The importance of genetic influences in asthma REVIEW H. Los* , G.H. Koppelman*
... It has long been established that genetic factors are very important in the pathogenesis of asthma. Familial aggregation of asthma was probably first described by Sennertus in 1650 [26]. At the beginning of this century, R. Cooke performed two large studies on the inheritance of atopy, one in 1916 a ...
... It has long been established that genetic factors are very important in the pathogenesis of asthma. Familial aggregation of asthma was probably first described by Sennertus in 1650 [26]. At the beginning of this century, R. Cooke performed two large studies on the inheritance of atopy, one in 1916 a ...
Additional file 1
... is “cacgtg”. Therefore, we initially assign “cacgtg” as the DNA binding sites of bh2b. The same search is performed on Ipmyb1, but no clear consensus can be draw from Jaspar database. The following search is based on the assumption that the binding sites of two collaborative TFs are not far apart (e ...
... is “cacgtg”. Therefore, we initially assign “cacgtg” as the DNA binding sites of bh2b. The same search is performed on Ipmyb1, but no clear consensus can be draw from Jaspar database. The following search is based on the assumption that the binding sites of two collaborative TFs are not far apart (e ...
THE GENETICS OF CAENORΉABDITIS ELEGANS
... organisms is a major unsolved problem in biology. Many of the molecular mechanisms involved in gene expression in prokaryotic microorganisms have already been found to exist in a relatively unmodified form in eukaryotic cells. The genetic code is universal and the mechanism of protein synthesis is m ...
... organisms is a major unsolved problem in biology. Many of the molecular mechanisms involved in gene expression in prokaryotic microorganisms have already been found to exist in a relatively unmodified form in eukaryotic cells. The genetic code is universal and the mechanism of protein synthesis is m ...
Molecular Characterization of Visual Pigments in
... Details of clone development are described below. Three opsin fragments (RhA, RhB, and RhC) were obtained by PCR from T. granarius ss cDNA. RhA fragment was amplified with Op-F1 and Op-R1 primers. PCR conditions comprised 3 min at 95 °C, 42 cycles of 15 s at 95 °C, 15 s at 40 °C, and 30 s at 72 °C. ...
... Details of clone development are described below. Three opsin fragments (RhA, RhB, and RhC) were obtained by PCR from T. granarius ss cDNA. RhA fragment was amplified with Op-F1 and Op-R1 primers. PCR conditions comprised 3 min at 95 °C, 42 cycles of 15 s at 95 °C, 15 s at 40 °C, and 30 s at 72 °C. ...
Unusual ADP-forming acetyl-coenzyme A synthetases from the
... H. marismortui was purified and characterized as a saltdependent, mesophilic ACD of homodimeric structure (166 kDa). The encoding gene was identified in the partially sequenced genome of H. marismortui and functionally expressed in Escherichia coli. The recombinant enzyme was reactivated from inclusio ...
... H. marismortui was purified and characterized as a saltdependent, mesophilic ACD of homodimeric structure (166 kDa). The encoding gene was identified in the partially sequenced genome of H. marismortui and functionally expressed in Escherichia coli. The recombinant enzyme was reactivated from inclusio ...
oto`s role in head and trunk development
... visceral endoderm, in the form of restricted expression of genes such as Lim1 and Hex, precedes discernible pattern in the overlying epiblast by at least 12 hours (reviewed in Beddington and Robertson, 1998, 1999). More recently a specific role for the AVE of the pregastrula mouse embryo in patterni ...
... visceral endoderm, in the form of restricted expression of genes such as Lim1 and Hex, precedes discernible pattern in the overlying epiblast by at least 12 hours (reviewed in Beddington and Robertson, 1998, 1999). More recently a specific role for the AVE of the pregastrula mouse embryo in patterni ...
Cellular Biology
... DNA strand and entire piece missing or an extra chromosome or even an extra complete set examples include Cri – du – chat mising piece of #5 or trisomy 21 ...
... DNA strand and entire piece missing or an extra chromosome or even an extra complete set examples include Cri – du – chat mising piece of #5 or trisomy 21 ...
The Homothorax homeoprotein activates the nuclear localization of
... (data not shown). Mutant hth and tss embryos have similar head defects. Two tss mutants (tss47 and tss470) were also defective for hth. These results suggested that the two genes are very closely located or overlapping, and may be under similar regulation and have similar developmental functions. Ge ...
... (data not shown). Mutant hth and tss embryos have similar head defects. Two tss mutants (tss47 and tss470) were also defective for hth. These results suggested that the two genes are very closely located or overlapping, and may be under similar regulation and have similar developmental functions. Ge ...
hhmi resource for new ap bio curriculum
... wild-type and mutant rock pocket mouse Mc1r genes and compare sequences to identify the locations and types of mutations responsible for the coat color variation described in the film. ...
... wild-type and mutant rock pocket mouse Mc1r genes and compare sequences to identify the locations and types of mutations responsible for the coat color variation described in the film. ...
Fulltext PDF - Indian Academy of Sciences
... (Catterall 1986). It is unlikely that veratridine resistance in mutant flies is due to direct involvement of stmA in the structure or function of the transmembrane sodium channels. Reasons for doubt arise from the observation that double mutants of stmA and para, a structural gene for neuronal volta ...
... (Catterall 1986). It is unlikely that veratridine resistance in mutant flies is due to direct involvement of stmA in the structure or function of the transmembrane sodium channels. Reasons for doubt arise from the observation that double mutants of stmA and para, a structural gene for neuronal volta ...
Organization and Integration of Large
... technological advances on the field of experimental methods and computational analysis tools, understanding of a multicellular organism, even a small one, is still not amenable. In contrast, the analysis of bacteria, prokaryotic organisms, on a genome-scale has become possible, providing insight int ...
... technological advances on the field of experimental methods and computational analysis tools, understanding of a multicellular organism, even a small one, is still not amenable. In contrast, the analysis of bacteria, prokaryotic organisms, on a genome-scale has become possible, providing insight int ...
Organization and Integration of Large-scale Datasets for
... technological advances on the field of experimental methods and computational analysis tools, understanding of a multicellular organism, even a small one, is still not amenable. In contrast, the analysis of bacteria, prokaryotic organisms, on a genome-scale has become possible, providing insight int ...
... technological advances on the field of experimental methods and computational analysis tools, understanding of a multicellular organism, even a small one, is still not amenable. In contrast, the analysis of bacteria, prokaryotic organisms, on a genome-scale has become possible, providing insight int ...
Molecular Network Controlling the Ovule Development in
... (Ishida et al., 2000). These two genes are essential for maintaining the meristem identity and the proper formation of organ boundaries. It is known that CUCs expression are repressed by auxin and their transcripts are cleaved by the auxin induced micro RNA164 product (Guo et al 2005; Shani ...
... (Ishida et al., 2000). These two genes are essential for maintaining the meristem identity and the proper formation of organ boundaries. It is known that CUCs expression are repressed by auxin and their transcripts are cleaved by the auxin induced micro RNA164 product (Guo et al 2005; Shani ...
Population Genetics - University of Evansville Faculty Web sites
... based on the specific kinds of bands that are produced on gels There are duplicated noncoding regions (or repetitive regions) of the DNA referred to as miniand microsatellite sequences This DNA is similar among closely related organisms – that is, there is a core sequence of nucleotides shared among ...
... based on the specific kinds of bands that are produced on gels There are duplicated noncoding regions (or repetitive regions) of the DNA referred to as miniand microsatellite sequences This DNA is similar among closely related organisms – that is, there is a core sequence of nucleotides shared among ...
Lactose tolerance
... tolerant populations who, due to damage caused by diseases of the stomach or intestines, can no longer properly produce lactase. 3. Congenital lactose intolerance. This is a condition where children are born unable to metabolise lactose. Before the 20th century it would normally have resulted in de ...
... tolerant populations who, due to damage caused by diseases of the stomach or intestines, can no longer properly produce lactase. 3. Congenital lactose intolerance. This is a condition where children are born unable to metabolise lactose. Before the 20th century it would normally have resulted in de ...
6. risk management plan
... Transfer of genes to other cotton plants ..................................................................... 54 Transfer of genes to other plant species ..................................................................... 54 B: Likelihood of the gene transfer hazard occurring .................... ...
... Transfer of genes to other cotton plants ..................................................................... 54 Transfer of genes to other plant species ..................................................................... 54 B: Likelihood of the gene transfer hazard occurring .................... ...
The development and evolutionary origin of barbels in
... developmental biology. In pursuit of this goal, we have examined the developmental genetic mechanisms that underlie growth and patterning in a largely overlooked group of morphological novelties: the barbels of fishes. Barbels are appendages that project from the head region in a large and disparate ...
... developmental biology. In pursuit of this goal, we have examined the developmental genetic mechanisms that underlie growth and patterning in a largely overlooked group of morphological novelties: the barbels of fishes. Barbels are appendages that project from the head region in a large and disparate ...
Suberin biosynthesis in O. sativa: characterisation of a cytochrome
... An organism is defined to be alive when it features certain characteristics: It has to have the ability to reproduce itself, a metabolism to absorb and convert energy from the environment and to build its own components, it has to be discrete from its surrounding media, and maintain its homoeostasis ...
... An organism is defined to be alive when it features certain characteristics: It has to have the ability to reproduce itself, a metabolism to absorb and convert energy from the environment and to build its own components, it has to be discrete from its surrounding media, and maintain its homoeostasis ...
Transvection Is Common Throughout the Drosophila
... DSCP, Drosophila synthetic core promoter; white, miniwhite used to score for integrations; pUC19, plasmid backbone from the CRM-GAL4 vector containing bacterial origin of replication and ampicillin resistance gene. (B–D) Maximum confocal z projection of the thoracic region of a wandering third insta ...
... DSCP, Drosophila synthetic core promoter; white, miniwhite used to score for integrations; pUC19, plasmid backbone from the CRM-GAL4 vector containing bacterial origin of replication and ampicillin resistance gene. (B–D) Maximum confocal z projection of the thoracic region of a wandering third insta ...
The Genera Staphylococcus and Macrococcus
... groups or masses was called “Staphylococcus” and another arranged in chains was named “Billroth’s Streptococcus.” A formal description of the genus Staphylococcus was provided by Rosenbach (1884). He divided the genus into the two species Staphylococcus aureus and S. albus. Zopf (1885) placed the ma ...
... groups or masses was called “Staphylococcus” and another arranged in chains was named “Billroth’s Streptococcus.” A formal description of the genus Staphylococcus was provided by Rosenbach (1884). He divided the genus into the two species Staphylococcus aureus and S. albus. Zopf (1885) placed the ma ...
TRANSLOCATIONS INVOLVING T H E THIRD AND THE FOURTH
... the third chromosome, one fragment being attached to the fourthchromosome. These gametes carry, therefore, the gene D and the normal allelomorph of ev. The other kind of gametes contains the normal (that is, the unbroken) third chromosome andthe free fourth chromosome. These gametes carry ey but do ...
... the third chromosome, one fragment being attached to the fourthchromosome. These gametes carry, therefore, the gene D and the normal allelomorph of ev. The other kind of gametes contains the normal (that is, the unbroken) third chromosome andthe free fourth chromosome. These gametes carry ey but do ...
24 Recombination Hotspots in Nonallelic Homologous Recombination
... NAHR hotspots appear to be relatively small (<2 kb) and are initiated by double-strand breaks. Gene conversion events as well as crossovers are enhanced at NAHR hotspots. Recent work has improved our understanding of the origins of NAHR and AHR hotspots, with both appearing to be relatively short-li ...
... NAHR hotspots appear to be relatively small (<2 kb) and are initiated by double-strand breaks. Gene conversion events as well as crossovers are enhanced at NAHR hotspots. Recent work has improved our understanding of the origins of NAHR and AHR hotspots, with both appearing to be relatively short-li ...
ORNAMENTAL WHITE CLOVER BREEDING AND LEAF TRAIT
... Although it is agreed that all leaf marks described above are dominant traits, there is disagreement as to the genetic control of these traits. Carnahan et al. (1955) and Brewbaker (1955) state that the expression of the various leaf marks is controlled by two different genes (V and R) that each con ...
... Although it is agreed that all leaf marks described above are dominant traits, there is disagreement as to the genetic control of these traits. Carnahan et al. (1955) and Brewbaker (1955) state that the expression of the various leaf marks is controlled by two different genes (V and R) that each con ...
Regulation of limb bud initiation and limbtype
... and although npnt is ubiquitously expressed during frog development at the time forelimb outgrowth is initiated, transcripts are enriched in pronephros. The correlation with pronephros is potentially significant since extirpation experiments in the chick have implicated nephrogenic mesoderm in foreli ...
... and although npnt is ubiquitously expressed during frog development at the time forelimb outgrowth is initiated, transcripts are enriched in pronephros. The correlation with pronephros is potentially significant since extirpation experiments in the chick have implicated nephrogenic mesoderm in foreli ...
Gene
A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term ""having a gene"" (e.g., ""good genes,"" ""hair colour gene"") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.The concept of a gene continues to be refined as new phenomena are discovered. For example, regulatory regions of a gene can be far removed from its coding regions, and coding regions can be split into several exons. Some viruses store their genome in RNA instead of DNA and some gene products are functional non-coding RNAs. Therefore, a broad, modern working definition of a gene is any discrete locus of heritable, genomic sequence which affect an organism's traits by being expressed as a functional product or by regulation of gene expression.