MetaXcan: Summary Statistics Based Gene-Level
... Over the last decade, GWAS have been successful in identifying genetic loci that robustly associate with multiple complex traits. However, the mechanistic understanding of these discoveries is still limited, hampering the translation of this knowledge into actionable targets. Studies of enrichment o ...
... Over the last decade, GWAS have been successful in identifying genetic loci that robustly associate with multiple complex traits. However, the mechanistic understanding of these discoveries is still limited, hampering the translation of this knowledge into actionable targets. Studies of enrichment o ...
THE EFFECT OF STRUCTURAL HETEROZYGOSITY ON
... nondisjunction proportional to quadrivalent frequency, one can estimate numerical nondisjunction to result in 1.2 percent of female gametes unbalanced for chromosome 3. Because quadrivalent frequency for chromosome 3 is reduced by the presence of Inversion 3a in the structurally hybrid allotetraploi ...
... nondisjunction proportional to quadrivalent frequency, one can estimate numerical nondisjunction to result in 1.2 percent of female gametes unbalanced for chromosome 3. Because quadrivalent frequency for chromosome 3 is reduced by the presence of Inversion 3a in the structurally hybrid allotetraploi ...
Disruption of an N-acetyltransferase gene in the
... in C1 and C8 appeared specific to Dazao, as mln shared the same genotype at these sites with another wild-type strain, Jingsong. We also detected an insertion in C7 of mln but not Dazao, but this mutation was found not to be mln specific after more wild-type and ...
... in C1 and C8 appeared specific to Dazao, as mln shared the same genotype at these sites with another wild-type strain, Jingsong. We also detected an insertion in C7 of mln but not Dazao, but this mutation was found not to be mln specific after more wild-type and ...
Genetic architecture and balancing selection: the life
... benefit from NFDS because their rarity allows them discreetly to access females, evading conflict. But the polymorphism of the three morphs seems to stem from a complex trade-off between sperm competition and male survival: faeders and satellites have poor survival compared with independents in cros ...
... benefit from NFDS because their rarity allows them discreetly to access females, evading conflict. But the polymorphism of the three morphs seems to stem from a complex trade-off between sperm competition and male survival: faeders and satellites have poor survival compared with independents in cros ...
Chromosomal Mutations - Virtual Learning Environment
... Duplicated genes are those, which are present in more than one copy in the haploid genome. Duplications can be dispersed or tandem. Dispersed duplications are found in a number of different locations while tandem duplications are found next to each other. Tandem duplications play a major role in evo ...
... Duplicated genes are those, which are present in more than one copy in the haploid genome. Duplications can be dispersed or tandem. Dispersed duplications are found in a number of different locations while tandem duplications are found next to each other. Tandem duplications play a major role in evo ...
the genetics of cell death - the Guo Lab!
... Drosophila melanogaster and mammals. a | In C. elegans, the adaptor protein CED-4 promotes the activation of the caspase CED-3. CED-4 activity is inhibited by the Bcl2 family member, CED-9. Various stimuli promote death by inducing tissue-specific expression of EGL-1, which disrupts CED-9 function. ...
... Drosophila melanogaster and mammals. a | In C. elegans, the adaptor protein CED-4 promotes the activation of the caspase CED-3. CED-4 activity is inhibited by the Bcl2 family member, CED-9. Various stimuli promote death by inducing tissue-specific expression of EGL-1, which disrupts CED-9 function. ...
Expression of the six chromate ion transporter
... homologues share 26–50 % amino acid sequence identity and 28–55 % sequence similarity among them (percentages for each homologous pair are presented in Table S2). Analysis of the genomic context of B. xenovorans chr genes showed that the chrA2 homologue, encoded on the megaplasmid replicon, forms pa ...
... homologues share 26–50 % amino acid sequence identity and 28–55 % sequence similarity among them (percentages for each homologous pair are presented in Table S2). Analysis of the genomic context of B. xenovorans chr genes showed that the chrA2 homologue, encoded on the megaplasmid replicon, forms pa ...
Practical Preimplantation Genetic Diagnosis
... of medicine, this is not yet a reality for most inherited conditions. Even with dramatic advancement in the field of gene therapy, there are not, unfortunately, many success stories to allow predicting its sound impact in the near future. Therefore, in the absence of radical treatment, prevention of ...
... of medicine, this is not yet a reality for most inherited conditions. Even with dramatic advancement in the field of gene therapy, there are not, unfortunately, many success stories to allow predicting its sound impact in the near future. Therefore, in the absence of radical treatment, prevention of ...
Genetics - Denton ISD
... e. Purebred refers to an organism with a pair of the same genes for a given trait (either dominant or recessive); this is known as being homozygous. f. Hybrid refers to an organism with two different genes for a trait (one dominant and one recessive); this is known as being heterozygous. ...
... e. Purebred refers to an organism with a pair of the same genes for a given trait (either dominant or recessive); this is known as being homozygous. f. Hybrid refers to an organism with two different genes for a trait (one dominant and one recessive); this is known as being heterozygous. ...
Genomic Organization of Evolutionarily Correlated Genes in
... positioning of evolutionarily correlated genes within Escherichia coli has recently been highlighted. To gain further insight into these different genetic organizations, we examined the compromise between chromosomal proximity and periodicity for all available eubacterial genomes by evaluating group ...
... positioning of evolutionarily correlated genes within Escherichia coli has recently been highlighted. To gain further insight into these different genetic organizations, we examined the compromise between chromosomal proximity and periodicity for all available eubacterial genomes by evaluating group ...
Inheritance and monhybrid
... Why do members of the same family look similar? Humans, like all organisms, inherit characteristics from their parents. How are characteristics passed on? 3 of 8 ...
... Why do members of the same family look similar? Humans, like all organisms, inherit characteristics from their parents. How are characteristics passed on? 3 of 8 ...
Mapping avirulence genes in the rice blast fungus Magnaporthe grisea
... genes. We have identified three genetically independent avirulence genes in M. grisea (AvrMedNoï-1, AvrIrat7-1, AvrKu86-1). Analysis of the segregation of avirulence towards a collection of rice cultivars suggests the occurrence of the same resistance gene in unrelated cultivars. In order to clone a ...
... genes. We have identified three genetically independent avirulence genes in M. grisea (AvrMedNoï-1, AvrIrat7-1, AvrKu86-1). Analysis of the segregation of avirulence towards a collection of rice cultivars suggests the occurrence of the same resistance gene in unrelated cultivars. In order to clone a ...
Project Title: Genetic Improvement of Photosynthetic Efficiency and
... associated with relevant developmental stages, total RNA samples will be collected and subjected to RNA seq based genome-wide profiling studies. From these genomic studies, in the context of genes specifically regulated differentially between the lines displaying photosynthetic efficiency compared t ...
... associated with relevant developmental stages, total RNA samples will be collected and subjected to RNA seq based genome-wide profiling studies. From these genomic studies, in the context of genes specifically regulated differentially between the lines displaying photosynthetic efficiency compared t ...
Kinds and Rates of Human Heritable Mutations
... in genes coding for globin polypeptides, constituents of hemoglobin. These approaches to identifying mutations are discussed in this chapter. The term “mutation rates” for particular types of mutations in specific regions of DNA is used frequently in this report. Mutation rates for different kinds o ...
... in genes coding for globin polypeptides, constituents of hemoglobin. These approaches to identifying mutations are discussed in this chapter. The term “mutation rates” for particular types of mutations in specific regions of DNA is used frequently in this report. Mutation rates for different kinds o ...
Neurogenetics User Manual
... ** All prices quoted are for NHS routine postnatal diagnostic tests, please contact the laboratory for price details on all other types of test. ***Please note that at present we have a backlog of samples waiting for NGS panel testing and the turnaround time for these tests is between 4 and 6 months ...
... ** All prices quoted are for NHS routine postnatal diagnostic tests, please contact the laboratory for price details on all other types of test. ***Please note that at present we have a backlog of samples waiting for NGS panel testing and the turnaround time for these tests is between 4 and 6 months ...
– findings from cross-species Anxiety genetics genome-wide approaches
... Anxiety disorders are complex diseases, which often occur in combination with major depression, alcohol use disorder, or general medical conditions. Anxiety disorders were the most common mental disorders within the EU states in 2010 with 14% prevalence. Anxiety disorders are triggered by environmen ...
... Anxiety disorders are complex diseases, which often occur in combination with major depression, alcohol use disorder, or general medical conditions. Anxiety disorders were the most common mental disorders within the EU states in 2010 with 14% prevalence. Anxiety disorders are triggered by environmen ...
... Identification and mapping of RAPD markers linked to the Rps1 locus. The screening of 400 decamer primers against the cultivar Williams (rps1-k) and its NIL Williams 82 (Rps1-k) resulted in the amplification of approximately 2,000 discrete DNA fragments ranging from 200 to 3,000 bp, with an average ...
CTSC and PapillonLefvre syndrome: detection of recurrent
... review of published mutations is presented in this update. Comparison of clinical features in affected families with the same mutation strongly confirm that identical mutations of the CTSC gene can give rise to multiple different phenotypes, making genotype–phenotype correlations difficult. Variable ...
... review of published mutations is presented in this update. Comparison of clinical features in affected families with the same mutation strongly confirm that identical mutations of the CTSC gene can give rise to multiple different phenotypes, making genotype–phenotype correlations difficult. Variable ...
Bladder Cancer: Allelic Deletions at and around the Retinoblastoma
... genetic instability of malignant cells. Any suggested pathogenetic pathway rests on sparse data. Although the simplicity of the “two-hit” model for tumor development built on inherited RB mutations is attractive, more events than two typically are suggested as important when tumor formation is model ...
... genetic instability of malignant cells. Any suggested pathogenetic pathway rests on sparse data. Although the simplicity of the “two-hit” model for tumor development built on inherited RB mutations is attractive, more events than two typically are suggested as important when tumor formation is model ...
Category 2000
... Peroxisome proliferator-activated receptor coactivator 1 (PPARGC1A) is a versatile coactivator with many functions, but is primarily involved in fat and energy metabolism. Therefore, it is a very interesting candidate gene for meat quality, which is one of the most important criteria in pig selectio ...
... Peroxisome proliferator-activated receptor coactivator 1 (PPARGC1A) is a versatile coactivator with many functions, but is primarily involved in fat and energy metabolism. Therefore, it is a very interesting candidate gene for meat quality, which is one of the most important criteria in pig selectio ...
Breeding and Selection in the Beef Herd
... therefore only possible through progeny testing. A major difficulty faced by beef producers is the problem of keeping the consumer happy. Consumers vary in their preferences and beef producers cannot satisfy changes in demand rapidly because beef production is in essence a long-term undertaking wher ...
... therefore only possible through progeny testing. A major difficulty faced by beef producers is the problem of keeping the consumer happy. Consumers vary in their preferences and beef producers cannot satisfy changes in demand rapidly because beef production is in essence a long-term undertaking wher ...
Genetic determination of yield related attributes in Brassica napus
... diallel is the set of all possible crosses between many genotypes i.e. they may be individuals, clones, homozygous lines etc. The diallel cross method is a stable and systematic experiment to investigate ...
... diallel is the set of all possible crosses between many genotypes i.e. they may be individuals, clones, homozygous lines etc. The diallel cross method is a stable and systematic experiment to investigate ...
simposi sobre infertilitat masculina: genètica i ambient
... aligns with its corresponding partner, or homolog, during the initial stages of meiosis. Each pair of chromosomes is then held together by means that are varied between species. Two of the most common mechanisms are the building of a protein lattice between the homologs known as the synaptonemal com ...
... aligns with its corresponding partner, or homolog, during the initial stages of meiosis. Each pair of chromosomes is then held together by means that are varied between species. Two of the most common mechanisms are the building of a protein lattice between the homologs known as the synaptonemal com ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse