Anadol - Square Pharmaceuticals Ltd.
... Tramadol should be used with caution in patients with increased intracranial pressure or head injury and patients with acute abdominal conditions. Use in Pregnancy and Lactation Safe use of tramadol in pregnancy has not been established. Tramadol has been shown to cross the placenta. There are no ad ...
... Tramadol should be used with caution in patients with increased intracranial pressure or head injury and patients with acute abdominal conditions. Use in Pregnancy and Lactation Safe use of tramadol in pregnancy has not been established. Tramadol has been shown to cross the placenta. There are no ad ...
File - Developing Anaesthesia
... hypoplasia, epiphyseal stippling and other abnormalities born to women treated with warfarin at less than 5mg/day. Maternal use of warfarin has also been associated with spontaneous abortion, central nervous system abnormalities and intracranial haemorrhage. Consultation with a specialist for furthe ...
... hypoplasia, epiphyseal stippling and other abnormalities born to women treated with warfarin at less than 5mg/day. Maternal use of warfarin has also been associated with spontaneous abortion, central nervous system abnormalities and intracranial haemorrhage. Consultation with a specialist for furthe ...
European Heart Rhythm Association Practical Guide on the use of
... patient card; information leaflets for patients and physicians), but there is a risk that multiple, and often slightly different, physician education tools could lead to more confusion than clarity. Based on these premises, the European Heart Rhythm Association (EHRA) set out to coordinate a unified ...
... patient card; information leaflets for patients and physicians), but there is a risk that multiple, and often slightly different, physician education tools could lead to more confusion than clarity. Based on these premises, the European Heart Rhythm Association (EHRA) set out to coordinate a unified ...
Acute Bacterial Skin Infections in Pediatric Medicine James Hedrick
... and in others, both organisms may be isolated. Other organisms, such as S. epidermidis, group B streptococci, Escherichia coli, Pseudomonas aeruginosa and other Gram-negative bacteria, are only occasionally involved. Anaerobic organisms may be present in some infections, such as cutaneous abscesses, ...
... and in others, both organisms may be isolated. Other organisms, such as S. epidermidis, group B streptococci, Escherichia coli, Pseudomonas aeruginosa and other Gram-negative bacteria, are only occasionally involved. Anaerobic organisms may be present in some infections, such as cutaneous abscesses, ...
Prescribing Information for BiDil
... mg/kg (12 times the MRHD of BiDil on a body surface area basis). Hydralazine hydrochloride is teratogenic in mice at 66 mg/kg and possibly in rabbits at 33 mg/kg (2 and 3 times the MRHD of BiDil on a body surface area basis). There are no animal studies assessing the teratogenicity of BiDil. A meta- ...
... mg/kg (12 times the MRHD of BiDil on a body surface area basis). Hydralazine hydrochloride is teratogenic in mice at 66 mg/kg and possibly in rabbits at 33 mg/kg (2 and 3 times the MRHD of BiDil on a body surface area basis). There are no animal studies assessing the teratogenicity of BiDil. A meta- ...
Hycodan® (hydrocodone bitartrate) - Bristol
... measures as necessary. The benefit to risk ratio should be carefully considered, especially in children with respiratory embarrassment (e.g. croup). Estimation of dosage relative to the child's age and weight is of great importance. Use in Patients with Chronic Pulmonary Disease: Monitor patients wi ...
... measures as necessary. The benefit to risk ratio should be carefully considered, especially in children with respiratory embarrassment (e.g. croup). Estimation of dosage relative to the child's age and weight is of great importance. Use in Patients with Chronic Pulmonary Disease: Monitor patients wi ...
supporting material
... 2. Calculate the total daily dose of inhaled corticosteroid and only select patients with a daily dose of 1000mcg BDP equivalent and above for the audit 3. Please use the data collection sheet on page 6 to record the data for the asthma patients. Use the data collection sheet on page 7 to record the ...
... 2. Calculate the total daily dose of inhaled corticosteroid and only select patients with a daily dose of 1000mcg BDP equivalent and above for the audit 3. Please use the data collection sheet on page 6 to record the data for the asthma patients. Use the data collection sheet on page 7 to record the ...
The Etiology and Antibiogram of Bacterial Causes of Conjunctivitis
... was more prevalent in the women than in males. The most probable reason for Neisseria gonorrhoea being more common in the females and the young children is because the disease takes time to manifest in women compared to men, therefore as a result it may end up affecting eyes of the children as there ...
... was more prevalent in the women than in males. The most probable reason for Neisseria gonorrhoea being more common in the females and the young children is because the disease takes time to manifest in women compared to men, therefore as a result it may end up affecting eyes of the children as there ...
Assessing the Plasma Pharmacokinetics, Tissue Distribution
... (Table 1) were dissolved in distilled water to yield the desired concentration (150 mg/kg oral and 15 mg/kg intravenous) of FM-VP4 with the desired level of radioactivity. The mean concentration of radiolabeled FM-VP4 in the dosing formulation was determined by liquid scintillation counting of aliqu ...
... (Table 1) were dissolved in distilled water to yield the desired concentration (150 mg/kg oral and 15 mg/kg intravenous) of FM-VP4 with the desired level of radioactivity. The mean concentration of radiolabeled FM-VP4 in the dosing formulation was determined by liquid scintillation counting of aliqu ...
Antihistamine Toxicosis
... unidentified metabolites. About 10% of cetirizine is excreted in feces, but it is not known whether this represents unabsorbed drug or excretion via biliary elimination. 5 Published half-lives vary greatly with Piperazine-derivative antihistamines; meclizine’s reported serum half-life is six hours, ...
... unidentified metabolites. About 10% of cetirizine is excreted in feces, but it is not known whether this represents unabsorbed drug or excretion via biliary elimination. 5 Published half-lives vary greatly with Piperazine-derivative antihistamines; meclizine’s reported serum half-life is six hours, ...
product information
... Under fasting conditions, both peak plasma levels (Cmax) and area under the curve (AUC) are roughly dose proportional up to 200 mg BD; at higher doses there are less than proportional increases in Cmax and AUC (see Pharmacokinetics, Food Effects). Absolute bioavailability studies have not been condu ...
... Under fasting conditions, both peak plasma levels (Cmax) and area under the curve (AUC) are roughly dose proportional up to 200 mg BD; at higher doses there are less than proportional increases in Cmax and AUC (see Pharmacokinetics, Food Effects). Absolute bioavailability studies have not been condu ...
A Reanalysis of the Collaborative Ocular Melanoma Study Medium
... Choroidal melanoma is the most prominent malignant ocular tumor in adults. Standard treatment since the early 1900’s has been enucleation of the involved eye. However, beginning in the 1930’s radiation therapy was proposed as a treatment that would allow the patient to keep their eye, and possibly s ...
... Choroidal melanoma is the most prominent malignant ocular tumor in adults. Standard treatment since the early 1900’s has been enucleation of the involved eye. However, beginning in the 1930’s radiation therapy was proposed as a treatment that would allow the patient to keep their eye, and possibly s ...
Ibuprofen lysine (NeoProfen) for the treatment of patent ductus
... from 2.8 to 1.9 mL/100 g/min after the 24-hour dose of indomethacin, while it increased from 2.3 to 2.5 mL/100 g/min after the 24-hour dose of ibuprofen (P < 0.001). There were no significant changes in mean cerebral oxygen delivery after the 48-hour doses of normal saline and ibuprofen. Contraindi ...
... from 2.8 to 1.9 mL/100 g/min after the 24-hour dose of indomethacin, while it increased from 2.3 to 2.5 mL/100 g/min after the 24-hour dose of ibuprofen (P < 0.001). There were no significant changes in mean cerebral oxygen delivery after the 48-hour doses of normal saline and ibuprofen. Contraindi ...
Gout
... with a reduced risk of recurrent attacks and tophi.22,39,40 It is uncertain whether a more stringent target of less than 5 mg per deciliter (297 μmol per liter) results in greater disease control.41,42 Therapy is generally continued indefinitely. Three classes of drugs are approved for lowering urat ...
... with a reduced risk of recurrent attacks and tophi.22,39,40 It is uncertain whether a more stringent target of less than 5 mg per deciliter (297 μmol per liter) results in greater disease control.41,42 Therapy is generally continued indefinitely. Three classes of drugs are approved for lowering urat ...
Australian public assessment report for Axitinib
... This work is copyright. You may reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction for any commercial purpose and reta ...
... This work is copyright. You may reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction for any commercial purpose and reta ...
Drug utilisation sub-committee (DUSC)
... of Health and the sponsor prior to listing) the analysis showed a greater number of patients were treated with sunitinib in years 2 to 4 of listing. The number of prescriptions for sunitinib were lower than expected. This suggests that patients treated with sunitinib received a lower number of presc ...
... of Health and the sponsor prior to listing) the analysis showed a greater number of patients were treated with sunitinib in years 2 to 4 of listing. The number of prescriptions for sunitinib were lower than expected. This suggests that patients treated with sunitinib received a lower number of presc ...
Prescribing Information - Auvi-Q
... hypertension or hyperthyroidism [see WARNINGS AND PRECAUTIONS (5.5)]. Arrhythmias, including fatal ventricular fibrillation, have been reported, particularly in patients with underlying cardiac disease or those receiving certain drugs [see WARNINGS AND PRECAUTIONS (5.5) and DRUG INTERACTIONS (7)]. R ...
... hypertension or hyperthyroidism [see WARNINGS AND PRECAUTIONS (5.5)]. Arrhythmias, including fatal ventricular fibrillation, have been reported, particularly in patients with underlying cardiac disease or those receiving certain drugs [see WARNINGS AND PRECAUTIONS (5.5) and DRUG INTERACTIONS (7)]. R ...
Dose Escalation in Preclinical Toxicology and Pharmacodynamic
... • Maximum tolerated dose (MTD) – animals cannot tolerate higher doses • Maximal feasible dose (MFD) – can’t physically dose any higher • Plateau in exposure – absorption-limited compounds • >50X the efficacious clinical exposure - can change based on clinical data • 1000 mg/kg – or 2000 mg/kg for cl ...
... • Maximum tolerated dose (MTD) – animals cannot tolerate higher doses • Maximal feasible dose (MFD) – can’t physically dose any higher • Plateau in exposure – absorption-limited compounds • >50X the efficacious clinical exposure - can change based on clinical data • 1000 mg/kg – or 2000 mg/kg for cl ...
Dabigatran - Surgical Critical Care. Net
... Alternatives to vitamin K antagonists have begun to emerge as options for patients with hypercoagulable states. The direct thrombin inhibitor (DTI) dabigatran etexilate is a prodrug which has gained FDA approval for the prevention of venous thromboembolism (VTE) after elective total knee or hip arth ...
... Alternatives to vitamin K antagonists have begun to emerge as options for patients with hypercoagulable states. The direct thrombin inhibitor (DTI) dabigatran etexilate is a prodrug which has gained FDA approval for the prevention of venous thromboembolism (VTE) after elective total knee or hip arth ...
10158-28698-1
... Intolerability and Efficacy of rosuvastatin therapy for patients with hypercholesterolemia Of 218 patients, 202 patients were treated with rosuvastatin (10 mg per day) for 12 weeks. other sixteen patients (10 male, 6 female) did not complete the study due to elevated transaminases, elevated CPK or i ...
... Intolerability and Efficacy of rosuvastatin therapy for patients with hypercholesterolemia Of 218 patients, 202 patients were treated with rosuvastatin (10 mg per day) for 12 weeks. other sixteen patients (10 male, 6 female) did not complete the study due to elevated transaminases, elevated CPK or i ...
bicalutamide-ga - Actavis think smart medicine
... Combination therapy (with medical castration) in advanced prostate cancer. In a large, multicentre, controlled clinical trial, 813 patients with previously untreated advanced prostate cancer were randomised to receive Bicalutamide 50 mg once daily (404 patients) or flutamide 250 mg three times a day ...
... Combination therapy (with medical castration) in advanced prostate cancer. In a large, multicentre, controlled clinical trial, 813 patients with previously untreated advanced prostate cancer were randomised to receive Bicalutamide 50 mg once daily (404 patients) or flutamide 250 mg three times a day ...
Age and Risks of FDA–Approved Long-Acting  -Adrenergic Receptor Agonists 2
... approved in the United States for the treatment of asthma, some of which had multiple approved delivery devices. Table 1 lists the products and a summary of their indications. All data that met prespecified criteria from randomized trials of all approved drugs and were available to the sponsors were ...
... approved in the United States for the treatment of asthma, some of which had multiple approved delivery devices. Table 1 lists the products and a summary of their indications. All data that met prespecified criteria from randomized trials of all approved drugs and were available to the sponsors were ...
tamoxifen - Cancer Care Ontario
... Tamoxifen is associated with increased rates of thromboembolic events, including stroke, deep vein thrombosis, pulmonary embolism, and microvascular thrombosis after breast reconstruction surgery. Higher rates of complications were observed in a retrospective study with patients who were taking tamo ...
... Tamoxifen is associated with increased rates of thromboembolic events, including stroke, deep vein thrombosis, pulmonary embolism, and microvascular thrombosis after breast reconstruction surgery. Higher rates of complications were observed in a retrospective study with patients who were taking tamo ...
Opioid conversion tips Changing to another oral opioid
... How can you tell if your patient is truly addicted to opioids? The following definitions are jointly from The American Academy of Pain Medicine, the American Pain Society, and the American Society of Addiction Medicine: Addiction: Addiction is a primary, chronic, neurobiologic disease, with genetic, ...
... How can you tell if your patient is truly addicted to opioids? The following definitions are jointly from The American Academy of Pain Medicine, the American Pain Society, and the American Society of Addiction Medicine: Addiction: Addiction is a primary, chronic, neurobiologic disease, with genetic, ...
Ofloxacin
Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.Ofloxacin was first patented in 1982 (European Patent Daiichi) and received approval from the U.S. Food and Drug Administration (FDA) on December 28, 1990. Ofloxacin is sold under a wide variety of brand names as well as generic drug equivalents, for oral and intravenous administration. Ofloxacin is also available for topical use, as eye drops and ear drops (marketed as Ocuflox and Floxin Otic respectively in the United States and marketed as Optiflox, eylox respectively in Jordan and Saudi Arabia).Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin.Ofloxacin has been associated with adverse drug reactions, such as tendon damage (including spontaneous tendon ruptures) and peripheral neuropathy (which may be irreversible); tendon damage may manifest long after therapy had been completed, and, in severe cases, may result in lifelong disabilities.