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... require an elaborate conceptual physical basis. While experimental biophysical methods (FRET, PALM etc.) might make essential contributions to elucidate such mechanisms, theoretical insights are expected to be minor in such a case. This is utterly different for mechanisms involving self-assembly or ...
... require an elaborate conceptual physical basis. While experimental biophysical methods (FRET, PALM etc.) might make essential contributions to elucidate such mechanisms, theoretical insights are expected to be minor in such a case. This is utterly different for mechanisms involving self-assembly or ...
Discrete molecular dynamics
... all possible collisions, the search algorithm is limited to a local search; only those atoms within the same local area are considered as having possible collisions. Once collisions are identified, only the atoms participating in collision are required to be updated after each event, resulting in fe ...
... all possible collisions, the search algorithm is limited to a local search; only those atoms within the same local area are considered as having possible collisions. Once collisions are identified, only the atoms participating in collision are required to be updated after each event, resulting in fe ...
Nucleic Acids Research
... positive patch on the protein surface. Earlier, we have shown that there is a high overlap between the largest electrostatic positive patches on protein surfaces and the DNA-binding interfaces (6). Figure 1 and Supplementary Figure S1 demonstrate the overlap (colored in green) between the largest po ...
... positive patch on the protein surface. Earlier, we have shown that there is a high overlap between the largest electrostatic positive patches on protein surfaces and the DNA-binding interfaces (6). Figure 1 and Supplementary Figure S1 demonstrate the overlap (colored in green) between the largest po ...
AMIN domains have a predicted role in localization of diverse
... domain architectures and conserved gene-neighborhoods, taken together with the available experimental data can be used to make functional predictions of uncharacterized proteins. We speculate that the role of the AMIN domain is to help localize and orient a range of transport and murein remodeling a ...
... domain architectures and conserved gene-neighborhoods, taken together with the available experimental data can be used to make functional predictions of uncharacterized proteins. We speculate that the role of the AMIN domain is to help localize and orient a range of transport and murein remodeling a ...
Dynamic in vivo interactions among Myc network members
... mad1 and mxi1 nullizygous mice have demonstrated distinct roles for the encoded proteins in tissue-speci®c negative control of cellular proliferation (Foley et al., 1998; Schreiber-Agus et al., 1998). Despite the well-described interactions of Myc network proteins, little is known about their distri ...
... mad1 and mxi1 nullizygous mice have demonstrated distinct roles for the encoded proteins in tissue-speci®c negative control of cellular proliferation (Foley et al., 1998; Schreiber-Agus et al., 1998). Despite the well-described interactions of Myc network proteins, little is known about their distri ...
12551_2008_5_MOESM1_ESM - Springer Static Content Server
... Polypeptides. Academic, New York At the time this was the most comprehensive compilation of data available on both fibrous proteins and the methodology used to study them. It still provides an excellent summary on the structures of many of the synthetic polypeptides that were used as model protein s ...
... Polypeptides. Academic, New York At the time this was the most comprehensive compilation of data available on both fibrous proteins and the methodology used to study them. It still provides an excellent summary on the structures of many of the synthetic polypeptides that were used as model protein s ...
The Characterization of the Olf-1/EBF
... 1993). Transgenic studies suggested that this site is important in directing olfactory-specific olfactory marker protein (OMP) expression in vivo (Walters et al., 1996). The factor that bound to this site, the Olf-1 protein, was identified by using a yeast genetic selection scheme, and its expressio ...
... 1993). Transgenic studies suggested that this site is important in directing olfactory-specific olfactory marker protein (OMP) expression in vivo (Walters et al., 1996). The factor that bound to this site, the Olf-1 protein, was identified by using a yeast genetic selection scheme, and its expressio ...
12.4 G Protein–Coupled Receptors and Second Messengers
... which are similar in sequence to the catalytic and regulatory domains of PKG (cGMP-dependent protein kinase). The tetrameric R2C2 complex is catalytically inactive, because an autoinhibitory domain of each R subunit occupies the substrate-binding site of each C subunit. When cAMP binds to two sites ...
... which are similar in sequence to the catalytic and regulatory domains of PKG (cGMP-dependent protein kinase). The tetrameric R2C2 complex is catalytically inactive, because an autoinhibitory domain of each R subunit occupies the substrate-binding site of each C subunit. When cAMP binds to two sites ...
