Purines/Pyrimidines LIGAND-SET™ (L2538)
... The Purines/Pyrimidines LIGAND-SET™ contains 2 mg of each ligand per well. Stock solutions can be readily prepared by adding 1 ml of DMSO to each well. The set also comes with a diskette containing a structural database, or SD file and a Microsoft Excel file containing the catalog number, name, rack ...
... The Purines/Pyrimidines LIGAND-SET™ contains 2 mg of each ligand per well. Stock solutions can be readily prepared by adding 1 ml of DMSO to each well. The set also comes with a diskette containing a structural database, or SD file and a Microsoft Excel file containing the catalog number, name, rack ...
IN SILICO SCREENING, SYNTHESIS AND IN VITRO EVALUATION OF SOME... DERIVATIVES AS DIHYDROFOLATE REDUCTASE INHIBITORS FOR ANTICANCER ACTIVITY:
... Objective: The main objective of this research was to in silico screen, synthesize, characterize and in vitro evaluate some quinazolin-/e/one derivatives as dihydrofolate reductase (DHFR) inhibitors for anti-cancer activity. Method: The present study reports a new series of Quinazoline and quinazoli ...
... Objective: The main objective of this research was to in silico screen, synthesize, characterize and in vitro evaluate some quinazolin-/e/one derivatives as dihydrofolate reductase (DHFR) inhibitors for anti-cancer activity. Method: The present study reports a new series of Quinazoline and quinazoli ...
Computer Aided Molecular Design
... nucleic acid structure and function How proteins control living processes ...
... nucleic acid structure and function How proteins control living processes ...
University of Groningen Sugar transport in
... coli, maltose transport occurs with a relatively high affinity of about 1 µM [4]. Substrate affinities of ABC transporters in the nanomolar range are usually observed only for substrates such as vitamins and iron which are found in very low concentrations in the environment. Uptake of substrates by ...
... coli, maltose transport occurs with a relatively high affinity of about 1 µM [4]. Substrate affinities of ABC transporters in the nanomolar range are usually observed only for substrates such as vitamins and iron which are found in very low concentrations in the environment. Uptake of substrates by ...
Principles of Immunochemical Techniques Used in Clinical
... enzyme molecules are conjugated to secondary (detection) antibodies, which bind to the primary antigen-antibody complex. When the appropriate substrate is added, the enzyme catalyzes the production of a colored end-product, which can be visualized and quantitated. The enzymes most often used are alk ...
... enzyme molecules are conjugated to secondary (detection) antibodies, which bind to the primary antigen-antibody complex. When the appropriate substrate is added, the enzyme catalyzes the production of a colored end-product, which can be visualized and quantitated. The enzymes most often used are alk ...
Slide 1
... test tube protocol. The net (blank corrected) average absorbance for each protein was calculated. The net absorbance for each protein is expressed as a ratio to the net absorbance for BSA (e.g., a ratio of 0.80 means that the protein produces 80% of the color obtained for an equivalent mass of BSA). ...
... test tube protocol. The net (blank corrected) average absorbance for each protein was calculated. The net absorbance for each protein is expressed as a ratio to the net absorbance for BSA (e.g., a ratio of 0.80 means that the protein produces 80% of the color obtained for an equivalent mass of BSA). ...
COMMUNICATION Engineering the Amine Transaminase from
... binding in the active site (Figure 1). These positions were then subjected to mutagenesis using distinct degenerate codons encoding hydrophobic amino acids selected based on the 3DM analysis (Supporting Information, Table S9). Thereby the active site is widened by the introduction of smaller hydroph ...
... binding in the active site (Figure 1). These positions were then subjected to mutagenesis using distinct degenerate codons encoding hydrophobic amino acids selected based on the 3DM analysis (Supporting Information, Table S9). Thereby the active site is widened by the introduction of smaller hydroph ...
