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Variant Effect Predictor Web interface Documentation
... A list of variant sources imported can be viewed here. Note that this feature is only available for species with an Ensembl Variation database. Equivalent to --check_existing. The VEP will also allow you to compare the alleles of your input variant to that of the existing variant by selecting "Yes a ...
... A list of variant sources imported can be viewed here. Note that this feature is only available for species with an Ensembl Variation database. Equivalent to --check_existing. The VEP will also allow you to compare the alleles of your input variant to that of the existing variant by selecting "Yes a ...
19. - 21. März 2014 in Essen - Deutsche Gesellschaft für
... kann. Im Prinzip erfordert die Datenauswertung lediglich einen Vergleich einer vollständigen Liste der sequenzierten Varianten mit einer umfassenden Liste von krankheitsverursachenden Varianten. In der Praxis stellen weniger die technischen Limitationen der Sequenziertechnik als die fehlende Annotat ...
... kann. Im Prinzip erfordert die Datenauswertung lediglich einen Vergleich einer vollständigen Liste der sequenzierten Varianten mit einer umfassenden Liste von krankheitsverursachenden Varianten. In der Praxis stellen weniger die technischen Limitationen der Sequenziertechnik als die fehlende Annotat ...
Mutations to nonsense codons in human genetic
... that nonsense suppression might one day prove to be a useful technique for the somatic gene therapy of human diseases caused by mutation to nonsense codons (1). Although there has been relatively little work in this area in the intervening years, there are several attractive aspects to such a strate ...
... that nonsense suppression might one day prove to be a useful technique for the somatic gene therapy of human diseases caused by mutation to nonsense codons (1). Although there has been relatively little work in this area in the intervening years, there are several attractive aspects to such a strate ...
Autosomal and X-chromosome imprinting
... and studies with these may further define the exact region subject to imprinting. Table 1 summarizes the frequencies with which the hypo- and hyperkinetic classes have been detected in studies with a series of different chromosome 2 translocations. It can be seen that, generally, the recovery varied ...
... and studies with these may further define the exact region subject to imprinting. Table 1 summarizes the frequencies with which the hypo- and hyperkinetic classes have been detected in studies with a series of different chromosome 2 translocations. It can be seen that, generally, the recovery varied ...
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... The gammaproteobacterium Nitrosococcus oceani (ATCC 19707) is a gram-negative obligate chemolithoautotroph capable of extracting energy and reducing power from the oxidation of ammonia to nitrite. Sequencing and annotation of the genome revealed a single circular chromosome (3,481,691 bp; GⴙC conten ...
... The gammaproteobacterium Nitrosococcus oceani (ATCC 19707) is a gram-negative obligate chemolithoautotroph capable of extracting energy and reducing power from the oxidation of ammonia to nitrite. Sequencing and annotation of the genome revealed a single circular chromosome (3,481,691 bp; GⴙC conten ...
Standard PDF - Wiley Online Library
... Determination of the number and identities of all proteins encoded in the P. carinii genome will require its sequencing. ...
... Determination of the number and identities of all proteins encoded in the P. carinii genome will require its sequencing. ...
Characterization of the cDNA and Gene Coding for the Biotin
... biotin synthase of Arabidopsis (Fig. 2). Direct demonstration of the identity of pBS-1 was obtained by expressing the cDNA in the E . coli strain R875, which carries a mutant allele of the bioB gene that codes for biotin synthase. Due to this mutation, strain R875 cannot grow on media that lack biot ...
... biotin synthase of Arabidopsis (Fig. 2). Direct demonstration of the identity of pBS-1 was obtained by expressing the cDNA in the E . coli strain R875, which carries a mutant allele of the bioB gene that codes for biotin synthase. Due to this mutation, strain R875 cannot grow on media that lack biot ...
MTHFR C677T and A1298C: Explained In Plain
... It is naturally formed in the body, but gets broken down (recycled) by Lmethyfolate (active folate). Said another way, a lack of L-methylfolate can lead to an increase in homocysteine. Although diet and lifestyle are major influences, your genetics are thought to be responsible for between 45-60% of ...
... It is naturally formed in the body, but gets broken down (recycled) by Lmethyfolate (active folate). Said another way, a lack of L-methylfolate can lead to an increase in homocysteine. Although diet and lifestyle are major influences, your genetics are thought to be responsible for between 45-60% of ...
Reproductive barriers in indica-japonica rice
... differentially expressed at MMC, MEI and AME. Large numbers of cell wall ...
... differentially expressed at MMC, MEI and AME. Large numbers of cell wall ...
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... heterochromatin region in the long arm of one of the chromosome 9. Heterochromatin polymorphisms are microscopically visible regions on chromosomes 1, 9, 16, the distal two thirds of the long arm of the Y chromosome and the satellites of the acrocentric chromosomes, with no apparent effect on the ph ...
... heterochromatin region in the long arm of one of the chromosome 9. Heterochromatin polymorphisms are microscopically visible regions on chromosomes 1, 9, 16, the distal two thirds of the long arm of the Y chromosome and the satellites of the acrocentric chromosomes, with no apparent effect on the ph ...
