Targeted Identification of Glycoproteins in Disease
... Many species of pathogenic bacteria are developing resistance to antibiotic treatments.(1) As such, there is a rising need for novel therapeutic targets. The glycosylated, or sugar-modified, proteins present on bacterial cell surfaces provide one such target.(2) Importantly, glycosylation patterns v ...
... Many species of pathogenic bacteria are developing resistance to antibiotic treatments.(1) As such, there is a rising need for novel therapeutic targets. The glycosylated, or sugar-modified, proteins present on bacterial cell surfaces provide one such target.(2) Importantly, glycosylation patterns v ...
`N17` region of huntingtin protein
... A nuclear export signal is a bit of a protein which acts like an ‘address label’ to tell the cell where to deliver a package - in this case the huntingtin protein. The nuclear export signal tells the cell to keep the protein out of the nucleus, where the all-important DNA is kept. Instead, a protein ...
... A nuclear export signal is a bit of a protein which acts like an ‘address label’ to tell the cell where to deliver a package - in this case the huntingtin protein. The nuclear export signal tells the cell to keep the protein out of the nucleus, where the all-important DNA is kept. Instead, a protein ...
Eli Martinez poster
... Manganese is an important trace nutrient involved in the detoxification of reactive oxygen species (ROS). Manganese also acts as an enzyme cofactor for superoxide dismutase and other enzymes. In bacteria, manganese and Mn-SOD allow bacteria to withstand ROS created from internal and external metabol ...
... Manganese is an important trace nutrient involved in the detoxification of reactive oxygen species (ROS). Manganese also acts as an enzyme cofactor for superoxide dismutase and other enzymes. In bacteria, manganese and Mn-SOD allow bacteria to withstand ROS created from internal and external metabol ...
212_spring_2005_oxygen transport
... Allosteric proteins are typically multisubunit proteins Small molecules know as allosteric effectors bind to the protein at sites that are spatially distinct from the ligand binding site and exert either a positive or negative effect on ligand binding ...
... Allosteric proteins are typically multisubunit proteins Small molecules know as allosteric effectors bind to the protein at sites that are spatially distinct from the ligand binding site and exert either a positive or negative effect on ligand binding ...
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... and optimise its anabolic effects. Testosterone is a powerful anabolic hormone that is released from the testes in males, and the ovaries and adrenal glands in females. Testosterone’s release is controlled by Luteinising Hormone (LH), secreted from the pituitary found at the base of the brain. Testo ...
... and optimise its anabolic effects. Testosterone is a powerful anabolic hormone that is released from the testes in males, and the ovaries and adrenal glands in females. Testosterone’s release is controlled by Luteinising Hormone (LH), secreted from the pituitary found at the base of the brain. Testo ...
Metabolic regulation of nitrogen fixation in Rhodospirillum rubrum
... Regulation of the DRAG/DRAT system These two enzymes are encoded by genes that are within the same operon (draT/draG/draB) and the expressed proteins have to work in a reciprocal manner; therefore it is postulated that both DRAG and DRAT themselves have to be posttranslationally regulated in vivo, b ...
... Regulation of the DRAG/DRAT system These two enzymes are encoded by genes that are within the same operon (draT/draG/draB) and the expressed proteins have to work in a reciprocal manner; therefore it is postulated that both DRAG and DRAT themselves have to be posttranslationally regulated in vivo, b ...
Leukaemia Section t(11;14)(q23;q32) Atlas of Genetics and Cytogenetics in Oncology and Haematology
... motifs (a AT hook and a CXXC domain), a DNA methyl transferase motif, a bromodomain. MLL is cleaved by taspase 1 into 2 proteins before entering the nucleus, called MLL-N and MLL-C. The FYRN and a FRYC domains of native MLL associate MLL-N and MLL-C in a stable complex; they form a multiprotein comp ...
... motifs (a AT hook and a CXXC domain), a DNA methyl transferase motif, a bromodomain. MLL is cleaved by taspase 1 into 2 proteins before entering the nucleus, called MLL-N and MLL-C. The FYRN and a FRYC domains of native MLL associate MLL-N and MLL-C in a stable complex; they form a multiprotein comp ...
Package `PPInfer`
... Description Interactions between proteins occur in many, if not most, biological processes. Most proteins perform their functions in networks associated with other proteins and other biomolecules. This fact has motivated the development of a variety of experimental methods for the identification of ...
... Description Interactions between proteins occur in many, if not most, biological processes. Most proteins perform their functions in networks associated with other proteins and other biomolecules. This fact has motivated the development of a variety of experimental methods for the identification of ...
clinical toxicology unit
... Laboratory, where results will be relayed back to the requesting clinicians within 24 hours. All requests should use PER-PAT 301 form, signed by the requesting doctor complete with diagnosis. All samples should be sent in plain tube (yellow cap). Samples can be taken at random times and fasting is n ...
... Laboratory, where results will be relayed back to the requesting clinicians within 24 hours. All requests should use PER-PAT 301 form, signed by the requesting doctor complete with diagnosis. All samples should be sent in plain tube (yellow cap). Samples can be taken at random times and fasting is n ...
an introduction to bioinorganic chemistry
... biochemistry, chemistry, crystallography, genetics, medicine, microbiology together with the effective application of advanced physical methods. Chairman, 7PthP International Conference on Bioinorganic chemistry Lubeck, GERMANY Organic chemistry at one time was thought to be the chemistry involved i ...
... biochemistry, chemistry, crystallography, genetics, medicine, microbiology together with the effective application of advanced physical methods. Chairman, 7PthP International Conference on Bioinorganic chemistry Lubeck, GERMANY Organic chemistry at one time was thought to be the chemistry involved i ...
Early states during protein folding - The Astbury Centre for Structural
... folding kinetics by adding kinetic traps? In order to answer these questions, we need to be able to detect all the species populated during folding and to characterise their structural, dynamic and spectroscopic properties in as much detail, and at as high a resolution, as possible. Whilst this can ...
... folding kinetics by adding kinetic traps? In order to answer these questions, we need to be able to detect all the species populated during folding and to characterise their structural, dynamic and spectroscopic properties in as much detail, and at as high a resolution, as possible. Whilst this can ...
prosite.excerpt
... It has been known for a long time [1] that potential N-glycosylation sites are specific to the consensus sequence Asn-Xaa-Ser/Thr. It must be noted that the presence of the consensus tripeptide is not sufficient to conclude that an asparagine residue is glycosylated, due to the fact that the folding ...
... It has been known for a long time [1] that potential N-glycosylation sites are specific to the consensus sequence Asn-Xaa-Ser/Thr. It must be noted that the presence of the consensus tripeptide is not sufficient to conclude that an asparagine residue is glycosylated, due to the fact that the folding ...
SISYPHUS—structural alignments for proteins with non
... essentially the same functions that either originate from different biological species or present different isoforms within the same organism; Family for proteins of related sequences but distinct functions; Superfamily for protein families sharing common functional and structural features. Near the ...
... essentially the same functions that either originate from different biological species or present different isoforms within the same organism; Family for proteins of related sequences but distinct functions; Superfamily for protein families sharing common functional and structural features. Near the ...
Fragment Screening by WAC - Transientic Interactions
... A WACTM column is usually very stable as the immobilized protein is significantly more stable than when present in solution. Proteins such as thrombin and Hsp90 has proven to maintain 90% ...
... A WACTM column is usually very stable as the immobilized protein is significantly more stable than when present in solution. Proteins such as thrombin and Hsp90 has proven to maintain 90% ...
Ab initio modelling tutorial (part II)
... multiple models as criteria for grouping – Normalized spatial deviation serves as a distance between heterogeneous models (e.g. bead models) – R.m.s.d. is employed for those with atom-to-atom correspondence (e.g. rigid body models) ...
... multiple models as criteria for grouping – Normalized spatial deviation serves as a distance between heterogeneous models (e.g. bead models) – R.m.s.d. is employed for those with atom-to-atom correspondence (e.g. rigid body models) ...
Elastin
... Elastin is an insoluble protein polymer synthesized from a precursor, TROPOELASTIN, which is a linear polypeptide composed of about 700 amino acids that are primarily small and nonpolar (for example, glycine, alanine, and valine). Tropoelastin is secreted by the cell into the extracellular space. Th ...
... Elastin is an insoluble protein polymer synthesized from a precursor, TROPOELASTIN, which is a linear polypeptide composed of about 700 amino acids that are primarily small and nonpolar (for example, glycine, alanine, and valine). Tropoelastin is secreted by the cell into the extracellular space. Th ...
Gene Section STK4 (serine/threonine kinase 4) Atlas of Genetics and Cytogenetics
... and a few additional codons. Exon 11 contains the stop codon and the 3' untranslated region. Other features of the STK4 gene, such as promoters or enhancer elements, have not been described. ...
... and a few additional codons. Exon 11 contains the stop codon and the 3' untranslated region. Other features of the STK4 gene, such as promoters or enhancer elements, have not been described. ...
