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Collaborative coupling between polymerase and helicase for
Collaborative coupling between polymerase and helicase for

... open a base pair to incorporate a new nucleotide (strand displacement synthesis activity). This phase gives rise to a large change in extension, typically 0.8 nm for a nucleotide incorporated at 10 pN. After reaching the end of the loop region, the enzyme only needs to extend the primer (primer ext ...
PDF
PDF

... In gametophytic apomixis, the unreduced embryo sac may arise from a somatic nucellar cell which acquires the developmental program of a functional megaspore, a mechanism referred to as apospory. Alternatively, if the embryo sac forms from a megaspore mother cell with suppressed or modified meiosis, ...
Comparative sequence analysis of the long repeat regions and
Comparative sequence analysis of the long repeat regions and

CURRICULUM VITAE Name: Antonella Spinazzola Nationality
CURRICULUM VITAE Name: Antonella Spinazzola Nationality

... mitochondrial neurogastrointestinalencephalomyopathy (MNGIE) (Science 1999, JBC 2000, and ClinChem 2004). A modified version of the test is now used in a fee-for-service diagnostic laboratory at Columbia University. Supervision of students Dr Spinazzola has supervised the work of 6 graduate students ...
Of mice and (wo)men: genotype–phenotype
Of mice and (wo)men: genotype–phenotype

... The genotype–phenotype correlations observed at the human BRCA1 gene may also be explained by similar models, as discussed above. Most likely, the primary outcome of loss of BRCA1 function in tumors is, both in mouse and man, the accumulation of DNA damage and the altered transcriptional response to ...
oto`s role in head and trunk development
oto`s role in head and trunk development

... plate (CP) is a structure at the anterior midline of the telencephalon that expresses Fgf8, a signaling molecule with important roles in a number of developmental processes including an early role in regulating telencephalic development (Shimamura and Rubenstein, 1997). Although a role for Fgf8 expr ...
Bicoid associates with the 5 -cap-bound complex of caudal mRNA
Bicoid associates with the 5 -cap-bound complex of caudal mRNA

... Germany; 2The Rockefeller University, Laboratories of Molecular Biophysics, New York, New York 10021, USA ...
Multiplex PCR for specific identification and determination of mating
Multiplex PCR for specific identification and determination of mating

... Multiplex PCR for specific identification and determination of mating type in Togninia minima (anamorph Phaeoacremonium aleophilum), a causal agent of esca disease of grapevine Mahdi ARZANLOU and Abolfazl NARMANI Plant Protection Department, Faculty of Agriculture, University of Tabriz, Tabriz, P.O. ...
Standards and guidelines for the interpretation of sequence
Standards and guidelines for the interpretation of sequence

... often lead to confusion because of incorrect assumptions of pathogenic and benign effects, respectively. Thus, it is recommended that both terms be replaced by the term “variant” with the following modifiers: (i) pathogenic, (ii) likely pathogenic, (iii) uncertain significance, (iv) likely benign, o ...
The qSD12 Locus Controls Offspring Tissue-Imposed
The qSD12 Locus Controls Offspring Tissue-Imposed

... 1994). Wild or weedy species developed these dormancy mechanisms during evolution to enhance their survival under adverse natural or in human-disturbed environments by selection for an optimum time to germinate. In contrast, many crop species have lost part or all dormancy mechanisms due to the sele ...
Relative Paucity of Genes Causing Inviability in Hybrids
Relative Paucity of Genes Causing Inviability in Hybrids

Document
Document

... types are involved and whether CRFs act through cell expansion or control of cell division or both. One approach to achieving this is through a detailed tissue and cellular level examination of the leaves and cotyledons of CRF mutants during development. In a parallel approach I will make use of tra ...
Drosophila WntD is a target and an inhibitor of the Dorsal/Twist/Snail
Drosophila WntD is a target and an inhibitor of the Dorsal/Twist/Snail

... maternally deposited RNA and the earliest zygotic expression is present at the anterior and posterior poles of early stage 4 embryos (Fig. 1C). Soon after, wntD is expressed in a few patches of ventral cells (Fig. 1D). This low level of expression remains in the ventral cells throughout the blastode ...
TRIPTYCHON and CAPRICE mediate lateral inhibition during
TRIPTYCHON and CAPRICE mediate lateral inhibition during

... factor in this process was postulated previously because the GL3-homologous R gene from maize triggers trichome formation in Arabidopsis when overexpressed (Lloyd et al., 1992, 1994). TRIPTYCHON (TRY) is the only known negative regulator of trichome development. In try mutants, ~5±10% of the trichom ...
19. - 21. März 2014 in Essen - Deutsche Gesellschaft für
19. - 21. März 2014 in Essen - Deutsche Gesellschaft für

... Prof. Dr. rer. nat. Bernhard Horsthemke, Essen Prof. Dr. med. Dietmar Lohmann, Essen Prof. Dr. med. Klaus Zerres, Aachen Prof. Dr. rer. nat. Kerstin Kutsche, Hamburg Prof. Dr. med. Jürgen Kohlhase, Freiburg Prof. Dr. med. Michael Speicher, Graz Prof. Dr. med. Wolfgang Berger, Zürich Prof. Dr. med. G ...
chicken.db - Bioconductor
chicken.db - Bioconductor

... chickenGO is an R object that provides mappings between manufacturer identifiers and the GO identifiers that they are directly associated with. This mapping and its reverse mapping (chickenGO2PROBE) do NOT associate the child terms from the GO ontology with the gene. Only the directly evidenced term ...
Exam Questions from Exam 1 – Basic Genetic Tests
Exam Questions from Exam 1 – Basic Genetic Tests

... Wild-type humbugs have brown bodies and brown eyes, and are not spotted. You have isolated mutations in three new autosomal humbug genes. The mutation sp gives a dominant phenotype of spotted bodies. The mutation gr gives a recessive phenotype of green bodies. The mutation bl gives the recessive phe ...
Increased transcription rates correlate with increased reversion rates
Increased transcription rates correlate with increased reversion rates

... & Schottel, 1991; Pease & Wolf, 1994). However, very few mRNA stability studies have been published. In fact, Bernstein et al. (2002) found published reports of RNA half-life for less than 0?5 % of the 4288 predicted ORFs in the E. coli genome. This small number of investigations could reflect the c ...
Application of molecular markers in plant breeding
Application of molecular markers in plant breeding

... genotypes can be done directly at the DNA-level in a non-destructive manner with no interference of the environment and regardless of the plant developmental stages, thus allowing a greater efficiency of field trials (Peleman & van der Voort, 2003). The use of molecular information can enhance bree ...
PAX6 mRNA Transcript Analysis in Various Ocular/Non
PAX6 mRNA Transcript Analysis in Various Ocular/Non

... Partial PAX6 is illegitimately expressed in mutant WBC lymphocytes and not in wild type WBC lymphocytes hence it needs to explore the function of PAX6 mRNA in mutant. These results suggest that the PAX6 gene expression patterns of is highly variable in each ocular/non-ocular tissue types and most li ...
Information for couples where one partner carries
Information for couples where one partner carries

... where the baby is attached to the mother. It develops from the tissues of the baby, not the mother, so it has the same make-up as the baby. It is made up of “chorionic villi”. The obstetrician can obtain a sample of chorionic villi either through the vagina, or through the abdomen (tummy). The best ...
Lactose digestion and maldigestion Koetse, Harmanna Antje
Lactose digestion and maldigestion Koetse, Harmanna Antje

... They provide high quality proteins as well as vitamins and are the most significant nutritional source of calcium. The ability to digest milk products is an important factor in the prevention of rickets and osteoporosis, especially in climates with a relatively low amount of sunshine, necessary to a ...
Reviews Sex linked recessive dystonia parkinsonism of Panay
Reviews Sex linked recessive dystonia parkinsonism of Panay

... than one aVected male. No male to male transmission occurred; hence, the inference of sex linked recessive transmission. In addition, it was noted that some patients had parkinsonian features and relatives with parkinsonism. The phenotype of XDP was described in 42 male patients from 21 families in ...
Genetic analysis of the floral initiation process (FLIP) in Arabidopsis
Genetic analysis of the floral initiation process (FLIP) in Arabidopsis

... Recent molecular and genetic analysis in both Arabidop sis and Antirrhinum majus have resulted in a model for the control of floral organ identity (Haughn and Somerville, 1988; Schwarz-Sommer et al., 1990; Bowman et al., 1991; Coen and Meyerowitz, 1991). The two basic tenets of the model are firstly ...
Wnt signaling
Wnt signaling

... A substantial body of evidence suggests that canonical Wnt signaling pathways similar to those in flies and vertebrates act in two post-embryonic processes, the control of QL progeny migration and VPC fate specification. Two other processes, P12 fate specification and contact mediated inhibition of ...
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Nutriepigenomics

Nutriepigenomics is the study of food nutrients and their effects on human health through epigenetic modifications. There is now considerable evidence that nutritional imbalances during gestation and lactation are linked to non-communicable diseases, such as obesity, cardiovascular disease, diabetes, hypertension, and cancer. If metabolic disturbances occur during critical time windows of development, the resulting epigenetic alterations can lead to permanent changes in tissue and organ structure or function and predispose individuals to disease.
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