Mendelian and Non-Mendelian Regulation of Gene Expression in
... www.nsf.gov/awardsearch/showAward.do?AwardNumber = 0820610). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist. ...
... www.nsf.gov/awardsearch/showAward.do?AwardNumber = 0820610). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist. ...
Control of the meiotic cell division program in plants | SpringerLink
... cells and function in the biogenesis of double-stranded RNA. Another possible link to posttranscriptional control of meiocyte fate comes from the analysis of MEIOSIS ARRESTED AT LEPTOTENE 2 (MEL2) in rice that encodes for protein with a RNA recognition motif. Loss of MEL2 function results in a failu ...
... cells and function in the biogenesis of double-stranded RNA. Another possible link to posttranscriptional control of meiocyte fate comes from the analysis of MEIOSIS ARRESTED AT LEPTOTENE 2 (MEL2) in rice that encodes for protein with a RNA recognition motif. Loss of MEL2 function results in a failu ...
Ectopic induction and reorganization of Wnt-1
... 1987), Xenopus (Noordermeer et al., 1989), and zebrafish (Molven et al., 1991)). In the mouse embryo, expression in this region is very dynamic (Wilkinson et al., 1987; Bally-Cuif et al., 1992; Paar et al., 1993): it starts at the one-somite stage as a broad domain encompassing what is probably most ...
... 1987), Xenopus (Noordermeer et al., 1989), and zebrafish (Molven et al., 1991)). In the mouse embryo, expression in this region is very dynamic (Wilkinson et al., 1987; Bally-Cuif et al., 1992; Paar et al., 1993): it starts at the one-somite stage as a broad domain encompassing what is probably most ...
Atlas of Genetics and Cytogenetics in Oncology and Haematology Scope
... Two patients with multiple osteochondromas demonstrated a germline mutation combined with loss of the remaining wild type allele in three osteochondromas, supporting the Knudson's two hit model for tumour suppressor genes in osteochondroma development; these results indicate that in cartilaginous ce ...
... Two patients with multiple osteochondromas demonstrated a germline mutation combined with loss of the remaining wild type allele in three osteochondromas, supporting the Knudson's two hit model for tumour suppressor genes in osteochondroma development; these results indicate that in cartilaginous ce ...
Exceptionally high levels of recombination
... correlates with higher recombination, thus the lower GC content is unlikely to be responsible for higher recombination in the bee. The relationship between the proportion of simple repeats and higher recombination rate in the bee genome has been documented in several mammalian species as well (Yu et ...
... correlates with higher recombination, thus the lower GC content is unlikely to be responsible for higher recombination in the bee. The relationship between the proportion of simple repeats and higher recombination rate in the bee genome has been documented in several mammalian species as well (Yu et ...
Recent Advances in Cytology
... unclear how they exchanged genetic material between them. The exchange of genetic material between homologous chromosomes, called crossing over, was presumed to happen during meiosis, and seemed to be the explanation for much of the variation begot by each successive generation in nature, and the tr ...
... unclear how they exchanged genetic material between them. The exchange of genetic material between homologous chromosomes, called crossing over, was presumed to happen during meiosis, and seemed to be the explanation for much of the variation begot by each successive generation in nature, and the tr ...
multicopy gene family evolution on primate y chromosomes
... Contrary to previous theories, the Y chromosome is an important determinant of male phenotype [15–17]. The Y chromosome has been found to be associated with male fertility in humans [18] and even less obvious traits like lifespan [19] and locomotive activity [20] in Drosophila species. Therefore, an ...
... Contrary to previous theories, the Y chromosome is an important determinant of male phenotype [15–17]. The Y chromosome has been found to be associated with male fertility in humans [18] and even less obvious traits like lifespan [19] and locomotive activity [20] in Drosophila species. Therefore, an ...
Genome-Wide Identification of Allelic Expression in Hypertensive
... Genomic SSLP data were available for 2 SHR lines (SHR/OlaHsd and SHRSP/Riv) and 1 WKY line (WKY/OlaHsd). These lines are closely related to, and may be identical to, the SHR/NCrl, SHR-A3, and WKY/NCrl lines, respectively, used in our studies. We used this data to assess the degree of allelic identit ...
... Genomic SSLP data were available for 2 SHR lines (SHR/OlaHsd and SHRSP/Riv) and 1 WKY line (WKY/OlaHsd). These lines are closely related to, and may be identical to, the SHR/NCrl, SHR-A3, and WKY/NCrl lines, respectively, used in our studies. We used this data to assess the degree of allelic identit ...
Genome-Wide Identification of Allelic Expression in Hypertensive Rats
... Genomic SSLP data were available for 2 SHR lines (SHR/OlaHsd and SHRSP/Riv) and 1 WKY line (WKY/OlaHsd). These lines are closely related to, and may be identical to, the SHR/NCrl, SHR-A3, and WKY/NCrl lines, respectively, used in our studies. We used this data to assess the degree of allelic identit ...
... Genomic SSLP data were available for 2 SHR lines (SHR/OlaHsd and SHRSP/Riv) and 1 WKY line (WKY/OlaHsd). These lines are closely related to, and may be identical to, the SHR/NCrl, SHR-A3, and WKY/NCrl lines, respectively, used in our studies. We used this data to assess the degree of allelic identit ...
Comprehensive Exam Mainul Islam Department of Computer
... • Nighthawk, a novel two-level genetic random testing system that encodes a value reuse policy. • Optimizing the Genetic Algorithm using a “Feature Subset Selection” tool to achieve nearly the same (90%) coverage 10 times faster. • The optimization learned from one set of classes (Java utils) is suc ...
... • Nighthawk, a novel two-level genetic random testing system that encodes a value reuse policy. • Optimizing the Genetic Algorithm using a “Feature Subset Selection” tool to achieve nearly the same (90%) coverage 10 times faster. • The optimization learned from one set of classes (Java utils) is suc ...
Fine mapping of Noonan/cardio-facio cutaneous syndrome
... of NS. Most CFC cases are sporadic, probably because these individuals are so severely affected that they do not reproduce. It is possible that in some families CFC syndrome is not related to a gene on 12q24, but this has not yet been documented. However, present and previous data indicate that in s ...
... of NS. Most CFC cases are sporadic, probably because these individuals are so severely affected that they do not reproduce. It is possible that in some families CFC syndrome is not related to a gene on 12q24, but this has not yet been documented. However, present and previous data indicate that in s ...
Problem Sets - MIT Biology
... dominant phenotypes were used (and these cannot be used in complementation tests), or strains that were not true-breeding were used. Using strains that are not true-breeding is not the proper way to do a complementation test, because then multiple genotypes and phenotypes are produced instead of jus ...
... dominant phenotypes were used (and these cannot be used in complementation tests), or strains that were not true-breeding were used. Using strains that are not true-breeding is not the proper way to do a complementation test, because then multiple genotypes and phenotypes are produced instead of jus ...
Good quality blastocyst from non-/mono
... In this study, we used array CGH to screen whole chromosomes. Although CGH has many advantages compared to fluorescent in situ hybridization (FISH) and is a gold standard [Handyside 2013] to identify aneuploid embryos in the clinic, it cannot detect whole ploidy errors for example distinguishing hap ...
... In this study, we used array CGH to screen whole chromosomes. Although CGH has many advantages compared to fluorescent in situ hybridization (FISH) and is a gold standard [Handyside 2013] to identify aneuploid embryos in the clinic, it cannot detect whole ploidy errors for example distinguishing hap ...
Mende an the Gee 11I+t
... garden peas in the abbey garden to study inheritance. Although the question of heredity had long been a focus of curiosity at the monastery, Mendel's fresh approach allowed him to deduce principles that had remained elusive to others. One reason Mendel probably chose to work with peas is that they a ...
... garden peas in the abbey garden to study inheritance. Although the question of heredity had long been a focus of curiosity at the monastery, Mendel's fresh approach allowed him to deduce principles that had remained elusive to others. One reason Mendel probably chose to work with peas is that they a ...
Leukaemia Section Classification of acute myeloid leukemias Atlas of Genetics and Cytogenetics
... and del(9)(q22); no adverse outcome have been noted for either additional abnormality.Tumoral manifestation such as bony chloromas, may be seen at presentation; in such cases the initial bone marrow aspiration may show a limited and misleadingly low number of blast cells. These should not be confuse ...
... and del(9)(q22); no adverse outcome have been noted for either additional abnormality.Tumoral manifestation such as bony chloromas, may be seen at presentation; in such cases the initial bone marrow aspiration may show a limited and misleadingly low number of blast cells. These should not be confuse ...
Gene Section ALDOB (aldolase B, fructose-bisphosphate) Atlas of Genetics and Cytogenetics
... protein sequence are: Arg 55 and Lys146 for binding of c-1-phosphate group of the substrate; Lys 299, the Schiff base for dihydroxyacetone-p; Try 363 for enzymatic activity toward fructose 1,6- bisphosphate site; Asp33, Glu187 and Lys229 residues for catalytic function. ...
... protein sequence are: Arg 55 and Lys146 for binding of c-1-phosphate group of the substrate; Lys 299, the Schiff base for dihydroxyacetone-p; Try 363 for enzymatic activity toward fructose 1,6- bisphosphate site; Asp33, Glu187 and Lys229 residues for catalytic function. ...
Etiology : cytogenetics and microdeletions - HAL
... and research of mutations in these genes. Beyond these technical pitfalls, array CGH has been shown to be a powerful tool that significantly helped in the identification of genes involved in various pathologic conditions. The first instance was the identification of the gene responsible for CHARGE s ...
