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Salair Inhaler
Salair Inhaler

... Salbutamol sulphate is indicated for the prevention and treatment of bronchospasm and acts on the β2 (beta-2) adrenoceptors of bronchial muscle at therapeutic doses, with little or no action on the β1 (beta-1) adrenoceptors of the heart. With its fast onset of action, it is particularly suitable for ...
ORALLY DISINTEGRATING DOSAGE FORMS: BREAKTHROUGH SOLUTION FOR NON-COMPLIANCE  Review Article
ORALLY DISINTEGRATING DOSAGE FORMS: BREAKTHROUGH SOLUTION FOR NON-COMPLIANCE Review Article

... issue tends to worsen in long term drug therapy [4]. Statistics showed that approximately 50% of patients on long-term therapy did not comply to the prescribed treatment [4]. Patients with long term treatment reported that they either never start or they stopped therapy completely within the first y ...
PRODUCT MONOGRAPH DESIPRAMINE
PRODUCT MONOGRAPH DESIPRAMINE

... surgery in patients taking desipramine hydrochloride. The contraindication regarding its concomitant use with MAO inhibitors should be noted, as well as the warning regarding patients taking thyroid medication. Desipramine hydrochloride, on the other hand, may decrease the action of other drugs; it ...
WHO Analgesic Ladder: Step 3 Methadone
WHO Analgesic Ladder: Step 3 Methadone

... this population e.g. 2.5 mg once daily. For frail elderly ...
Pediatric/Neonatal Doses of Antiretroviral Drugs
Pediatric/Neonatal Doses of Antiretroviral Drugs

... Antacids and buffered medications (including ddI buffered tablets) decrease ATV concentrations if taken at the same time – space by 1 – 2 hours. • H2 receptor antagonists and proton pump inhibitors decrease ATV levels. Check drug interaction resource for recommendations on dosing ATV when coadminist ...
Data Sheet
Data Sheet

... required since the use of nonsteroidal anti-inflammatory drugs may result in deterioration of renal function. The dose should be kept as low as possible and renal function should be monitored in these patients. ...
Management of Status Epilepticus D. DURHAM
Management of Status Epilepticus D. DURHAM

... Objective: To review the aetiology and treatment of status epilepticus and present a practical approach to its management. Data sources: A review of studies reported from 1966 to 1998 and identified through a MEDLINE search of the English-language literature on metabolic and toxic seizures and statu ...
Halcion: Yesterday, Today, and Tomorrow
Halcion: Yesterday, Today, and Tomorrow

...  Phenobarbital (and other barbiturates)  Modafinil (Provigil)  St. John’s wort (hypericum)  Cigarette smoke (aryl hydrocarbons) ...
Taxotere® product monograph
Taxotere® product monograph

... potential hazard to the fetus. Nursing Women: It is not known whether TAXOTERE is excreted in human milk. Because many drugs are excreted in human milk, and because of the potential for serious adverse reactions in nursing infants from TAXOTERE, breastfeeding must be discontinued during TAXOTERE the ...
1 HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights
1 HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights

... Than Placebo in three 12-Week Clinical Trials1 ...
mechanisms of la toxicity
mechanisms of la toxicity

... potential target sites are altered by the increased cardiac output state.  Pregnancy results in decreased plasma protein, thereby increasing the free drug concentration in the vascular compartment. Oestrogen and progesterone also appear to alter cardiomyocyte electrophysiology to increase arrhythmo ...
Acetylsalicylic acid Krka gastro
Acetylsalicylic acid Krka gastro

... Increased risk of bleeding due to inhibited thrombocyte function, injury of the duodenal mucosa and displacement of oral anticoagulants from their plasma protein binding sites. The bleeding time should be monitored (see section 4.4). Particularly, treatment with acetylsalicylic acid should not be in ...
Niti Sardana and Timothy J. Craig 2011;128;1173 DOI: 10.1542/peds.2011-0546
Niti Sardana and Timothy J. Craig 2011;128;1173 DOI: 10.1542/peds.2011-0546

... Google to develop this review. Articles that are necessary for the understanding and use of the new therapeutic options for HAE were chosen, and studies of high quality were used to support the use of therapies, and in most cases, results from phase III studies were used. RESULTS: Until recently, th ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... complications. Tacrolimus has long been used in organ transplant patients and has been shown to have potent immunosuppressive activity. Moreover, tacrolimus has also been reported to inhibit calcineurin 100 times more effectively than cyclosporine.1 To evaluate the risks and benefits of tacrolimus ey ...
Product Monograph
Product Monograph

