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Fungal cell wall chitinases and glucanases
Fungal cell wall chitinases and glucanases

... known to have roles during morphogenesis but no biochemical function had been identified for these proteins until Mouyna et al. (2000a) demonstrated that recombinant Gas1p, Phr1p and Phr2p each has 1,3-b-glucanosyltransferase activity similar to that of A. fumigatus Gel1p. Furthermore, expression of ...
FOXP2: the language gene
FOXP2: the language gene

... • Lai and colleagues studied the KE family in which a severe speech and language disorder is transmitted as an autosomal dominant single-gene trait. • Affected family members have a severe impairment in the selection and sequencing of fine orofacial movements, which are necessary for articulation. ...
Forward to the special issue on Hox/Tale transcription factors in
Forward to the special issue on Hox/Tale transcription factors in

... vivo are also discussed, and these studies are put into the context of more general transcriptional regulatory mechanisms. To date, a myriad of studies have highlighted various domains and motifs within the Hox proteins that control their functional properties. One important limit of our understandi ...
A Role for Endogenous Transforming Growth Factor 1 in
A Role for Endogenous Transforming Growth Factor 1 in

... mice does not result from the inflammatory syndrome that causes the demise of these animals, and cannot be attributed simply to delayed development. Discussion TGF-b1 2/2 mice represent the first animal model in which an absolute deficiency of LC (or other nonlymphoid DC) has been identified. Decrea ...
Ch15ChromoBasisInheritance
Ch15ChromoBasisInheritance

...  M onosomy X or X0 1 in every 5000 births  varied degree of effects  webbed neck  short stature  sterile ...
Class XII biology Worksheet genetics and evolution
Class XII biology Worksheet genetics and evolution

... to become functional. D’09 According to Hardy-Weinberg’s principle the allele frequency of a population remains constant. How do you interpret the change of frequency of alleles in a population? AI’09 When and at what end does the ‘tailing’ of hnRNA take place? AI’09 At which ends do ‘ capping’ and ...
Cluster analysis
Cluster analysis

... A reliable and precise classification of tumours is essential for successful diagnosis and treatment of cancer. Current methods for classifying human malignancies rely on a variety of morphological, clinical, and molecular variables. In spite of recent progress, there are still uncertainties in diag ...
Ch14_Genetics
Ch14_Genetics

... • Third: if the two alleles at a locus differ, then one (the dominant allele) determines the organism’s appearance, and the other (the recessive allele) has no noticeable effect on appearance • In the flower-color example, the F1 plants had purple flowers because the allele for that trait is ...
Organ system heterogeneity DB: a database for
Organ system heterogeneity DB: a database for

... heterogeneity value or distance to the first entity. For an entity of interest, additional information related to its organ system distribution and more details on its phenotypes at the HLT level linked to the different organ systems can be retrieved by following the ‘Select’ link on the right. Inte ...
Controlling morpholino experiments: don`t stop making antisense
Controlling morpholino experiments: don`t stop making antisense

... Judith S. Eisen1 and James C. Smith2,* ...
Haploid embryonic stem cells serve as a new tool for mammalian
Haploid embryonic stem cells serve as a new tool for mammalian

... other cell types is also essential. The generation of monkey phES cells suggests that haploid ES cells are also tolerated in primates, and thus it is valuable to derive human haploid ES cells in the future. Also, although monkey haploid ES cells should be useful in primate gene function research and ...
PDF - Journal of Cancer Metastasis and Treatment
PDF - Journal of Cancer Metastasis and Treatment

... role in working against tumors.[29] T-lymphocyte, especially T killer cell, is the most important in defending cells against tumors. CTLA-4 molecule expresses on T-lymphocyte as an inhibitor and plays different roles in T-cell activity. It could inhibit amplification of T cells or even induce apopto ...
BISC403 Genetic and Evolutionary Biology Spring, 2011 May 16
BISC403 Genetic and Evolutionary Biology Spring, 2011 May 16