A Statistical Method for Finding Transcriptional Factor Binding Sites
... Allows for overlapping occurrences (in both orientations), which lends to complex dependencies Statistical significance of a motif (s) is based on the frequencies of shorter (more frequent) oligonucleotides ...
... Allows for overlapping occurrences (in both orientations), which lends to complex dependencies Statistical significance of a motif (s) is based on the frequencies of shorter (more frequent) oligonucleotides ...
Strain in Protein Structures as Viewed Through Nonrotameric Side
... A nonredundant set of 3D structures was compiled from the Protein Data Bank (PDB)11 with recorded ligands. By using the method of Heringa et al.,12 a maximally sized set of proteins was gathered with minimal sequence lengths of 80 residues (see below), resolutions ⱕ 1.8 Å, and sequence identities ⱕ ...
... A nonredundant set of 3D structures was compiled from the Protein Data Bank (PDB)11 with recorded ligands. By using the method of Heringa et al.,12 a maximally sized set of proteins was gathered with minimal sequence lengths of 80 residues (see below), resolutions ⱕ 1.8 Å, and sequence identities ⱕ ...
Haemoglobin (Roll no. 22
... • Decrease of hemoglobin, with or without an absolute decrease of red blood cells, leads to symptoms of anemia. As absence of iron decreases heme synthesis, red blood cells in iron deficiency anemia are hypochromic (lacking the red hemoglobin pigment) and microcytic (smaller than normal). • Sickle ...
... • Decrease of hemoglobin, with or without an absolute decrease of red blood cells, leads to symptoms of anemia. As absence of iron decreases heme synthesis, red blood cells in iron deficiency anemia are hypochromic (lacking the red hemoglobin pigment) and microcytic (smaller than normal). • Sickle ...
Slides - Stanford University
... Probabilistic Completeness The probability that a roadmap fails to correctly capture the connectivity of the free space goes to 0 exponentially in the number of milestones (~ running time). Random sampling is convenient incremental scheme for approximating the free space ...
... Probabilistic Completeness The probability that a roadmap fails to correctly capture the connectivity of the free space goes to 0 exponentially in the number of milestones (~ running time). Random sampling is convenient incremental scheme for approximating the free space ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.
... Ligand and water molecules. Docking was done using software AutoDock 4.0 and its patch AutoDock Vina. The complete docking steps could be stated as follows: first of all the water molecules were eliminated from the protein. After the removal of water molecules the pdb file of the macromolecule 3Q6E ...
... Ligand and water molecules. Docking was done using software AutoDock 4.0 and its patch AutoDock Vina. The complete docking steps could be stated as follows: first of all the water molecules were eliminated from the protein. After the removal of water molecules the pdb file of the macromolecule 3Q6E ...
Transcript I
... o At the same time RNA polymerase is binding to a promoter region. o Once the RNA polymerase is bound, nothing is going to take place because it needs another enhancer in order for RNA transcription to take place o The area of the transcription (N-terminal end of protein) will bind first and then ex ...
... o At the same time RNA polymerase is binding to a promoter region. o Once the RNA polymerase is bound, nothing is going to take place because it needs another enhancer in order for RNA transcription to take place o The area of the transcription (N-terminal end of protein) will bind first and then ex ...
Phosphate binding sites identification in protein
... binding sites (PbSs) even if the biological relevance of this specific ligand is beyond question. The methods that predict binding sites for specific ligands in a protein structure can be classified as ‘comparative’ or ‘non-comparative’ (12). Comparative methods search for structural similarities betwe ...
... binding sites (PbSs) even if the biological relevance of this specific ligand is beyond question. The methods that predict binding sites for specific ligands in a protein structure can be classified as ‘comparative’ or ‘non-comparative’ (12). Comparative methods search for structural similarities betwe ...
Additional file 11 cd00120: MCM1, Agamous, Deficiens, and SRF
... subfamily there are three other sites that could be important in specificity determination. Two of these sites (see Table SM3) were identified as a phosphorylation sites in the MADS_MEF2-like subfamily and were linked to increased DNA binding affinity (1, 2) . The third one is a part of the dimeriza ...
