Distortion of quantitative genomic and expression
... regarding reproducibility of these techniques have been raised by cross-validation studies in different laboratories (1–5). Strategies to mitigate variability in the results obtained from replicate studies have focused on standardizing technical factors, such as array production, RNA synthesis, labe ...
... regarding reproducibility of these techniques have been raised by cross-validation studies in different laboratories (1–5). Strategies to mitigate variability in the results obtained from replicate studies have focused on standardizing technical factors, such as array production, RNA synthesis, labe ...
The alternative splicing of tau exon10 and its
... repeats (4R) whereas exclusion leads to isoforms containing only three repeats (3R). The ratio between 3R and 4R isoforms is tightly controlled via alternative splicing in the human adult nervous system and distortion of this balance results in neurodegeneration. Previous studies showed that several ...
... repeats (4R) whereas exclusion leads to isoforms containing only three repeats (3R). The ratio between 3R and 4R isoforms is tightly controlled via alternative splicing in the human adult nervous system and distortion of this balance results in neurodegeneration. Previous studies showed that several ...
document
... Brown midrib (BMR) corn varieties have a natural mutation that results in low lignin in their cell walls, leading to increased digestibility, which is a highly desirable trait for silage maize production. Based on the sequence information from the public database, we designed oligos to amplify the C ...
... Brown midrib (BMR) corn varieties have a natural mutation that results in low lignin in their cell walls, leading to increased digestibility, which is a highly desirable trait for silage maize production. Based on the sequence information from the public database, we designed oligos to amplify the C ...
Quantitative trait loci associated with maximal exercise endurance in
... endurance of an individual can impact all-cause mortality rates (31), mortality rates from hypertension (7), smoking-related and non-smoking-related cancers (21), and stroke (22). A tremendous amount of research has considered the modifying role of environmental factors on maximal aerobic exercise ( ...
... endurance of an individual can impact all-cause mortality rates (31), mortality rates from hypertension (7), smoking-related and non-smoking-related cancers (21), and stroke (22). A tremendous amount of research has considered the modifying role of environmental factors on maximal aerobic exercise ( ...
Xq28 duplications
... like other X chromosome anomalies, also varies if the child is a boy or a girl. In general, duplication of Xq28 has a milder effect, or no obvious effect in girls since girls have two X chromosomes and the chromosome with the duplication is usually the one that is switched off. As a result, the extr ...
... like other X chromosome anomalies, also varies if the child is a boy or a girl. In general, duplication of Xq28 has a milder effect, or no obvious effect in girls since girls have two X chromosomes and the chromosome with the duplication is usually the one that is switched off. As a result, the extr ...
The new cardiac genetic testing panels
... to enable informative genetic testing for HCM and for this to be provided as an NHS service in the UK. Even earlier, in the 1980s, the BHF began to fund Dr (now BHF Professor) Steve Humphries in his search to identify the genetic causes of familial hyperlipidemia (FH). Continuous BHF funding for Pro ...
... to enable informative genetic testing for HCM and for this to be provided as an NHS service in the UK. Even earlier, in the 1980s, the BHF began to fund Dr (now BHF Professor) Steve Humphries in his search to identify the genetic causes of familial hyperlipidemia (FH). Continuous BHF funding for Pro ...
Amber Extract
... traced back to Stone Age. Amber amulet made of Baltic amber was found in Egyptian tombs. Baltic countries have about 100 Neolithic burial sites in which amber is included. Amber has been credited with numerous beneficial properties both physical and spiritual. The Ancient Romans and Greeks used it t ...
... traced back to Stone Age. Amber amulet made of Baltic amber was found in Egyptian tombs. Baltic countries have about 100 Neolithic burial sites in which amber is included. Amber has been credited with numerous beneficial properties both physical and spiritual. The Ancient Romans and Greeks used it t ...
Molecular Biology and Applied Genetics
... approach, in which the gene products themselves are purified and their activities studied in vitro. Genetics tells that a gene product has a role in the process that are studying in vivo, but it doesn’t necessarily tell how direct that role is. Biochemistry, by contrast, tells what a factor can do i ...
... approach, in which the gene products themselves are purified and their activities studied in vitro. Genetics tells that a gene product has a role in the process that are studying in vivo, but it doesn’t necessarily tell how direct that role is. Biochemistry, by contrast, tells what a factor can do i ...
PDF
... Tsh expression is first detected at low levels in a subpopulation of tubule cells at embryonic stage 13 (Fig. 2A,B). Based on their position on the posterior-facing side of the tubule (Denholm et al., 2003), we identify these cells as SCs. Tsh expression increases so that by stage 16, high levels ar ...
... Tsh expression is first detected at low levels in a subpopulation of tubule cells at embryonic stage 13 (Fig. 2A,B). Based on their position on the posterior-facing side of the tubule (Denholm et al., 2003), we identify these cells as SCs. Tsh expression increases so that by stage 16, high levels ar ...
MOLECULAR RECOGNITION AND RESPONSE IN POLLEN AND
... S-haplotype specificity displayed by each of these hybrid S-RNases. In constructing these chimeric genes, one allele of the S-RNase gene was used as the backbone, and the sequence for a region of another allele was swapped into the corresponding region of the backbone allele. When pairs of S-RNases ...
... S-haplotype specificity displayed by each of these hybrid S-RNases. In constructing these chimeric genes, one allele of the S-RNase gene was used as the backbone, and the sequence for a region of another allele was swapped into the corresponding region of the backbone allele. When pairs of S-RNases ...
inactivation of the odontogenic ameloblast
... this cluster (Bonass et al., 1998; Moffatt et al., 2006a). Among these were amelotin (Amtn) (Iwasaki et al., 2005; Moffatt et al., 2006b), odontogenic ameloblast-associated (Odam, originally termed as APin) (Moffatt et al., 2008), and SCPP-Proline/Glutamine (P/Q)-rich-1 (Scpppq1) (Kawasaki, 2009; Mo ...
... this cluster (Bonass et al., 1998; Moffatt et al., 2006a). Among these were amelotin (Amtn) (Iwasaki et al., 2005; Moffatt et al., 2006b), odontogenic ameloblast-associated (Odam, originally termed as APin) (Moffatt et al., 2008), and SCPP-Proline/Glutamine (P/Q)-rich-1 (Scpppq1) (Kawasaki, 2009; Mo ...
Functional Interactions of Genes Mediating Convergent Extension
... Varga and Westerfield, University of Oregon, Eugene, OR, personal communication). Several recent studies indicate that the division of the eye field into two involves Hedgehog signaling from cells located in the midline of the developing neuroectoderm. Members of the hedgehog (hh) gene family, consi ...
... Varga and Westerfield, University of Oregon, Eugene, OR, personal communication). Several recent studies indicate that the division of the eye field into two involves Hedgehog signaling from cells located in the midline of the developing neuroectoderm. Members of the hedgehog (hh) gene family, consi ...
Molecular characterization of glutathione peroxidase
... upstream of the start codon respectively (Fig. 1). Cis-acting DNA elements in promoters are responsible for interacting with corresponding transcription factors to control transcription of related genes in response to a variety of environmental and developmental signals. Both human GPx1 and GPx2 pro ...
... upstream of the start codon respectively (Fig. 1). Cis-acting DNA elements in promoters are responsible for interacting with corresponding transcription factors to control transcription of related genes in response to a variety of environmental and developmental signals. Both human GPx1 and GPx2 pro ...
univERsity oF copEnhAGEn
... RILs accumulated two aliphatic glucosinolates (4-methylsulfinylbutyl [4-MSO] and 4-methylthiobutyl [4-MT]) that are not found in the parental accessions. Transgressive segregation for this biosynthetic capability was previously observed in the Ler x Cvi RIL population and shown to result from epistas ...
... RILs accumulated two aliphatic glucosinolates (4-methylsulfinylbutyl [4-MSO] and 4-methylthiobutyl [4-MT]) that are not found in the parental accessions. Transgressive segregation for this biosynthetic capability was previously observed in the Ler x Cvi RIL population and shown to result from epistas ...
Provisional PDF
... Jiangsu, Anhui, Hubei, and Liaoning (Shen et al., 2014). With the rapid increase of the E. sinensis aquacultural industry, numerous diseases have recently evolved, thus resulting in huge economic losses (Shen et al., 2015). For example, hepatopancreatic necrosis disease (HPND, “shuibiezi” in Chinese ...
... Jiangsu, Anhui, Hubei, and Liaoning (Shen et al., 2014). With the rapid increase of the E. sinensis aquacultural industry, numerous diseases have recently evolved, thus resulting in huge economic losses (Shen et al., 2015). For example, hepatopancreatic necrosis disease (HPND, “shuibiezi” in Chinese ...
De novo mutations in human genetic disease
... affect specific genes and nucleotides. Mutations causing severe genetic diseases are often highly disruptive to gene function and tend to affect important domains of developmental genes. An open question is whether these mutations occur mainly in the germline, during embryogenesis or somatically. A ...
... affect specific genes and nucleotides. Mutations causing severe genetic diseases are often highly disruptive to gene function and tend to affect important domains of developmental genes. An open question is whether these mutations occur mainly in the germline, during embryogenesis or somatically. A ...
Confrontation of scabrous expressing and non
... the eye disc have not yet been characterized. Nevertheless, it is thought that at least part of the region known as the morphogenetic furrow (MF; reviewed by Tomlinson, 1988; Ready, 1989) has the properties of a neurogenic region, since reduction in the activity of the neurogenic locus Notch in the ...
... the eye disc have not yet been characterized. Nevertheless, it is thought that at least part of the region known as the morphogenetic furrow (MF; reviewed by Tomlinson, 1988; Ready, 1989) has the properties of a neurogenic region, since reduction in the activity of the neurogenic locus Notch in the ...
as Adobe PDF - Edinburgh Research Explorer
... the specification of subtypes of VM in mice (Lettice et al. 1999) and flies (Azpiazu and Frasch 1993). This high level of functional conservation suggests that the underlying transcriptional circuitry governing VM development may also be conserved. To date, most progress has been made in elucidating ...
... the specification of subtypes of VM in mice (Lettice et al. 1999) and flies (Azpiazu and Frasch 1993). This high level of functional conservation suggests that the underlying transcriptional circuitry governing VM development may also be conserved. To date, most progress has been made in elucidating ...
Chapter 2 - psychpro.us
... • Genome-wide association method - Identify genetic variations linked to a particular disease • Human genome consists of many genes that collaborate: – Both with each other and with nongenetic factors inside and outside the body ...
... • Genome-wide association method - Identify genetic variations linked to a particular disease • Human genome consists of many genes that collaborate: – Both with each other and with nongenetic factors inside and outside the body ...
Scriver Charles R. Garrod`s Croonian Lectures (1908)
... the medical profession and efforts to show their inheritance and congenital nature were of little help to the practice of medicine in Garrod_s lifetime. Moreover, the opinion that these disorders were Fnot of much moment_ because they were quite benign in the younger patient and thus were Fsports_, ...
... the medical profession and efforts to show their inheritance and congenital nature were of little help to the practice of medicine in Garrod_s lifetime. Moreover, the opinion that these disorders were Fnot of much moment_ because they were quite benign in the younger patient and thus were Fsports_, ...
multicopy gene family evolution on primate y chromosomes
... Contrary to previous theories, the Y chromosome is an important determinant of male phenotype [15–17]. The Y chromosome has been found to be associated with male fertility in humans [18] and even less obvious traits like lifespan [19] and locomotive activity [20] in Drosophila species. Therefore, an ...
... Contrary to previous theories, the Y chromosome is an important determinant of male phenotype [15–17]. The Y chromosome has been found to be associated with male fertility in humans [18] and even less obvious traits like lifespan [19] and locomotive activity [20] in Drosophila species. Therefore, an ...
Control of Cleavage Cycles in Drosophila Embryos by fru¨ hstart
... before the surrounding cells (Figure 3D; data not shown). Cleavage divisions could also be stopped before cycle 12, when higher amounts of RNA were applied or injected before pole cell formation. These embryos did not enter cellularization. Instead, the nuclei stopped dividing and developed an abnor ...
... before the surrounding cells (Figure 3D; data not shown). Cleavage divisions could also be stopped before cycle 12, when higher amounts of RNA were applied or injected before pole cell formation. These embryos did not enter cellularization. Instead, the nuclei stopped dividing and developed an abnor ...
Genomic organisation of the Mal d 1 gene cluster on linkage group
... micro-synteny among Malus and Prunus (Dirlewanger et al. 2004; Chen et al. 2008; Sargent et al. 2009), and, because of this, genomic advances in peach are also of use in apple genetics (Shulaev et al. 2008). For instance, eight Bet v 1-like genes have been identified in peach. These genes, designate ...
... micro-synteny among Malus and Prunus (Dirlewanger et al. 2004; Chen et al. 2008; Sargent et al. 2009), and, because of this, genomic advances in peach are also of use in apple genetics (Shulaev et al. 2008). For instance, eight Bet v 1-like genes have been identified in peach. These genes, designate ...