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How do proteins recognize DNA
How do proteins recognize DNA

... (TATAAT) is the most conserved part of the promoter. Expression of various genes (or operons) is controlled by various σ factors that recognize the -10 to -35 region. Different σ factors recognize different sequences. The α subunit recognizes an upstream element (-40 to -70 base pairs, TTGACA) of th ...
A single amino acid substitution in the haemagglutinin
A single amino acid substitution in the haemagglutinin

... intracerebral pathogenicity index (ICPI) tests. As shown in Table 3, the MDT in embryonated chicken eggs was 89 h for rAnh-wt, and 85 h for rAhn-I192M virus, while the ICPI values were 0.91 and 1.10, respectively. These results indicate that these viruses can be classified as mesogens, according to ...
Lecture 2
Lecture 2

... tRNA: transfer RNA → brings in the amino acids ...
Carbon-Based Molecules
Carbon-Based Molecules

... Proteins are different based on the number and order of amino acids. A protein’s function depends on the specific order of the amino acids, which affects the shape of the protein. The side groups of each amino acid can interact with each other and affect the protein’s shape. For example, hydrogen bo ...
Chicken eggshell matrix proteins related to anti
Chicken eggshell matrix proteins related to anti

... M. (1994).The primary structure of hyalocyanin, an archeal blue copper protein, predicts a lipid anchor for membrane fixation. The journal of biological chemistry, 269(21): 14939-14945. MINE, Y., OBERLE, C. and KASSAIFY, Z. (2003). Eggshell matrix proteins as defence mechanism of avian eggshell. Jou ...
Compounds of Living Things
Compounds of Living Things

... also contains salt. There are different types of salt. The salt you usually eat is sodium chloride. There are other salts that are made of elements such as potassium and calcium. All of these salts are present in your body and have vital functions. Salts help transport materials in and out of the ce ...
AP Cell Signaling
AP Cell Signaling

... You should now be able to: 1. Describe the nature of a ligand-receptor interaction and state how such interactions initiate a signal-transduction system 2. Compare and contrast G protein-coupled receptors, tyrosine kinase receptors, and ligand-gated ion channels 3. List two advantages of a multiste ...
called Oxidative phosphorylation.
called Oxidative phosphorylation.

... a. Chemiosmotic theory b. ATP synthase • Physiological implications of aerobic metabolism ...
Electron Transport Chain and Oxidative phosphorylation So far we
Electron Transport Chain and Oxidative phosphorylation So far we

... a. Chemiosmotic theory b. ATP synthase • Physiological implications of aerobic metabolism ...
Protein reutilisation in corms of Colchicum autumnale
Protein reutilisation in corms of Colchicum autumnale

... different proteolytic systems: vacuolar proteolysis, selective nuclear and cytosolic proteolysis, and organellar proteolysis. Because each cellular compartment is af- ...
Ubiquitin-Mediated Control of Plant Hormone
Ubiquitin-Mediated Control of Plant Hormone

... emerging data demonstrates that regulated protein degradation rivals the well-studied area of transcriptional regulation for importance in cellular regulation. In this Update, we will highlight current research findings that illustrate the contributions of the UPS to phytohormone signaling. We will a ...
In-vivo detection of binary PKA network interactions upon activation
In-vivo detection of binary PKA network interactions upon activation

... the pathological cell condition, specifically PPIs emanating from GTPases and kinases4,16,25,26. A simple PPI reporter assay that can be used in different model systems would be convenient for drug discovery in several respects. Besides the quantification of selected wild type and mutationally modif ...
WHEAT NUTRIENTS Carbohydrate Protein Fat Others
WHEAT NUTRIENTS Carbohydrate Protein Fat Others

... one slice of white bread contains 0.5 grams. ...
Using the Inquiry Page in a High School Classroom
Using the Inquiry Page in a High School Classroom

... A mutation in the gene coding for the CFTR (cystic fibrosis transmembrane receptor) protein causes CF. CF is caused when a child inherits two copies of this defective (mutated) gene, one from each parent. The CFTR protein is a Cl- channel located on the plasma membrane of epithelial cells of the lun ...
The Chemical Building Blocks of Life
The Chemical Building Blocks of Life

... Each amino acid has unique chemical properties determined by the nature of the side group (indicated by R) covalently bonded to the central carbon atom. For example, when the side group is —CH2OH, the amino acid (serine) is polar, but when the side group is —CH3, the amino acid (alanine) is nonpolar ...
F1: Multiple alignment and its meaning
F1: Multiple alignment and its meaning

... Active sites (i.e. binding sites) are hard to mutate successfully (why?) Structure-defining amino acids are hard to change successfully (why?) ...
ijbbaug
ijbbaug

... EPR spectra of the binary, PSA-copper(II) (1:1 and 2:1) and ternary systems, PSA-copper(II)-amino acid (1:1:1) have been studied. In binary system, two distinct EPR features have been observed, one of the features (towards the low field), showing broad and overlapping signals is attributed to non-sp ...
Structure and function of the chloroplast signal recognition particle
Structure and function of the chloroplast signal recognition particle

... formation with cpSRP. By analogy, with the co-translational targeting system where binding of cytosolic SRP54 to a substrate protein is mediated via its hydrophobic signal sequence, it was shown that a hydrophobic domain within LHCP is required for the post-translational binding to cpSRP (DeLille et ...
Exploring Mouse Protein Function via Multiple Approaches
Exploring Mouse Protein Function via Multiple Approaches

... 1% of the more than 13 million protein sequences available have been experimentally annotated with essential functions; the remaining proteins have been marked with putative, uncharacterized, hypothetical, unknown or inferred functions [1]. Although physical experimental approaches, including high-t ...
Poster - Physiology and Endocrinology: Male reproduction, deers
Poster - Physiology and Endocrinology: Male reproduction, deers

... major protein categories belong to carbohydrate metabolism and protein folding were highly enriched in the Biological process category, implying the important roles of the 2 processes in spermatogenesis. Further analysis of Biological process category revealed 43 proteins associated with reproductiv ...
Carnosine: can understanding its actions on energy metabolism and
Carnosine: can understanding its actions on energy metabolism and

... mitochondrial dysfunction; this frequently leads to cells reverting to glycolysis for ATP generation [30]. Consequently, it is likely that a subtle balance in the regulation of glycolysis and oxidative phosphorylation is critical throughout the lifespan [31]. Literature reports indicate that post-mi ...


... the protein in I ml of the conidiol suspension with 0.2 ml 50% TCA, shake well and spin down. (3) Wash two times with a mixture of 3 parts ethyl alcohol and one part ethyl ether and a third time with ethyl ether to remove corotenoid colw and other lipids. (4) Let the ether ewporate from the pellet a ...
The Endoplasmic Reticulum Glucosyltransferase
The Endoplasmic Reticulum Glucosyltransferase

... strates are glycoproteins, the original E7 in CI2 was replaced by a cysteine (E7C) to which a high mannose-type glycopeptide derived from bovine thyroglobulin was attached through a bifunctional chemical cross-linker (glycosylated CI2s are to be referred to as GCI2s). The original glutamic acid resi ...
A Method to Identify Protein Sequences that Fold into a Known
A Method to Identify Protein Sequences that Fold into a Known

... 3D structure profiles. In order to search a sequence database for are subdivided into two types, labeled P, and P, in order of the proteins most compatible with an environment string, we used increasing polarity. Since we treat water as polar, exposed positions the Profile method (25, 26), which was ...
11_Lecture_picture version
11_Lecture_picture version

... • Most water-soluble signal molecules bind to receptor proteins in the plasma membrane • There are three main types of membrane receptors: – G protein-coupled receptors – Receptor tyrosine kinases – Ion channel receptors ...
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Protein–protein interaction



Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.In fact, proteins are vital macromolecules, at both cellular and systemic levels, but they rarely act alone. Diverse essential molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. Indeed, these interactions are at the core of the entire interactomics system of any living cell and so, unsurprisingly, aberrant PPIs are on the basis of multiple diseases, such as Creutzfeld-Jacob, Alzheimer's disease, and cancer.PPIs have been studied from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and disease pathogenesis, as well as provide putative new therapeutic targets.
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