Extrapolation to the whole human genome
... pseudogenes based on whether there is a continuous span of homology that is >70% of the length of the closest matching human protein (i.e. with introns removed), or whether there is evidence of polyadenylation. We have applied our approach to chromosomes 21 and 22, the first parts of the human genom ...
... pseudogenes based on whether there is a continuous span of homology that is >70% of the length of the closest matching human protein (i.e. with introns removed), or whether there is evidence of polyadenylation. We have applied our approach to chromosomes 21 and 22, the first parts of the human genom ...
Identification of novel micro RNAs and their targets in Cocos
... contains the genes required for reverse transcriptase, integrase and gag (Wilhelm and Wilhelm.,2001). The gene that had Copia like transposons has blast match to gag pol protein from Glycine max and previous findings support the existence of SIRI, a copia/Ty1-like retrotransposon element encoding a ...
... contains the genes required for reverse transcriptase, integrase and gag (Wilhelm and Wilhelm.,2001). The gene that had Copia like transposons has blast match to gag pol protein from Glycine max and previous findings support the existence of SIRI, a copia/Ty1-like retrotransposon element encoding a ...
No more than 14: the end of the amphioxus Hox cluster
... Since Edward Lewis discovery of the Bithorax complex of Drosophila [1], the Hox gene cluster has captivated the imagination of developmental and evolutionary biologists. Hox genes are a subclass of homeobox transcription factors deeply involved in the regulation of body patterning in metazoans [2]. ...
... Since Edward Lewis discovery of the Bithorax complex of Drosophila [1], the Hox gene cluster has captivated the imagination of developmental and evolutionary biologists. Hox genes are a subclass of homeobox transcription factors deeply involved in the regulation of body patterning in metazoans [2]. ...
A novel C. elegans zinc finger transcription factor, lsy
... family. For example, in adult animals, the gcy-7 gene is exclusively expressed in ASEL, whereas the gcy-5 gene is exclusively expressed in ASER (Fig. 1). The expression of these two terminally differentiated states requires the activity of a set of gene regulatory factors that interact with one anot ...
... family. For example, in adult animals, the gcy-7 gene is exclusively expressed in ASEL, whereas the gcy-5 gene is exclusively expressed in ASER (Fig. 1). The expression of these two terminally differentiated states requires the activity of a set of gene regulatory factors that interact with one anot ...
Document
... • For example: Human Blood Types (ABO blood groups) • Blood cells have a carbohydrate marker that is found on the surface of red blood cells. • These markers are called: A substance or B substance. • They are recognized by antibodies present in the blood serum of individuals for foreign carbohydrate ...
... • For example: Human Blood Types (ABO blood groups) • Blood cells have a carbohydrate marker that is found on the surface of red blood cells. • These markers are called: A substance or B substance. • They are recognized by antibodies present in the blood serum of individuals for foreign carbohydrate ...
1st set of Journal Clubs this Wednesday!
... Negative control: ‘Brake in car is on unless something causes it to be released.’ Positive control: ‘An activator causes the accelerator pedal to be pushed.’ Cis-acting sequence: Can only function if on same piece of DNA that its regulating Trans-acting factor: A gene product that can act in ‘trans’ ...
... Negative control: ‘Brake in car is on unless something causes it to be released.’ Positive control: ‘An activator causes the accelerator pedal to be pushed.’ Cis-acting sequence: Can only function if on same piece of DNA that its regulating Trans-acting factor: A gene product that can act in ‘trans’ ...
A Maize Glutaredoxin Gene, Abphyl2, Regulates
... was nearly 2-fold that of the wild type (96 6 12 mm, n = 17, P < 0.0001) (Figure 1J). We introgressed Abph2 into various inbred lines, and the decussate phenotype was maintained in B73 and A619, whereas it became weaker in W22, W23, and Mo17 backgrounds. Interestingly, Abph2 showed stronger expressi ...
... was nearly 2-fold that of the wild type (96 6 12 mm, n = 17, P < 0.0001) (Figure 1J). We introgressed Abph2 into various inbred lines, and the decussate phenotype was maintained in B73 and A619, whereas it became weaker in W22, W23, and Mo17 backgrounds. Interestingly, Abph2 showed stronger expressi ...
Increasing the denaturation temperature during the first cycles of
... Although preferential amplification of a particular allele sometimes occurs with conventional PCR, often because of size differences in the amplified fragments (Walsh et al., 1992), random ADO has not been reported with non-limiting target DNA. It seems likely, therefore, that ADO is specific for si ...
