gsea user guide
... dataset. For example, before running hierarchical clustering, you might remove genes that have low variance across the dataset. This prevents flat genes from driving the clustering result and improves processing time by focusing on a smaller number of interesting genes. The GSEA algorithm does not f ...
... dataset. For example, before running hierarchical clustering, you might remove genes that have low variance across the dataset. This prevents flat genes from driving the clustering result and improves processing time by focusing on a smaller number of interesting genes. The GSEA algorithm does not f ...
Mendel and Punnet Square Quiz - etec-510-2011
... d) Heterozygous parents will have one dominant capital letter allele and one recessive lower case allele. There is a chance that some offspring is going to be homozygous. 8. In fruit flies, long wing is dominant over vestigial wing. If two flies that are homozygous dominant and homozygous recessive ...
... d) Heterozygous parents will have one dominant capital letter allele and one recessive lower case allele. There is a chance that some offspring is going to be homozygous. 8. In fruit flies, long wing is dominant over vestigial wing. If two flies that are homozygous dominant and homozygous recessive ...
Can blue-eyed parents produce brown
... independent variations in coat pattern. A study of these coat colour mutations has in turn allowed the identification of some 60 genes that are responsible and contribute to the melanin formation of melanocyte cells [3]. Comparison of different forms of these genes, known as polymorphisms, has provi ...
... independent variations in coat pattern. A study of these coat colour mutations has in turn allowed the identification of some 60 genes that are responsible and contribute to the melanin formation of melanocyte cells [3]. Comparison of different forms of these genes, known as polymorphisms, has provi ...
Chapter 14: MENDEL AND THE GENE IDEA
... The dominant allele is the one that is expressed (it exerts its phenotypic effect) in a heterozygote. It is identified with a uppercase (capital) letter, usually the first letter of the trait. Recessive Allele whose phenotypic effect is not observed in a heterozygote; its expression is masked by ...
... The dominant allele is the one that is expressed (it exerts its phenotypic effect) in a heterozygote. It is identified with a uppercase (capital) letter, usually the first letter of the trait. Recessive Allele whose phenotypic effect is not observed in a heterozygote; its expression is masked by ...
Supplementary Infomation (doc 1650K)
... (only had imputed genotypes) in the larger MICROS sample investigated here, but not in other cohorts. The low-quality imputation in the region also could not support multi-marker analysis in the present GWAS and might explain why we did not replicate it in the EGCUT samples – also used in the earlie ...
... (only had imputed genotypes) in the larger MICROS sample investigated here, but not in other cohorts. The low-quality imputation in the region also could not support multi-marker analysis in the present GWAS and might explain why we did not replicate it in the EGCUT samples – also used in the earlie ...
Supplementary Data - Word file
... §S2.3. The Random Breakage Model of Genome Evolution As described in the main text, it has long been proposed that genomes evolve according to random breakage model which predicts that distances between breakpoints should follow an exponential distribution of the form f(x) = 1/L e-x/L, where L is t ...
... §S2.3. The Random Breakage Model of Genome Evolution As described in the main text, it has long been proposed that genomes evolve according to random breakage model which predicts that distances between breakpoints should follow an exponential distribution of the form f(x) = 1/L e-x/L, where L is t ...
lntraclonal mating in Trypanosoma brucei is
... However, further analysis of cloned progeny trypanosomes from one of the out-crosses using RFLP markers, molecular karyotyping and RAPD (random amplification of polymorphic DNA) produced unequivocal evidence that intraas well as interclone mating had occurred. The progeny of interclone mating were d ...
... However, further analysis of cloned progeny trypanosomes from one of the out-crosses using RFLP markers, molecular karyotyping and RAPD (random amplification of polymorphic DNA) produced unequivocal evidence that intraas well as interclone mating had occurred. The progeny of interclone mating were d ...
False Discovery Rates
... rate is designed to quantify this type of trade-off, making it particularly useful for performing many hypothesis tests on high-dimensional data sets. Hypothesis testing in high-dimensional genomics data sets has been particularly influential in increasing the popularity of false discovery rates (St ...
... rate is designed to quantify this type of trade-off, making it particularly useful for performing many hypothesis tests on high-dimensional data sets. Hypothesis testing in high-dimensional genomics data sets has been particularly influential in increasing the popularity of false discovery rates (St ...
Supplemental Tables
... 1993; VIEIRA et al. 1997). End sequences from 593 of these P1 clones that map to unique sites within the genome were generated to anchor the assembly onto the polytene chromosome map. In cases where a reference sequence of D. virilis was available for the in situ localized probe, position of the seq ...
... 1993; VIEIRA et al. 1997). End sequences from 593 of these P1 clones that map to unique sites within the genome were generated to anchor the assembly onto the polytene chromosome map. In cases where a reference sequence of D. virilis was available for the in situ localized probe, position of the seq ...
Direct Deletion Analysis in Two Duchenne Muscular Dystrophy
... locus STR 7A for the proband (II2), who should have been heterozygous (allels b and c) (Fig. 2a STR 7A). The hemizygosity was suspected because a similar pattern to that obtained for the father was observed in the proband. Also, a reduction in the signal was seen where the maternal allele (2bp light ...
... locus STR 7A for the proband (II2), who should have been heterozygous (allels b and c) (Fig. 2a STR 7A). The hemizygosity was suspected because a similar pattern to that obtained for the father was observed in the proband. Also, a reduction in the signal was seen where the maternal allele (2bp light ...
Plant Two-Component Signaling Systems and the Role of Response
... plants. Although the ARR2 gene was expressed in almost all Arabidopsis organs, particularly high -glucuronidase activity was observed in pollen grains (Lohrmann et al., 2001). A similar expression pattern is described for the nuclear genes for components of the mitochondrial respiratory complex I ( ...
... plants. Although the ARR2 gene was expressed in almost all Arabidopsis organs, particularly high -glucuronidase activity was observed in pollen grains (Lohrmann et al., 2001). A similar expression pattern is described for the nuclear genes for components of the mitochondrial respiratory complex I ( ...
Gene Section EVI1 (ecotropic viral integration site 1 (EVI1) and
... expression of EVI1, it has been suggested that this gene plays an important role in development and could be involved in organogenesis, cell migration, cell growth, and differentiation. In the mouse, homozygous disruption of the 6th exon of the Evi1 gene lead to embryonic lethality, with widespread ...
... expression of EVI1, it has been suggested that this gene plays an important role in development and could be involved in organogenesis, cell migration, cell growth, and differentiation. In the mouse, homozygous disruption of the 6th exon of the Evi1 gene lead to embryonic lethality, with widespread ...
Imprinting and Seed Development
... endosperm might be derived from a supernumerary embryo that took on an embryo-nourishing function or from a female gametophyte that was later sexualized (Friedman, 2001). Arabidopsis endosperm development begins with the division of the triploid primary endosperm nucleus, which precedes the division ...
... endosperm might be derived from a supernumerary embryo that took on an embryo-nourishing function or from a female gametophyte that was later sexualized (Friedman, 2001). Arabidopsis endosperm development begins with the division of the triploid primary endosperm nucleus, which precedes the division ...
Analyzing the Paper
... “I don’t really care why C57/B6 mice are different than DBA2 mice. That’s not why we’re doing this. We’re doing this to find out why some people are different from other people. . . . Once you get good enough evidence that it’s likely to be a particular gene in humans, simply start the human study. ...
... “I don’t really care why C57/B6 mice are different than DBA2 mice. That’s not why we’re doing this. We’re doing this to find out why some people are different from other people. . . . Once you get good enough evidence that it’s likely to be a particular gene in humans, simply start the human study. ...
Regulation of Muscle Growth and Sarcomeric Protein Gene
... theory is that these proteinases may be re- a lesser extent during postmolt in a number sponding to an increase in calcium titre in of different crustacean species (Chang, the haemolymph during the premolt. 1993). The elevations in protein synthesis Further evidence for differential muscle in Homaru ...
... theory is that these proteinases may be re- a lesser extent during postmolt in a number sponding to an increase in calcium titre in of different crustacean species (Chang, the haemolymph during the premolt. 1993). The elevations in protein synthesis Further evidence for differential muscle in Homaru ...
The Underlying Similarity of Diversity Measures Used in
... biology in the field of ecology, where it is used to compute the diversity of species, see [11] pp.7-8. While less common, entropic diversity has also been used for the genetic diversity of populations in the EC field [12]. ...
... biology in the field of ecology, where it is used to compute the diversity of species, see [11] pp.7-8. While less common, entropic diversity has also been used for the genetic diversity of populations in the EC field [12]. ...
Klotho interferes with a novel FGF-signalling pathway and
... glucosidase‐like KL1 domain of mammalian Klotho. We have used a genetic approach to investigate the functional activity of Klotho in C. elegans. Here, we report that whereas Klotho requires EGL‐15 (FGFR) and EGL‐17 to promote longevity and oxidative stress resistance, it is not involved in the regul ...
... glucosidase‐like KL1 domain of mammalian Klotho. We have used a genetic approach to investigate the functional activity of Klotho in C. elegans. Here, we report that whereas Klotho requires EGL‐15 (FGFR) and EGL‐17 to promote longevity and oxidative stress resistance, it is not involved in the regul ...
cimmyt - Syngenta Foundation
... allow us to identify the presence of specific genes already present in an organism that govern traits of interest. Genetic engineering involves the insertion of native or foreign gene(s) into a host organism (microorganism, plant or animal) in order to increase the value or usefulness of the organis ...
... allow us to identify the presence of specific genes already present in an organism that govern traits of interest. Genetic engineering involves the insertion of native or foreign gene(s) into a host organism (microorganism, plant or animal) in order to increase the value or usefulness of the organis ...
Table xx - Hindawi
... Salmonella infection both lines show down regulation of this pathway. After 24 h infection with Salmonella this subpathway shows a higher expression in line B compared to line A. From these results it cannot be concluded whether both lines react similarly or the reaction differs between the lines. A ...
... Salmonella infection both lines show down regulation of this pathway. After 24 h infection with Salmonella this subpathway shows a higher expression in line B compared to line A. From these results it cannot be concluded whether both lines react similarly or the reaction differs between the lines. A ...
HOM-C/Hox genes and four interacting loci
... Each ray comprises the dendritic endings of two neurons and a support cell. The ends of the rays are located at reproducible positions in the cuticle, giving the male a characteristic, species-specific posterior morphology (Fig. 1D). In our previous studies we described the cellular mechanisms invol ...
... Each ray comprises the dendritic endings of two neurons and a support cell. The ends of the rays are located at reproducible positions in the cuticle, giving the male a characteristic, species-specific posterior morphology (Fig. 1D). In our previous studies we described the cellular mechanisms invol ...
Characterization of chaperonin 10 (Cpn10)
... the E. histolytica gene encoding Cpn10 Searches of preliminary data generated by the E. histolytica genome project at the Sanger Institute revealed several clones with sequence similarity to the human Cpn10 protein sequence. PCR primers based on these clones, when used in PCR reactions on E. histoly ...
... the E. histolytica gene encoding Cpn10 Searches of preliminary data generated by the E. histolytica genome project at the Sanger Institute revealed several clones with sequence similarity to the human Cpn10 protein sequence. PCR primers based on these clones, when used in PCR reactions on E. histoly ...
Genetics and heritability of coronary artery disease and myocardial
... are the genes that are, if mutated, directly responsible for the pathogenesis of disease. In this case, mutations can be clearly defined as the primary cause of the disease. An unequivocal diagnosis can be made for such mutations on the basis of a molecular analysis (as a rule, identification of the ...
... are the genes that are, if mutated, directly responsible for the pathogenesis of disease. In this case, mutations can be clearly defined as the primary cause of the disease. An unequivocal diagnosis can be made for such mutations on the basis of a molecular analysis (as a rule, identification of the ...
Genome-wide search for signatures of selection in three
... The domestication process, breed development and the more recent progress in animal breeding methods such as genetic improvement programs, have led to species modifications which are of interest to animal science from morphological, behavioral, productive, adaptive and, consequently, genetic points o ...
... The domestication process, breed development and the more recent progress in animal breeding methods such as genetic improvement programs, have led to species modifications which are of interest to animal science from morphological, behavioral, productive, adaptive and, consequently, genetic points o ...
Charcot-Marie
... preference being to wait until they are adult and can make their own decision about testing. The interpretation of predictive testing can be difficult in rare causes of CMT as the information is not always available about whether having an abnormal gene means that a person will always develop the d ...
... preference being to wait until they are adult and can make their own decision about testing. The interpretation of predictive testing can be difficult in rare causes of CMT as the information is not always available about whether having an abnormal gene means that a person will always develop the d ...
STRIVE Report Series No.65
... other stakeholders on a range of questions in relation to environmental protection. These reports are intended as contributions to the necessary debate on the protection of the environment. ...
... other stakeholders on a range of questions in relation to environmental protection. These reports are intended as contributions to the necessary debate on the protection of the environment. ...
Gene expression profiling
In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment. Many experiments of this sort measure an entire genome simultaneously, that is, every gene present in a particular cell.DNA microarray technology measures the relative activity of previously identified target genes. Sequence based techniques, like serial analysis of gene expression (SAGE, SuperSAGE) are also used for gene expression profiling. SuperSAGE is especially accurate and can measure any active gene, not just a predefined set. The advent of next-generation sequencing has made sequence based expression analysis an increasingly popular, ""digital"" alternative to microarrays called RNA-Seq. However, microarrays are far more common, accounting for 17,000 PubMed articles by 2006.