Lo, Frederick: Three Recently Developed Algorithms for Aligning Distantly Related Proteins
... the query and template sequences are both short. However, as the sequences lengthen, it quickly becomes unfeasible due to limitations in both time and space to examine the entire search space of possible alignments. For near optimal sequence alignment, being able to effectively limit the search spac ...
... the query and template sequences are both short. However, as the sequences lengthen, it quickly becomes unfeasible due to limitations in both time and space to examine the entire search space of possible alignments. For near optimal sequence alignment, being able to effectively limit the search spac ...
Homology Modeling a Fast Tool for Drug Discovery
... Major goal of structural biology involve formation of protein-ligand complexes; in which the protein molecules act energetically in the course of binding. Therefore, perceptive of protein-ligand interaction will be very important for structure based drug design. Lack of knowledge of 3D structures ha ...
... Major goal of structural biology involve formation of protein-ligand complexes; in which the protein molecules act energetically in the course of binding. Therefore, perceptive of protein-ligand interaction will be very important for structure based drug design. Lack of knowledge of 3D structures ha ...
Structure and function of human lactalbumin made lethal to tumor
... and oleic acid, indicative of the direct interactions between oleic acid and the aromatic residues [6]. In addition, ELOA is characterized by similar thermal stability to equine lysozyme, its thermal unfolding occurred within the same broad temperature range from 30 to 80 C. However, two consecutiv ...
... and oleic acid, indicative of the direct interactions between oleic acid and the aromatic residues [6]. In addition, ELOA is characterized by similar thermal stability to equine lysozyme, its thermal unfolding occurred within the same broad temperature range from 30 to 80 C. However, two consecutiv ...
INTRODUCTION
... irregular ellipsoidal in shape and typically contain a single copy of mtDNA encased in the mitochondrial transcription factor TFAM. The average nucleoid diameter is around 220 nm in HepG2 cells. On fragmentation of the mitochondrial reticulum there is one nucleoid per minimal sized fragment. The cry ...
... irregular ellipsoidal in shape and typically contain a single copy of mtDNA encased in the mitochondrial transcription factor TFAM. The average nucleoid diameter is around 220 nm in HepG2 cells. On fragmentation of the mitochondrial reticulum there is one nucleoid per minimal sized fragment. The cry ...
Chapter 2 - Water - Technicalsymposium
... All work done at 4oC to minimize degradation. 1- preparation of the protein solution With appropriate buffer, must first disrupt cells by mechanical homogenization with either detergent and/or enzyme treatment. Use a centrifuge to separate into pellet and supernatant. 2- fractionation (relies on pro ...
... All work done at 4oC to minimize degradation. 1- preparation of the protein solution With appropriate buffer, must first disrupt cells by mechanical homogenization with either detergent and/or enzyme treatment. Use a centrifuge to separate into pellet and supernatant. 2- fractionation (relies on pro ...
Metal Complex in the Blood - Department of Chemistry, IIT Bombay
... body's metabolic reactions. This environment must include a supply of nutrients (e.g., sugars and vitamins, to supply the building blocks for cells and enable biochemical reactions) and oxygen (to provide energy for the body; the process of using oxygen to make the body's energy supply is described ...
... body's metabolic reactions. This environment must include a supply of nutrients (e.g., sugars and vitamins, to supply the building blocks for cells and enable biochemical reactions) and oxygen (to provide energy for the body; the process of using oxygen to make the body's energy supply is described ...
Journal of Molecular Biology
... ribbon diagram, b-strands and a-helices are colored light yellow and red, respectively. The carbohydrate moiety is shown as space-filling model with carbon and oxygen atoms colored grey and red, respectively. ...
... ribbon diagram, b-strands and a-helices are colored light yellow and red, respectively. The carbohydrate moiety is shown as space-filling model with carbon and oxygen atoms colored grey and red, respectively. ...
(PSD) July 2015 PBAC Meeting
... The submission presented a summary of the clinical trial data for glycomacropeptidecontaining supplements, which was presented in the minor submissions for Camino Pro Bettermilk®, Complete® and Restore® considered by the PBAC in July 2012. The submission claimed that such products are shown to provi ...
... The submission presented a summary of the clinical trial data for glycomacropeptidecontaining supplements, which was presented in the minor submissions for Camino Pro Bettermilk®, Complete® and Restore® considered by the PBAC in July 2012. The submission claimed that such products are shown to provi ...
