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Mendel and modern genetics: the legacy for today
Mendel and modern genetics: the legacy for today

... develop a generalized theory of heredity, but was far more immediate and practical – to establish patterns of hybridization that would have been of interest to agricultural breeders and others in 19th-century Moravia; and (2) Mendel never proposed that there were material particles, ‘factors’ or ‘An ...
The development and evolutionary origin of barbels in
The development and evolutionary origin of barbels in

... members of the Bone morphogenetic protein (Bmp), Distal-less (Dlx), Fibroblast growth factor (Fgf), Hedgehog (Hh), Tumor necrosis factor (Tnf), and Tnf receptor families. Other genes with roles in appendage development were absent from barbels, however, including members of the Dachshund (Dach) and ...
Assessing homology at different levels of the biological hierarchy
Assessing homology at different levels of the biological hierarchy

Gene Section WWC1 (WW and C2 domain containing 1)
Gene Section WWC1 (WW and C2 domain containing 1)

... In the field of neuroscience, KIBRA is associated with human memory performance (Papassotiropoulos et al., 2006). The single nucleotide polymorphism (SNP) of the ninth intron of KIBRA gene, rs17070145, is associated with human episodic memory performance. Carriers of the T to C single nucleotide in ...
Input signals to the plant circadian clock
Input signals to the plant circadian clock

... to dark-adapted plants (Covington et al., 2001). Red and blue light gave similar results, again suggesting that both phy and cry photoreceptors participate. Repeating these experiments in photoreceptor mutants and with different amplitudes of light pulse should now identify the particular contributi ...
phenotype describes a new mutation affecting
phenotype describes a new mutation affecting

... Clark, 1987). Abscisic acid (ABA) plays an important role during the maturation stage of embryogenesis. For example, it prevents precocious germination and is involved in the regulation of several genes (Davies and Jones, 1994). In maize, mutations affecting ABA metabolism are recognized because the ...
Leptin regulation of lipid homeostasis: dietary and metabolic
Leptin regulation of lipid homeostasis: dietary and metabolic

... et al. 2002a). These data provide additional evidence that fatty acids can serve as a direct signal of nutrient abundance to the central nervous system, and these effects share common central mechanistic pathways with hormones such as leptin and insulin that regulate whole-body energy homeostasis. M ...
Transcript Isoform Differences Across Human Tissues Are
Transcript Isoform Differences Across Human Tissues Are

... Important biological processes are regulated by the expression of alternative isoforms 8,9 , and their mis-regulation has been observed in many diseases, including cancer 10,11,12,13 . For dozens of genes, it has been experimentally demonstrated that alternative isoforms result in proteins with diff ...
Effect of the Polymorphisms of Keratin Associated Protein 8.2 Gene
Effect of the Polymorphisms of Keratin Associated Protein 8.2 Gene

... Goats with genotype AA exhibited the thinnest fibre diameter (<15 µm) when compared with those from animals with other genotypes (p<0.01). The mean difference was about 0.5 microns in fibre diameter between genotype AA and other genotypes. Genotypes with allele D or B had significantly increased fib ...
informe tecnológico de patentes
informe tecnológico de patentes

... disorder caused by the expression of mutant huntingtin protein (Htt). Suppression of Htt expression, using RNA interference, might be an effective therapy. However, if reduction of wild-type protein is not well tolerated in the brain, it may be necessary to suppress just the product of the mutant al ...
Prediction and investigation of novel proteins in DNA double
Prediction and investigation of novel proteins in DNA double

... broken ends to close proximity and Dnl4/Lif1/Nej1 ligates the DNA ends. Protein-protein interaction (PPI) has been utilized in functional genomics studies to identify novel proteins involved in different pathways based on their PPI profiles. In this study we aim to screen for novel proteins involved ...
hered short rev master..hered 366 .. Page265
hered short rev master..hered 366 .. Page265

... (Brakefield, 1984; Brakefield & van Noordwijk, 1985). The ...
Cardiovascular proteomics
Cardiovascular proteomics

... • 1 gene product is mutated but many proteins are affected, and these are not necessarily known • a lot of these diseases are chronic; the body has been trying to compensate causing further changes in proteins ...
The development of apical embryonic pattern in Arabidopsis
The development of apical embryonic pattern in Arabidopsis

Predicting_tRNA_and_tmRNA_genes_12-2-16
Predicting_tRNA_and_tmRNA_genes_12-2-16

... The phages that contain more than 1 tRNA within their genomes tend to localize the tRNAs to certain regions of the genomes (also called “tRNA clusters” in the phage tRNA literature.) It is highly unusual that a phage with multiple tRNAs will contain a sole tRNA distant genomically from all the other ...
Predicting tRNA and tmRNA genes Aragorn - SEA
Predicting tRNA and tmRNA genes Aragorn - SEA

... The phages that contain more than 1 tRNA within their genomes tend to localize the tRNAs to certain regions of the genomes (also called “tRNA clusters” in the phage tRNA literature.) It is highly unusual that a phage with multiple tRNAs will contain a sole tRNA distant genomically from all the other ...
1 FRQ-interacting RNA Helicase (FRH) Mediates Negative and
1 FRQ-interacting RNA Helicase (FRH) Mediates Negative and

... feedback, we engineered a strain bearing (1) a selectable marker under control of the frq promoter, and (2) a means through which FRQ could be overexpressed. In this strain, when FRQ is overexpressed, the selectable marker should be turned off unless the feedback loop connecting FRQ to repression is ...
Bacteriophage A cloning system for the construction of
Bacteriophage A cloning system for the construction of

... endonucleases at the cloning site, subsequent treatment with phosphatase to ensure high insertion rates would be unnecessary. (iv) DNA inserts can be cloned in a known orientation relative to vector-encoded expression signals. The cloning vector XORF8 possesses a multiple cloning site (MCS) containi ...
The Effect of OmpA Expression on Hfr Conjugation Efficiency
The Effect of OmpA Expression on Hfr Conjugation Efficiency

... made for each dilution. There is also a possibility the increased number of colonies counted on the C149 and C149 (pCCK06-1) plates are not statistically significant, as only one of several dilution plates contained countable (30 to 300) colonies. Duplicate or triplicate plates for each dilution wou ...
Exclusion of known corneal dystrophy genes in an autosomal
Exclusion of known corneal dystrophy genes in an autosomal

... coding exons and flanking intronic regions of TGFBI or in the nine coding exons and flanking intronic regions of ZEB1. Testing of an affected individual’s DNA against the Asper Corneal Dystrophy microarray Version 2.0 (302 mutations in 12 genes: COL8A2 (Collagen, Type VIII, Alpha-2), TGFBI, ...
It has now been over twenty years since two then
It has now been over twenty years since two then

... transgenic Atlantic salmon (Salmo salar) developed to improve the economics of salmon aquaculture by reducing time to market and cost of production. The product of 20 years of innovation, AquAdvantage® Salmon contain a single copy of the (Chinook) salmon growth hormone gene. The “all-salmon” transge ...
Microsoft Word (Chapter 3) - DORAS
Microsoft Word (Chapter 3) - DORAS

... Region II is typically located in the C-terminus of outer membrane receptors and has the consensus sequence (F/I/L/M/V)XXX(I/L/V)XNLX(D/N)(K/R)XY. The amino acid sequence of the mature FhuA1 was analysed and found to contain the motif ASLNVANLFDKEY at position 596 - 609, which shows good homology to ...
Transcriptional Attenuation
Transcriptional Attenuation

... DNA segment that encodes the 1:2 RNA hairpin (Fig. 2). RNA polymerase is released from the pause site when the ribosome approaches on the nascent transcript. Once RNA polymerase leaves the pause site, the rate at which th ribosome synthesizes the remainder of the leader peptide and releases the mRNA ...
The disease characteristics of different strains of scrapie in Sinc
The disease characteristics of different strains of scrapie in Sinc

GSEA - Bioinformatics Unit
GSEA - Bioinformatics Unit

... use HUGO gene symbols to identify the genes in the gene sets. 2. Choose false to use your expression dataset "as is." In this case, you are using the probe identifiers that are in your expression dataset for the analysis. The gene sets that you use for the analysis must also use these probe identifi ...
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Nutriepigenomics

Nutriepigenomics is the study of food nutrients and their effects on human health through epigenetic modifications. There is now considerable evidence that nutritional imbalances during gestation and lactation are linked to non-communicable diseases, such as obesity, cardiovascular disease, diabetes, hypertension, and cancer. If metabolic disturbances occur during critical time windows of development, the resulting epigenetic alterations can lead to permanent changes in tissue and organ structure or function and predispose individuals to disease.
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