Drug Dosing Adjustments in Patients with Chronic Kidney
... chronic kidney disease is the presence of kidney damage or a reduction in the glomerular filtration rate (GFR) for three months or longer. The K/DOQI chronic kidney disease staging system (Table 1) is based on GFR.1 Inappropriate dosing in patients with chronic kidney disease can cause toxicity or i ...
... chronic kidney disease is the presence of kidney damage or a reduction in the glomerular filtration rate (GFR) for three months or longer. The K/DOQI chronic kidney disease staging system (Table 1) is based on GFR.1 Inappropriate dosing in patients with chronic kidney disease can cause toxicity or i ...
Slide 1
... – 100 mg/m2, 235 mg/m2, 472 mg/m2, and 628 mg/m2 Need priors to initiate model – Prior studies Has there been a previous phase I study using this drug? – Investigator’s clinical intuition about high and low doses What dose would you expect 90% toxicity? What dose would you expect 10% toxicity? – Red ...
... – 100 mg/m2, 235 mg/m2, 472 mg/m2, and 628 mg/m2 Need priors to initiate model – Prior studies Has there been a previous phase I study using this drug? – Investigator’s clinical intuition about high and low doses What dose would you expect 90% toxicity? What dose would you expect 10% toxicity? – Red ...
NYMALIZE PRODUCT FACT SHEET
... ----------------------USE IN SPECIFIC POPULATIONS------------------------ Pregnancy: Based on animal data may cause fetal harm (8.1) ...
... ----------------------USE IN SPECIFIC POPULATIONS------------------------ Pregnancy: Based on animal data may cause fetal harm (8.1) ...
RITALIN® (METHYLPHENIDATE): CLINICAL EXPERIENCES
... IJL our experience, Ritalin is effective m antagonizing the actions of barbiturates. The action does not appear to be a specific antagonism but rather an independent central nervous system stimulation which raises the level of alertness or wakefulness. In moderate doses it has little effect on the b ...
... IJL our experience, Ritalin is effective m antagonizing the actions of barbiturates. The action does not appear to be a specific antagonism but rather an independent central nervous system stimulation which raises the level of alertness or wakefulness. In moderate doses it has little effect on the b ...
MIOSTAT - Medsafe
... Carcinogenicity: Studies in animals to evaluate the carcinogenic potential have not been conducted. Effects on Fertility: Studies have not been performed to evaluate the effect of topical ocular administration of carbachol on human fertility. Use in Pregnancy: Category B2- There are no adequate and ...
... Carcinogenicity: Studies in animals to evaluate the carcinogenic potential have not been conducted. Effects on Fertility: Studies have not been performed to evaluate the effect of topical ocular administration of carbachol on human fertility. Use in Pregnancy: Category B2- There are no adequate and ...
Product Information: Calcipotriol and betamethasone (as
... aberration or mouse micronucleus test). Betamethasone dipropionate was not genotoxic in the Ames mutagenicity assay, the mouse lymphoma TK locus assay or in the rat micronucleus test. Use in Pregnancy (Category B1) There are no adequate data from the use of Daivobet® gel in pregnant women. Daivobet® ...
... aberration or mouse micronucleus test). Betamethasone dipropionate was not genotoxic in the Ames mutagenicity assay, the mouse lymphoma TK locus assay or in the rat micronucleus test. Use in Pregnancy (Category B1) There are no adequate data from the use of Daivobet® gel in pregnant women. Daivobet® ...
soung_htn
... 42 yo man w/ new diagnosis of HTN, average BP 145/90 after intensive lifestyle improvements. Normal serum electrolytes and creatinine, UA negative, EKG wnl. Otherwise healthy. Which of the following is the most appropriate next step in management? A) Lisinopril B) Chlorthalidone C) Amlodipine D) H ...
... 42 yo man w/ new diagnosis of HTN, average BP 145/90 after intensive lifestyle improvements. Normal serum electrolytes and creatinine, UA negative, EKG wnl. Otherwise healthy. Which of the following is the most appropriate next step in management? A) Lisinopril B) Chlorthalidone C) Amlodipine D) H ...
Appendix 5 - Cancer Care Ontario
... excretion of a drug, leading to higher drug levels for longer periods of time and therefore an increase in toxicity. Also, for drugs that are predominantly excreted by the kidney, very good renal function may lead to relatively lower drug levels and even a decrease in the effectiveness of the drug. ...
... excretion of a drug, leading to higher drug levels for longer periods of time and therefore an increase in toxicity. Also, for drugs that are predominantly excreted by the kidney, very good renal function may lead to relatively lower drug levels and even a decrease in the effectiveness of the drug. ...
Comparing Treatments for Age-Related Macular Degeneration
... for Avastin. As treatment for AMD continues indefinitely, the financial impact will also continue. The choice of drug and dosing regimen must balance the comparable effects on vision, the possibility of true differences in adverse events, and the 40-fold difference in cost per dose between Avastin a ...