... Although preferential amplification of a particular allele sometimes occurs with conventional PCR, often because of size differences in the amplified fragments (Walsh et al., 1992), random ADO has not been reported with non-limiting target DNA. It seems likely, therefore, that ADO is specific for si ...
Genomics Reveal Ancient Forms of Stanniocalcin in Amphioxus and
... homologs both shared moderate (450%) amino-acid identity with their fish counterparts, as well as the conserved structural features. The expression of mammalian stanniocalcin was widespread throughout both endocrine and non-endocrine tissues, leading to the suggestion that it might serve a more auto ...
... homologs both shared moderate (450%) amino-acid identity with their fish counterparts, as well as the conserved structural features. The expression of mammalian stanniocalcin was widespread throughout both endocrine and non-endocrine tissues, leading to the suggestion that it might serve a more auto ...
Word - The Open University
... The Acknowledgements section is also used to bring to your attention any other Special Restrictions which may apply to the content. For example there may be times when the Creative Commons Non-Commercial Sharealike licence does not apply to any of the content even if owned by us (The Open University ...
... The Acknowledgements section is also used to bring to your attention any other Special Restrictions which may apply to the content. For example there may be times when the Creative Commons Non-Commercial Sharealike licence does not apply to any of the content even if owned by us (The Open University ...
Supercoils in plant DNA: nucleoid
... No similar studies aimed at the elucidation of the higher order organization of nuclear DNA in plants have been conducted. Plants share many common features with the other eukaryotes, but there are also many peculiarities distinguishing them. For example, they possess unusually large genomes, highly ...
... No similar studies aimed at the elucidation of the higher order organization of nuclear DNA in plants have been conducted. Plants share many common features with the other eukaryotes, but there are also many peculiarities distinguishing them. For example, they possess unusually large genomes, highly ...
WGCNA: an R package for weighted correlation network analysis
... for calculating module membership measures. Correlation networks facilitate network based gene screening methods that can be used to identify candidate biomarkers or therapeutic targets. These methods have been successfully applied in various biological contexts, e.g. cancer, mouse genetics, yeast g ...
... for calculating module membership measures. Correlation networks facilitate network based gene screening methods that can be used to identify candidate biomarkers or therapeutic targets. These methods have been successfully applied in various biological contexts, e.g. cancer, mouse genetics, yeast g ...
Detection of Large Expansions in SCA8 Using a Fluorescent Repeat
... sizes. However, these are not suitable for screening tests. Performing a combination of these examinations as a screening test is complex, cumbersome and time-consuming. On the other hand, there are many human genetic diseases that are caused by expansion of short tandem repeats. Since Warner et al ...
... sizes. However, these are not suitable for screening tests. Performing a combination of these examinations as a screening test is complex, cumbersome and time-consuming. On the other hand, there are many human genetic diseases that are caused by expansion of short tandem repeats. Since Warner et al ...
10.1 - My Haiku
... 10.1.U7 Independent assortment of genes is due to the random orientation of pairs of homologous chromosomes in meiosis I. “The presence of an allele of one of the genes in a gamete has no influence over which allele of another gene is present.” ...
... 10.1.U7 Independent assortment of genes is due to the random orientation of pairs of homologous chromosomes in meiosis I. “The presence of an allele of one of the genes in a gamete has no influence over which allele of another gene is present.” ...
TBK1 Gene Duplication and Normal
... NTG patients (0.62%) were found to carry TBK1 gene duplications, whereas no such mutations were identified in 1116 controls. TBK1 duplications have been detected in African American, white, and Asian NTG patients, suggesting that although these mutations are rare, they may be found worldwide. Moreov ...
... NTG patients (0.62%) were found to carry TBK1 gene duplications, whereas no such mutations were identified in 1116 controls. TBK1 duplications have been detected in African American, white, and Asian NTG patients, suggesting that although these mutations are rare, they may be found worldwide. Moreov ...
Document
... Allelic heterogeneity t it Allelic heterogeneity • Allelic heterogeneity is an important cause of clinical variation. Many loci possess more than one mutant allele; in fact, at a given locus there may be several or many mutations. Sometimes, these different mutations result in clinically indisting ...
... Allelic heterogeneity t it Allelic heterogeneity • Allelic heterogeneity is an important cause of clinical variation. Many loci possess more than one mutant allele; in fact, at a given locus there may be several or many mutations. Sometimes, these different mutations result in clinically indisting ...
Genetic control of broad-spectrum resistance to turnip mosaic virus
... B1S1 families were derived were surveyed to identify loci exhibiting an excess of homozygotes. Four loci at the top of R4 (pN220e3, pW205e1, pN202e1 and pW103e2) were homozygous in all 19 B1 individuals and this degree of linkage was highly significant (x2519, P51.3161025). However, ten B1 individua ...
... B1S1 families were derived were surveyed to identify loci exhibiting an excess of homozygotes. Four loci at the top of R4 (pN220e3, pW205e1, pN202e1 and pW103e2) were homozygous in all 19 B1 individuals and this degree of linkage was highly significant (x2519, P51.3161025). However, ten B1 individua ...
$doc.title
... is the gene product of the ntrC gene. Moreover, it is not just the NtrC (NRI) that is required, because NRI has to be activated into NRI -phosphate by becoming phosphorylated. NRI is a DNA binding protein which, when phosphorylated binds to specific sequences of DNA and confers initiation activity o ...
... is the gene product of the ntrC gene. Moreover, it is not just the NtrC (NRI) that is required, because NRI has to be activated into NRI -phosphate by becoming phosphorylated. NRI is a DNA binding protein which, when phosphorylated binds to specific sequences of DNA and confers initiation activity o ...
Boundary elements and nuclear organization
... (CCCTC-binding factor), an evolutionarily conserved protein implicated in the activity of most described vertebrate boundary elements and thought to be necessary for the enhancer-blocking activity of HS4 (Bell et al., 1999). Recently, a detailed molecular characterization of the b-globin 54 kb regio ...
... (CCCTC-binding factor), an evolutionarily conserved protein implicated in the activity of most described vertebrate boundary elements and thought to be necessary for the enhancer-blocking activity of HS4 (Bell et al., 1999). Recently, a detailed molecular characterization of the b-globin 54 kb regio ...
PDF
... genes (Kawasaki et al., 1999; Martindale, 2005). Recently, it has been reported that some organizer genes, including nog, chd and gsc, are expressed in the Nematostella gastrula, but their spatiotemporal expression patterns are not like those of their vertebrate counterparts (Matus et al., 2006). In ...
... genes (Kawasaki et al., 1999; Martindale, 2005). Recently, it has been reported that some organizer genes, including nog, chd and gsc, are expressed in the Nematostella gastrula, but their spatiotemporal expression patterns are not like those of their vertebrate counterparts (Matus et al., 2006). In ...
pdf - Open Textbooks Project
... Genetics is the study of heredity. Johann Gregor Mendel set the framework for genetics long before chromosomes or genes had been identified, at a time when meiosis was not well understood. Mendel selected a simple biological system and conducted methodical, quantitative analyses using large sample s ...
... Genetics is the study of heredity. Johann Gregor Mendel set the framework for genetics long before chromosomes or genes had been identified, at a time when meiosis was not well understood. Mendel selected a simple biological system and conducted methodical, quantitative analyses using large sample s ...
Environmental Microbiology
... mechanism of phase variation (van der Woude et al., 1996; Henderson et al., 1999). Methylation of GATC sites in the genome is dependent on deoxyadenosine methylase (dam), which binds to the GATC site and methylates adenosine at the N6 position (Palmer and Marinus, 1994). Normally, methylation provid ...
... mechanism of phase variation (van der Woude et al., 1996; Henderson et al., 1999). Methylation of GATC sites in the genome is dependent on deoxyadenosine methylase (dam), which binds to the GATC site and methylates adenosine at the N6 position (Palmer and Marinus, 1994). Normally, methylation provid ...
How does chromosome behavior account for Mendel`s Principles ?
... A geneticist wants to map the position of three dominant/recessive allele pairs (A/a, B/b, and F/f) relative to each other in D. melanogaster (fruit flies). For simplicity let’s say all the dominant alleles are on the same chromosome. Where should she begin? 1. Do AaBb x aabb and look for recombinan ...
... A geneticist wants to map the position of three dominant/recessive allele pairs (A/a, B/b, and F/f) relative to each other in D. melanogaster (fruit flies). For simplicity let’s say all the dominant alleles are on the same chromosome. Where should she begin? 1. Do AaBb x aabb and look for recombinan ...
1 Haploinsufficient loss of multiple 5q genes may
... Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series. Blood. 2003;102(1):43-52. ...
... Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series. Blood. 2003;102(1):43-52. ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse