Flexible expressed region analysis for RNA
... feature-level analysis. The package is available from Bioconductor at www.bioconductor.org/packages/ derfinder. INTRODUCTION The increased flexibility of RNA sequencing (RNA-seq) has made it possible to characterize the transcriptomes of a diverse range of experimental systems, including human tissu ...
... feature-level analysis. The package is available from Bioconductor at www.bioconductor.org/packages/ derfinder. INTRODUCTION The increased flexibility of RNA sequencing (RNA-seq) has made it possible to characterize the transcriptomes of a diverse range of experimental systems, including human tissu ...
Characterization of Star and its interactions with
... enhances the wing phenotype of Egfrtop mutations (J. Price and T. Schüpbach, personal communication). Here we present results that are consistent with the idea that Star and Egfr participate in a common signal transduction pathway. While the Drosophila embryo provides an ideal system for the analysi ...
... enhances the wing phenotype of Egfrtop mutations (J. Price and T. Schüpbach, personal communication). Here we present results that are consistent with the idea that Star and Egfr participate in a common signal transduction pathway. While the Drosophila embryo provides an ideal system for the analysi ...
Vitamin D receptor gene polymorphisms in type 1 diabetes mellitus
... including lymphocytes (activated T lymphocytes, B cells), antigen-presenting cells (including monocytes, macrophages, dendritic cells) and pancreatic islet cells [11–13]. Although many polymorphisms exist in the VDR gene, their effect on VDR protein function and signalling is unknown [14]. Based on ...
... including lymphocytes (activated T lymphocytes, B cells), antigen-presenting cells (including monocytes, macrophages, dendritic cells) and pancreatic islet cells [11–13]. Although many polymorphisms exist in the VDR gene, their effect on VDR protein function and signalling is unknown [14]. Based on ...
Evaluation of the phylogenetic position of the planctomycete
... (Nesbo et al., 2001; Daubin et al., 2001), the informational ribosomal and DNA-directed RNA polymerase genes seem to be the best-suited genes, encoding multisubunit proteins whose sequences can be concatenated to infer phylogeny. In addition, it has been demonstrated recently that the extent to whic ...
... (Nesbo et al., 2001; Daubin et al., 2001), the informational ribosomal and DNA-directed RNA polymerase genes seem to be the best-suited genes, encoding multisubunit proteins whose sequences can be concatenated to infer phylogeny. In addition, it has been demonstrated recently that the extent to whic ...
Identification of Human Polymorphisms in the Phenylthio
... A PDF of a Microsoft Word file that contains the introduction in this paper, followed by a detailed protocol for the entire project – from DNA preparation to sequence analyses and project presentation - is also linked to this Web page. A list of reagents and instructions for their preparation is in ...
... A PDF of a Microsoft Word file that contains the introduction in this paper, followed by a detailed protocol for the entire project – from DNA preparation to sequence analyses and project presentation - is also linked to this Web page. A list of reagents and instructions for their preparation is in ...
Use of wheat gene resources with different grain colour in breeding
... and snow mould, and frequent drying of grain. Lines with purple pericarp often exhibit small grains, whereas their resistance to FHB is usually good. Back-crosses are used for the transmission of non-traditional colour into the genetic background of common wheat varieties. It will be important to un ...
... and snow mould, and frequent drying of grain. Lines with purple pericarp often exhibit small grains, whereas their resistance to FHB is usually good. Back-crosses are used for the transmission of non-traditional colour into the genetic background of common wheat varieties. It will be important to un ...
An extreme cytoplasmic bottleneck in the modern European
... levels of cytoplasmic and nuclear diversity in the gene pool of the European cultivated potato (Solanum tuberosum ssp. tuberosum). Primers designed from the complete chloroplast sequence of tobacco (Nicotiana tabacum) were used to amplify polymorphic products in a range of potato cultivars. Combinin ...
... levels of cytoplasmic and nuclear diversity in the gene pool of the European cultivated potato (Solanum tuberosum ssp. tuberosum). Primers designed from the complete chloroplast sequence of tobacco (Nicotiana tabacum) were used to amplify polymorphic products in a range of potato cultivars. Combinin ...
Thyroid Hormone and Adipocyte Differentiation
... was often included in the ‘‘differentiation cocktail.’’ In this way it is difficult to predict if the effects observed are due to the process of differentiation itself or to the action of the hormones added. During the adipose differentiation of 3T3F442A or 3T3-L1 cells, there is a large increase in ...
... was often included in the ‘‘differentiation cocktail.’’ In this way it is difficult to predict if the effects observed are due to the process of differentiation itself or to the action of the hormones added. During the adipose differentiation of 3T3F442A or 3T3-L1 cells, there is a large increase in ...
A genome-wide scan in affected sibling pairs with
... linkage analysis is based on the assumption that there is no LD in the analyzed data. Therefore r 2 is set at a particularly low level of 0.1. A total of 18 379 SNPs remained after cleaning. Complying with the MIAME standards, raw data are available through the ArrayExpress Archive: http://www.ebi.a ...
... linkage analysis is based on the assumption that there is no LD in the analyzed data. Therefore r 2 is set at a particularly low level of 0.1. A total of 18 379 SNPs remained after cleaning. Complying with the MIAME standards, raw data are available through the ArrayExpress Archive: http://www.ebi.a ...
A conserved blueprint for the eye? - treisman lab
... visual system and can bind to essential sites in the ey enhancer,(3,10) is a good candidate for such a factor. Expression of eya, so and dac in the eye disc begins in the second larval instar, prior to the onset of photoreceptor differentiation,(5,7,8) although so has an earlier role, independent of ...
... visual system and can bind to essential sites in the ey enhancer,(3,10) is a good candidate for such a factor. Expression of eya, so and dac in the eye disc begins in the second larval instar, prior to the onset of photoreceptor differentiation,(5,7,8) although so has an earlier role, independent of ...
P.Point Lecture Template - Green River Community College
... occurring even in the same family, have rarely been identified. We report on a family with four affected individuals, three brothers (B1–3) and their uncle, displaying strikingly different external genitalia: B1, ambiguous; B2, severe micropenis; B3, slight micropenis; and uncle, micropenis and peno ...
... occurring even in the same family, have rarely been identified. We report on a family with four affected individuals, three brothers (B1–3) and their uncle, displaying strikingly different external genitalia: B1, ambiguous; B2, severe micropenis; B3, slight micropenis; and uncle, micropenis and peno ...
Chromosome Variations
... but which contains cells with two or more different chromosome compositions. For instance, it is possible to be 46,XY / 45,X. Some cells are normal male (XY) cells, while others are Turner syndrome female cells. This is caused by chromosome loss or non-disjunction in one of the first few mitoses of ...
... but which contains cells with two or more different chromosome compositions. For instance, it is possible to be 46,XY / 45,X. Some cells are normal male (XY) cells, while others are Turner syndrome female cells. This is caused by chromosome loss or non-disjunction in one of the first few mitoses of ...
Cooperative Effects of Bacterial Mutations Affecting A N Gene
... A variant that can grow well in bacteria carrying either component mutation, Snu or nus -. The restrictive effect of the Supernus strain is far greater than would be expected if the restriction was due to an additive effect of the two component mutations. This implies that there might be an interact ...
... A variant that can grow well in bacteria carrying either component mutation, Snu or nus -. The restrictive effect of the Supernus strain is far greater than would be expected if the restriction was due to an additive effect of the two component mutations. This implies that there might be an interact ...
Marfan syndrome in the third Millennium
... Neonatal Marfan syndrome is the most severe form of the disorder. Affected new-borns display severe cardiac valve regurgitation and dilatation of the proximal aorta which usually lead to heart failure and death in the first year of life. Skeletal manifestations such as arachodactyly, dolichostenomel ...
... Neonatal Marfan syndrome is the most severe form of the disorder. Affected new-borns display severe cardiac valve regurgitation and dilatation of the proximal aorta which usually lead to heart failure and death in the first year of life. Skeletal manifestations such as arachodactyly, dolichostenomel ...
Quantitative expression of cholera toxin mRNA in Vibrio cholerae
... (González-Bonilla et al., 1994; DiRita et al., 1996). In this study, we compared the Ct value of classical V. cholerae with El Tor strains with three different CTX arrangements, A, B and C. The results demonstrated the production of lower levels of CT mRNA in the El Tor strains with the various CTX ...
... (González-Bonilla et al., 1994; DiRita et al., 1996). In this study, we compared the Ct value of classical V. cholerae with El Tor strains with three different CTX arrangements, A, B and C. The results demonstrated the production of lower levels of CT mRNA in the El Tor strains with the various CTX ...
here - Genetics
... unique nucleotide sequence for the locus in question, and thus constitutes the designation of an allele. In bacterial genetics, the practice of using a plus (+) sign to indicate the wildtype allele of a locus has been borrowed from the genetic nomenclature system used for other organisms. Thus, araB ...
... unique nucleotide sequence for the locus in question, and thus constitutes the designation of an allele. In bacterial genetics, the practice of using a plus (+) sign to indicate the wildtype allele of a locus has been borrowed from the genetic nomenclature system used for other organisms. Thus, araB ...
Accepted Version - CSIRO Research Publications Repository
... Another mutant phenotype seen in the ddm1 background, change of plant structure (short and compact inflorescence with reduced plant height), is bns (BONSAI), which is unstably inherited in the presence of the DDM1 gene. The BNS gene encodes a protein with similarity to the mammalian cell cycle regul ...
... Another mutant phenotype seen in the ddm1 background, change of plant structure (short and compact inflorescence with reduced plant height), is bns (BONSAI), which is unstably inherited in the presence of the DDM1 gene. The BNS gene encodes a protein with similarity to the mammalian cell cycle regul ...
A study of anticipation in families with hereditary non
... been associated with HNPCC. Three additional MMR genes, PMS2, MLH3 and PMS1, whose importance is not totally clear, also have been associated with HNPCC (Peltomaki 2005). Besides the mismatch repair of the post-replicative DNA, the MMR gene products are involved in a number of other essential functi ...
... been associated with HNPCC. Three additional MMR genes, PMS2, MLH3 and PMS1, whose importance is not totally clear, also have been associated with HNPCC (Peltomaki 2005). Besides the mismatch repair of the post-replicative DNA, the MMR gene products are involved in a number of other essential functi ...
Genome
... The goal of this exercise is to gain experience using BLAST, particularly blastN, and the UCSC genome browser to answer biologically relevant questions. Jian Ma | Sequence Comparison and Genome Alignment | 2015 ...
... The goal of this exercise is to gain experience using BLAST, particularly blastN, and the UCSC genome browser to answer biologically relevant questions. Jian Ma | Sequence Comparison and Genome Alignment | 2015 ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse