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INDIGO-BINDING DOMAINS IN CELLULASE MOLECULES
INDIGO-BINDING DOMAINS IN CELLULASE MOLECULES

... residues seem to play a major role in binding indigo. Indigo is a hydrophobic compound (insoluble in water), and its aromatic rings may interact with the aromatic rings of Tyr, Trp and Phe, as well as with side chains of other non-polar amino acids, via the hydrophobic interactions. Another mechanis ...
An LL-Diaminopimelate Aminotransferase
An LL-Diaminopimelate Aminotransferase

... LL-DAP-AT activity. None of the other genes produced such an activity. At4g33680 was annotated as a 461-amino acid, class I/II family aminotransferase. The first 36 amino acids were predicted by TargetP to be a transit peptide for localization of the protein to plastids. The closest paralog to At4g3 ...
Repression
Repression

... Unique by having both ATP-dep remodelling activity + HDAC Central factor : Mi-2ß (CHD4) contains both chromodomain + DNA helicase/ATPase à la SWI/SNF MTA-2 is a metastasis-related zinc finger + leucin-zipper some examples on recruitment (Ikaros) ...
Accurate Modeling of Organic Molecular Crystals by Dispersion
Accurate Modeling of Organic Molecular Crystals by Dispersion

... complexes41). The small DFTB-D3 MADs for these sets of 0.95, 1.66, 1.74, and 5.90 kcal/mol confirm the picture drawn above. This also indicates that the S66 × 8 test set seems to be representative for a large number of systems.36 Though the results are worse than those for standard density functional ...
By-product utilization
By-product utilization

... processing plants can be used for feed, food, and useful products. European starch processing plants are recovering potato protein concentrates as animal feed. Single-celled protein are unicelled organisms grown on an industrial scale specifically for their protein content under controlled fermentat ...
Flippase Activity Detected with Unlabeled Lipids by Shape Changes
Flippase Activity Detected with Unlabeled Lipids by Shape Changes

... flippase activity of yeast ER was first reconstituted into proteoVOLUME 282 • NUMBER 21 • MAY 25, 2007 ...
The Three-dimensional Structure of 4-Hydroxybenzoyl
The Three-dimensional Structure of 4-Hydroxybenzoyl

... Presently, little is known concerning the evolutionary history of these 4-chlorobenzoate degrading enzymes. The exposure of bacteria to such compounds could have first occurred with the introduction of synthetic chlorinated aromatics into the environment and thus, the acquisition of the 4-chlorobenz ...
Non-coding RNAs - Structural Biology Labs
Non-coding RNAs - Structural Biology Labs

... are never translated into proteins • Of those 98%, about 50-70% are introns • The rest originate from non-protein genes, including rRNA, tRNA and a vast number of other non-coding RNAs (ncRNAs) • Even introns have been shown to contain ncRNAs, for example snoRNAs • It is thought that there might be ...
Macromolecule Virtual Lab
Macromolecule Virtual Lab

... f. A saturated fatty acid has maximum number of _______________ atoms in its chain. g. A molecule of fat has ____(#) fatty acid chains and a phospholipid has ____(#) fatty acid chains. h. How can the main structural backbone of all steroids be described? I. Amino acids are bonded together in differe ...
Chitosan Nanoparticles as Drug Carriers
Chitosan Nanoparticles as Drug Carriers

... have a monolithic-type structure (matrix) in which drugs are dispersed or adsorbed onto their surfaces. Nanocapsules exhibit a membrane-wall structure and drugs are entrapped in the core or ...
S13DobrzanskiPoland
S13DobrzanskiPoland

Evolution and Function of the Plant Cell Wall
Evolution and Function of the Plant Cell Wall

Gene Section HDAC3 (histone deacetylase 3) Atlas of Genetics and Cytogenetics
Gene Section HDAC3 (histone deacetylase 3) Atlas of Genetics and Cytogenetics

... specific promoters. Thus, HDAC3 is able to regulate osteoblast differentiation and bone formation via its association with the osteoblast master protein, Runx2, and the inhibition of the trans-activity of Runx2. Likewise, in hematopoietic stem cells, HDAC3, but not other class I HDACs, directly asso ...
Protein Structure Prediction Based on Neural Networks
Protein Structure Prediction Based on Neural Networks

... and knowledge of a protein’s 3D structure improves the analysis of protein functions, particularly for drug design [2]. Being aware of the 3D structure of a protein enables pharmacologists to select a binding protein to moderate its functions. Pharmacologists may choose a drug which is easy to synt ...
Partial Purification and Characterization of Three Flavonol
Partial Purification and Characterization of Three Flavonol

... II summarizes the relative activities of the three when assayed against different substrates. The 3-ST exhibited strict specificity for position 3 of several flavonols in the following order of decreasing activity, with rhamnetin > isorhamnetin > quercetin > patuletin > kaempferol, as sulfate accept ...
Type="Italic">AtGRP7 is involved in the
Type="Italic">AtGRP7 is involved in the

... stress responses. First, we found that the expression level of AtGRP7 was strongly repressed by ABA, NaCl and mannitol treatments. Second, we showed that the atgrp7-1 mutant is more sensitive to ABA, NaCl and mannitol compared with the wild type in both seed germination and root growth assays. Final ...
protein, glutathione, essential oils, energy, weight loss
protein, glutathione, essential oils, energy, weight loss

... chlorophyll. Chlorophyll has been shown to be effective in overcoming protein deficiency anemia. Sprouts also have a regenerating effect on the human body because of their high concentration of RNA, DNA, protein and essential nutrients which can be found only in living cells. Like humans, plants mus ...
The Molecular Basis of Diversity in the
The Molecular Basis of Diversity in the

... The external coincidence model proposes that the circadian clock sets a light-sensitive phase within the day-night cycle, and that floral responses occur under a particular daylength that exposes plants to light during the light-sensitive phase. Recent moleculargenetic studies of the flowering-time ...
Reactive cysteine in proteins: Protein folding - Genoma
Reactive cysteine in proteins: Protein folding - Genoma

... target proteins of thioredoxin include ribonucleotide reductase (important for DNA synthesis), methionine sulfoxide reductase, peroxiredoxins and transcription factors such as p53 and NF-kB (reviewed by Powis and Montfort, 2001). Since thioredoxin plays multiple roles, it was surprising to observe t ...
PLoS Pathogens
PLoS Pathogens

... SrfH/SseI (Figure 3A). There is no sequence similarity among the C termini of those T3SEs from the different groups. One example of terminal reassortment within this group involves SspH2 and SrfH, which share 88% amino acid identity in ...
Transcription factor IIIA (TFIIIA) in the second decade
Transcription factor IIIA (TFIIIA) in the second decade

... internal control region of the 5 S RNA gene are shown as a rectangular box (Pieler et al., 1985, 1987). The nucleotide sequence of the C box region is shown below the rectangular box. The substitutions of base-pairs that reduce the TFIIIA binding are indicated by arrowheads (Veldhoen et al., 1994). ...
Nutrient-Sensing Mechanisms across Evolution - Sabatini Lab
Nutrient-Sensing Mechanisms across Evolution - Sabatini Lab

... Prokaryotes Bacteria have evolved many interesting mechanisms for sensing diverse nutrients, undoubtedly an adaptation to living in environments where the concentrations and types of nutrients can vary unpredictably. We have chosen to discuss mechanisms that serve as examples of important concepts, ...
Effects of rare codon clusters on high-level expression
Effects of rare codon clusters on high-level expression

... one major and two minor molecular weight species. The major truncated species coincided with a +1 frameshift occurring at the second codon o f an AGG tandem located at positions 208-209. Co-expression o f the argU gene completely eliminated this prematurely terminated species, but did not affect the ...
a healthy diet for an athlete includes the proper ratio of simple carbs
a healthy diet for an athlete includes the proper ratio of simple carbs

... Your blood sugar levels will begin to rise immediately, but, will rise gradually and predicting when they will stop rising will be a mystery. Consuming the fat with the simple carbs slows down the rate at which your body can convert the carbs to sugar (or a source of energy). The human body first tr ...
Kinetic Role of Helix Caps in Protein Folding Is Context
Kinetic Role of Helix Caps in Protein Folding Is Context

... proper cellular function. If the native state is the functional species, then that function is lost during any time spent in the unfolded state or in the folding process. The denatured or unfolded ensemble of structures may be more susceptible to protein turnover through cellular degradation pathway ...
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Protein–protein interaction



Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.In fact, proteins are vital macromolecules, at both cellular and systemic levels, but they rarely act alone. Diverse essential molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. Indeed, these interactions are at the core of the entire interactomics system of any living cell and so, unsurprisingly, aberrant PPIs are on the basis of multiple diseases, such as Creutzfeld-Jacob, Alzheimer's disease, and cancer.PPIs have been studied from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and disease pathogenesis, as well as provide putative new therapeutic targets.
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