... for Avastin. As treatment for AMD continues indefinitely, the financial impact will also continue. The choice of drug and dosing regimen must balance the comparable effects on vision, the possibility of true differences in adverse events, and the 40-fold difference in cost per dose between Avastin a ...
Clofazimine (Lamprene, B663) in the Treatment of Lepromatous
... skin generally and the lesions was obvious in nine cases, but only four patients actually complained. In a fifth patient, mild pigmentation was accompanied by ichthyosis of the extensor aspects of the extremities. Patient 26 developed conspicuous black pigmentation of lesions on the face similar to ...
... skin generally and the lesions was obvious in nine cases, but only four patients actually complained. In a fifth patient, mild pigmentation was accompanied by ichthyosis of the extensor aspects of the extremities. Patient 26 developed conspicuous black pigmentation of lesions on the face similar to ...
Valtrex - GlaxoSmithKline
... Thrombotic Thrombocytopenic Purpura/ Hemolytic Uremic Syndrome (TTP/HUS) Thrombotic Thrombocytopenic Purpura/ Hemolytic Uremic Syndrome (TTP/HUS), in some cases resulting in death, has occurred in patients with advanced HIV-1 disease, and also in allogenic bone marrow transplant and renal transplant ...
... Thrombotic Thrombocytopenic Purpura/ Hemolytic Uremic Syndrome (TTP/HUS) Thrombotic Thrombocytopenic Purpura/ Hemolytic Uremic Syndrome (TTP/HUS), in some cases resulting in death, has occurred in patients with advanced HIV-1 disease, and also in allogenic bone marrow transplant and renal transplant ...
Chronobiology and Chronotherapeutics – Possible Strategy for
... or progressive development to second- or third-degree AV block requires a reduction in dosage or, in rare instances, discontinuation of verapamil and institution of appropriate therapy depending upon the clinical situation. Patients with hypertrophic cardiomyopathy (IHSS): In 120 patients with hyper ...
... or progressive development to second- or third-degree AV block requires a reduction in dosage or, in rare instances, discontinuation of verapamil and institution of appropriate therapy depending upon the clinical situation. Patients with hypertrophic cardiomyopathy (IHSS): In 120 patients with hyper ...
1 SUMMARY OF PRODUCT CHARACTERISTICS 1 - CBG-MEB
... serious and sometimes fatal reactions have been reported in patients receiving an SSRI in combination with an irreversible, non-selective monoamine oxidase inhibitor (MAOI). These cases presented with features resembling serotonin syndrome (which may be confounded with [or diagnosed as] neuroleptic ...
... serious and sometimes fatal reactions have been reported in patients receiving an SSRI in combination with an irreversible, non-selective monoamine oxidase inhibitor (MAOI). These cases presented with features resembling serotonin syndrome (which may be confounded with [or diagnosed as] neuroleptic ...
... thinner, more sensitive skin is associated with an increased susceptibility to common corticosteroid side effects. In my practice, I have prescribed Cloderm Cream for treatment of various sites. I have even prescribed the formulation for eyelid dermatitis. Data suggest topical corticosteroids can be ...
High Prevalence of Demodex brevis Infestation in Chalazia
... presence (yes) or absence (no). The independent samples t test was used to determine age matching between the 2 groups. The Pearson chi-square test and Fisher exact test were used for the rest of comparative and correlative analyses between the 2 groups. For those data with high standard deviations, ...
... presence (yes) or absence (no). The independent samples t test was used to determine age matching between the 2 groups. The Pearson chi-square test and Fisher exact test were used for the rest of comparative and correlative analyses between the 2 groups. For those data with high standard deviations, ...
Evaluation of co-trimoxazole in the treatment of multidrug-resistant tuberculosis
... (MIC) is considered to be the important pharmacokinetic/pharmcodynamic parameter in predicting the efficacy of SXT [5]. Very little is known about the pharmacodynamics of SXT [5]. There are only a few publications on the pharmacokinetic parameters of SXT, none of which include TB patients (table 1) ...
... (MIC) is considered to be the important pharmacokinetic/pharmcodynamic parameter in predicting the efficacy of SXT [5]. Very little is known about the pharmacodynamics of SXT [5]. There are only a few publications on the pharmacokinetic parameters of SXT, none of which include TB patients (table 1) ...
vitekta - Gilead
... clinical trials of another drug and may not reflect the rates observed in practice. The safety assessment of VITEKTA is primarily based on data from a controlled clinical trial, Study 145, in which 712 HIV-1 infected, antiretroviral treatment-experienced adults received VITEKTA (N=354) or raltegravi ...
