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Introduction to Protein-protein Interaction
Introduction to Protein-protein Interaction

... PROTEIN STRUCTURE ...
Slide 1 - Purdue Computer Science
Slide 1 - Purdue Computer Science

... • This high-level goal is achieved through a number of specific technical objectives: – Mapping interactions associated with cellular aging (in yeast) – Identifying tissue types for which yeast is a suitable model organism (by understanding conservation of tissue-specific networks in yeast) – For th ...
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... Protein Identification by Mass Spectrometry MALDI-MS and MALDI-MS/MS were performed on an Applied Biosystems 4700 Proteomics Analyzer with TOF/TOF ion optics. Data were acquired in positive MS reflector mode with five spots of standard (ABI4700 Calibration Mixture) for calibration. Mass spectra were ...
Micro Lab Unit 1 Flashcards
Micro Lab Unit 1 Flashcards

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AP Biology Test 1 Organic Chemistry Part III. Organic Molecules 1
AP Biology Test 1 Organic Chemistry Part III. Organic Molecules 1

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Unbinding forces of single antibody-antigen
Unbinding forces of single antibody-antigen

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bIOCHEMISTRY

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...  RNA: ribonucleic acids  DNA: deoxyribonucleic acids  Strand and Orientation  DNA: a molecule; a chain of simple molecules; Double chain;  repetitions of the same basic unit->a sugar: 2’-deoxyribose (脱氧核糖) attached to a phosphate residue (磷酸残基) > sugar molecule: 5 carbon atoms 1’-5’  the backb ...
Final Examination
Final Examination

... 9. The most unusual aspect of hydrophobic interactions, compared to other non-covalent bonds, is that  hydrophobic interactions do not require participation by a hydrogen atom  hydrophobic interactions only occurs in the presence of ions  hydrophobic interactions appear to be bonding together of ...
Protein Synthesis
Protein Synthesis

... made from its instructions could be made INCORRECTLY • Mutation: any permanent change in the DNA sequence in a gene or chromosome. • Factors that cause mutations: X rays, sunlight, and some chemicals ...
Red meat and protein
Red meat and protein

... Diets must provide the right balance of amino acids and nitrogen essential for the body to be able to synthesise protein for growth and maintenance. Protein quality is a measure of how well or poorly the body can use a given protein to meet its needs. This is dependent on the essential amino acid co ...
Document
Document

...  The covalent bonds to maintain the primary structure  peptide bonds, disulfide bonds  The peptide chain is known as the backbone, and the "R" groups are known as side chains.  The primary structure is usually shown using abbreviations (three letters or one letter) for the amino acid residues,fr ...
Molecular Biology Databases
Molecular Biology Databases

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Protein C Deficiency - Torbay and South Devon NHS Foundation Trust
Protein C Deficiency - Torbay and South Devon NHS Foundation Trust

... How does this deficiency of protein C come about? Usually by inheritance from your mother or father. Your doctor will exclude other causes before deciding that you have an inherited deficiency. The diagnosis is definite if more than one member of a family is shown to have low levels of protein C. ...
unraveling the unknown unknowns in the metagenomic protein
unraveling the unknown unknowns in the metagenomic protein

... and allow performing more holistic approaches to study marine ecosystems. Moreover, metagenomics proofed being valuable in discovering missing pieces in marine biological processes. However, metagenomics not only expanded our limited view on the diversity of the known protein universe, it also incre ...
Popular Scientific Summary: Disorder and Environmental Chaos
Popular Scientific Summary: Disorder and Environmental Chaos

... (intrinsically disordered proteins), and 44% of all human proteins have disordered regions. Not much work has been done on intrinsically disordered proteins, but recently it has been uncovered that they are actually very common and numerous in cells and they have been found to play extremely importa ...
OverviewLecture1
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... • DNA makes protein and protein (enzymes) make everything else. • 20 Amino acids • Amino acid properties • Motifs • Domains • Biological units ...
Tertiary Protein Structure
Tertiary Protein Structure

... really “Random coil”. They tend to have specified conformation. In crystal structures you can only see things that have one conformation. Crystallization of protein reveals the detailed structure. Why? Its not an alpha helix so it might be a loop that’s hydrogen bonded. Its interacting with other pa ...
CHAPTER 6 - Richsingiser.com
CHAPTER 6 - Richsingiser.com

... Classification Schemes for the Protein Universe Are Based on Domains • Common features of SCOP and CATH: • Class is determined from overall composition of secondary structure elements in a domain • Fold describes the number, arrangement, and connections of these secondary structure elements • Super ...
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... Both enhancers and silencers affect transcription rate. Each has unique DNA sequence for the binding of regulatory proteins. Enhancer sequences contain multiple binding sites for trans-acting regulatory proteins. Enhancers could be located upstream from the promoter, downstream from the gene, or eve ...
Previously in Cell Bio
Previously in Cell Bio

... model14. The a-subunit is shown as checkered, and the b-subunit as a solid line. The two hairpin loops in each subunit are marked ...
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Protein–protein interaction



Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.In fact, proteins are vital macromolecules, at both cellular and systemic levels, but they rarely act alone. Diverse essential molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. Indeed, these interactions are at the core of the entire interactomics system of any living cell and so, unsurprisingly, aberrant PPIs are on the basis of multiple diseases, such as Creutzfeld-Jacob, Alzheimer's disease, and cancer.PPIs have been studied from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and disease pathogenesis, as well as provide putative new therapeutic targets.
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