Chlamydia effector proteins and new insights into chlamydial
... The role of chlamydial effector proteins in inclusion biogenesis and the modulation of host cellular functions Studies with inhibitors of bacterial protein synthesis suggest that the modulation of the host cellular function described above requires the activity of chlamydial proteins. All Chlamydiae ...
... The role of chlamydial effector proteins in inclusion biogenesis and the modulation of host cellular functions Studies with inhibitors of bacterial protein synthesis suggest that the modulation of the host cellular function described above requires the activity of chlamydial proteins. All Chlamydiae ...
Whole body protein synthesis is an average of the synthesis rates
... repetitions of 3 s-bursts at 100 Hz to mimic resistance training) to identify signalling present during increased protein synthesis. What he noted, significant to this article and discussion, was that HFS significantly increased myofibrillar and sarcoplasmic protein synthesis 3 h after stimulation 5 ...
... repetitions of 3 s-bursts at 100 Hz to mimic resistance training) to identify signalling present during increased protein synthesis. What he noted, significant to this article and discussion, was that HFS significantly increased myofibrillar and sarcoplasmic protein synthesis 3 h after stimulation 5 ...
GPCRs10
... • Many receptors show constitutive activity even when expressed at physiol levels (e.g., rat dopamine D1, rat, human hist H2, human dopamine D3, and human 5-HT1A). • Inverse agonists. • Mutations have been identified that incr the basal activity w/o affecting the ability of agonists to further activ ...
... • Many receptors show constitutive activity even when expressed at physiol levels (e.g., rat dopamine D1, rat, human hist H2, human dopamine D3, and human 5-HT1A). • Inverse agonists. • Mutations have been identified that incr the basal activity w/o affecting the ability of agonists to further activ ...
Optimization of Ammonium Sulfate Concentration for Purification of
... Total soluble proteins isolated from transgenic plant leaf biomass and GA733P -FcK present therein were analyzed by SDSPAGE and western blot analyses, respectively (Figures 3A,B, respectively). In order to confirm the effect of the second ammonium sulfate concentration for TSP precipitation after homo ...
... Total soluble proteins isolated from transgenic plant leaf biomass and GA733P -FcK present therein were analyzed by SDSPAGE and western blot analyses, respectively (Figures 3A,B, respectively). In order to confirm the effect of the second ammonium sulfate concentration for TSP precipitation after homo ...
Characterizing the O-glycosylation landscape of human plasma
... annotations we found that O-glycans were over-represented close (6 15 amino acids) to tandem repeat regions, protease cleavage sites, within propeptides, and located on a select group of protein domains. The importance of O-glycosites in proximity to proteolytic cleavage sites was further supported ...
... annotations we found that O-glycans were over-represented close (6 15 amino acids) to tandem repeat regions, protease cleavage sites, within propeptides, and located on a select group of protein domains. The importance of O-glycosites in proximity to proteolytic cleavage sites was further supported ...
Plant nuclear proteomics inside the cell maestro
... In this scenario, proteomics is a rising field of research, and solves, at least partially, the problem of studying several proteins at the same time. It can be defined traditionally as the systematic analysis of the proteome, the protein complement expressed by a genome [3]. Nowadays, proteomics stud ...
... In this scenario, proteomics is a rising field of research, and solves, at least partially, the problem of studying several proteins at the same time. It can be defined traditionally as the systematic analysis of the proteome, the protein complement expressed by a genome [3]. Nowadays, proteomics stud ...
Fabrication of novel biomaterials through molecular self
... entirely different molecules. These well-defined sequences allow the hydrophilic heads have one or two charged amino acids and the peptides to undergo ordered self-assembly, in a process resembling hydrophobic tails have four or more consecutive hydrophobic amino acids (see figures in refs. 33–35). ...
... entirely different molecules. These well-defined sequences allow the hydrophilic heads have one or two charged amino acids and the peptides to undergo ordered self-assembly, in a process resembling hydrophobic tails have four or more consecutive hydrophobic amino acids (see figures in refs. 33–35). ...
Fats - Cobb Learning
... Fat that is not used as energy is stored as adipose tissue. Excess body fat can lead to unhealthful weight gain and obesity. Excess fat can lead to type 2 diabetes. ...
... Fat that is not used as energy is stored as adipose tissue. Excess body fat can lead to unhealthful weight gain and obesity. Excess fat can lead to type 2 diabetes. ...
Does Plant Cell Death Induced by Ptr ToxA Require Toxin Entry?
... Sensitive Leaves ONLY Western blot with anti-ToxA antibody ...
... Sensitive Leaves ONLY Western blot with anti-ToxA antibody ...
