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... Brucellosis infection of cattle has serious economic consequences for the cattle industry. Not only does it cause losses from abortion, but it also creates marketing limitations and farmers must pay to test cattle to reassure trading partners that the product is clean. When infection occurs, the dis ...
... Brucellosis infection of cattle has serious economic consequences for the cattle industry. Not only does it cause losses from abortion, but it also creates marketing limitations and farmers must pay to test cattle to reassure trading partners that the product is clean. When infection occurs, the dis ...
PD-1 / PD-L1 Combination Therapies
... Keytruda, initially for melanoma but with additional indications now getting under way. What does the industry do for an encore? There are several late-stage antibodies that work in identical or similar ways – tremelimumab, atezolizumab and durvalumab – and slightly further away stands an amazing ar ...
... Keytruda, initially for melanoma but with additional indications now getting under way. What does the industry do for an encore? There are several late-stage antibodies that work in identical or similar ways – tremelimumab, atezolizumab and durvalumab – and slightly further away stands an amazing ar ...
curriculum vitae
... MOA (see publications) Designed and implemented Pre-Clinical non-GLP Tox and PK/PD studies of smallmolecule leads Developed and implemented in vitro and in vivo POC studies for Type 1 Diabetes and Multiple Sclerosis Altered Peptide Ligand (APL) programs (mouse models and human samples) (see publ ...
... MOA (see publications) Designed and implemented Pre-Clinical non-GLP Tox and PK/PD studies of smallmolecule leads Developed and implemented in vitro and in vivo POC studies for Type 1 Diabetes and Multiple Sclerosis Altered Peptide Ligand (APL) programs (mouse models and human samples) (see publ ...
Host responses in periodontal diseases: a preview
... inflammatory responses in diabetic subjects appear to increase the risk for vascular disorders. Nassar et al. (13) have proposed the interesting hypothesis that long-term hyperglycemia supports anaerobic infection in periodontal sites owing to an environment of exacerbated innate immunity. Persisten ...
... inflammatory responses in diabetic subjects appear to increase the risk for vascular disorders. Nassar et al. (13) have proposed the interesting hypothesis that long-term hyperglycemia supports anaerobic infection in periodontal sites owing to an environment of exacerbated innate immunity. Persisten ...
A simple model of growth form-dependent recovery from disease in
... influence of growth form on disease recovery in sessile animals in general, because sponges are structurally simple and homogeneous and yet display a great variety of growth forms. Disproportionately frequent reports of disease in unusually large sponges, e.g., ‘‘loggerhead’’ (Spheciospongia vespariu ...
... influence of growth form on disease recovery in sessile animals in general, because sponges are structurally simple and homogeneous and yet display a great variety of growth forms. Disproportionately frequent reports of disease in unusually large sponges, e.g., ‘‘loggerhead’’ (Spheciospongia vespariu ...
Anthrax: Biology of Bacillus anthracis - ePrints@IISc
... present in a variety of cell surface proteins like matriCURRENT SCIENCE, VOL. 82, NO. 10, 25 MAY 2002 ...
... present in a variety of cell surface proteins like matriCURRENT SCIENCE, VOL. 82, NO. 10, 25 MAY 2002 ...
The Cryosauna is Used to Treat Auto
... — Some autoimmune diseases run in families, such as lupus and multiple sclerosis. It is also common for different types of autoimmune diseases to affect different members of a single family. Inheriting certain genes can make it more likely to get an autoimmune disease. But a combination of genes and ...
... — Some autoimmune diseases run in families, such as lupus and multiple sclerosis. It is also common for different types of autoimmune diseases to affect different members of a single family. Inheriting certain genes can make it more likely to get an autoimmune disease. But a combination of genes and ...
Law on Protection of Population against Infectious Disease
... responsibilities of legal entities and natural persons in the field of protection of the population from infectious diseases. CHAPTER I GENERAL PROVISIONS Article 1. Definition of Terms In this Law terms given below are used in the following meaning: infectious diseases – disorders of human health t ...
... responsibilities of legal entities and natural persons in the field of protection of the population from infectious diseases. CHAPTER I GENERAL PROVISIONS Article 1. Definition of Terms In this Law terms given below are used in the following meaning: infectious diseases – disorders of human health t ...
Brucellosis Clinical picture
... 1. Eradication of brucellosis in animals is the key to prevention in humans. • surveillance, serologic testing, quarantine and massive immunization of animals in areas with high infection rates ...
... 1. Eradication of brucellosis in animals is the key to prevention in humans. • surveillance, serologic testing, quarantine and massive immunization of animals in areas with high infection rates ...
The Immune Response to Helicobacter pylori
... follow a profound knowledge of immunopathological events during natural H. pylori infection and factors leading to resolution of infection: mandatory is a new knowledge about the interplay of the innate response to H. pylori, mucosal inflammation, H. pylori virulence factors inducing immune response ...
... follow a profound knowledge of immunopathological events during natural H. pylori infection and factors leading to resolution of infection: mandatory is a new knowledge about the interplay of the innate response to H. pylori, mucosal inflammation, H. pylori virulence factors inducing immune response ...
Protect Your Baby for Life What is Hepatitis B?
