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BIOL 112 – Principles of Zoology
BIOL 112 – Principles of Zoology

... significantly lower levels of methylated DNA than inactive genes. A gene for methylation is essential for development in mice (turning off a gene also can be important). Methylation results in a human disease called fragile X syndrome; FMR-1 gene is silenced by methylation. ...
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... are derived from the same parent cell/organism through cell division. Coding region ²WKHUHJLRQRIDJHQHWKDWLVDFWLYHO\ transcribed into mRNA. Development ²WKHFRRUGLQDWLRQRIWKHIDWHVRILQGLvidual cells arising from stem cells within an embryo. The cells arising from stem cells are genetica ...
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< 1 ... 866 867 868 869 870 871 872 873 874 ... 895 >

Epigenetics of human development

Development before birth, including gametogenesis, embryogenesis, and fetal development, is the process of body development from the gametes are formed to eventually combine into a zygote to when the fully developed organism exits the uterus. Epigenetic processes are vital to fetal development due to the need to differentiate from a single cell to a variety of cell types that are arranged in such a way to produce cohesive tissues, organs, and systems.Epigenetic modifications such as methylation of CpGs (a dinucleotide composed of a 2'-deoxycytosine and a 2' deoxyguanosine) and histone tail modifications allow activation or repression of certain genes within a cell, in order to create cell memory either in favor of using a gene or not using a gene. These modifications can either originate from the parental DNA, or can be added to the gene by various proteins and can contribute to differentiation. Processes that alter the epigenetic profile of a gene include production of activating or repressing protein complexes, usage of non-coding RNAs to guide proteins capable of modification, and the proliferation of a signal by having protein complexes attract either another protein complex or more DNA in order to modify other locations in the gene.
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