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data sheet
data sheet

... abuse of methylphenidate. CONCERTA should be given cautiously to patients with a history of drug or alcohol dependence. Chronic abusive use can lead to marked tolerance and psychological dependence with varying degrees of abnormal behaviour. Patient age, the presence of risk factors for substance us ...
DRUG NAME: Sorafenib
DRUG NAME: Sorafenib

... Fertility: Animal studies indicate that sorafenib may impair male and female fertility. ...
Guidelines for Opioids EN
Guidelines for Opioids EN

... Guidelines for the Conversion from p.o. to Transdermal Route and from Transdermal Route to p.o.  From 12 hours sustained release p.o. to Transdermal:  Apply the patch and give last p.o. dose  From Transdermal to 12 hours sustained p.o.:  Remove the patch and give the first p.o. dose after 8 hour ...
1 ENDOCET (Oxycodone and Acetaminophen Tablets, USP) CII Rx
1 ENDOCET (Oxycodone and Acetaminophen Tablets, USP) CII Rx

... milligrams per day, and often involve more than one acetaminophen containing product. The excessive intake of acetaminophen may be intentional to cause self-harm or unintentional as patients attempt to obtain more pain relief or unknowingly take other acetaminophen-containing products. The risk of a ...
Fluvoxamine as a cause of stimulation, mania and
Fluvoxamine as a cause of stimulation, mania and

... SSRI-induced mania and psychosis are becoming such recognized entities that animal research is being conducted with the aim of unraveling their biochemical mechanisms [48]. 3.4. Confirmation of SSRI-Induced manic-like episodes and aggressive behaviour in adults The previous section of this paper foc ...
Edoxaban versus Warfarin in Patients with Atrial Fibrillation
Edoxaban versus Warfarin in Patients with Atrial Fibrillation

... a vitamin K antagonist underwent randomization after the INR was 2.5 or less. Randomization was stratified according to the following characteristics: CHADS2 score of 2 or 3 versus a score of 4, 5, or 6 and status with respect to the need for a reduction in the edoxaban dose.6 The high-dose edoxaban ...
Acetaminophen: Old drug, new warnings
Acetaminophen: Old drug, new warnings

... Well tolerated and relatively safe At recommended doses, acetaminophen is well tolerated, and it is considered relatively safe when used according to labeling instructions. Rarely, patients experience an erythematous or urticarial rash or other allergic complications.1 However, acetaminophen is ...
http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021995s025lbl.pdf. Accessed January 24, 2013.
http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021995s025lbl.pdf. Accessed January 24, 2013.

... When JANUVIA was used in combination with a sulfonylurea or with insulin, medications known to cause hypoglycemia, the incidence of hypoglycemia was increased over that of placebo used in combination with a sulfonylurea or with insulin. [See Adverse Reactions (6.1).] Therefore, a lower dose of sulfo ...
Atorvastatin
Atorvastatin

... primarily used to lower cholesterol and triglycerides in patients with hypercholesterolemia and mixed dyslipidemia. At the maximum recommended dosage, atorvastatin has greater LDLlowering efficacy relative to the maximum recommended dosage of other HMG-CoA reductase inhibitors. In a dose-dependent m ...
Appendix D: Commonly Used Antihypertensive Drugs 1
Appendix D: Commonly Used Antihypertensive Drugs 1

... or partially covered.*; Limited Coverage: requires Special Authority for coverage. Limited Coverage benefits approved by Special Authority may be fully or partially covered.*; RDP: Reference Drug Program. Drugs included in the RDP are comparable agents of the same therapeutic class. Patients receive ...
Product Monograph - AstraZeneca Canada
Product Monograph - AstraZeneca Canada

... PLATO data do not suggest that the higher frequency of dyspnea with BRILINTA 90 mg is due to new or worsening heart or lung disease. In patients who underwent pulmonary function testing in the clinical program, there was no indication of an adverse effect of BRILINTA 90 mg on pulmonary function. Spe ...
pediatric handbook
pediatric handbook

... Synergy with beta-lactams for severe S. aureus and Enterococcus infections: 3mg/kg/day IV ÷ q8h *gentamicin on long- Doses as high as 10mg/kg/DAY IV q24h recommended in patients with cystic fibrosis. term back-order until Spring 2016-use (Inhaled tobramycin for CF patients): 80mg bid to tid via inha ...
Data Sheet ALPHAGAN P 1.5
Data Sheet ALPHAGAN P 1.5

... During the studies there was a loss of effect in some patients. The IOP-lowering efficacy observed with brimonidine eye drops during the first month of therapy may not always reflect the long-term level of IOP reduction. Patients prescribed IOP-lowering medication should be routinely monitored for I ...
FEB 06  2004 Memorandum
FEB 06 2004 Memorandum

... PSK has been studied \rigorously and over 350 articles have been published on this subject in peer-reviewed journals. including u;ell-controlled clinical studies. PSK has been an appro\ ed drug in Japan since 1977 while PSI’ is used both as drug and dietq supplement in China. ...
1 Phenol Synonym: carbolic acid CAS: 108-95
1 Phenol Synonym: carbolic acid CAS: 108-95

... The major use of phenol is in manufacture of phenolic resins and other chemicals, such as bisphenol A, caprolactam, alkyl phenols etc. It is also used as a disinfectant, a reagent in chemical analysis, and a preservative for pharmaceuticals [1]. Human toxicity Phenol is considered to be very toxic t ...
•	  Increase in Blood Pressure: Monitor blood pressure and... at appropriate intervals.  Use with caution in patients for
• Increase in Blood Pressure: Monitor blood pressure and... at appropriate intervals. Use with caution in patients for

... who elects to use ADDERALL XR for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient. 2 DOSAGE and ADMINISTRATION 2.1 Dosing Considerations for all Patients Individualize the dosage according to the therapeutic needs and response of the p ...
Document
Document

... aggregation of human washed platelets (PIC509.4 with 30 mol/L ADP)  Does not require conversion to an active metabolite  Immediately active after IV infusion  Half-life of 3 to 6 minutes ...
A closer look at… - American Academy of Dermatology
A closer look at… - American Academy of Dermatology

... animal studies have shown an increased tumorigenic risk with the use of pharmacologically similar drugs (e.g., retinoids) when exposed to UV irradiation in the laboratory or sunlight. Although the significance of these findings to humans is not clear, patients should be advised to avoid or minimize ex ...
NEWER ANTIPLATELETS
NEWER ANTIPLATELETS

... aggregation of human washed platelets (PIC509.4 with 30 mol/L ADP)  Does not require conversion to an active metabolite  Immediately active after IV infusion  Half-life of 3 to 6 minutes ...


... The necropsy findings of this experiment are supported by previous reports35, 36. Who observed lesions of fibrinous airsacculitis, pericarditis and perihepatitis after systemic inoculation of E. coli (O78) in chickens. Regarding the results of mortalities, organ lesion scores and isolation of the or ...
Newer Agents for the Management of Overactive Bladder
Newer Agents for the Management of Overactive Bladder

... have shown that these newer agents decrease the frequency of incontinence episodes, the number of voids per day, and the number and severity of urgency episodes compared with placebo. These agents also have been shown to improve quality of life in women with overactive bladder and urinary incontinen ...
PERCOCET Tablets Rx only Prescribing Information DESCRIPTION
PERCOCET Tablets Rx only Prescribing Information DESCRIPTION

... relief or unknowingly take other paracetamol-containing products. The risk of acute liver failure is higher in individuals with underlying liver disease and in individuals who ingest alcohol while taking paracetamol. Instruct patients to look for paracetamol or APAP on package labels and not to use ...


... Impression-Severity of Illness rating. Doses from 75 to 225 mg/day were superior to placebo in outpatient studies and a mean dose of about 350 mg/day was effective in inpatients. Data from the 2 fixed-dose outpatient studies were suggestive of a dose-responserelationship in the range of 75 to 225 mg ...
Generic substitution in the treatment of epilepsy
Generic substitution in the treatment of epilepsy

... were previously well-controlled while on a brand AED, who experienced a breakthrough seizure or an increase in seizure frequency when switched to the corresponding generic AED on the same dosing regimen. The physicians treating these patients believed that the change to the generic was the reason fo ...
Table of Contents
Table of Contents

... the infection improves. Ointment can be used instead of drops at bedtime. Note that chloramphenicol should not be used for more than a few days at a time as bone marrow suppression, although rare after eye drops, can occur with long-term use. Ciprofloxacin (Ciloxan) or framycetin (Soframycin) are ac ...
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Ofloxacin



Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.Ofloxacin was first patented in 1982 (European Patent Daiichi) and received approval from the U.S. Food and Drug Administration (FDA) on December 28, 1990. Ofloxacin is sold under a wide variety of brand names as well as generic drug equivalents, for oral and intravenous administration. Ofloxacin is also available for topical use, as eye drops and ear drops (marketed as Ocuflox and Floxin Otic respectively in the United States and marketed as Optiflox, eylox respectively in Jordan and Saudi Arabia).Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin.Ofloxacin has been associated with adverse drug reactions, such as tendon damage (including spontaneous tendon ruptures) and peripheral neuropathy (which may be irreversible); tendon damage may manifest long after therapy had been completed, and, in severe cases, may result in lifelong disabilities.
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