... subfamily there are three other sites that could be important in specificity determination. Two of these sites (see Table SM3) were identified as a phosphorylation sites in the MADS_MEF2-like subfamily and were linked to increased DNA binding affinity (1, 2) . The third one is a part of the dimeriza ...
3. G-protein-coupled receptors
... 3.3. Ligand binding site - varies depending on receptor type 3.4. Bacteriorhodopsin & rhodopsin family (2 slides) ...
... 3.3. Ligand binding site - varies depending on receptor type 3.4. Bacteriorhodopsin & rhodopsin family (2 slides) ...
3. G-protein-coupled receptors
... 3.3. Ligand binding site - varies depending on receptor type 3.4. Bacteriorhodopsin & rhodopsin family (2 slides) ...
... 3.3. Ligand binding site - varies depending on receptor type 3.4. Bacteriorhodopsin & rhodopsin family (2 slides) ...
Hybrid tryptophan aporepressor containing ligand binding sites
... ture of CR2 has been deduced from the DNA sequence 15 of its clone. Human CR2 is a membrane glycoprotein of ...
... ture of CR2 has been deduced from the DNA sequence 15 of its clone. Human CR2 is a membrane glycoprotein of ...
Characterizing transcription factor binding sites using formaldehyde
... be optimized for binding of the factor that actually contacts DNA. An example of a binding site that is refractory to in vitro analysis comes from the ChET8 promoter. ChET8 was originally identified in a screen for E2F1 target genes and was confirmed as containing a strong in vivo binding site for mul ...
... be optimized for binding of the factor that actually contacts DNA. An example of a binding site that is refractory to in vitro analysis comes from the ChET8 promoter. ChET8 was originally identified in a screen for E2F1 target genes and was confirmed as containing a strong in vivo binding site for mul ...
Design, Synthesis, Biological Activity and Molecular Dynamics
... Reversible protein tyrosine phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs) is of paramount importance in the regulation of the signaling events that underlie such fundamental processes as growth and proliferation, diff ...
... Reversible protein tyrosine phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs) is of paramount importance in the regulation of the signaling events that underlie such fundamental processes as growth and proliferation, diff ...
DESIGN AND SYNTHESIS OF TRIPHENYL-1H-PYRAZOLE DERIVATIVES AS ANTICANCER AGENTS
... potent anticancer agents but their undesirable side effects delineates the urgent need for the development of NCEs as effective anticancer agents. In addition, the design, development, and commercialization of a drug is a tedious, time consuming and costintensive process. For these reasons, any tool ...
... potent anticancer agents but their undesirable side effects delineates the urgent need for the development of NCEs as effective anticancer agents. In addition, the design, development, and commercialization of a drug is a tedious, time consuming and costintensive process. For these reasons, any tool ...
Protein quantification and detection methods
... fluorescent or Dabsyl-Cl). Perform RP-HPLC analysis and compare your sample to standards. You need sophisticated instrumentation for this method. ...
... fluorescent or Dabsyl-Cl). Perform RP-HPLC analysis and compare your sample to standards. You need sophisticated instrumentation for this method. ...
Stockholm University
... Galanin is a neuropeptide found throughout the central and peripheral nervous systems of a wide range of species, ranging from human and mouse to frog and tuna. Galanin mediates its physiological roles through three receptors (GalR1–3), all members of the G-protein coupled receptor family. In mappin ...
... Galanin is a neuropeptide found throughout the central and peripheral nervous systems of a wide range of species, ranging from human and mouse to frog and tuna. Galanin mediates its physiological roles through three receptors (GalR1–3), all members of the G-protein coupled receptor family. In mappin ...
Alignment between domain region and whole enzyme
... polar or no-polar etc. the residues found at active sites are given in fig.6 and fig.7 ...
... polar or no-polar etc. the residues found at active sites are given in fig.6 and fig.7 ...