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•The normal control of cell division •How cancer arises from defects
•The normal control of cell division •How cancer arises from defects

... The cell cycle is driven by protein synthesis and degradation Cyclin B induces its own destruction via the Anaphase Promoting Complex (APC) ...
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Open File

... pass to the next cell cycle phase. Eventually, the cyclin degrades, deactivating the Cdk, thus signaling exit from a particular phase. There are two classes of cyclins: mitotic cyclins and G1 cyclins. ...
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... attached to a spindle fiber at the centromere. Centromere is a protein that joins the two “sister” chromatids, or replicated chromosome pairs Summarize! ...
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Mitosis

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Cell cycle and mitosis

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BI0I 121 cell and tissues
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Cell Cycle Study Guide
Cell Cycle Study Guide

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Cells - Organelles and Cell Cycle
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Slide 1

... Cells contain elaborate arrays of protein fibres called the cyctoskelton that serve such functions as: • Gives the cell shape and allows it to change shape when required • providing mechanical strength • locomotion • chromosome separation in mitosis and meiosis • intracellular transport of organelle ...
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Select this.

... they are responsible for organization of the cytoplasm and intracellular transport of organelles and vesicles they help to determine cell shape and polarity they participate in a variety of motile activities (the movement chromosomes during mitosis, the beating of cilia) disruption or depolymerisati ...
Grade 10 Science – The Cell Cycle
Grade 10 Science – The Cell Cycle

... Grade 10 Science – The Cell Cycle Prophase (Phase 1) This is the first phase of mitosis. During prophase, the nuclear envelope around the nucleus starts to break down and all the chromosomes start to coil up in the centre of the cell. Since the DNA strands duplicated during interphase, each chromos ...
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... remodelling of the entire cell-cycle network rather than simply a restriction of the canonical cell cycle as previously suggested. ...
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study guide for biology final 2008
study guide for biology final 2008

... Know all the main events associated with each stage of the cell cycle; be able to identify each phase of mitosis. You will not draw it yourself. Know the main differences between mitosis in animals and plants Understand how cancer is related to cell division Know chromosome structure and the relatio ...
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11-4 Meiosis - Little Miami Schools
11-4 Meiosis - Little Miami Schools

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Appendix C
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The Cell Cycle
The Cell Cycle

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Spindle checkpoint



During the process of cell division, the spindle checkpoint prevents separation of the duplicated chromosomes until each chromosome is properly attached to the spindle apparatus. In order to preserve the cell's identity and proper function, it is necessary to maintain the appropriate number of chromosomes after each cell division. An error in generating daughter cells with fewer or greater number of chromosomes than expected (a situation termed aneuploidy), may lead in best case to cell death, or alternatively it may generate catastrophic phenotypic results. Examples include: In cancer cells, aneuploidy is a frequent event, indicating that these cells present a defect in the machinery involved in chromosome segregation, as well as in the mechanism ensuring that segregation is correctly performed. In humans, Down syndrome appears in children carrying in their cells one extra copy of chromosome 21, as a result of a defect in chromosome segregation during meiosis in one of the progenitors. This defect will generate a gamete (spermatozoide or oocyte) with an extra chromosome 21. After fecundation, this gamete will generate an embryo with three copies of chromosome 21.The mechanisms verifying that all the requirements to pass to the next phase in the cell cycle have been fulfilled are called checkpoints. All along the cell cycle, there are different checkpoints. The checkpoint ensuring that chromosome segregation is correct is termed spindle assembly checkpoint (SAC), spindle checkpoint or mitotic checkpoint. During mitosis or meiosis, the spindle checkpoint prevents anaphase onset until all chromosomes are properly attached to the spindle. To achieve proper segregation, the two kinetochores on the sister chromatids must be attached to opposite spindle poles (bipolar orientation). Only this pattern of attachment will ensure that each daughter cell receives one copy of the chromosome.
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