogenetic tree (homoplasies). Homoplasies are caused by horizontal DNA transfer between unrelated strains (recombination) or by independent mutations. The homoplasy test calculates the H ratio, the frequency of observed synonymous homoplasies relative to the freque ...
... branches of a maximum parsimony phylogenetic tree (homoplasies). Homoplasies are caused by horizontal DNA transfer between unrelated strains (recombination) or by independent mutations. The homoplasy test calculates the H ratio, the frequency of observed synonymous homoplasies relative to the freque ...
Evolution of Gene Order and Chromosome Number in
... genome duplication. They appear to be rare, because the chromosomes of the other species of Saccharomyces sensu stricto (S. paradoxus, S. bayanus, S. pastorianus) are generally collinear with those of S. cerevisiae. Ryu et al. (1996) mapped one legitimate reciprocal translocation of this type, betwe ...
... genome duplication. They appear to be rare, because the chromosomes of the other species of Saccharomyces sensu stricto (S. paradoxus, S. bayanus, S. pastorianus) are generally collinear with those of S. cerevisiae. Ryu et al. (1996) mapped one legitimate reciprocal translocation of this type, betwe ...
as a PDF - CiteSeerX
... homologous recombination and is also likely to affect recombination between diverged DNAs. For example, altered semiconservative replication in yeast DNA polymerase mutants can increase homologous recombination severalfold in a variety of systems, although the reason remains unclear (3, 28). Long in ...
... homologous recombination and is also likely to affect recombination between diverged DNAs. For example, altered semiconservative replication in yeast DNA polymerase mutants can increase homologous recombination severalfold in a variety of systems, although the reason remains unclear (3, 28). Long in ...
Neutral lipid storage disease with subclinical myo
... biopsy performed to unravel the cause of the hyperCKemia revealed massive TG storage, which was not confined to skeletal muscle, but also involved peripheral blood granulocytes and cultured skin fibroblasts. Proton spectroscopy showed excessive intracellular TG in the heart and, to a lesser extent, in ...
... biopsy performed to unravel the cause of the hyperCKemia revealed massive TG storage, which was not confined to skeletal muscle, but also involved peripheral blood granulocytes and cultured skin fibroblasts. Proton spectroscopy showed excessive intracellular TG in the heart and, to a lesser extent, in ...
Slide 1
... Chapter 13 Genetics and Biotechnology Section 1: Applied Genetics Section 2: DNA Technology ...
... Chapter 13 Genetics and Biotechnology Section 1: Applied Genetics Section 2: DNA Technology ...
- Opus: Online Publications Store
... Recombination is ubiquitous in multicellular plants, animals and even fungi. Many studies have shown that recombination can generate a great amount of genetic innovations, but it is also believed to damage well-adapted lineages, causing debates over how organisms cope with such disruptions. Using an ...
... Recombination is ubiquitous in multicellular plants, animals and even fungi. Many studies have shown that recombination can generate a great amount of genetic innovations, but it is also believed to damage well-adapted lineages, causing debates over how organisms cope with such disruptions. Using an ...
Article 1 Title: The pseudoautosomal regions of the U/V sex
... chromosomes occur only in females and males, respectively (in contrast with the X, for example, which can occur in males and females). At present however, few empirical data are available for haploid sexual systems to test these various predictions. We have recently shown that the UV sex chromosomes ...
... chromosomes occur only in females and males, respectively (in contrast with the X, for example, which can occur in males and females). At present however, few empirical data are available for haploid sexual systems to test these various predictions. We have recently shown that the UV sex chromosomes ...
Two-Exon Skipping Due to a Point Mutation in p67
... known, the low matching scores of the splicing sequences to the consensus atthe acceptorsite of intron7 and the mutated splice donorsite of intron 9in thepresent case seem to affect site recognition. Shapiro and Senapathy” proposed that such matching scores area useful wayto predictrecognition of th ...
... known, the low matching scores of the splicing sequences to the consensus atthe acceptorsite of intron7 and the mutated splice donorsite of intron 9in thepresent case seem to affect site recognition. Shapiro and Senapathy” proposed that such matching scores area useful wayto predictrecognition of th ...
Prostate Cancer – a genetic puzzle.
... correct instructions or "code" for making its protein so that the protein can perform the proper function for the cell. • The code for these instructions is found in the DNA – the DNA makes us unique ...
... correct instructions or "code" for making its protein so that the protein can perform the proper function for the cell. • The code for these instructions is found in the DNA – the DNA makes us unique ...
Site-specific recombinase technology

Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse