Epigenetic Effects of Psychological Stressors in Humans
... between maltreated and not maltreated subjects was noted.28 More specifically, the researchers proved that childhood sexual abuse led to hypermethylation of the promoter of NR3C1 gene in peripheral blood in comparison to methylation patterns of subjects without sexual abuse incidents during childhoo ...
... between maltreated and not maltreated subjects was noted.28 More specifically, the researchers proved that childhood sexual abuse led to hypermethylation of the promoter of NR3C1 gene in peripheral blood in comparison to methylation patterns of subjects without sexual abuse incidents during childhoo ...
Monitoring BCR-ABL transcript levels by real-time
... when, according to the current recommendation,3 it was replaced by ABL. In order to compare results previously obtained using the B2M gene and those obtained using the ABL gene, we performed RQ-PCR on 50 peripheral blood or bone marrow fresh and stored leukemic samples in duplicate with both ABL and ...
... when, according to the current recommendation,3 it was replaced by ABL. In order to compare results previously obtained using the B2M gene and those obtained using the ABL gene, we performed RQ-PCR on 50 peripheral blood or bone marrow fresh and stored leukemic samples in duplicate with both ABL and ...
STRIVE Report Series No.65
... other stakeholders on a range of questions in relation to environmental protection. These reports are intended as contributions to the necessary debate on the protection of the environment. ...
... other stakeholders on a range of questions in relation to environmental protection. These reports are intended as contributions to the necessary debate on the protection of the environment. ...
Explanation of Mendel`s work
... experimental results. In every case the actual values are surprisingly close to those expected. The expected values are based on the probability of the various types of gametes combining in a certain way. The expected and actual values are rarely identical: we should not expect them to be so any mor ...
... experimental results. In every case the actual values are surprisingly close to those expected. The expected values are based on the probability of the various types of gametes combining in a certain way. The expected and actual values are rarely identical: we should not expect them to be so any mor ...
PowerPoint Presentation - Folie 1
... smoker or another organism), organisms have to reduce the needed sulfur themselves. In many microorganisms this function is performed by a very common pathway for assimilatory sulfate reduction, leading from sulfate to sulfide, which is then incorporated in various sulfur containing metabolites (Fig ...
... smoker or another organism), organisms have to reduce the needed sulfur themselves. In many microorganisms this function is performed by a very common pathway for assimilatory sulfate reduction, leading from sulfate to sulfide, which is then incorporated in various sulfur containing metabolites (Fig ...
Correction to “Frequency of Undetected CYP2D6
... The frequency of hybrids genes in CYP2D6*4 and CYP2D6*10 samples is reported for both heterozygous or homozygous and heterozygous alone. We did not determine whether one or both chromosomes contained a hybrid tandem in homozygous samples. For this reason, to determine the risk that a CYP2D6*4 or CYP ...
... The frequency of hybrids genes in CYP2D6*4 and CYP2D6*10 samples is reported for both heterozygous or homozygous and heterozygous alone. We did not determine whether one or both chromosomes contained a hybrid tandem in homozygous samples. For this reason, to determine the risk that a CYP2D6*4 or CYP ...
An SMN-Dependent U12 Splicing Event Essential for Motor
... changes (Figures 1B, S1C, and S1D), indicating that they are SMN dependent. Next, we analyzed 28 U12 introns from 25 genes (Table S1) representing a diverse spectrum of features such as splice-site subtype, intron length, intron position, number of U12 introns, total number of introns, evolutionary ...
... changes (Figures 1B, S1C, and S1D), indicating that they are SMN dependent. Next, we analyzed 28 U12 introns from 25 genes (Table S1) representing a diverse spectrum of features such as splice-site subtype, intron length, intron position, number of U12 introns, total number of introns, evolutionary ...
RNA-Seq Alignment v1.0 App Guide
... Filtering—Bowtie filters the input reads against abundant sequences, such as mitochondrial or ribosomal sequences, as defined by iGenomes at support.illumina.com/sequencing/sequencing_software/igenome.html. } Only sequences that do not align against abundant sequences are passed through to the next ...
... Filtering—Bowtie filters the input reads against abundant sequences, such as mitochondrial or ribosomal sequences, as defined by iGenomes at support.illumina.com/sequencing/sequencing_software/igenome.html. } Only sequences that do not align against abundant sequences are passed through to the next ...
High-Level Expression in Escherichia coli of Alkaline Phosphatase
... stable at temperatures above 80oC, activated by Mg2+, and inhibited by Zn2+. In contrast, Zn2+ is essential for the activity of E. coli APase [1, 2, 7]. The gene encoding Tca APase was recently cloned into E. coli and the primary structure was deduced from its nucleotide sequence [9]. Like E. coli e ...
... stable at temperatures above 80oC, activated by Mg2+, and inhibited by Zn2+. In contrast, Zn2+ is essential for the activity of E. coli APase [1, 2, 7]. The gene encoding Tca APase was recently cloned into E. coli and the primary structure was deduced from its nucleotide sequence [9]. Like E. coli e ...
PAX6 mRNA Transcript Analysis in Various Ocular/Non
... levels from one tissue type to another. However, expression profiles for the maintenance/housekeeping genes exhibit similar patterns for each specific tissue type (Figure 1A). As a primary attempt three samples of ocular tissues such as lens epithelium, normal WBC lymphocytes, and the HeLa RNA were ...
... levels from one tissue type to another. However, expression profiles for the maintenance/housekeeping genes exhibit similar patterns for each specific tissue type (Figure 1A). As a primary attempt three samples of ocular tissues such as lens epithelium, normal WBC lymphocytes, and the HeLa RNA were ...
Types of RNA
... Transfer RNA (tRNA) is a small RNA chain of about 80 nucleotides that transfers a specific amino acid to a growing polypeptide chain at the ribosomal site of protein synthesis during translation. It has sites for amino acid attachment and an anticodon region for codon recognition that binds to a spe ...
... Transfer RNA (tRNA) is a small RNA chain of about 80 nucleotides that transfers a specific amino acid to a growing polypeptide chain at the ribosomal site of protein synthesis during translation. It has sites for amino acid attachment and an anticodon region for codon recognition that binds to a spe ...
Identification of chromosome intervals from 129 and C57BL/6 mouse
... developed an autoimmune phenotype. The humoral autoimmunity in this congenic strain was indistinguishable to that observed in a mouse carrying a deletion of the Apcs gene, located within the lupus-linked genomic region on distal chromosome 1 and considered as a candidate gene for murine SLE.6 Theref ...
... developed an autoimmune phenotype. The humoral autoimmunity in this congenic strain was indistinguishable to that observed in a mouse carrying a deletion of the Apcs gene, located within the lupus-linked genomic region on distal chromosome 1 and considered as a candidate gene for murine SLE.6 Theref ...
Bowel Cancer and Inherited Predisposition
... genes that normally control orderly growth and division of our cells throughout life. These genes can therefore be thought of normally acting as ‘cancer protection’ genes. Variations to the information in one of these ‘cancer protection’ genes such as a breast or bowel cell may cause the process of ...
... genes that normally control orderly growth and division of our cells throughout life. These genes can therefore be thought of normally acting as ‘cancer protection’ genes. Variations to the information in one of these ‘cancer protection’ genes such as a breast or bowel cell may cause the process of ...
Tumor metastasis-associated human MTA1 gene and its MTA1
... Using differential cDNA library screening techniques based on metastatic and nonmetastatic rat mammary adenocarcinoma cell lines, we previously cloned and sequenced the metastasis-associated gene mta1. Using homology to the rat mta1 gene, we cloned the human MTA1 gene and found it to be over-express ...
... Using differential cDNA library screening techniques based on metastatic and nonmetastatic rat mammary adenocarcinoma cell lines, we previously cloned and sequenced the metastasis-associated gene mta1. Using homology to the rat mta1 gene, we cloned the human MTA1 gene and found it to be over-express ...
The causal meaning of Fisher`s average effect
... translated into well-understood concepts such as covariance and regression without dealing with his ‘ special’ notions of average excess and average effect. In the following, we show that the two definitions of the average effect can be reconciled, in the case of genotype–environment independence, for ...
... translated into well-understood concepts such as covariance and regression without dealing with his ‘ special’ notions of average excess and average effect. In the following, we show that the two definitions of the average effect can be reconciled, in the case of genotype–environment independence, for ...
PowerPoint Presentation - No Slide Title
... SeattleSNPs Haplotype Summary • More haplotypes per gene than previously described • <50% of African-American chromosomes are represented by common shared haplotypes • Block structure is preserved across discovery strategies for only a fraction of the genes • Evidence for hotspots of recombination ...
... SeattleSNPs Haplotype Summary • More haplotypes per gene than previously described • <50% of African-American chromosomes are represented by common shared haplotypes • Block structure is preserved across discovery strategies for only a fraction of the genes • Evidence for hotspots of recombination ...
Respiratory terminal oxidases in the facultative chemoheterotrophic
... processes share several components, making cyanobacteria the only cells in which these two most important bioenergetic processes occur in the same cellular compartment. The cytoplasmic membrane, in contrast, does not contain a functional photosynthetic electron transport chain, but probably contains ...
... processes share several components, making cyanobacteria the only cells in which these two most important bioenergetic processes occur in the same cellular compartment. The cytoplasmic membrane, in contrast, does not contain a functional photosynthetic electron transport chain, but probably contains ...
Multiple Barriers to Nonhomologous DNA End Joining
... The following mutations were used and have been previously described: spn-A1, spn-A093, spn-BBU, and spn-D150 (Ghabrial et al. 1998; Abdu et al. 2003; Jang et al. 2003; Staeva-Vieira et al. 2003), mei-2181, mei-2186 (Carpenter and Sandler 1974; McKim et al. 1996), rec1 and rec2 (Blanton et al. 2005) ...
... The following mutations were used and have been previously described: spn-A1, spn-A093, spn-BBU, and spn-D150 (Ghabrial et al. 1998; Abdu et al. 2003; Jang et al. 2003; Staeva-Vieira et al. 2003), mei-2181, mei-2186 (Carpenter and Sandler 1974; McKim et al. 1996), rec1 and rec2 (Blanton et al. 2005) ...
The genetics of diabetes mellitus
... 18 (HLA-C) to 72 (HLA-DR), which gives several million possible haplotypes. For example, there are several loci at DR β region, such as DRB1, DRB2, DRB3, DRB9 and DRA. A further resolution gives rise to generic level HLA typing. Polymorphisms in the genes encoding specific peptide chains of the HLA ...
... 18 (HLA-C) to 72 (HLA-DR), which gives several million possible haplotypes. For example, there are several loci at DR β region, such as DRB1, DRB2, DRB3, DRB9 and DRA. A further resolution gives rise to generic level HLA typing. Polymorphisms in the genes encoding specific peptide chains of the HLA ...
The Informational Gene and the Substantial Body: On the
... occurs at other levels, there must be “genes” at those levels. As formal theory, this reflexive definition of the gene in terms of evolutionary theory works, but it deprives empirical science of the conceptual resources needed to look for material evidence of genes at other levels. Thus the problem ...
... occurs at other levels, there must be “genes” at those levels. As formal theory, this reflexive definition of the gene in terms of evolutionary theory works, but it deprives empirical science of the conceptual resources needed to look for material evidence of genes at other levels. Thus the problem ...
... look anything like the rest of my family. Everyone in my family has brown eyes, but mine are blue. I have straight red hair, no one else in my family has red hair and most of my family has curly hair. Do you think they are just trying to hide the fact that I really was adopted? How can you explain a ...
Insulin-like growth factor (IGF) signalling is required for early dorso
... These findings suggest that neural induction in the Xenopus embryo is favoured by low Smad1 activity and high MAPK signalling (Pera et al., 2003). A study in cultured cells indicates that IGF signalling pathways in zebrafish are similar to those in mammalian systems and that IGF-1 binds to the IGF-1 ...
... These findings suggest that neural induction in the Xenopus embryo is favoured by low Smad1 activity and high MAPK signalling (Pera et al., 2003). A study in cultured cells indicates that IGF signalling pathways in zebrafish are similar to those in mammalian systems and that IGF-1 binds to the IGF-1 ...
Chapter 4 - DORAS
... shown to consist of TonB-dependent outer membrane haem specific receptors and inner membrane haem ABC transporters. In S. meliloti 242 an outer membrane receptor, ShmR, specific for haem uptake has been identified (Battistoni et al., 2002). A ShmR homologue and an inner membrane ABC transport system ...
... shown to consist of TonB-dependent outer membrane haem specific receptors and inner membrane haem ABC transporters. In S. meliloti 242 an outer membrane receptor, ShmR, specific for haem uptake has been identified (Battistoni et al., 2002). A ShmR homologue and an inner membrane ABC transport system ...
Gene expression profiling
In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment. Many experiments of this sort measure an entire genome simultaneously, that is, every gene present in a particular cell.DNA microarray technology measures the relative activity of previously identified target genes. Sequence based techniques, like serial analysis of gene expression (SAGE, SuperSAGE) are also used for gene expression profiling. SuperSAGE is especially accurate and can measure any active gene, not just a predefined set. The advent of next-generation sequencing has made sequence based expression analysis an increasingly popular, ""digital"" alternative to microarrays called RNA-Seq. However, microarrays are far more common, accounting for 17,000 PubMed articles by 2006.