View - Rai University
... by George H. Shull more than century years ago, in which he scientifically described heterosis and laid the foundation of modern hybrid breeding in maize, the exploitation of heterosis in crop and tree species has greatly expanded and the acreage under hybrid cultivars has steadily increased. Thus, ...
... by George H. Shull more than century years ago, in which he scientifically described heterosis and laid the foundation of modern hybrid breeding in maize, the exploitation of heterosis in crop and tree species has greatly expanded and the acreage under hybrid cultivars has steadily increased. Thus, ...
Developing a Bioassay for Triclosan Toxicity Abstract
... impairment of cardiac and skeletal muscle observed by Cherednichenko et al (). Furthermore, the decrease of actin can also affect cell growth. Actin plays a critical role in the cytoskeleton and cell division. Actin’s interaction with myosin allows the microtubules to contract during cytokinesis. Th ...
... impairment of cardiac and skeletal muscle observed by Cherednichenko et al (). Furthermore, the decrease of actin can also affect cell growth. Actin plays a critical role in the cytoskeleton and cell division. Actin’s interaction with myosin allows the microtubules to contract during cytokinesis. Th ...
Causes that Make a Difference - Philsci
... actually made the difference, such as Mary’s striking the match. This distinction is elusive, and it is tempting to dismiss it as illusory. On this view, there is an ontological difference between causes and non-causes, but there is no ontological difference among causes. This was the position taken ...
... actually made the difference, such as Mary’s striking the match. This distinction is elusive, and it is tempting to dismiss it as illusory. On this view, there is an ontological difference between causes and non-causes, but there is no ontological difference among causes. This was the position taken ...
Distalless and dachshund pattern both plesiomorphic
... genetic mechanism for the evolutionary transition from the three‐ to the two‐segmented cheliceral type (Sharma et al. 2012b). To date, the functional significance of the expression domains of Dll and dac in chelicerate orders with the plesiomorphic cheliceral type has not been tested. Functional gene ...
... genetic mechanism for the evolutionary transition from the three‐ to the two‐segmented cheliceral type (Sharma et al. 2012b). To date, the functional significance of the expression domains of Dll and dac in chelicerate orders with the plesiomorphic cheliceral type has not been tested. Functional gene ...
Chromosome location and characterization of genes for grain
... contributing to their low grain yield. LDN(521-3A) produced weak plants and were the shortest in plant height and they had the smallest spikes of the LDN-DIC lines. LDN(742-2B) produced weak stands, with plants significantly shorter than LDN, and had the highest severity of foliar diseases such as t ...
... contributing to their low grain yield. LDN(521-3A) produced weak plants and were the shortest in plant height and they had the smallest spikes of the LDN-DIC lines. LDN(742-2B) produced weak stands, with plants significantly shorter than LDN, and had the highest severity of foliar diseases such as t ...
THE GENETICS AND REPRODUCTIVE ISOLATING MECHANISMS
... The case of Pieris napi L. and bryonia? Ochsenheimer has wasted much ink in arguments among taxonomists as to whether bryonia: is a distinct species or only a subspecies of napi, without having brought about a satisfactory explanation. Even after the extensive work of MULLER and KAUTZ (1938), a turn ...
... The case of Pieris napi L. and bryonia? Ochsenheimer has wasted much ink in arguments among taxonomists as to whether bryonia: is a distinct species or only a subspecies of napi, without having brought about a satisfactory explanation. Even after the extensive work of MULLER and KAUTZ (1938), a turn ...
Unveiling the physiological and molecular basis of Mycobacterium
... species, namely M. tuberculosis, the main etiological agent of human tuberculosis (TB), and M. bovis, the causative agent of bovine tuberculosis (bTB), one of the most relevant zoonosis in the world. The complex pathogenesis of MTC bacteria is influenced by several factors, including host and bacter ...
... species, namely M. tuberculosis, the main etiological agent of human tuberculosis (TB), and M. bovis, the causative agent of bovine tuberculosis (bTB), one of the most relevant zoonosis in the world. The complex pathogenesis of MTC bacteria is influenced by several factors, including host and bacter ...
Histological classification and molecular genetics of meningiomas
... papillary, and rhabdoid meningiomas, which are consistently associated with more aggressive clinical features. The histological variants most commonly diagnosed in pathology specimens are meningothelial, fibrous, and transitional meningioma (figure 1, panel 1). Meningothelial meningiomas are histologi ...
... papillary, and rhabdoid meningiomas, which are consistently associated with more aggressive clinical features. The histological variants most commonly diagnosed in pathology specimens are meningothelial, fibrous, and transitional meningioma (figure 1, panel 1). Meningothelial meningiomas are histologi ...
Inbreeding in Cattle
... (the degree to which a sire or dam will pass his or her characteristics consistently). This is more than counteracted by the decline in selection intensity and loss of genetic variation. Selection intensity is a function of the proportion of bull and heifer candidates that are actually selected. Sel ...
