Serotonin 5-HT Receptors: Chemical Neuronatomy in the
... these species using [3H]mesulergine. The distribution of 5-HT2C receptor binding sites in the human brain is somewhat different from that found in the rat brain (Pazos and Palacios 1985; Hoyer et al. 1986). In the rat hippocampus, 5-HT2C receptor binding sites are located in the stratum lacunosum m ...
... these species using [3H]mesulergine. The distribution of 5-HT2C receptor binding sites in the human brain is somewhat different from that found in the rat brain (Pazos and Palacios 1985; Hoyer et al. 1986). In the rat hippocampus, 5-HT2C receptor binding sites are located in the stratum lacunosum m ...
Differential Internalization of the Prostaglandin F2α Receptor
... 1997). These two isoforms are generated by alternative mRNA splicing that gives rise to differences in their intracellular carboxyl-terminal domain. Studies on these receptor isoforms have demonstrated that upon stimulation with PGF2␣ more than one signaling pathway can be activated. Thus, stimulati ...
... 1997). These two isoforms are generated by alternative mRNA splicing that gives rise to differences in their intracellular carboxyl-terminal domain. Studies on these receptor isoforms have demonstrated that upon stimulation with PGF2␣ more than one signaling pathway can be activated. Thus, stimulati ...
Chemical Messengers
... • Exactly what it sounds like: – Two cells contact each other and… • some types of immune responses can start • cells know where they are… – neurons during growth and development ...
... • Exactly what it sounds like: – Two cells contact each other and… • some types of immune responses can start • cells know where they are… – neurons during growth and development ...
MECHANISMS OF INTERCELLULAR COMMUNICATION
... DIRECT EFFECTS • CONFORMATIONAL CHANGE OF RECEPTOR MOLECULE CHANGES MEMBRANE PERMEABILITY • ESPECIALLY SODIUM, CHLORIDE AND CALCIUM IONS • ACETYLCHOLINE—a neurotransmitter • SEROTONIN---a hormone and neurotransmitter • GLYCINE—a neurotransmitter • GABA---a neurotransmitter • GROWTH HORMONE---a horm ...
... DIRECT EFFECTS • CONFORMATIONAL CHANGE OF RECEPTOR MOLECULE CHANGES MEMBRANE PERMEABILITY • ESPECIALLY SODIUM, CHLORIDE AND CALCIUM IONS • ACETYLCHOLINE—a neurotransmitter • SEROTONIN---a hormone and neurotransmitter • GLYCINE—a neurotransmitter • GABA---a neurotransmitter • GROWTH HORMONE---a horm ...
Local Accumulation of Acetylcholine Receptors Is
... in part via lateral migration of diffusely expressed receptors. Using a model system-cultured Xenopus muscle cells exposed to electric fields-we have shown that AChRs, concentrated at the cathode-facing cell pole, continue to aggregate there after the field is terminated (Stollberg and Fraser, 1988) ...
... in part via lateral migration of diffusely expressed receptors. Using a model system-cultured Xenopus muscle cells exposed to electric fields-we have shown that AChRs, concentrated at the cathode-facing cell pole, continue to aggregate there after the field is terminated (Stollberg and Fraser, 1988) ...
Loss-of-Function Polymorphic Variants of the Human Angiotensin II
... Whole-Cell Saturation Radioligand Binding Assay. Wholecell saturation binding was performed using COS-7 cells that were transfected as described above for the competitive radioligand binding. Cells were incubated in DMEM containing various concentrations of the radioligand [tyrosyl-3,5-3H]Ang II (5- ...
... Whole-Cell Saturation Radioligand Binding Assay. Wholecell saturation binding was performed using COS-7 cells that were transfected as described above for the competitive radioligand binding. Cells were incubated in DMEM containing various concentrations of the radioligand [tyrosyl-3,5-3H]Ang II (5- ...
From Hans Selye`s discovery of biological stress to the
... activates the sympathetic nervous system inducing the systemic release of catecholamines involved in the ”fight or flight” response. The locus coeruleus is also activated by CRF and its noradrenergic projections to the forebrain contributes to the arousal and alertness. Convergent preclinical eviden ...
... activates the sympathetic nervous system inducing the systemic release of catecholamines involved in the ”fight or flight” response. The locus coeruleus is also activated by CRF and its noradrenergic projections to the forebrain contributes to the arousal and alertness. Convergent preclinical eviden ...
Membrane receptors in the gastrointestinal tract
... cytosolic surface of the plasma membrane. The c-ras genes are expressed during normal human development in fetuses at 12 to 18 weeks gestation (29). This time subsequent to embryogenesis coincides with a general situation of rapid cell proliferation and differentiation. The p21 ras protein expresses ...
... cytosolic surface of the plasma membrane. The c-ras genes are expressed during normal human development in fetuses at 12 to 18 weeks gestation (29). This time subsequent to embryogenesis coincides with a general situation of rapid cell proliferation and differentiation. The p21 ras protein expresses ...
G-protein-coupled receptor kinases
... either purified and reconstituted into phospholipid vesicles (3) or prepared as plasma membrane fractions from cells overexpressing receptor protein (4). More recently, cotransfection of cells with both epitope-tagged receptors and GRKs has allowed testing for effects of individual GRKs on receptor ...
... either purified and reconstituted into phospholipid vesicles (3) or prepared as plasma membrane fractions from cells overexpressing receptor protein (4). More recently, cotransfection of cells with both epitope-tagged receptors and GRKs has allowed testing for effects of individual GRKs on receptor ...
The role of P2 receptors in controlling infections by intracellular
... infection, revealing upregulation of the receptor during both in vivo and in vitro infection with L. amazonensis [54]. These changes were correlated with functional responses, as reflected by an increase in ATPe-mediated plasma– membrane permeabilisation and host-cell apoptosis ([54] and Chaves et a ...
... infection, revealing upregulation of the receptor during both in vivo and in vitro infection with L. amazonensis [54]. These changes were correlated with functional responses, as reflected by an increase in ATPe-mediated plasma– membrane permeabilisation and host-cell apoptosis ([54] and Chaves et a ...
COMMUNICATION Two categories of mammalian galactose
... ligands makes primary interactions with the macrophage galactose lectin, but binding is enhanced by secondary interactions with adjacent terminal galactose, GalNAc, fucose, or NeuAc residues. Binding of the macrophage galactose lectin is also observed to a few other galactoseterminated ligands inclu ...
... ligands makes primary interactions with the macrophage galactose lectin, but binding is enhanced by secondary interactions with adjacent terminal galactose, GalNAc, fucose, or NeuAc residues. Binding of the macrophage galactose lectin is also observed to a few other galactoseterminated ligands inclu ...
References - BioMed Central
... SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway: inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors: binding to JAK2 inhibits its kinase activity W ...
... SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway: inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors: binding to JAK2 inhibits its kinase activity W ...
Fundamentals of Cell Biology
... A brief look at some common signaling pathways • Key Concepts: – Hundreds of different receptors, signaling proteins, and effectors combine into a complex network of interacting pathways within a single cell. – Despite the tremendous complexity of signaling networks, many share common features that ...
... A brief look at some common signaling pathways • Key Concepts: – Hundreds of different receptors, signaling proteins, and effectors combine into a complex network of interacting pathways within a single cell. – Despite the tremendous complexity of signaling networks, many share common features that ...
Redistribution of Mannose-6-Phosphate Receptors Induced by
... punctate intracellular staining was seen which was concentrated in the juxtanuclear or Golgi region (Fig. 1 B) . In cells treated with tunicamycin (Fig. 1 C) or cycloheximide (Fig. 1 D), no morphological changes were detected by phase-contrast microscopy. By immunofluorescence the receptors were see ...
... punctate intracellular staining was seen which was concentrated in the juxtanuclear or Golgi region (Fig. 1 B) . In cells treated with tunicamycin (Fig. 1 C) or cycloheximide (Fig. 1 D), no morphological changes were detected by phase-contrast microscopy. By immunofluorescence the receptors were see ...
Identification of the Sites of Asparagine
... function, i.e., our previous data resulted from amino acid substitutions introduced per se but not from disruption of glycosylation, or 2) although interpretation of our previous data was correct, TSHR cannot tolerate multiple mutations at glycosylation sites. That is, these two sites are critical, ...
... function, i.e., our previous data resulted from amino acid substitutions introduced per se but not from disruption of glycosylation, or 2) although interpretation of our previous data was correct, TSHR cannot tolerate multiple mutations at glycosylation sites. That is, these two sites are critical, ...
Transforming Growth Factor-Яs and Vascular Disorders
... type I and II receptor complexes activating Smad-dependent and Smad-independent signals, which regulate proliferation, differentiation, and survival. They are potent regulators of vascular development and vessel remodeling and play key roles in atherosclerosis and restenosis, regulating endothelial, ...
... type I and II receptor complexes activating Smad-dependent and Smad-independent signals, which regulate proliferation, differentiation, and survival. They are potent regulators of vascular development and vessel remodeling and play key roles in atherosclerosis and restenosis, regulating endothelial, ...
Transcription factors
... RXR is a common partner in >10 different pathways – can be silent (non-permissive) – can be active (permissive) – offers another means to regulate dimeric receptors • rexinoids (RXR selective compounds) are being used clinically in treatment of diabetes, breast cancer and other diseases. – at least ...