... clinical trials of another drug and may not reflect the rates observed in practice. The safety assessment of VITEKTA is primarily based on data from a controlled clinical trial, Study 145, in which 712 HIV-1 infected, antiretroviral treatment-experienced adults received VITEKTA (N=354) or raltegravi ...
Anticoagulation for Atrial Fibrillation in the Elderly Abstract
... increases with age, the absolute risk of warfarin-associated ICH is relatively low at around 0.2% to 0.6% per year [18]. However, a post-hoc analysis of the ATRIA study by Fang et al. [19] showed that warfarin-associated ICH had a very high mortality rate (60% in the first 30 days). McGrath et al. [ ...
... increases with age, the absolute risk of warfarin-associated ICH is relatively low at around 0.2% to 0.6% per year [18]. However, a post-hoc analysis of the ATRIA study by Fang et al. [19] showed that warfarin-associated ICH had a very high mortality rate (60% in the first 30 days). McGrath et al. [ ...
Management of delirium in children and adolescents
... olanzapine vs ziprasidone • A retrospective study comparing the efficacy of IM ziprasidone and IM olanzapine PRN in 100 juvenile (younger than 18 years) psychiatric inpatients found that these medications were similar in terms of their ability to address inpatient ...
... olanzapine vs ziprasidone • A retrospective study comparing the efficacy of IM ziprasidone and IM olanzapine PRN in 100 juvenile (younger than 18 years) psychiatric inpatients found that these medications were similar in terms of their ability to address inpatient ...
Calcium Channel Blocking Agents
... Dosage Adjustment Renal dysfunction: no adjustment Hepatic dysfunction: consider 2.5 mg as initial daily dose for hypertension and 5 mg as initial daily dose for angina ...
... Dosage Adjustment Renal dysfunction: no adjustment Hepatic dysfunction: consider 2.5 mg as initial daily dose for hypertension and 5 mg as initial daily dose for angina ...
Beneficial therapeutic effects of hemoperfusion
... Abstract. – OBJECTIVE: Most of StevensJohnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe drug eruptions. There is currently no established treatment due to a lack of controlled/blinded studies. High-dose glucocorticoids and intravenous immunoglobulins (IVIG) therapy have been wid ...
... Abstract. – OBJECTIVE: Most of StevensJohnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe drug eruptions. There is currently no established treatment due to a lack of controlled/blinded studies. High-dose glucocorticoids and intravenous immunoglobulins (IVIG) therapy have been wid ...
Doping with the anabolic steroid Stanozolol: experimental
... Interestingly, there is no difference in volume fraction and numerical density of collagen fibrils in the tendons which were both exercised and given Stanozolol compared to those which were only exercised and received placebo. By far the most striking result is the appearance of dysplastic collagen ...
... Interestingly, there is no difference in volume fraction and numerical density of collagen fibrils in the tendons which were both exercised and given Stanozolol compared to those which were only exercised and received placebo. By far the most striking result is the appearance of dysplastic collagen ...
Full Prescribing Information
... methylergonovine is rapidly distributed from plasma to peripheral tissues within 2 to 3 minutes or less. The bioavailability after oral administration was reported to be about 60% with no accumulation after repeated doses. During delivery, with intramuscular injection, bioavailability increased to 7 ...
... methylergonovine is rapidly distributed from plasma to peripheral tissues within 2 to 3 minutes or less. The bioavailability after oral administration was reported to be about 60% with no accumulation after repeated doses. During delivery, with intramuscular injection, bioavailability increased to 7 ...
Management of ocular sarcoidosis - Sarcoidosis, Vasculitis and
... 281 (77%) of the 365 MTX treated patients remained on MTX either as a single agent or in combination with other immunosuppressive therapies. The most common reason for MTX discontinuation was disease resolution, which occurred in 13% of cases. An additional 40 patients experienced drug withdrawal ei ...
... 281 (77%) of the 365 MTX treated patients remained on MTX either as a single agent or in combination with other immunosuppressive therapies. The most common reason for MTX discontinuation was disease resolution, which occurred in 13% of cases. An additional 40 patients experienced drug withdrawal ei ...
Ofloxacin
Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.Ofloxacin was first patented in 1982 (European Patent Daiichi) and received approval from the U.S. Food and Drug Administration (FDA) on December 28, 1990. Ofloxacin is sold under a wide variety of brand names as well as generic drug equivalents, for oral and intravenous administration. Ofloxacin is also available for topical use, as eye drops and ear drops (marketed as Ocuflox and Floxin Otic respectively in the United States and marketed as Optiflox, eylox respectively in Jordan and Saudi Arabia).Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin.Ofloxacin has been associated with adverse drug reactions, such as tendon damage (including spontaneous tendon ruptures) and peripheral neuropathy (which may be irreversible); tendon damage may manifest long after therapy had been completed, and, in severe cases, may result in lifelong disabilities.