... (the degree to which a sire or dam will pass his or her characteristics consistently). This is more than counteracted by the decline in selection intensity and loss of genetic variation. Selection intensity is a function of the proportion of bull and heifer candidates that are actually selected. Sel ...
HLA-A, -B
... A*0101, *0301, Cw*0701,*0702, B*0702,*0801, DRB1*0301,*1501, DQA1*0501,*0102, DQB1*0201,*0602 composed from 2 haplotypes from the parents: A*0101 : Cw*0701 : B*0801 : DRB1*0301 : DQA1*0501 : DQB1*0201 (by serotyping A1-Cw7-B8-DR3-DQ2) A*0301 : Cw*0702 : B*0702 : DRB1*1501 : DQA1*0102 : DQB1*0602 (by ...
... A*0101, *0301, Cw*0701,*0702, B*0702,*0801, DRB1*0301,*1501, DQA1*0501,*0102, DQB1*0201,*0602 composed from 2 haplotypes from the parents: A*0101 : Cw*0701 : B*0801 : DRB1*0301 : DQA1*0501 : DQB1*0201 (by serotyping A1-Cw7-B8-DR3-DQ2) A*0301 : Cw*0702 : B*0702 : DRB1*1501 : DQA1*0102 : DQB1*0602 (by ...
A Unified Approach to the Evolutionary Consequences of Genetic
... 2006; Cuzin et al. 2008; Wagner et al. 2008). Such mechanisms can mediate effects of parental genotype on offspring phenotype (Nelson et al. 2010; Yazbek et al. 2010). Many nongenetically transmitted factors also reflect the influence of parental environment and therefore can sometimes serve as vehi ...
... 2006; Cuzin et al. 2008; Wagner et al. 2008). Such mechanisms can mediate effects of parental genotype on offspring phenotype (Nelson et al. 2010; Yazbek et al. 2010). Many nongenetically transmitted factors also reflect the influence of parental environment and therefore can sometimes serve as vehi ...
Genotype C of hepatitis B virus can be classified into at least two
... detected in Asia could be classified into at least two subgroups, which we named HBV/C1 and HBV/C2. Notably, HBV/C1 was found only in southeast Asia including Vietnam, Myanmar and Thailand, while HBV/C2 was found in Far East Asia including Japan, Korea and China. By means of phylogenetic analysis in ...
... detected in Asia could be classified into at least two subgroups, which we named HBV/C1 and HBV/C2. Notably, HBV/C1 was found only in southeast Asia including Vietnam, Myanmar and Thailand, while HBV/C2 was found in Far East Asia including Japan, Korea and China. By means of phylogenetic analysis in ...
Cold-induced silencing by long antisense transcripts of an
... demethylase activity of FLOWERING LOCUS D (FLD)5,6. FLC is also repressed by prolonged cold and epigenetically silenced by a Polycomb mechanism involving a PHD–PRC2 (plant homeodomain–Polycomb repressive complex 2) complex2, in a process known as vernalization3,7. To understand the roles of non-codi ...
... demethylase activity of FLOWERING LOCUS D (FLD)5,6. FLC is also repressed by prolonged cold and epigenetically silenced by a Polycomb mechanism involving a PHD–PRC2 (plant homeodomain–Polycomb repressive complex 2) complex2, in a process known as vernalization3,7. To understand the roles of non-codi ...
Basic Principles of Heredity
... Genes frequently come in different versions called alleles (Figure 3.3). In Mendel’s crosses, seed shape was determined by a gene that exists as two different alleles: one allele encodes round seeds and the other encodes wrinkled seeds. All alleles for any particular gene will be found at a specific ...
... Genes frequently come in different versions called alleles (Figure 3.3). In Mendel’s crosses, seed shape was determined by a gene that exists as two different alleles: one allele encodes round seeds and the other encodes wrinkled seeds. All alleles for any particular gene will be found at a specific ...
Pyruvate : NADP+ Oxidoreductase from the Mitochondrion of
... the earliest eukaryotic cells (Martin and Müller 1998). In principle, three alternative explanations could currently account for the distribution of PFO among eukaryotes and its evident correlation with the amitochondriate phenotype. The first possible explanation is that the host of mitochondrial ...
... the earliest eukaryotic cells (Martin and Müller 1998). In principle, three alternative explanations could currently account for the distribution of PFO among eukaryotes and its evident correlation with the amitochondriate phenotype. The first possible explanation is that the host of mitochondrial ...
Gene
![](https://commons.wikimedia.org/wiki/Special:FilePath/Gregor_Mendel.png?width=300)
A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term ""having a gene"" (e.g., ""good genes,"" ""hair colour gene"") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.The concept of a gene continues to be refined as new phenomena are discovered. For example, regulatory regions of a gene can be far removed from its coding regions, and coding regions can be split into several exons. Some viruses store their genome in RNA instead of DNA and some gene products are functional non-coding RNAs. Therefore, a broad, modern working definition of a gene is any discrete locus of heritable, genomic sequence which affect an organism's traits by being expressed as a functional product or by regulation of gene expression.