... and research of mutations in these genes. Beyond these technical pitfalls, array CGH has been shown to be a powerful tool that significantly helped in the identification of genes involved in various pathologic conditions. The first instance was the identification of the gene responsible for CHARGE s ...
How Does the Polled Trait Work?
... I want to here explain how the polled trait is inherited. I will then go into some technical detail with some diagrams for those who are interested in what is behind it. “Polled” means naturally hornless. (Some polled animals may have scurs, which are small, harmless growths in the horn area.) Many ...
... I want to here explain how the polled trait is inherited. I will then go into some technical detail with some diagrams for those who are interested in what is behind it. “Polled” means naturally hornless. (Some polled animals may have scurs, which are small, harmless growths in the horn area.) Many ...
Human Phenotypes
... 1. In sweet peas the gene for the red color in flowers (R) is dominant over the gene for the white flowers (r). If a homozygous red-flowered plant is crossed with a white-flowered plant, what will be the genotype of the offspring? What will be the result of the next generation if the first offspring ...
... 1. In sweet peas the gene for the red color in flowers (R) is dominant over the gene for the white flowers (r). If a homozygous red-flowered plant is crossed with a white-flowered plant, what will be the genotype of the offspring? What will be the result of the next generation if the first offspring ...
A surge of late-occurring meiotic double
... genes, we generated a mouse line in which both SPO11 and the CRE-recombinase were expressed by a bacterial artificial chromosome (BAC), under the Spo11 promoter (Spo11-IRESCre mice) [see Supplemental Fig. 1 and (Pellegrini et al. 2011)]. The analysis of CRE-recombinase activity in vivo revealed that ...
... genes, we generated a mouse line in which both SPO11 and the CRE-recombinase were expressed by a bacterial artificial chromosome (BAC), under the Spo11 promoter (Spo11-IRESCre mice) [see Supplemental Fig. 1 and (Pellegrini et al. 2011)]. The analysis of CRE-recombinase activity in vivo revealed that ...
PDF + SI - Development - The Company of Biologists
... INTRODUCTION During early embryonic development, the embryo progresses from a single layer of epithelial cells (the epiblast) to a three-dimensional structure composed of several layers and territories. As part of this complex process, embryonic cells integrate environmental cues to acquire positio ...
... INTRODUCTION During early embryonic development, the embryo progresses from a single layer of epithelial cells (the epiblast) to a three-dimensional structure composed of several layers and territories. As part of this complex process, embryonic cells integrate environmental cues to acquire positio ...
asense is a Drosophila neural precursor gene and is
... trulation in the nuclei of single cells that are in the process of segregating from the neuroectodermal epithelium, but not in the surrounding cells of the proneural cluster (Fig. 1B,C). By contrast, proneural genes such as sc, l’sc (Cabrera et al., 1987; Romani et al., 1987) and ac (Fig. 1A) alread ...
... trulation in the nuclei of single cells that are in the process of segregating from the neuroectodermal epithelium, but not in the surrounding cells of the proneural cluster (Fig. 1B,C). By contrast, proneural genes such as sc, l’sc (Cabrera et al., 1987; Romani et al., 1987) and ac (Fig. 1A) alread ...
Two Linked Blood Pressure Quantitative Trait Loci on
... from each end of the original strain suggests that there are two linked QTLs in the region covered by the original congenic strain. As the strains become progressively shorter at each end, BP effects were still retained at each end. Two nonoverlapping strains, S.MNS⫻5 and S.MNS⫻3, had significant BP ...
... from each end of the original strain suggests that there are two linked QTLs in the region covered by the original congenic strain. As the strains become progressively shorter at each end, BP effects were still retained at each end. Two nonoverlapping strains, S.MNS⫻5 and S.MNS⫻3, had significant BP ...
Lethal Mutations and Balanced Lethal Systems in
... the haploid segregants. Absence of any allele from among these segregants suggested a lethal linked in coupling with that allele. Scoring was limited to sectors phenotypically distinct from the parent diploids, which were non-fluffy and had green conidia. With this limitation, diploid I isolates wer ...
... the haploid segregants. Absence of any allele from among these segregants suggested a lethal linked in coupling with that allele. Scoring was limited to sectors phenotypically distinct from the parent diploids, which were non-fluffy and had green conidia. With this limitation, diploid I isolates wer ...
X-inactivation
X-inactivation (also called lyonization) is a process by which one of the two copies of the X chromosome present in female mammals is inactivated. The inactive X chromosome is silenced by its being packaged in such a way that it has a transcriptionally inactive structure called heterochromatin. As nearly all female mammals have two X chromosomes, X-inactivation prevents them from having twice as many X chromosome gene products as males, who only possess a single copy of the X chromosome (see dosage compensation). The choice of which X chromosome will be inactivated is random in placental mammals such as humans, but once an X chromosome is inactivated it will remain inactive throughout the lifetime of the cell and its descendants in the organism. Unlike the random X-inactivation in placental mammals, inactivation in marsupials applies exclusively to the paternally derived X chromosome.