The ATP-Cone: An Evolutionarily Mobile, ATP
... Allosteric regulation is a common mechanism by which the activity of enzymes is modulated by the concentrations of their products, substrates and other small regulatory molecules. Structural studies have suggested that these functions frequently reside in compact globular domains that are distinct f ...
... Allosteric regulation is a common mechanism by which the activity of enzymes is modulated by the concentrations of their products, substrates and other small regulatory molecules. Structural studies have suggested that these functions frequently reside in compact globular domains that are distinct f ...
Biochemistry Lecture 4 9/6/01
... – First H+ released from aa is much more easily given up than second H+ ...
... – First H+ released from aa is much more easily given up than second H+ ...
application of hydroxyapatite in protein purification
... or pyrophosphates (P2O74-) and occasionally hydrogen or hydroxide ions. Calcium hydroxyapatite (CaHAp) has an important role in development of medical sciences as a basic components of hard tissues of bone and dental [1]. The applications of hydroxyapatite are not only limited as frames or motion de ...
... or pyrophosphates (P2O74-) and occasionally hydrogen or hydroxide ions. Calcium hydroxyapatite (CaHAp) has an important role in development of medical sciences as a basic components of hard tissues of bone and dental [1]. The applications of hydroxyapatite are not only limited as frames or motion de ...
RIBOSOME-INACTIVATING PROTEINS: A Plant Perspective
... limits clinical efficacy as a cancer therapy (96). Nevertheless, refined approaches to inhibit toxicity are showing promise (7, 76) and a number of clinical trials are ongoing (53, 96). ...
... limits clinical efficacy as a cancer therapy (96). Nevertheless, refined approaches to inhibit toxicity are showing promise (7, 76) and a number of clinical trials are ongoing (53, 96). ...
Purification and Partial Characterization of a Latent Serine Protease
... column (1 X 4 cm) equilibrated with the same buffer. The protease activity, which was eluted in the flowthrough fractions unlike the first ion-exchange chromatography, were pooled and concentrated by ultraflltration using a centricon (Amicon). Mter concentration, the samples were loaded on a Superos ...
... column (1 X 4 cm) equilibrated with the same buffer. The protease activity, which was eluted in the flowthrough fractions unlike the first ion-exchange chromatography, were pooled and concentrated by ultraflltration using a centricon (Amicon). Mter concentration, the samples were loaded on a Superos ...
Role of Pro-297 in the catalytic mechanism of sheep liver... hydroxymethyltransferase
... different amino acid residues in substrate binding and catalysis. In addition, both the enzymes catalyse decarboxylation, racemization and transamination, for example, apart from their physiological reaction. Site-directed mutagenesis and X-ray crystallographic studies of AATase had identified Arg-3 ...
... different amino acid residues in substrate binding and catalysis. In addition, both the enzymes catalyse decarboxylation, racemization and transamination, for example, apart from their physiological reaction. Site-directed mutagenesis and X-ray crystallographic studies of AATase had identified Arg-3 ...
Origin and evolution of peptide-modifying
... (2OGFeDO) with the double-stranded b-helix fold (DSBH), which includes numerous enzymes acting on diverse substrates such as: amino acids and proteins (e.g. EGL-9, prolyl and lysyl hydroxylases), small molecules (e.g. clavaminate synthase, isopenicillin synthase and plant leukoanthocyanin hydroxylas ...
... (2OGFeDO) with the double-stranded b-helix fold (DSBH), which includes numerous enzymes acting on diverse substrates such as: amino acids and proteins (e.g. EGL-9, prolyl and lysyl hydroxylases), small molecules (e.g. clavaminate synthase, isopenicillin synthase and plant leukoanthocyanin hydroxylas ...
Slide 1
... • Carbohydrate attached to a lipid • Some are glycerol based, but most are sphingosine based • Glycosphingolipids • Cerebrosides • Gangliosides ...
... • Carbohydrate attached to a lipid • Some are glycerol based, but most are sphingosine based • Glycosphingolipids • Cerebrosides • Gangliosides ...
Sec2 Protein Contains a Coiled-Coil Domain Essential for Vesicular
... for all vesicular transport events. Such a general role has been suggested for the product of the SEC18 gene (Wilson et al., 1989). In addition to components that act generally, there must also be components that are required for only a single event or subset of events. Components involved in regula ...
