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JAK/STAT signalling • Binding of cytokines (small protein ligands) to
JAK/STAT signalling • Binding of cytokines (small protein ligands) to

... Only  switched  on  in  response  to  a  signal  (applies  to  signalling  proteins   and  to  genes)   Enzymes  that  phosphorylate  other  proteins   The  idea  that  DNA  makes  RNA  which  makes  protein   An  intermediate  in  sign ...
The Nobel Prize in Chemistry 2012 Robert J. Lefkowitz Brian K. Kobilka PRESSMEDDELANDE
The Nobel Prize in Chemistry 2012 Robert J. Lefkowitz Brian K. Kobilka PRESSMEDDELANDE

... sense their environment. Scientists knew that hormones such as adrenalin had powerful effects: increasing blood pressure and making the heart beat faster. They suspected that cell surfaces contained some kind of recipient for hormones. But what these receptors actually consisted of and how they work ...
Pharmacology Corner: Drug-Receptor Interactions
Pharmacology Corner: Drug-Receptor Interactions

... channel to open and allowing ions to flow through) or indirectly (for example, causing a cascade of events in a cell that eventually causes protein production). The molecules (drugs, supplements, chemicals, hormones, neurotransmitters, peptides) that bind to receptors are called ligands. Ligands bin ...
Receptor Superfamilies
Receptor Superfamilies

... Receptors are protein switches that control biochemical processes in a cell. The switches are turned on through the binding of molecules called ligands. Much as a substrate binds an enzyme to trigger a reaction, a ligand reversibly attaches to a binding site on a receptor protein to activate a cellu ...
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Leukotriene B4 receptor 2

Leukotriene B4 receptor 2, also known as BLT2, BLT2 receptor, and BLTR2, is a Integral membrane protein that is encoded by the LTB4R2 gene in humans and the Ltbr2 gene in mice.Discovered several years after the leukotriene B4 receptor 1 (BLT1), BLT2 receptor binds leukotriene B4 (LTB4) with far lower affinity than the BLT1 receptor does and therefore has been termed the low affinity LTB4 receptor. Sometime after its initial discovery, the BLT2 receptor was shown to bind and become activated by several other arachidonic acid metabolites, one of which, 12-hydroxyheptadecatrienoic acid (12-HHT), has 10- to 100-fold higher affinity for it than does LTB4; 12-HHT fails to bind or activate BLT1 receptors. While BLT2 receptors have some actions similar to BLT1 receptors, they have other actions which clearly oppose those of BLT1 in regulating inflammation and allergic responses; BLT2 receptors also have actions that extend beyond those of BLT1 receptors. Laboratory, animal, and other pre-clinical studies suggest that BLT2 receptors may be involved not only in inflammation and allergy but also in human cancer.
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