Eukaryotic Cilia and Flagella, and Bardet
... BBS mutation pool (Li et al., 2004). In C. elegans, a promoter motif called the X-box was found in several genes need for functional cilia (Li et al., 2004). The FABB proteome is enriched about 6-fold for C. elegans gene containing the X-box. Genes downstream of X-box, including BBS5, are believed t ...
... BBS mutation pool (Li et al., 2004). In C. elegans, a promoter motif called the X-box was found in several genes need for functional cilia (Li et al., 2004). The FABB proteome is enriched about 6-fold for C. elegans gene containing the X-box. Genes downstream of X-box, including BBS5, are believed t ...
MONOCLONAL ANTIBODY TO HUMAN C3/C3a/C3a
... The monoclonal antibody 2898 recognizes the C-terminus of human complement protein C3a. The antibody recognizes intact C3, C3a as well as C3a-desArg. C3 is the most abundant protein of the complement system with serum protein levels of about 1.3 mg/ml. The complement system is an important part of t ...
... The monoclonal antibody 2898 recognizes the C-terminus of human complement protein C3a. The antibody recognizes intact C3, C3a as well as C3a-desArg. C3 is the most abundant protein of the complement system with serum protein levels of about 1.3 mg/ml. The complement system is an important part of t ...
Poster
... 3) ERa-Estradiol complex enters the nucleus and its DBD binds to DNA acting as a transcription factor. 4) The gene activated by ER is transcribed and eventually translated into the respective protein. Synthesized Pathway(with Tamoxifen) A)Tamoxifen, a first generation breast cancer drug that acts as ...
... 3) ERa-Estradiol complex enters the nucleus and its DBD binds to DNA acting as a transcription factor. 4) The gene activated by ER is transcribed and eventually translated into the respective protein. Synthesized Pathway(with Tamoxifen) A)Tamoxifen, a first generation breast cancer drug that acts as ...
Document
... Bowater Lectures in Brno, Feb. 2013 4 lectures on linked topics will be delivered during the ...
... Bowater Lectures in Brno, Feb. 2013 4 lectures on linked topics will be delivered during the ...
Deciphering the genetic code Dr. Syndey Brenner estabilished mRNA
... Insulin (hormone) can regulate protein translation: o Stimulates via activation of eIF4E (initiation factor) o Normally, eIF4E is bound to an inhibitor protein, 4EBinding factor o When insulin binds to it’s receptor that results in phosphorylation of 4EBP and that releases eIF4E for initiation of ...
... Insulin (hormone) can regulate protein translation: o Stimulates via activation of eIF4E (initiation factor) o Normally, eIF4E is bound to an inhibitor protein, 4EBinding factor o When insulin binds to it’s receptor that results in phosphorylation of 4EBP and that releases eIF4E for initiation of ...
15 Tacks and a 4 Foot Toober
... • And keeping all of the polar white tacks on the surface of the protein. After everyone has folded their toober as best they can, the teacher can point out: • Every toober had a different random sequence of tacks (amino acids) and therefore each toober (protein) folded into a different structure. • ...
... • And keeping all of the polar white tacks on the surface of the protein. After everyone has folded their toober as best they can, the teacher can point out: • Every toober had a different random sequence of tacks (amino acids) and therefore each toober (protein) folded into a different structure. • ...
PDF Datastream - Brown Digital Repository
... bacterial processes such as cell wall biogenesis as well as the promise of finding potential vaccine- or drug-targets for virulent bacteria. Meanwhile, rapid development in mass spectrometry based proteomics, especially quantitative analysis of targeted proteome, received increased research interest ...
... bacterial processes such as cell wall biogenesis as well as the promise of finding potential vaccine- or drug-targets for virulent bacteria. Meanwhile, rapid development in mass spectrometry based proteomics, especially quantitative analysis of targeted proteome, received increased research interest ...
Proteomics
Proteomics is the large-scale study of proteins, particularly their structures and functions. Proteins are vital parts of living organisms, as they are the main components of the physiological metabolic pathways of cells. The term proteomics was first coined in 1997 to make an analogy with genomics, the study of the genome. The word proteome is a portmanteau of protein and genome, and was coined by Marc Wilkins in 1994 while working on the concept as a PhD student.The proteome is the entire set of proteins, produced or modified by an organism or system. This varies with time and distinct requirements, or stresses, that a cell or organism undergoes. Proteomics is an interdisciplinary domain formed on the basis of the research and development of the Human Genome Project; it is also emerging scientific research and exploration of proteomes from the overall level of intracellular protein composition, structure, and its own unique activity patterns. It is an important component of functional genomics.While proteomics generally refers to the large-scale experimental analysis of proteins, it is often specifically used for protein purification and mass spectrometry.