Datasheet - Santa Cruz Biotechnology, Inc.
... Three mammalian fringe family members, namely Manic Fringe, Radical Fringe and Lunatic Fringe, have been identified as proteins related to Drosophila Fringe, a protein involved in development. Fringe proteins act upstream of the Notch signaling pathway and are involved in boundary determination duri ...
... Three mammalian fringe family members, namely Manic Fringe, Radical Fringe and Lunatic Fringe, have been identified as proteins related to Drosophila Fringe, a protein involved in development. Fringe proteins act upstream of the Notch signaling pathway and are involved in boundary determination duri ...
Gene Section MLL (myeloid/lymphoid or mixed lineage leukemia) Atlas of Genetics and Cytogenetics
... (e.g. desacetylation/acetylation); MLL-N acts as a transcriptional repressor; MLL can be associated with more than 30 proteins, including the core components of the SWI/SNF chromatin remodeling complex and the transcription complex TFIID. MLL binds promotors of HOX genes through acetylation and meth ...
... (e.g. desacetylation/acetylation); MLL-N acts as a transcriptional repressor; MLL can be associated with more than 30 proteins, including the core components of the SWI/SNF chromatin remodeling complex and the transcription complex TFIID. MLL binds promotors of HOX genes through acetylation and meth ...
Unraveling the Genetic Mysteries of the Corneal Dystrophies
... Autosomal recessive; least common and most severe; early onset Three types have been described based upon the presence of antigenic keratan sulfate Vision more severely affected than in other stromal dystrophies Characterized by stromal haze, and milky white opacities (glucosamineglycans; descemet’s ...
... Autosomal recessive; least common and most severe; early onset Three types have been described based upon the presence of antigenic keratan sulfate Vision more severely affected than in other stromal dystrophies Characterized by stromal haze, and milky white opacities (glucosamineglycans; descemet’s ...
SVPaper050711
... 0.16M SVs were mapped to base pair resolution allowing us to infer that insertion of retrotransposons causes more than half of SVs. Yet, despite their prevalence, SVs are less likely than other sequence variants to cause geneexpression or quantitative phenotypic variation. We identified 24 SVs that ...
... 0.16M SVs were mapped to base pair resolution allowing us to infer that insertion of retrotransposons causes more than half of SVs. Yet, despite their prevalence, SVs are less likely than other sequence variants to cause geneexpression or quantitative phenotypic variation. We identified 24 SVs that ...
High grade B-cell lymphomas (HGBL): Altered terminology in the
... BCR/proliferation: Has more abundant expression of cell-cycle regulatory genes (CDK2, MCM family members, etc.); increased expression of DNA repair genes (PMS2, H2AX, PTIP, P53); higher levels of BCR signaling cascade components (CD19, Ig, CD79a, SYK, BLK) and B-cell-related transcription factors (P ...
... BCR/proliferation: Has more abundant expression of cell-cycle regulatory genes (CDK2, MCM family members, etc.); increased expression of DNA repair genes (PMS2, H2AX, PTIP, P53); higher levels of BCR signaling cascade components (CD19, Ig, CD79a, SYK, BLK) and B-cell-related transcription factors (P ...
the hemophilia gene, click here
... HEMOPHILIA, A GENETIC DISORDER Hemophilia is a genetic disorder. This means that it is caused by a change or a mutation in a gene. The mutation causes the gene to not work properly. Like other genetic health problems, hemophilia can be passed from generation to generation. In about 3 out of 10 cases ...
... HEMOPHILIA, A GENETIC DISORDER Hemophilia is a genetic disorder. This means that it is caused by a change or a mutation in a gene. The mutation causes the gene to not work properly. Like other genetic health problems, hemophilia can be passed from generation to generation. In about 3 out of 10 cases ...
Genetics - York University
... How was evolution possible if Mendel’ Mendel’s conception was correct? Darwin required that subsequent generations of a species exhibit a set of characteristics that varied, but around a different center. • Answer: Mutations. ...
... How was evolution possible if Mendel’ Mendel’s conception was correct? Darwin required that subsequent generations of a species exhibit a set of characteristics that varied, but around a different center. • Answer: Mutations. ...
Expression and characterization of 1
... purified. It showed selectivity and high activity towards the substrate ACC: K M=3.4F0.2 mM and k cat=146F5 min-1 at pH 8.0 and 22 8C. The enzyme displayed optimal activity at pH 8.0 with a sharp decline to essentially no activity below pH 6.5 and a slightly less severe tapering in activity at highe ...
... purified. It showed selectivity and high activity towards the substrate ACC: K M=3.4F0.2 mM and k cat=146F5 min-1 at pH 8.0 and 22 8C. The enzyme displayed optimal activity at pH 8.0 with a sharp decline to essentially no activity below pH 6.5 and a slightly less severe tapering in activity at highe ...
Genetic epidemiology of psoriasis and psoriatic arthritis
... greater than 2 between the first and second degrees of relatedness, the data are consistent with a multilocus model.5 As this factor was 7 in the Faroe Islands study and 8 in the Swedish study, a multilocus model for psoriasis is predicted.3 Another method for quantitating the burden of genetic dise ...
... greater than 2 between the first and second degrees of relatedness, the data are consistent with a multilocus model.5 As this factor was 7 in the Faroe Islands study and 8 in the Swedish study, a multilocus model for psoriasis is predicted.3 Another method for quantitating the burden of genetic dise ...
no isthmus and pax2.1 in zebrafish tubulogenesis
... noitb21 and null noi− alleles. The noi glomerulus is complete with podocytes and surrounding parietal epithelium (Bowman’s capsule), suggesting glomerular differentiation and morphogenesis does not require pax2.1. Unlike the mouse or human pax2 mutations, which behave haploinsufficiently, noi hetero ...
... noitb21 and null noi− alleles. The noi glomerulus is complete with podocytes and surrounding parietal epithelium (Bowman’s capsule), suggesting glomerular differentiation and morphogenesis does not require pax2.1. Unlike the mouse or human pax2 mutations, which behave haploinsufficiently, noi hetero ...
Information for couples where one partner carries
... Haemoglobin S/D disorder is an uncommon type of sickle cell disorder. Children with sickle cell disorders are healthy at birth, but most become anaemic in the first year of life. This means they have less haemoglobin in their blood than other people. They may be thinner than others, and may tire mor ...
... Haemoglobin S/D disorder is an uncommon type of sickle cell disorder. Children with sickle cell disorders are healthy at birth, but most become anaemic in the first year of life. This means they have less haemoglobin in their blood than other people. They may be thinner than others, and may tire mor ...
A MIAME-compliant Microarray Database
... • In the first experiment, they found some genes regulated by addition of GA-4 • They made GFP fusions to three of these genes ...
... • In the first experiment, they found some genes regulated by addition of GA-4 • They made GFP fusions to three of these genes ...
Two Linked Blood Pressure Quantitative Trait Loci on
... from each end of the original strain suggests that there are two linked QTLs in the region covered by the original congenic strain. As the strains become progressively shorter at each end, BP effects were still retained at each end. Two nonoverlapping strains, S.MNS⫻5 and S.MNS⫻3, had significant BP ...
... from each end of the original strain suggests that there are two linked QTLs in the region covered by the original congenic strain. As the strains become progressively shorter at each end, BP effects were still retained at each end. Two nonoverlapping strains, S.MNS⫻5 and S.MNS⫻3, had significant BP ...
Analysis of clones carrying repeated DNA sequences in two YAC
... five (9%) of the 53 YAC clones analyzed in these contigs are not collinear with chromosomal DNA, but are chimaeric between single-copy nuclear DNA and repetitive DNA sequences. The same kind of analysis of YAC end probes was performed on EW YAC clones. None of the 47 EW YAC end probes derived from 3 ...
... five (9%) of the 53 YAC clones analyzed in these contigs are not collinear with chromosomal DNA, but are chimaeric between single-copy nuclear DNA and repetitive DNA sequences. The same kind of analysis of YAC end probes was performed on EW YAC clones. None of the 47 EW YAC end probes derived from 3 ...
X-Chromosome dosage compensation
... compensation machinery in only one sex? Third, what are the cis-acting recruitment sites that target X chromosomes for regulation by the dosage compensation complex? Fourth, how is gene expression coordinately controlled along an entire X chromosome? Fifth, what is the molecular mechanism for fine-t ...
... compensation machinery in only one sex? Third, what are the cis-acting recruitment sites that target X chromosomes for regulation by the dosage compensation complex? Fourth, how is gene expression coordinately controlled along an entire X chromosome? Fifth, what is the molecular mechanism for fine-t ...
Deletions of NF1 gene and exons detected by multiplex ligation
... is known, and thus preventing unambiguous molecular diagnosis.18 A minority (,4%) of patients carry typical 1.2– 1.4 Mb deletions that delete the NF1 gene and its flanking regions.19 20 These patients generally exhibit a severe phenotype characterised by more neurofibromas at an earlier age, a lower ...
... is known, and thus preventing unambiguous molecular diagnosis.18 A minority (,4%) of patients carry typical 1.2– 1.4 Mb deletions that delete the NF1 gene and its flanking regions.19 20 These patients generally exhibit a severe phenotype characterised by more neurofibromas at an earlier age, a lower ...
Embryonic Development following Somatic Cell
... [FC] > 5, FPKM > 5) that can be classified into five groups by unsupervised hierarchical cluster analysis (Figure 1D). Of these 3,775 differentially expressed genes, 1,549 were activated in both SCNT and IVF embryos (groups 1 and 2). Gene ontology (GO) analysis revealed that these genes were signif ...
... [FC] > 5, FPKM > 5) that can be classified into five groups by unsupervised hierarchical cluster analysis (Figure 1D). Of these 3,775 differentially expressed genes, 1,549 were activated in both SCNT and IVF embryos (groups 1 and 2). Gene ontology (GO) analysis revealed that these genes were signif ...
A PCR approach to determine the distribution of toxin genes in
... The closely related Clostridium novyi and Clostridium botulinum types C and D are of current interest because of their association with serious infections in injecting drug users (C. novyi type A) and equine and feline dysautonomias (C. botulinum types C/D). The species are defined by the major toxi ...
... The closely related Clostridium novyi and Clostridium botulinum types C and D are of current interest because of their association with serious infections in injecting drug users (C. novyi type A) and equine and feline dysautonomias (C. botulinum types C/D). The species are defined by the major toxi ...
Translational control of regA, a key gene controlling
... Karin Babinger1, Armin Hallmann2 and Rüdiger Schmitt1,* The complete division of labour between the reproductive and somatic cells of the green alga Volvox carteri is controlled by three types of genes. One of these is the regA gene, which controls terminal differentiation of the somatic cells. Here ...
... Karin Babinger1, Armin Hallmann2 and Rüdiger Schmitt1,* The complete division of labour between the reproductive and somatic cells of the green alga Volvox carteri is controlled by three types of genes. One of these is the regA gene, which controls terminal differentiation of the somatic cells. Here ...
A Pseudomonas syringae pv. tomato DC3000 mutant
... 1964; Mysore and Ryu, 2004). Type-II non-host and racespecific resistance against P. syringae often appear similar. When inoculated at a low level, P. syringae strains will grow well initially in plants with either type of resistance, but growth is sustained for several days and necrotic symptoms ar ...
... 1964; Mysore and Ryu, 2004). Type-II non-host and racespecific resistance against P. syringae often appear similar. When inoculated at a low level, P. syringae strains will grow well initially in plants with either type of resistance, but growth is sustained for several days and necrotic symptoms ar ...
Flower symmetry and shape in Antirrhinum
... The shapes of organisms and of their parts are often described in terms of symmetries. Clearly, however, symmetry is not equivalent to shape, since instances of diverse organisms or parts with the same symmetries and different shapes can be readily found. Even within species, a level at which symmet ...
... The shapes of organisms and of their parts are often described in terms of symmetries. Clearly, however, symmetry is not equivalent to shape, since instances of diverse organisms or parts with the same symmetries and different shapes can be readily found. Even within species, a level at which symmet ...
Interferon Gamma Gene Polymorphism as a Biochemical Marker in
... may or may not harm the host. These mechanisms are activated by immunoglobulin (Ig) E, which leads to the release of mast cells. The most common familial IgE-related diseases include allergic rhinitis, atopic dermatitis, allergic asthma, and allergic conjunctivitis. These are known as atopic disease ...
... may or may not harm the host. These mechanisms are activated by immunoglobulin (Ig) E, which leads to the release of mast cells. The most common familial IgE-related diseases include allergic rhinitis, atopic dermatitis, allergic asthma, and allergic conjunctivitis. These are known as atopic disease ...
Ribotyping of Clostridium perfringens from industrially produced
... Among 111 Cl. perfringens isolates from ground meat 107 distinctly different ribotype patterns were detected. In only four cases two Cl. perfringens isolates showed an identical ribopattern. Figure 1 shows an example of the variability of the ribotype patterns. The number of DIG labelled bands of Cl ...
... Among 111 Cl. perfringens isolates from ground meat 107 distinctly different ribotype patterns were detected. In only four cases two Cl. perfringens isolates showed an identical ribopattern. Figure 1 shows an example of the variability of the ribotype patterns. The number of DIG labelled bands of Cl ...