... RXR is a common partner in >10 different pathways – can be silent (non-permissive) – can be active (permissive) – offers another means to regulate dimeric receptors • rexinoids (RXR selective compounds) are being used clinically in treatment of diabetes, breast cancer and other diseases. – at least ...
Cell Communication
... – How G protein-coupled receptors, receptor tyrosine kinases, ligandgated ion channels, and intracellular receptors receive cell signals and start transduction – How a cell signal is amplified by a phosphorylation cascade, via second messengers (such as cAMP or Ca2+ ions) and protein kinases. – How ...
... – How G protein-coupled receptors, receptor tyrosine kinases, ligandgated ion channels, and intracellular receptors receive cell signals and start transduction – How a cell signal is amplified by a phosphorylation cascade, via second messengers (such as cAMP or Ca2+ ions) and protein kinases. – How ...
Effect of Steroid Hormones and Retinoids on the Formation of
... acid (at-RA), RU486 (mifepristone), dimethyl sulfoxide (DMSO), and charcoal-stripped, delipidated bovine calf serum were purchased from Sigma (St Louis, MO). R1881 (methyltrienolone) was obtained from NEN (Boston, MA). 1,25-Dihydroxyvitamin D3 (Ro 21-5535) was kindly provided by Dr M.R. Uskoković ( ...
... acid (at-RA), RU486 (mifepristone), dimethyl sulfoxide (DMSO), and charcoal-stripped, delipidated bovine calf serum were purchased from Sigma (St Louis, MO). R1881 (methyltrienolone) was obtained from NEN (Boston, MA). 1,25-Dihydroxyvitamin D3 (Ro 21-5535) was kindly provided by Dr M.R. Uskoković ( ...
20150324133963
... • Most of the cells in the thyroid are called follicular cells, but there are others called parafollicular cells (or C cells) which produce another important hormone called calcitonin. The thyroid also has four teensy glands called the parathyroid glands, which are embedded in the back of the thyr ...
... • Most of the cells in the thyroid are called follicular cells, but there are others called parafollicular cells (or C cells) which produce another important hormone called calcitonin. The thyroid also has four teensy glands called the parathyroid glands, which are embedded in the back of the thyr ...
Chapter 9 Signal Transduction and Cell Growth
... and functions of the cell by activating intracellular signal transduction proteins, and regulates gene expression through the relocation of intracellular signaling molecules to the nucleus. While a large number of physical and chemical stimuli exist in the environment, organisms respond only to part ...
... and functions of the cell by activating intracellular signal transduction proteins, and regulates gene expression through the relocation of intracellular signaling molecules to the nucleus. While a large number of physical and chemical stimuli exist in the environment, organisms respond only to part ...
Expression and transcriptional activity of progesterone receptor A
... one PR isoform, usually PRA, is seen in cancers, suggests that disrupted progesterone signaling may play a role in development or progression of breast cancer. ...
... one PR isoform, usually PRA, is seen in cancers, suggests that disrupted progesterone signaling may play a role in development or progression of breast cancer. ...
5.3 G Protein-Coupled Receptors
... helices connected by alternating extracellular and intracellular loops, with the amino terminus located on the extracellular side and the carboxy terminus on the intracellular side. Apart from that feature, the overall sequence homology among the G protein-coupled receptors is low. Significant seq ...
... helices connected by alternating extracellular and intracellular loops, with the amino terminus located on the extracellular side and the carboxy terminus on the intracellular side. Apart from that feature, the overall sequence homology among the G protein-coupled receptors is low. Significant seq ...
Cloning, Expression, and Pharmacological Characterization of a
... Alto, CA). PCR was performed using gene specific primers corresponding to the putative coding sequence of the gene from an unfinished genomic sequence (GenBank accession number AC007922), and AP adaptor primers (Clontech). The complete AXOR35 cDNA was isolated from human bone marrow and leukocytes b ...
... Alto, CA). PCR was performed using gene specific primers corresponding to the putative coding sequence of the gene from an unfinished genomic sequence (GenBank accession number AC007922), and AP adaptor primers (Clontech). The complete AXOR35 cDNA was isolated from human bone marrow and leukocytes b ...
Molecular Cloning and Pharmacological Characterization of a
... The predicted protein (638 amino acids) shows the typical seven hydrophobic regions putatively forming the seven TM domains characteristic for G protein-coupled receptors. An eighth hydrophobic region at the amino-terminal part of the protein, as is present in many invertebrate G protein-coupled neu ...
... The predicted protein (638 amino acids) shows the typical seven hydrophobic regions putatively forming the seven TM domains characteristic for G protein-coupled receptors. An eighth hydrophobic region at the amino-terminal part of the protein, as is present in many invertebrate G protein-coupled neu ...