... for all vesicular transport events. Such a general role has been suggested for the product of the SEC18 gene (Wilson et al., 1989). In addition to components that act generally, there must also be components that are required for only a single event or subset of events. Components involved in regula ...
Role of Dietary Soy Protein in Obesity
... soybeans varies from 36% to 56% [24-27]. Protein content of soybean from different areas are quantitatively different with those grown in the southern United States having high concentration of crude protein [24]. Differences in crude protein and amino acid composition of soybeans exist both within ...
... soybeans varies from 36% to 56% [24-27]. Protein content of soybean from different areas are quantitatively different with those grown in the southern United States having high concentration of crude protein [24]. Differences in crude protein and amino acid composition of soybeans exist both within ...
Table S1 Genes with similar expression patterns in Qing2
... Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ...
... Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ...
Protein_Structure_Final_Powerpoint
... Amino acid side chains are in part responsible for protein folding Molecular interactions determine tertiary and quaternary structures DNA mutations can affect protein function Unconserved regions are predicted to serve as key sites where functional changes occur Multiple Sequence alignment reveals ...
... Amino acid side chains are in part responsible for protein folding Molecular interactions determine tertiary and quaternary structures DNA mutations can affect protein function Unconserved regions are predicted to serve as key sites where functional changes occur Multiple Sequence alignment reveals ...
Anatomy and Physiology, 5/e Chapter 27: Nutrition and Metabolism
... This chapter begins by differentiating between the terms nutrition and metabolism. Proper nutrition requires a balance of the three basic food types—carbohydrates, fats, and proteins—plus essential vitamins and minerals. Metabolism, on the other hand, is basically the use the body makes of foods aft ...
... This chapter begins by differentiating between the terms nutrition and metabolism. Proper nutrition requires a balance of the three basic food types—carbohydrates, fats, and proteins—plus essential vitamins and minerals. Metabolism, on the other hand, is basically the use the body makes of foods aft ...
www.iplantcollaborative.org
... • “Most of the down-regulated genes in the hybrid were found related to protein processing (maturation and degradation).” ...
... • “Most of the down-regulated genes in the hybrid were found related to protein processing (maturation and degradation).” ...
Denaturation of hemoglobin in the presence of tannic acid
... Tannic acid (TA) is a natural gallotannin and is comprised of a pentagalloylglucose core esterified at all functional hydroxyl groups with gallic acid molecules (see Scheme) [4]. TA belongs to the class of hydrolysable tannins and is found in numerous plants and foods. It generally can be extracted ...
... Tannic acid (TA) is a natural gallotannin and is comprised of a pentagalloylglucose core esterified at all functional hydroxyl groups with gallic acid molecules (see Scheme) [4]. TA belongs to the class of hydrolysable tannins and is found in numerous plants and foods. It generally can be extracted ...
Improving the Content of Essential Amino Acids in
... abnormal seed germination (Falco et al., 1995; Mazur et al., 1999). Yet, shifting Lys overproduction into the endosperm enabled free Lys accumulation in maize grains to over 4,000 ppm, compared to less than 100 ppm in control plants, with no detectable negative effect on seed germination (Frizzi et ...
... abnormal seed germination (Falco et al., 1995; Mazur et al., 1999). Yet, shifting Lys overproduction into the endosperm enabled free Lys accumulation in maize grains to over 4,000 ppm, compared to less than 100 ppm in control plants, with no detectable negative effect on seed germination (Frizzi et ...
Proteomics insights: proteins related to larval attachment and
... The transition in an animal from a pelagic larval stage to a sessile benthic juvenile typically requires major morphological and behavioral changes. Larval competency, attachment and initiation of metamorphosis are thought to be regulated by intrinsic chemical signals and specific sets of proteins. ...
... The transition in an animal from a pelagic larval stage to a sessile benthic juvenile typically requires major morphological and behavioral changes. Larval competency, attachment and initiation of metamorphosis are thought to be regulated by intrinsic chemical signals and specific sets of proteins. ...
How Some Mycoplasmas Evade Host Immune Responses
... surface of the mycoplasma. For example, for mycoplasmas that produce a R40 Vsa protein, that nap is about 26 nm thick, whereas it is about 16 nm thick on mycoplasmas producing a R3 protein. We believe that the shield is contained within the nap. When mycoplasmas produce a long Vsa protein, the thic ...
... surface of the mycoplasma. For example, for mycoplasmas that produce a R40 Vsa protein, that nap is about 26 nm thick, whereas it is about 16 nm thick on mycoplasmas producing a R3 protein. We believe that the shield is contained within the nap. When mycoplasmas produce a long Vsa protein, the thic ...
paper describing HSSP
... values for single residues, pairs of residues, short oligopeptides or short sequence patterns. Both kinds of methods are severely limited by the size of the database in which one performs searches or from which one derives structural preferences. For example, in order to have on the average 5 occurr ...
... values for single residues, pairs of residues, short oligopeptides or short sequence patterns. Both kinds of methods are severely limited by the size of the database in which one performs searches or from which one derives structural preferences. For example, in order to have on the average 5 occurr ...
Classification and Phylogenetic Analysis of the cAMP
... Sequence Identification. Abbreviations in the first column in Table 1 are used in all subsequent figures and tables. Thirty full-length and eight fragments of eukaryotic R-subunit sequences were identified by an extensive search of all major databases (Table 1) using known regulatory subunits as que ...
... Sequence Identification. Abbreviations in the first column in Table 1 are used in all subsequent figures and tables. Thirty full-length and eight fragments of eukaryotic R-subunit sequences were identified by an extensive search of all major databases (Table 1) using known regulatory subunits as que ...
Integrative Assignment
... Homo sapiens is the primate species to which all modern humans belong. The closest relatives are chimpanzees from which they are distinguished by greater size, a peculiar distribution of hair, and a larger carbon footprint. Humans are primarily terrestrial animals and can be found on all continents ...
... Homo sapiens is the primate species to which all modern humans belong. The closest relatives are chimpanzees from which they are distinguished by greater size, a peculiar distribution of hair, and a larger carbon footprint. Humans are primarily terrestrial animals and can be found on all continents ...
Slide 1
... Gene annotation should make sense in the context of the organism We have main archives (Genbank), and currated databases (Refseq, SwissProt), and protein classification database (COG, Pfam), and many, many ...
... Gene annotation should make sense in the context of the organism We have main archives (Genbank), and currated databases (Refseq, SwissProt), and protein classification database (COG, Pfam), and many, many ...
Statistical potential-based amino acid similarity
... By definition, commonly used amino acid similarity matrices (AA matrices) that are derived from a set of homologous proteins, such as the BLOSUM36 or PAM37 series, do not work well for proteins of fold level similarity. Note here that if a better AA matrix for distantly related proteins is developed, ...
... By definition, commonly used amino acid similarity matrices (AA matrices) that are derived from a set of homologous proteins, such as the BLOSUM36 or PAM37 series, do not work well for proteins of fold level similarity. Note here that if a better AA matrix for distantly related proteins is developed, ...
Modulating the cobalt redox potential through imidazole hydrogen
... the cofactor is replaced by a protein histidine (“His”) anchoring group (“His-on” conguration). This mode of protein-cofactor binding is shown in Fig. 1 (ref. 10) and encountered, amongst others, in MeCbl-dependent methionine synthase (MetH) as well as AdoCbl dependent methylmalonyl CoA mutase (MCM ...
... the cofactor is replaced by a protein histidine (“His”) anchoring group (“His-on” conguration). This mode of protein-cofactor binding is shown in Fig. 1 (ref. 10) and encountered, amongst others, in MeCbl-dependent methionine synthase (MetH) as well as AdoCbl dependent methylmalonyl CoA mutase (MCM ...
Protein–protein interaction
Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.In fact, proteins are vital macromolecules, at both cellular and systemic levels, but they rarely act alone. Diverse essential molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. Indeed, these interactions are at the core of the entire interactomics system of any living cell and so, unsurprisingly, aberrant PPIs are on the basis of multiple diseases, such as Creutzfeld-Jacob, Alzheimer's disease, and cancer.PPIs have been studied from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and disease pathogenesis, as well as provide putative new therapeutic targets.