Tetracyclines
... and no dosage adjustment is needed for patients with renal insufficiency. In addition to the tetracycline class effects, the chief adverse effect of tigecycline is nausea, which occurs in up to one third of patients, and occasionally vomiting. Neither nausea nor vomiting usually requires discontinua ...
... and no dosage adjustment is needed for patients with renal insufficiency. In addition to the tetracycline class effects, the chief adverse effect of tigecycline is nausea, which occurs in up to one third of patients, and occasionally vomiting. Neither nausea nor vomiting usually requires discontinua ...
Safety of formoterol in asthma clinical trials: an update Malcolm R. Sears
... outcomes (including mortality) were identified. Many questions were not readily answered because of the structure of those studies, particularly whether the outcomes related directly to adverse effects of LABA treatment or to undertreatment with anti-inflammatory medications such as inhaled corticos ...
... outcomes (including mortality) were identified. Many questions were not readily answered because of the structure of those studies, particularly whether the outcomes related directly to adverse effects of LABA treatment or to undertreatment with anti-inflammatory medications such as inhaled corticos ...
Product Monograph - AstraZeneca Canada
... FASLODEX is found in rats' milk at levels significantly higher than those in rat plasma. It is not known if fulvestrant is excreted in human milk. However, since many drugs are excreted in human milk, and because of the potential for serious adverse reactions from FASLODEX in nursing infants, a deci ...
... FASLODEX is found in rats' milk at levels significantly higher than those in rat plasma. It is not known if fulvestrant is excreted in human milk. However, since many drugs are excreted in human milk, and because of the potential for serious adverse reactions from FASLODEX in nursing infants, a deci ...
Aspen Adrenaline, Solution for injection
... should be considered in asthmatic patients who show paradoxical worsening of their condition following use of the drug. Gangrene. Interarterial administration must be avoided as marked vasoconstriction may result in gangrene. Local ischaemic necrosis can occur from repeated injections in one site. U ...
... should be considered in asthmatic patients who show paradoxical worsening of their condition following use of the drug. Gangrene. Interarterial administration must be avoided as marked vasoconstriction may result in gangrene. Local ischaemic necrosis can occur from repeated injections in one site. U ...
Informational Sheet Template-1.doc.docx
... There were also two 72-week studies that monitored changes in FVC. In one of the 72-week studies, people taking Esbriet had an average decline of 318 mL in FVC, compared with a 475 mL decline for people who did not take Esbriet. The average treatment difference was 157 mL The other 72-week study did ...
... There were also two 72-week studies that monitored changes in FVC. In one of the 72-week studies, people taking Esbriet had an average decline of 318 mL in FVC, compared with a 475 mL decline for people who did not take Esbriet. The average treatment difference was 157 mL The other 72-week study did ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These
... during HCV treatment with VIEKIRA XR and during post-treatment follow-up. Initiate appropriate patient management for HBV infection as clinically indicated. 5.2 Risk of Hepatic Decompensation and Hepatic Failure in Patients with Cirrhosis Hepatic decompensation and hepatic failure, including liver t ...
... during HCV treatment with VIEKIRA XR and during post-treatment follow-up. Initiate appropriate patient management for HBV infection as clinically indicated. 5.2 Risk of Hepatic Decompensation and Hepatic Failure in Patients with Cirrhosis Hepatic decompensation and hepatic failure, including liver t ...
MIRAPEX ER Prescribing Information
... Case reports and the results of cross-sectional studies suggest that patients can experience intense urges to gamble, increased sexual urges, intense urges to spend money, binge eating, and/or other intense urges, and the inability to control these urges while taking one or more of the medications, ...
... Case reports and the results of cross-sectional studies suggest that patients can experience intense urges to gamble, increased sexual urges, intense urges to spend money, binge eating, and/or other intense urges, and the inability to control these urges while taking one or more of the medications, ...
Answers Small Group II
... dose was within the normal therapeutic range (10-20 mg/L), however, the patient has been complaining of nausea, insomnia, and nervousness. Calculate a new maintenance infusion of theophylline to reduce the serum concentration to 12 mg/L. ...
... dose was within the normal therapeutic range (10-20 mg/L), however, the patient has been complaining of nausea, insomnia, and nervousness. Calculate a new maintenance infusion of theophylline to reduce the serum concentration to 12 mg/L. ...
Vertebral fractures - Osteoporosis Canada
... patients. Renal function was carefully monitored in subgroups, and no differences in either efficacy outcome or renal function were found between the treated and placebo groups. However, the Phase III clinical trials for all bisphosphonates used as osteoporosis therapy excluded patients with chronic ...
... patients. Renal function was carefully monitored in subgroups, and no differences in either efficacy outcome or renal function were found between the treated and placebo groups. However, the Phase III clinical trials for all bisphosphonates used as osteoporosis therapy excluded patients with chronic ...
severe COPD - Millennium Organization
... • is a drug that acts as a selective, long-acting PDE-4 inhibitor. • It has anti-inflammatory effects and is used as an orally administered drug for the treatment of inflammatory conditions of the lungs such as COPD. • In June 2010, Daxas was approved in the EU for severe COPD associated with chroni ...
... • is a drug that acts as a selective, long-acting PDE-4 inhibitor. • It has anti-inflammatory effects and is used as an orally administered drug for the treatment of inflammatory conditions of the lungs such as COPD. • In June 2010, Daxas was approved in the EU for severe COPD associated with chroni ...
arteether - WHO archives - World Health Organization
... provided to support this was virtually non-existent and could not be evaluated. In fact, it appears that the drug may have been registered without any experience in children since children under 14 years were excluded from the clinical trials that according to the Company's reports were the basis of ...
... provided to support this was virtually non-existent and could not be evaluated. In fact, it appears that the drug may have been registered without any experience in children since children under 14 years were excluded from the clinical trials that according to the Company's reports were the basis of ...
Busulfex - Otsuka Canada Home
... thereof. The patient should be monitored for signs of local or systemic infection or bleeding and their hematologic status evaluated frequently. Caution should be exercised when administering the recommended dose of BUSULFEX to patients with a history of seizure disorder, head trauma, or receiving o ...
... thereof. The patient should be monitored for signs of local or systemic infection or bleeding and their hematologic status evaluated frequently. Caution should be exercised when administering the recommended dose of BUSULFEX to patients with a history of seizure disorder, head trauma, or receiving o ...
The Role of Dexmedetomidine (Precedex®) - RT Journal On-Line
... safety and efficacy of dexmedetomidine in 30 patients who needed mechanical ventilation after surgery. A score between 60 and 70 was needed to achieve adequate sedation. If the target level was unattainable with the study drug alone, the patient was given additional boluses of propofol, followed by ...
... safety and efficacy of dexmedetomidine in 30 patients who needed mechanical ventilation after surgery. A score between 60 and 70 was needed to achieve adequate sedation. If the target level was unattainable with the study drug alone, the patient was given additional boluses of propofol, followed by ...
AusPAR Lenvatinib mesilate - Therapeutic Goods Administration
... External beam radiation may be useful in patients with metastatic DTC that is refractory to radioiodine or in patients whose tumours do not concentrate radioiodine. Management of persistent or recurrent disease (minimal versus extensive) is also discussed. A subset of patients has radioiodine negati ...
... External beam radiation may be useful in patients with metastatic DTC that is refractory to radioiodine or in patients whose tumours do not concentrate radioiodine. Management of persistent or recurrent disease (minimal versus extensive) is also discussed. A subset of patients has radioiodine negati ...
AusPAR: Regorafenib
... Bayer proposes registration of 40 mg, unscored, film-coated tablets. These are light-pink ovals (16 x 7 mm) marked “Bayer” and “40” on opposite sides. They are presented in an high density polyethylene (HDPE) bottle, with a child-resistant cap, of 28 tablets as a pack of 1 or 3 bottles (that is, 84 ...
... Bayer proposes registration of 40 mg, unscored, film-coated tablets. These are light-pink ovals (16 x 7 mm) marked “Bayer” and “40” on opposite sides. They are presented in an high density polyethylene (HDPE) bottle, with a child-resistant cap, of 28 tablets as a pack of 1 or 3 bottles (that is, 84 ...
Antiinfective Agents
... person will experience a mild form of a reaction that occurs with alcohol and disulfiram. Symptoms include nausea, abdominal cramps, flushing, vomiting, and headache. The reaction can happen if the patient ingests any form of alcohol including foods, drinks, and mouth rinses containing alcohol. Some ...
... person will experience a mild form of a reaction that occurs with alcohol and disulfiram. Symptoms include nausea, abdominal cramps, flushing, vomiting, and headache. The reaction can happen if the patient ingests any form of alcohol including foods, drinks, and mouth rinses containing alcohol. Some ...
Amiodarone Induced Ocular Toxicity
... The ADR was not studied for dose dependent response and in view of its uncertain mechanism it is difficult to comment on type of ADR. Amiodarone is a benzofuran derivative that has been effective for the treatment of both supraventricular and ventricular tachyarrhythmias. Due to ocular, dermatologic ...
... The ADR was not studied for dose dependent response and in view of its uncertain mechanism it is difficult to comment on type of ADR. Amiodarone is a benzofuran derivative that has been effective for the treatment of both supraventricular and ventricular tachyarrhythmias. Due to ocular, dermatologic ...
First Dose in Humans
... rats using the rat CD28specific homologus antibody. Optimal PD responses between 0.3 and1 mg/ kg MABEL 0.5 mg/kg Safe starting dose 5 µg/kg, based on safety criteria for trials with a single microdose ...
... rats using the rat CD28specific homologus antibody. Optimal PD responses between 0.3 and1 mg/ kg MABEL 0.5 mg/kg Safe starting dose 5 µg/kg, based on safety criteria for trials with a single microdose ...
spontaneous corneal perforation and
... Pus, mucous in consistency and greenish in colour, appears in copious amounts. Unless specific adequate treatment is initiated immediately, panophthalmitis can develop (1,4,8). At first, when evaluating this case, the diagnosis of a postsplenectomy syndrome (PSS), which is an endogenous endophtalmit ...