... plasmid carrying the lac operon. If the genotype of this cell for these five genes is - + + + - + - c + + (I p o Z Y /I p o Z Y ), what will be the phenotype for ß-galactosidase expression? inducible constitutive absent (not expressed under any conditions) the same as lactose permease expression Con ...
Physical Mapping of a 670-kb Region of Chromosomes XVI and XVII
Physical Mapping of a 670-kb Region of Chromosomes XVI and XVII

... loci h49 and jl8 were located near a telomeric region, agarose blocks containing whole chromosomal T. cruzi DNA were incubated with increasing amounts of exonuclease Bal31 following digestion with SfiI restriction enzyme (Fig. 3). The loci h49 were located in two SfiI fragments of 350 kb and 450 kb ...
Postdoctoral Fellowship - CSOF4
Postdoctoral Fellowship - CSOF4

... initiated at CSIRO led to the discovery and characterisation of a new mutant gene in wheat which results in reduced stem growth late in development but which does not compromise early growth. Agronomic assessments have shown that the gene has good potential to replace conventional DELLA dwarfing gen ...
Genes: Structure, Replication, and Mutation
Genes: Structure, Replication, and Mutation

... 7. Most bacterial genes have at least four major parts, each with different functions: promoters, leaders, coding regions, and trailers. 8. Mutations are stable, heritable alterations in the gene sequence and usually, but not always, produce phenotypic changes. Nucleic acids are altered in several d ...
Application No. DIR 108 SUMMARY INFORMATION
Application No. DIR 108 SUMMARY INFORMATION

... All GM InVigor® x Roundup Ready® canola lines proposed for commercial release contain genes conferring tolerance to the herbicides glufosinate-ammonium and glyphosate. In addition, some GM InVigor® x Roundup Ready® lines may contain genes conferring a hybrid breeding system and/or an antibiotic resi ...
The Basques in Europe: a genetic analysis.
The Basques in Europe: a genetic analysis.

... etc., are the major source of data for measuring variations in extant human populations. Blood types and electrophoretic variants are genetically controlled markers, i.e. their transmission from one generation to the following one and their distribution in different populations can be predicted by p ...
Transcriptional profiling of wheat caryopsis development using
Transcriptional profiling of wheat caryopsis development using

... Triticum aestivum cv. Bobwhite was grown to maturity in 10-inch pots (6 plants per pot) in the greenhouse with maximum daytime temperature of 24C and minimum nighttime temperature of 17C. Natural light was supplemented with 100 W high-pressure sodium lights to maintain a day length of 16 h. Plants ...
Meiosis - Montville.net
Meiosis - Montville.net

... • The sexual life cycle in animals involves meiosis ...
Gene Section DLX6 (distal-less homeobox 6) Atlas of Genetics and Cytogenetics
Gene Section DLX6 (distal-less homeobox 6) Atlas of Genetics and Cytogenetics

The linear chromosome of the plant
The linear chromosome of the plant

... and psyllids (Psyllidae) [1]. Phytoplasmas were recently assigned to the novel provisional genus Candidatus Phytoplasma [2]. They represent a monophyletic group within the class Mollicutes (trivial name mycoplasmas), which has evolved from Gram-positive bacteria [3]. Mycoplasmas are among the smalle ...
The Diversity of Life
The Diversity of Life

... dominant ...
Biochemistry and Genetics of Tay-Sachs Disease
Biochemistry and Genetics of Tay-Sachs Disease

... splicing and consequent instability of the mRNA. 42 The effective result was absence of normal mRNA and, therefore, the absence of the a-subunit product. More significant than the actual identification of the mutation was the remarkable discovery that it was not the only one responsible for the infa ...
Triple-hit lymphoma
Triple-hit lymphoma

... lymphoma was diagnosed using morphology, flow cytometry, immunochemistry, and cytogenetics. Since many triple-hit lymphomas have not been documented in the literature, it is important to bring attention to this entity, as this lymphoma has different prognostic and therapeutic implications than other ...
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Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
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