Increased MS Protein Identifi cation Rates Using 75 cm Long nano
... Reproducibility of the chromatographic separation is the number one requisite for a reliable comparison among different runs and ultimately obtaining quantitative information about the proteome under analysis. Figure 2 shows representative chromatograms for each of the columns and gradients. As it c ...
... Reproducibility of the chromatographic separation is the number one requisite for a reliable comparison among different runs and ultimately obtaining quantitative information about the proteome under analysis. Figure 2 shows representative chromatograms for each of the columns and gradients. As it c ...
Chapter 15. Recognition of foreign molecules by the immune system
... Structural details and comparisons of the coreceptor-Lck complexes. In addition to metal coordination, hydrophobic cores stabilize the CD4 (A) and CD8 (B) complexes. In CD4, phosphorylation of Ser 408 (and to a lesser extent Ser415) promotes CD4 internalization. These residues are exposed in the co ...
... Structural details and comparisons of the coreceptor-Lck complexes. In addition to metal coordination, hydrophobic cores stabilize the CD4 (A) and CD8 (B) complexes. In CD4, phosphorylation of Ser 408 (and to a lesser extent Ser415) promotes CD4 internalization. These residues are exposed in the co ...
The UUAG-specific RNA Binding Protein, Heterogeneous Nuclear
... It is also common to find an auxiliary RNA-binding motif present in addition to RBDs within the same molecule. Thus, RBD class RNA binding proteins typically possess several RNA-binding domains as modules. It has not been well studied, however, how these modular domains participate together in bindi ...
... It is also common to find an auxiliary RNA-binding motif present in addition to RBDs within the same molecule. Thus, RBD class RNA binding proteins typically possess several RNA-binding domains as modules. It has not been well studied, however, how these modular domains participate together in bindi ...
Paul McCain Presentation
... Parkin-expressing cells treated with CCCP segregated into two distinct populations. Perinuclear mitochondria were aggregated in nuclear exterior and retained both Tom20 and Hsp60. Peripheral mitochondria showed no aggregation and no change in Hsp60 but a loss ...
... Parkin-expressing cells treated with CCCP segregated into two distinct populations. Perinuclear mitochondria were aggregated in nuclear exterior and retained both Tom20 and Hsp60. Peripheral mitochondria showed no aggregation and no change in Hsp60 but a loss ...
Leukaemia Section t(9;22)(q34;q11) in ALL Atlas of Genetics and Cytogenetics
... Clinics Frequent CNS involvement, even at diagnosis; blood data: high WBC (50-150 X 109/l). Cytology CD10+ in most cases, sometimes CD19+ CD10-. Treatment BMT is indicated. Prognosis Is very poor, especially in lymphoid-committed progenitor cases; the breakpoint in M-bcr or in m-bcr (see below) does ...
... Clinics Frequent CNS involvement, even at diagnosis; blood data: high WBC (50-150 X 109/l). Cytology CD10+ in most cases, sometimes CD19+ CD10-. Treatment BMT is indicated. Prognosis Is very poor, especially in lymphoid-committed progenitor cases; the breakpoint in M-bcr or in m-bcr (see below) does ...
april7_maindocument_jvirol
... Since the full length recombinant protein aggregated and was degraded under a variety of experimental conditions, we sought to identify stable domains that were resistant to mild proteolysis. We used limiting amounts of trypsin and V8 protease. The digestion pattern with the V8 protease was not very ...
... Since the full length recombinant protein aggregated and was degraded under a variety of experimental conditions, we sought to identify stable domains that were resistant to mild proteolysis. We used limiting amounts of trypsin and V8 protease. The digestion pattern with the V8 protease was not very ...
Intrinsically disordered proteins
An intrinsically disordered protein (IDP) is a protein that lacks a fixed or ordered three-dimensional structure. IDPs cover a spectrum of states from fully unstructured to partially structured and include random coils, (pre-)molten globules, and large multi-domain proteins connected by flexible linkers. They constitute one of the main types of protein (alongside globular, fibrous and membrane proteins).The discovery of IDPs has challenged the traditional protein structure paradigm, that protein function depends on a fixed three-dimensional structure. This dogma has been challenged over the last decades by increasing evidence from various branches of structural biology, suggesting that protein dynamics may be highly relevant for such systems. Despite their lack of stable structure, IDPs are a very large and functionally important class of proteins. In some cases, IDPs can adopt a fixed three-dimensional structure after binding to other macromolecules.