... Pus, mucous in consistency and greenish in colour, appears in copious amounts. Unless specific adequate treatment is initiated immediately, panophthalmitis can develop (1,4,8). At first, when evaluating this case, the diagnosis of a postsplenectomy syndrome (PSS), which is an endogenous endophtalmit ...
Corresponding author: Carsten H. Meyer, MD, Department of Oph- thalmology, Philipps University–
... MIC90 (minimum inhibitory concentration) of 0.5 µg/mL for A fumigatus reported in various studies.1-3,5 Voriconazole also has been shown to be effective for endogenous Fusarium endophthalmitis8 and Paecilomyces lilacinus endophthalmitis.9 In larger clinical studies of systemic fungal diseases, the m ...
... MIC90 (minimum inhibitory concentration) of 0.5 µg/mL for A fumigatus reported in various studies.1-3,5 Voriconazole also has been shown to be effective for endogenous Fusarium endophthalmitis8 and Paecilomyces lilacinus endophthalmitis.9 In larger clinical studies of systemic fungal diseases, the m ...
COPD: FIXING the FIXABLES in 2003
... Prevalence 5.9% of U.S. population or about 24,000,000 adults (ATS Gold Paper 2004) In 2000 there were 122,000 deaths (CDC data) For the first time more women than men 2nd to heart disease as a cause of disability Annual cost 2002 est. $32.1 billion 70% of the patients were less than 65 ...
... Prevalence 5.9% of U.S. population or about 24,000,000 adults (ATS Gold Paper 2004) In 2000 there were 122,000 deaths (CDC data) For the first time more women than men 2nd to heart disease as a cause of disability Annual cost 2002 est. $32.1 billion 70% of the patients were less than 65 ...
Isentress - Merck.com
... hypersensitivity reaction and toxic epidermal necrolysis. Immediately discontinue treatment with ISENTRESS or ISENTRESS HD and other suspect agents if severe hypersensitivity, severe rash, or rash with systemic symptoms or liver aminotransferase elevations develops and monitor clinical status, inclu ...
... hypersensitivity reaction and toxic epidermal necrolysis. Immediately discontinue treatment with ISENTRESS or ISENTRESS HD and other suspect agents if severe hypersensitivity, severe rash, or rash with systemic symptoms or liver aminotransferase elevations develops and monitor clinical status, inclu ...
Phase 1 Trial Design: Is 3 + 3 the Best?
... incidence of DLTs, is referred to as the maximum administered dose (MAD). The MTD is typically defined as the dose level immediately below the MAD and corresponds with the RP2D.9 In the event that the MTD is not reached, other non–toxicity-based end points can be considered in order to recommend a d ...
... incidence of DLTs, is referred to as the maximum administered dose (MAD). The MTD is typically defined as the dose level immediately below the MAD and corresponds with the RP2D.9 In the event that the MTD is not reached, other non–toxicity-based end points can be considered in order to recommend a d ...
Tussionex (hydrocodone resin complex
... Phenyltoloxamine, acts as competitive inhibitor of histamine2. As with other antihistamines, it is possible that its sedative and tranquillizing characteristics may contribute to its antitussive action.3 In addition, phenyltoloxamine in a similar manner to other antihistamines has been shown to pote ...
... Phenyltoloxamine, acts as competitive inhibitor of histamine2. As with other antihistamines, it is possible that its sedative and tranquillizing characteristics may contribute to its antitussive action.3 In addition, phenyltoloxamine in a similar manner to other antihistamines has been shown to pote ...
Intravitreal Amphotericin B
... Intravitreal Voriconazole has been shown to be less toxic to the retina than intravitreal Amphotericin B. Based on animal models, intravitreal Voriconazole (VCZ) appears to be nontoxic up to doses of 100 μg. ...
... Intravitreal Voriconazole has been shown to be less toxic to the retina than intravitreal Amphotericin B. Based on animal models, intravitreal Voriconazole (VCZ) appears to be nontoxic up to doses of 100 μg. ...
Ofloxacin
Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.Ofloxacin was first patented in 1982 (European Patent Daiichi) and received approval from the U.S. Food and Drug Administration (FDA) on December 28, 1990. Ofloxacin is sold under a wide variety of brand names as well as generic drug equivalents, for oral and intravenous administration. Ofloxacin is also available for topical use, as eye drops and ear drops (marketed as Ocuflox and Floxin Otic respectively in the United States and marketed as Optiflox, eylox respectively in Jordan and Saudi Arabia).Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin.Ofloxacin has been associated with adverse drug reactions, such as tendon damage (including spontaneous tendon ruptures) and peripheral neuropathy (which may be irreversible); tendon damage may manifest long after therapy had been completed, and, in severe cases, may result in lifelong disabilities.