The Effects of Whey Protein and Leucine Supplementation
... protein or carbohydrate supplement in the morning and once again in the evening. The NON-SUP group did not receive any supplement. The subjects were encouraged to continue with their normal dietary habits with the addition of the protein or carbohydrate supplement as this would be similar to the way ...
... protein or carbohydrate supplement in the morning and once again in the evening. The NON-SUP group did not receive any supplement. The subjects were encouraged to continue with their normal dietary habits with the addition of the protein or carbohydrate supplement as this would be similar to the way ...
Metal Complex in the Blood - Department of Chemistry | Washington
... What causes this color change in the blood? We know that the shape of the heme group and the hemoglobin protein change, depending on whether hemoglobin is oxygenated or deoxygenated. The two conformations must have different light-absorbing properties. The oxygenated conformation of hemoglobin must ...
... What causes this color change in the blood? We know that the shape of the heme group and the hemoglobin protein change, depending on whether hemoglobin is oxygenated or deoxygenated. The two conformations must have different light-absorbing properties. The oxygenated conformation of hemoglobin must ...
Higher plant cellulose synthases | Genome Biology | Full Text
... protein is an amino acid domain that bears some resemblance to a zinc finger or LIM transcription factor. It is thought that this domain might play a role in protein-protein interactions in the CesA complex. Within this domain is a strictly conserved sequence motif, the CxxC motif, beginning 10-40 ...
... protein is an amino acid domain that bears some resemblance to a zinc finger or LIM transcription factor. It is thought that this domain might play a role in protein-protein interactions in the CesA complex. Within this domain is a strictly conserved sequence motif, the CxxC motif, beginning 10-40 ...
Improving penicillin biosynthesis in Penicillium chrysogenum
... DS17690 (Harris et al., 2006) was used as a high PEN production strain of P. chrysogenum. Sporulation of mycelia was stimulated by growth on R agar (Bartoszewska et al., 2011) at 25 1C for 10–11 days. For production of PEN V, spores were inoculated in 50 ml PEN production medium (Nijland et al., 201 ...
... DS17690 (Harris et al., 2006) was used as a high PEN production strain of P. chrysogenum. Sporulation of mycelia was stimulated by growth on R agar (Bartoszewska et al., 2011) at 25 1C for 10–11 days. For production of PEN V, spores were inoculated in 50 ml PEN production medium (Nijland et al., 201 ...
Expip is a cargo adaptor for Sec24p ... export the plasma membrane H+ ATPase from the
... Overview of the secretory pathway Translocation into the ER Cargo proteins of the secretory pathway enter the pathway at the ER, the surface of which is coated with ribosomes that allow coupling of protein translation with translocation into the ER. As newly synthesized proteins emerge from the rib ...
... Overview of the secretory pathway Translocation into the ER Cargo proteins of the secretory pathway enter the pathway at the ER, the surface of which is coated with ribosomes that allow coupling of protein translation with translocation into the ER. As newly synthesized proteins emerge from the rib ...
Background information map of Eragrain®-Teff
... B-complex. It has a significantly high content on minerals, such as iron, calcium, zinc and magnesium. Due to the low content of phytic acid and the presence of vitamin C in Eragrain®-Teff, the human body can actually absorb these minerals. White and dark varieties of Eragrain®-Teff do not differ si ...
... B-complex. It has a significantly high content on minerals, such as iron, calcium, zinc and magnesium. Due to the low content of phytic acid and the presence of vitamin C in Eragrain®-Teff, the human body can actually absorb these minerals. White and dark varieties of Eragrain®-Teff do not differ si ...
Supplementary Notes - Word file
... In PvGR, however, two additional key residues corresponding to Ser286 and Ser349 of firefly luciferases are mutated to Thr and Cys residues, respectively. ...
... In PvGR, however, two additional key residues corresponding to Ser286 and Ser349 of firefly luciferases are mutated to Thr and Cys residues, respectively. ...
Electron microscopy in structural studies of Photosystem II
... Figure 1. Schematic diagram illustrating freeze-fracture/etching of thylakoid membrane of higher plants. In freeze-fracture a sample is rapidly frozen at temperatures below −100 ◦ C to produce a planes of fractures through the specimen. Fracture planes tend to pass along the central hydrophobic plan ...
... Figure 1. Schematic diagram illustrating freeze-fracture/etching of thylakoid membrane of higher plants. In freeze-fracture a sample is rapidly frozen at temperatures below −100 ◦ C to produce a planes of fractures through the specimen. Fracture planes tend to pass along the central hydrophobic plan ...
Cloning and sequence analysis of putative type II fatty
... The cultivated peanut is a valuable source of dietary oil and ranks fifth among the world oil crops. Plant fatty acid biosynthesis is catalysed by type II fatty acid synthase (FAS) in plastids and mitochondria. By constructing a full-length cDNA library derived from immature peanut seeds and homology ...
... The cultivated peanut is a valuable source of dietary oil and ranks fifth among the world oil crops. Plant fatty acid biosynthesis is catalysed by type II fatty acid synthase (FAS) in plastids and mitochondria. By constructing a full-length cDNA library derived from immature peanut seeds and homology ...
Citační ohlasy podle WoS – F. Cvrčková (k 31.1.2005)
... 11. Singer, T; Haefner, S; Hoffmann, M; Fischer, M; Ilyina, J; Hilt, W. 2003. Sit4 phosphatase is functionally linked to the ubiquitinproteasome system. GENETICS 164 (4): 1305-1321. 12. Sreenivasan, A; Bishop, AC; Shokat, KM; Kellogg, DR. 2003. Specific inhibition of Elm1 kinase activity reveals fun ...
... 11. Singer, T; Haefner, S; Hoffmann, M; Fischer, M; Ilyina, J; Hilt, W. 2003. Sit4 phosphatase is functionally linked to the ubiquitinproteasome system. GENETICS 164 (4): 1305-1321. 12. Sreenivasan, A; Bishop, AC; Shokat, KM; Kellogg, DR. 2003. Specific inhibition of Elm1 kinase activity reveals fun ...
Transcriptional control by the TGF/Smad signaling system
... The Smad proteins are a family of transcription factors found in vertebrates, insects and nematodes (Figure 2) (Heldin et al., 1997; MassagueÂ, 1998). To date, the Smads are the only TGF-b receptor substrates with a demonstrated ability to propagate signals. The mechanism of activation of the TGF-b ...
... The Smad proteins are a family of transcription factors found in vertebrates, insects and nematodes (Figure 2) (Heldin et al., 1997; MassagueÂ, 1998). To date, the Smads are the only TGF-b receptor substrates with a demonstrated ability to propagate signals. The mechanism of activation of the TGF-b ...
Role of Streptococcus sanguinis sortase A in bacterial
... Streptococcus sanguinis, a normal inhabitant of the human oral cavity, has low cariogenicity, though colonization on tooth surfaces by this bacterium initiates aggregation by other oral bacteria and maturation of dental plaque. Additionally, S. sanguinis is frequently isolated from infective endocar ...
... Streptococcus sanguinis, a normal inhabitant of the human oral cavity, has low cariogenicity, though colonization on tooth surfaces by this bacterium initiates aggregation by other oral bacteria and maturation of dental plaque. Additionally, S. sanguinis is frequently isolated from infective endocar ...
Time-Resolved Fluorescence Imaging Reveals
... presence of a continuous bidirectional flow of membrane and proteins into and out of the Golgi. Moreover, most of the processing enzymes are highly dynamic themselves, as they continuously cycle between the Golgi and the ER. One possible mechanism responsible for intra-Golgi concentration (as describ ...
... presence of a continuous bidirectional flow of membrane and proteins into and out of the Golgi. Moreover, most of the processing enzymes are highly dynamic themselves, as they continuously cycle between the Golgi and the ER. One possible mechanism responsible for intra-Golgi concentration (as describ ...
Sensory control of longevity by the ODR-3 and GPA
... signals that affect life span, although the nature of the sensory neurons involved suggests that both odorants and water-soluble cues might be important13,14,17. The Kenyon lab has identified 2 putative odorant receptors that play a role in regulating longevity, but the ligands of the receptors are ...
... signals that affect life span, although the nature of the sensory neurons involved suggests that both odorants and water-soluble cues might be important13,14,17. The Kenyon lab has identified 2 putative odorant receptors that play a role in regulating longevity, but the ligands of the receptors are ...
Protein–protein interaction
Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.In fact, proteins are vital macromolecules, at both cellular and systemic levels, but they rarely act alone. Diverse essential molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. Indeed, these interactions are at the core of the entire interactomics system of any living cell and so, unsurprisingly, aberrant PPIs are on the basis of multiple diseases, such as Creutzfeld-Jacob, Alzheimer's disease, and cancer.PPIs have been studied from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and disease pathogenesis, as well as provide putative new therapeutic targets.