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Biology 30 June 1999 Grade 12 Diploma Exam
Biology 30 June 1999 Grade 12 Diploma Exam

... away with dark foreboding as your heart races and your stomach becomes nauseous.” This description was given by a person experiencing a “panic attack” induced by the injection of cholecystokinin (CCK). CCK is a molecule with different functions in different parts of the body. In the brain, it acts a ...
Gene Section ATF2 (activating transcription factor 2) Atlas of Genetics and Cytogenetics
Gene Section ATF2 (activating transcription factor 2) Atlas of Genetics and Cytogenetics

... of the chromatin structure. An ATF2-independent HAT activity is involved in the amino acid regulation of ASNS transcription (Bruhat et al., 2007). The histone variant macroH2A recruitement into nucleosomes could confer an epigenetic mark for gene repression. The constitutive DNA binding of the ATF2/ ...
The Rad50 Signature Motif: Essential to ATP Binding and
The Rad50 Signature Motif: Essential to ATP Binding and

... organisms, and requires the coordinated activities of evolutionarily conserved protein assemblies. One of the most critical of these is the Mre11/ Rad50 (M/R) complex, which is present in all three biological kingdoms, but is not well-understood at the biochemical level. Previous structural analysis ...
C3H/HeJ
C3H/HeJ

... between APN, an in-house strain with low CYP1A2 expression, and C3H/HeJ, a laboratory strain expressing normal CYP1A2 levels, determined that this phenotype is mediated by three quantitative trait loci (QTL) localized to chromosomes 1, 4 and 9, as previously reported. The QTL on chromosome 9 co-loca ...
Origin and Distribution of Calvin Cycle Fructose and
Origin and Distribution of Calvin Cycle Fructose and

... (Lingulodinium, Amphidinium), a chlorarachniophyte (Bigelowiella), and a euglenophyte (Euglena). Altogether 53 cytosolic sequences of animals, fungi, kinetoplastids, the slime mould Dictyostelium, the oomycete Phytophthora, the ciliate Tetrahymena, and the apicomplexan parasite Toxoplasma were inclu ...
Natural Variation in Sensitivity to a Loss of Chloroplast Translation in
Natural Variation in Sensitivity to a Loss of Chloroplast Translation in

... dominant Tsu-0 suppressor unlinked to the EMB locus should enable 75% of the mutant seeds in siliques of selfed F1 heterozygotes to reach a later stage of development. In addition, three classes of F2 heterozygotes are expected in the next generation: those with a late seed phenotype, those with an ...
Y11 Revision material - Biology - Whitworth Community High School
Y11 Revision material - Biology - Whitworth Community High School

... Explain why better adapted organisms are more likely to survive. □ Recognise this is part of the theory of natural ...
Access Presentation
Access Presentation

... • Activated by tyrosine kinase receptors and Ras • PI3K is activated, increasing PIP3 and activation of Akt/PKB • Akt/PKB can phosphorylate pro-apoptotic proteins, inhibiting them ...
no isthmus and pax2.1 in zebrafish tubulogenesis
no isthmus and pax2.1 in zebrafish tubulogenesis

SERIES ‘‘GENETICS OF ASTHMA AND COPD IN THE POSTGENOME ERA’’
SERIES ‘‘GENETICS OF ASTHMA AND COPD IN THE POSTGENOME ERA’’

... airway compartments that this and other key inflammatory pathways interact with that are important in disease expression, rather than focussing on whether cells are simply present or not. For example, mast cells present in smooth muscle are closely related to BHR [22], whereas eosinophils measured i ...
Vascular Endothelial Growth Factor and Its Receptors in Embryonic
Vascular Endothelial Growth Factor and Its Receptors in Embryonic

... The circulation of blood cells via blood vessels is critical for maintaining vertebrate homeostasis by supplying oxygen and nutrients to the various organs and by providing a conduit for the excretion of waste products. Capillaries are made up of endothelial cells (EC) that form a lumen and become c ...
Brassinosteroids Rescue the Deficiency of CYP90, a Cytochrome
Brassinosteroids Rescue the Deficiency of CYP90, a Cytochrome

... because in the presence of suitable carbon and nitrogen sources plants are capable of heterotrophic growth and can complete their life cycle in the dark (for reviews see Deng, 1994; Kendrick and Kronenberg, 1994). The exclusion of light signaling offers a relatively simple system for the genetic dis ...
Imposition of Crossover Interference through the
Imposition of Crossover Interference through the

... Zip2 foci along chromosomes III, IV, and XIV revealed that Zip2 foci are distributed in a manner similar to that found for chromosome XV. Like chromosome XV, chromosomes III and IV show a decreased frequency of Zip2 foci in the interval containing the centromere. The density of Zip2 foci (i.e., foci ...
EFFECT OF VARIOUS BIOMOLECULES FOR NORMAL FUNCTIONING OF HUMAN SPERM... FERTILIZATION: A REVIEW Research Article
EFFECT OF VARIOUS BIOMOLECULES FOR NORMAL FUNCTIONING OF HUMAN SPERM... FERTILIZATION: A REVIEW Research Article

... cell membrane of the spermatozoa, its ability to become potentially fusogenic and therefore, for the quality of the semen. Several reports indicates that a close correlation between the fatty acid composition of spermatozoa and sperm motility as one of the main determinants of quality of the semen. ...
A tandem repeat in decay accelerating factor 1 induced autoimmunity
A tandem repeat in decay accelerating factor 1 induced autoimmunity

... Although there is evidence that DAF mRNA stability can be affected by tissue specific factors [17] and inflammation [18], most studies suggest that expression is primarily modulated at transcription [15–17, 19, 20]. The human DAF promoter has been identified, the transcription start site mapped, and ...
glo-3, a novel Caenorhabditis elegans gene, is required for lysosome
glo-3, a novel Caenorhabditis elegans gene, is required for lysosome

... expression initiates in embryonic intestinal precursors and persists almost exclusively in intestinal cells through adulthood. GLO-3::GFP localizes to the gut granule membrane, suggesting it could play a direct role in the trafficking events at the gut granule. smg-1(-) suppression of glo-3(-) non-s ...
Mice lacking desmocollin 1 show epidermal fragility accompanied
Mice lacking desmocollin 1 show epidermal fragility accompanied

... together, Dsc1 and Dsc3 are mixed in the same desmosomes. Thus, the Dsc1:Dsc3 ratio increases with stratification, indicating turnover during epidermal differentiation and showing that adhesion at different levels in the epidermis involves different combinations of desmosomal cadherins (North et al. ...
Solid Tumour Section Kidney: Nephroblastoma (Wilms tumor) Atlas of Genetics and Cytogenetics
Solid Tumour Section Kidney: Nephroblastoma (Wilms tumor) Atlas of Genetics and Cytogenetics

... except the sequence coding KTS at the end of exon 9. Transcriptional Variant C, 2978 bp, lacks exon 5 but has the additional sequence coding KTS at the end of exon 9. Transcriptional Variant D, 3029 bp, has all 10 exons and the additional sequence coding KTS at the end of exon 9. This transcript is ...
Congenital hereditary cataracts
Congenital hereditary cataracts

... congenital, human cataracts with the corresponding mouse models. First, early events will be influenced by genes coding for transcription factors like Pax6, Pitx3, Maf or Sox. If the lens is maturing, mutations affecting the lens membranes (aquaporins/Mip, Lim-2 or connexins) or the structural prote ...
The EGF-CFC Protein One-Eyed Pinhead Is Essential for
The EGF-CFC Protein One-Eyed Pinhead Is Essential for

... embryogenesis when the three germ layers are generated, the embryonic axes are patterned, and distinct cell types are specified. Genetic analyses in mouse and zebrafish have highlighted the fundamental role of signaling by the TGFb molecule Nodal during mesoderm and endoderm development (Zhou et al. ...
The DELLA protein family and gibberellin signal transduction
The DELLA protein family and gibberellin signal transduction

... development are a default state and that the DELLA proteins are key repressors of GAmediated growth and development. Mutant analysis indicates that GA does not directly promote growth; rather it overcomes the repression of the DELLA proteins by causing them to be degraded. The N-terminal domain of t ...
The roles of the Drosophila JAK/STAT pathway
The roles of the Drosophila JAK/STAT pathway

... been found in the nematode C. elegans (Lui et al., 1999), and three STAT-like molecules have been identi®ed in the slime mould Dictyostelium (M Fukazawa and JG Williams, unpublished data reported in Williams, 1999). However, neither organism appears to have JAK-like protein kinases. In the Drosophil ...
RT2 Profiler™ PCR Arrays: Pathway
RT2 Profiler™ PCR Arrays: Pathway

... The RT2 Profiler PCR Array System is the most reliable and accurate tool for analyzing the expression of a focused panel of genes using SYBR Green-based real-time PCR. It brings together the quantitative performance of real-time PCR and the multiple gene profiling capability of microarrays. Each PCR ...
Host-Plasmid Interactions in Saccharomyces
Host-Plasmid Interactions in Saccharomyces

... The most plausible explanation for the observed increase in the stability of YRp7M with increasing ploidy is that its copy number increases proportionately, thus decreasing the probability of segregating plasmid-free cells in the absence of a functional centromere. Therefore the copy numbers of both ...
PDF
PDF

... mammalian embryo is still controversial and has not been universally accepted (Gardner, 2001; Piotrowska et al., 2001; Hiiragi and Solter, 2004). E-cadherin mutant embryos have been used to study the impact of cell-cell interaction on embryo development and cell fate determination. The absence of E- ...
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Polycomb Group Proteins and Cancer

The Polycomb-group proteins (PcGs) are a family of proteins that use epigenetic mechanisms to maintain or repress expression of their target genes. They were originally discovered in Drosophila (fruit flies), though they've been shown to be conserved in many species due to their vital roles in embryonic development. These proteins' ability to alter gene expression has made them targets of investigation for research groups seeking to understand disease pathology and oncology.
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