... seizure disorders accompanied by mental retardation, and those with organic brain disease may be at particular risk. Experience has indicated that children under the age of 2 years are at a considerably increased risk of developing fatal hepatotoxicity, especially those on multiple anticonvulsants ( ...
Absorbed Dose
Absorbed Dose

... Method of intrapenile injection. A cross section of the penis illustrates the corpora cavernosa surrounded by the thick outer fibrous sheath (tunica. albuginea) .The needle is inserted at a ninety-degree angle to the penile shaft and must penetrate the tunica albuginea to make contact with the corpu ...
Cardiovascular Pharmacology
Cardiovascular Pharmacology

... usual doses have no direct effect on the contractile proteins, or the interactions between them digitalis glycosides bind specifically to the Na+/K+-ATP'ase, inhibit its enzymatic activity and impair the active transport of the two cations this results in a gradual increase in the intracellular Na+ ...
Serum Creatinine Measuring serum creatinine is a useful and
Serum Creatinine Measuring serum creatinine is a useful and

... The kidney's properties of high blood flow, filtration, reabsorption and concentration allow nephrotoxins to accumulate. A patient's BUN and creatinine should always be checked before giving nephrotoxic drugs. If either level is above the normal range, the drug should be held and the patient's physi ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These
HIGHLIGHTS OF PRESCRIBING INFORMATION These

... Pregnancy Category C: There are no adequate and well-controlled trials of sumatriptan injection in pregnant women. In developmental toxicity studies in rats and rabbits, oral administration of sumatriptan to pregnant animals was associated with embryolethality, fetal abnormalities, and pup mortality ...
managing insomnia
managing insomnia

... history of insomnia that is likely to persist (e.g. stress that is likely to be long term). Hypnotics are best avoided for someone with a history of chronic insomnia because the risks of long term use are high. Behavioural therapies are more durable and safer long term.6 Short acting benzodiazepine ...
Product Monograph
Product Monograph

... supervision of clinicians experienced in intubation, ventilator management, and general care of premature infants. During the doing procedure, transient episodes of bradycardia and decreased oxygen saturation have been reported (see ADVERSE REACTIONS). If these occur, stop the dosing procedure and i ...
IJBCP International Journal of Basic & Clinical
IJBCP International Journal of Basic & Clinical

... corresponding cellular injury, as well as by inhibiting pro-inflammatory cytokines. DMF is an orally administered, enteric-coated microtablet preparation. There was a 44-53% reduction in annualized relapse rate with the use of DMF in patients with relapsing form of MS. The most common adverse reacti ...
Fluoxetin Mylan dispersible tablet ENG SmPC
Fluoxetin Mylan dispersible tablet ENG SmPC

... The risk of withdrawal symptoms may be dependent on several factors, including the duration and dose of therapy and the rate of dose reduction. Dizziness, sensory disturbances (including paraesthesia), sleep disturbances (including insomnia and intense dreams), asthenia, agitation or anxiety, nausea ...
end of life medicines information pack
end of life medicines information pack

... A Guide to Equivalent Doses for Opioid Drugs N.B - this is to be used as a guide rather than a set of definitive equivalences. Most data on doses is based on single dose studies so is not necessarily applicable in chronic use, also individual patients may metabolise different drugs at varying rates ...
This reprint contains information which is not found in the FDA
This reprint contains information which is not found in the FDA

... Acute interstitial nephritis has been observed in patients taking PPIs. Discontinue ACIPHEX if acute interstitial nephritis develops ...
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Ofloxacin



Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.Ofloxacin was first patented in 1982 (European Patent Daiichi) and received approval from the U.S. Food and Drug Administration (FDA) on December 28, 1990. Ofloxacin is sold under a wide variety of brand names as well as generic drug equivalents, for oral and intravenous administration. Ofloxacin is also available for topical use, as eye drops and ear drops (marketed as Ocuflox and Floxin Otic respectively in the United States and marketed as Optiflox, eylox respectively in Jordan and Saudi Arabia).Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin.Ofloxacin has been associated with adverse drug reactions, such as tendon damage (including spontaneous tendon ruptures) and peripheral neuropathy (which may be irreversible); tendon damage may manifest long after therapy had been completed, and, in severe cases, may result in lifelong disabilities.
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