Mitochondrial diseases and the role of the yeast models
... yeast the effect of the mutations identified in patients. An A114P missense mutation in the human Ant1 protein was found to be associated with autosomal dominant PEO (adPEO) (Kaukonen et al., 2000). A128P mutation of the S. cerevisiae Aac2 protein, equivalent to A114P in human Ant1, causes a decreas ...
... yeast the effect of the mutations identified in patients. An A114P missense mutation in the human Ant1 protein was found to be associated with autosomal dominant PEO (adPEO) (Kaukonen et al., 2000). A128P mutation of the S. cerevisiae Aac2 protein, equivalent to A114P in human Ant1, causes a decreas ...
Neurospora Spore Killers Sk-2 and Sk
... of the tetrad give rise to round ascospores; even those nuclei that contain a wild-type allele are round. The cause of dominance is probably rearrangements and/or deletions that prevent the wild-type allele from pairing with a homolog. MSUD is implicated in these ascusdominant phenotypes of these mu ...
... of the tetrad give rise to round ascospores; even those nuclei that contain a wild-type allele are round. The cause of dominance is probably rearrangements and/or deletions that prevent the wild-type allele from pairing with a homolog. MSUD is implicated in these ascusdominant phenotypes of these mu ...
FUNCTIONAL INVESTIGATION OF ARABIDOPSIS
... Callose synthesis occurs at specific stages of cell wall development in all cell types, and in response to pathogen attack, wounding and physiological stresses. We isolated promoters of 12 Arabidopsis callose synthase (CalS1-12) genes and demonstrated that different callose synthases are expressed s ...
... Callose synthesis occurs at specific stages of cell wall development in all cell types, and in response to pathogen attack, wounding and physiological stresses. We isolated promoters of 12 Arabidopsis callose synthase (CalS1-12) genes and demonstrated that different callose synthases are expressed s ...
6. risk management plan
... Risk assessment and deemed licence conditions for general release of INGARD® and Roundup Ready® cotton ........................................................................................... 21 Approvals for Bollgard II® cotton in other countries ................................................. ...
... Risk assessment and deemed licence conditions for general release of INGARD® and Roundup Ready® cotton ........................................................................................... 21 Approvals for Bollgard II® cotton in other countries ................................................. ...
Genetics: Mendelian Genetics (1) Patterns of Inheritance
... earlobes, others have free earlobes. The genes that influence these traits are inherited independently. As a result, some people who can roll their tongues also have attached earlobes, while other tongue rollers have detached earlobes. Independent assortment was first described in the midnineteenth ...
... earlobes, others have free earlobes. The genes that influence these traits are inherited independently. As a result, some people who can roll their tongues also have attached earlobes, while other tongue rollers have detached earlobes. Independent assortment was first described in the midnineteenth ...
Gene List for Cucurbita species
... interest can be used as markers in marker-assisted selection. Unlike random markers, these genespecific, allele-specific markers are completely linked to the genes of interest. Genes can be isolated through widespread sequencing of genomic or cDNA libraries, through map-based cloning, or by function ...
... interest can be used as markers in marker-assisted selection. Unlike random markers, these genespecific, allele-specific markers are completely linked to the genes of interest. Genes can be isolated through widespread sequencing of genomic or cDNA libraries, through map-based cloning, or by function ...
C 2: A A -
... analysis of blaVEB-1-like genes was the isolation of P. aeruginosa strains from an intensive care unit of a Kuwaiti hospital harboring blaVEB–like genes, blaVEB-1a and blaVEB-1b, that differ from the blaVEB-1 gene by nucleotide substitutions in the DNA sequence encoding the leader peptide (50) (Tabl ...
... analysis of blaVEB-1-like genes was the isolation of P. aeruginosa strains from an intensive care unit of a Kuwaiti hospital harboring blaVEB–like genes, blaVEB-1a and blaVEB-1b, that differ from the blaVEB-1 gene by nucleotide substitutions in the DNA sequence encoding the leader peptide (50) (Tabl ...
Breeding Policy - Selkirk Rex Cat Club
... From the beginning these cats generated much interest as show visitors and exhibitors became aware of the new breed. The first three breeders in 2002 quickly grew to include many well established catteries throughout the UK. These cats were the ideal companion to any British Shorthaired, Persian & E ...
... From the beginning these cats generated much interest as show visitors and exhibitors became aware of the new breed. The first three breeders in 2002 quickly grew to include many well established catteries throughout the UK. These cats were the ideal companion to any British Shorthaired, Persian & E ...
NO sensing by FNR: regulation of the Escherichia coli NO
... the ¯avohaemoglobin-encoding gene of E.coli, hmp, is upregulated by NO and RNS; this appears not to involve SoxRS (Poole et al., 1996). We have reported (MembrilloHernaÂndez et al., 1998) a mechanism of hmp gene regulation that involves interaction between S-nitrosothiols and Hcy. Intracellular Hcy ...
... the ¯avohaemoglobin-encoding gene of E.coli, hmp, is upregulated by NO and RNS; this appears not to involve SoxRS (Poole et al., 1996). We have reported (MembrilloHernaÂndez et al., 1998) a mechanism of hmp gene regulation that involves interaction between S-nitrosothiols and Hcy. Intracellular Hcy ...
CFTR Mutations in Congenital Absence of Vas Deferens
... found that the partial penetrance can be explained by another genetic factor, namely the polymorphic TGm locus in front of the Tn locus (11). Different alleles can be found depending on the number of TG repeats found at this locus. The higher number of TG repeats, the less efficient exon 9 splicing ...
... found that the partial penetrance can be explained by another genetic factor, namely the polymorphic TGm locus in front of the Tn locus (11). Different alleles can be found depending on the number of TG repeats found at this locus. The higher number of TG repeats, the less efficient exon 9 splicing ...
1 - Krishikosh
... metaphase, anaphase and telophase. In prophase, the chromosomes become visible in the light microscope presumably due to coiling, shortening and thickening, and adding protein matrix to their mass as the process continues. By late prophase, the two identical or "sister" chromatids may be seen. The c ...
... metaphase, anaphase and telophase. In prophase, the chromosomes become visible in the light microscope presumably due to coiling, shortening and thickening, and adding protein matrix to their mass as the process continues. By late prophase, the two identical or "sister" chromatids may be seen. The c ...
Complete genome sequence of the thermophilic Thermus sp
... size that is below 2.5 Mb. They also display a high G + C content that may correlate with their thermophilic lifestyle. CCB_US3_UF1 has a higher number of predicted protein coding sequences (2279) than HB27 (2210) and HB8 (2173), but lower than that of T. scotoductus SA-01 (2458). They also share a ...
... size that is below 2.5 Mb. They also display a high G + C content that may correlate with their thermophilic lifestyle. CCB_US3_UF1 has a higher number of predicted protein coding sequences (2279) than HB27 (2210) and HB8 (2173), but lower than that of T. scotoductus SA-01 (2458). They also share a ...
Product description P048-C1-0315 LMNA-MYOT - MRC
... polymorphism in the sequence detected by a probe can also cause a reduction in relative peak height, even when not located exactly on the ligation site! In addition, some probe signals are more sensitive to sample purity and small changes in experimental conditions. Therefore, deletions and duplicat ...
... polymorphism in the sequence detected by a probe can also cause a reduction in relative peak height, even when not located exactly on the ligation site! In addition, some probe signals are more sensitive to sample purity and small changes in experimental conditions. Therefore, deletions and duplicat ...
Laboratory testing of CYP2D6 alleles in relation to tamoxifen therapy
... Disclaimer: Disease-specific statements are intended to augment the current general ACMG Standards and Guidelines for Clinical Genetic Laboratories. Individual laboratories are responsible for meeting the Clinical Laboratory Improvement Amendments (CLIA)/College of American Pathologists (CAP) qualit ...
... Disclaimer: Disease-specific statements are intended to augment the current general ACMG Standards and Guidelines for Clinical Genetic Laboratories. Individual laboratories are responsible for meeting the Clinical Laboratory Improvement Amendments (CLIA)/College of American Pathologists (CAP) qualit ...
The pleiotropic structure of the genotype–phenotype
... In relation to senescence, for example, it was proposed that mutant genes that are beneficial to development and reproduction are deleterious after reproductive age, which may explain why all species have a limited lifespan17. Despite the importance of pleiotropy, few empirical data were available o ...
... In relation to senescence, for example, it was proposed that mutant genes that are beneficial to development and reproduction are deleterious after reproductive age, which may explain why all species have a limited lifespan17. Despite the importance of pleiotropy, few empirical data were available o ...
Gene replacement with the human BRCA1 locus
... protein was correctly translated and stabilized following exposure to DNA damage. From these results, it is apparent that signi®cant conservation of function exists between human and mouse genes. This is notable since the mature proteins are only 60% identical at the amino acid level (Lane et al., 1 ...
... protein was correctly translated and stabilized following exposure to DNA damage. From these results, it is apparent that signi®cant conservation of function exists between human and mouse genes. This is notable since the mature proteins are only 60% identical at the amino acid level (Lane et al., 1 ...
Adenomatous Polyp
... What types of mutations are likely to be present in such a lesion? There is progressive accumulation of mutations during the conversion of adenomas to carcinomas. In this scheme, mutations of the APC gene (resulting in homozygous loss of this tumor suppressor gene) are believed to occur first. (Pat ...
... What types of mutations are likely to be present in such a lesion? There is progressive accumulation of mutations during the conversion of adenomas to carcinomas. In this scheme, mutations of the APC gene (resulting in homozygous loss of this tumor suppressor gene) are believed to occur first. (Pat ...
A novel role for the floral homeotic gene APETALA2
... valves and replum, respectively. In ful rpl double mutants, the valve margin identity genes become ectopically expressed, and, as a result, the entire outer surface of the ovary takes on valve margin identity. We carried out a genetic screen in this sensitized genetic background and identified a sup ...
... valves and replum, respectively. In ful rpl double mutants, the valve margin identity genes become ectopically expressed, and, as a result, the entire outer surface of the ovary takes on valve margin identity. We carried out a genetic screen in this sensitized genetic background and identified a sup ...
Cross Breeding Suris and Huacayas
... Breeding suris can be achieved by using two completely different methods. By breeding pure suris to pure suris, or by the controversial method of crossing suris with huacayas. When using the term pure suri I am referring to a suri that is carrying two dominate suri genes, or stated another way a hom ...
... Breeding suris can be achieved by using two completely different methods. By breeding pure suris to pure suris, or by the controversial method of crossing suris with huacayas. When using the term pure suri I am referring to a suri that is carrying two dominate suri genes, or stated another way a hom ...
Dissolving Dominance
... about parental influence in inheritance. At the same time, however, he provided a foundation for another misconception. That is, he primed a tradition of attributing the appearance of certain traits to the traits themselves. For later interpreters of Mendel, certain traits appeared because they were ...
... about parental influence in inheritance. At the same time, however, he provided a foundation for another misconception. That is, he primed a tradition of attributing the appearance of certain traits to the traits themselves. For later interpreters of Mendel, certain traits appeared because they were ...
2. Assessing the probative value of DNA evidence
... of statistical evidence and probabilistic reasoning, to assist judges, lawyers, forensic scientists and other expert witnesses in coping with the demands of modern criminal litigation. The Guides are being written by a multidisciplinary team principally comprising a statistician (Aitken), an academi ...
... of statistical evidence and probabilistic reasoning, to assist judges, lawyers, forensic scientists and other expert witnesses in coping with the demands of modern criminal litigation. The Guides are being written by a multidisciplinary team principally comprising a statistician (Aitken), an academi ...
Inbreeding in Cattle
... (the degree to which a sire or dam will pass his or her characteristics consistently). This is more than counteracted by the decline in selection intensity and loss of genetic variation. Selection intensity is a function of the proportion of bull and heifer candidates that are actually selected. Sel ...
... (the degree to which a sire or dam will pass his or her characteristics consistently). This is more than counteracted by the decline in selection intensity and loss of genetic variation. Selection intensity is a function of the proportion of bull and heifer candidates that are actually selected. Sel ...
Novel p53 mutants selected in BRCA
... p21Waf1, are shown in Figure 3. These segregated broadly into two groups. Group 1 comprises those mutants (181C, 219H, 158H and 240R) which transactivate p21Waf1 and mdm2 (181C and 219H also transactivate PIG3) but not Bax or IGF BP-3. Group 2 consists of those mutants (150I, 199R, 202S and 215C) wh ...
... p21Waf1, are shown in Figure 3. These segregated broadly into two groups. Group 1 comprises those mutants (181C, 219H, 158H and 240R) which transactivate p21Waf1 and mdm2 (181C and 219H also transactivate PIG3) but not Bax or IGF BP-3. Group 2 consists of those mutants (150I, 199R, 202S and 215C) wh ...
Assessing the Probative Value of DNA Evidence
... of statistical evidence and probabilistic reasoning, to assist judges, lawyers, forensic scientists and other expert witnesses in coping with the demands of modern criminal litigation. The Guides are being written by a multidisciplinary team principally comprising a statistician (Aitken), an academi ...
... of statistical evidence and probabilistic reasoning, to assist judges, lawyers, forensic scientists and other expert witnesses in coping with the demands of modern criminal litigation. The Guides are being written by a multidisciplinary team principally comprising a statistician (Aitken), an academi ...