... Your baby’s father and everyone else who lives in your house should go to the doctor or clinic to be tested. Testing your family members helps to tell if they have Hepatitis B. If they do not have Hepatitis B, the doctor will talk to them about getting the Hepatitis B vaccine to protect them from ge ...
... Your baby’s father and everyone else who lives in your house should go to the doctor or clinic to be tested. Testing your family members helps to tell if they have Hepatitis B. If they do not have Hepatitis B, the doctor will talk to them about getting the Hepatitis B vaccine to protect them from ge ...
Chapter 1 - Research Explorer
... express a Th2 profile. In addition, the Th1/Th2 balance in periodontitis has been investigated and currently periodontitis is considered as a Th2-type disease. We hypothesized that the Th2 pattern in periodontitis may be accentuated by smoking, accelerating disease progression and relapse in treate ...
... express a Th2 profile. In addition, the Th1/Th2 balance in periodontitis has been investigated and currently periodontitis is considered as a Th2-type disease. We hypothesized that the Th2 pattern in periodontitis may be accentuated by smoking, accelerating disease progression and relapse in treate ...
General research methods on pathogen of potato late blight
... few plants to most plants in a field. Leaves may drop off. Stems. When the disease is sever, lesions may develop on petioles and stems, where they expand lengthwise. The colors of the lesions is black. Infected stems are weakened, and may cause death of plant parts above the lesion. Tubers. Infected ...
... few plants to most plants in a field. Leaves may drop off. Stems. When the disease is sever, lesions may develop on petioles and stems, where they expand lengthwise. The colors of the lesions is black. Infected stems are weakened, and may cause death of plant parts above the lesion. Tubers. Infected ...
EFFECTS OF PSYCHOLOGICAL STRESS ON GLUCOCORTICOID
... health and readiness of military units worldwide with reported rates of annual influenza infection as high as 45%. Vaccination to prevent infections stimulates a transient, inflammatory response, counterbalanced by the anti-inflammatory effects of increased cortisol secretion which enhances antibody ...
... health and readiness of military units worldwide with reported rates of annual influenza infection as high as 45%. Vaccination to prevent infections stimulates a transient, inflammatory response, counterbalanced by the anti-inflammatory effects of increased cortisol secretion which enhances antibody ...
Control of Bovine Viral Diarrhea Virus in Ruminants
... as reservoirs for BVDV. BVDV infections have been identified in Old and New World camelids. In New World camelids, seroprevalence rates o20% have been reported in both North and South America.24–26 In North America, highest antibody titers to BVDV were detected on farms on which PI crias were present ...
... as reservoirs for BVDV. BVDV infections have been identified in Old and New World camelids. In New World camelids, seroprevalence rates o20% have been reported in both North and South America.24–26 In North America, highest antibody titers to BVDV were detected on farms on which PI crias were present ...
Two cases of human cutaneous anthrax in
... handling its meat, presented to a primary care practice in September 2014 with a wound on the volar side of his right forearm. The wound was about 3 cm in diameter and covered with a black crust. The area was slightly oedematous. At the regional general hospital, he was diagnosed as having allergic ...
... handling its meat, presented to a primary care practice in September 2014 with a wound on the volar side of his right forearm. The wound was about 3 cm in diameter and covered with a black crust. The area was slightly oedematous. At the regional general hospital, he was diagnosed as having allergic ...
FEMS Microbiology Ecology
... (P < 0:05) of germination of ascospores was observed at both log 4 and log 8 cfu (colony forming units) ml1 of bacterial populations. In the population study, the pathogen had no significant effect (P < 0:05) on bacterial populations; however, a significant (P < 0:05) increase in bacterial populations ...
... (P < 0:05) of germination of ascospores was observed at both log 4 and log 8 cfu (colony forming units) ml1 of bacterial populations. In the population study, the pathogen had no significant effect (P < 0:05) on bacterial populations; however, a significant (P < 0:05) increase in bacterial populations ...
Helicobacter pylori vaccines and mechanisms of effective
... mouse model was developed and protective immunity demonstrated,23 it was found that oral delivery of helicobacterspecific IgA monoclonal antibodies at the same time as challenge with H. felis protected mice against colonization.24 Many of the following studies found an association between protective ...
... mouse model was developed and protective immunity demonstrated,23 it was found that oral delivery of helicobacterspecific IgA monoclonal antibodies at the same time as challenge with H. felis protected mice against colonization.24 Many of the following studies found an association between protective ...
here - EPLAW Patent Blog
... eradication of particular diseases. Eradication (or near eradication) has been achieved for several human diseases, most famously for smallpox. Examples of well known diseases for which there are vaccines include rabies, diphtheria, pertussis (whooping cough), tetanus, polio, measles, mumps and rube ...
... eradication of particular diseases. Eradication (or near eradication) has been achieved for several human diseases, most famously for smallpox. Examples of well known diseases for which there are vaccines include rabies, diphtheria, pertussis (whooping cough), tetanus, polio, measles, mumps and rube ...
MSM Immune Health Science Brief
... The immune response involves a multitude of different cells and active molecules, but the key messenger molecules that coordinate efforts are the cytokines, which include both pro-inflammatory and anti-inflammatory molecules. IL-1, IL-6, and TNF-α are the primary cytokines involved in the innate imm ...
... The immune response involves a multitude of different cells and active molecules, but the key messenger molecules that coordinate efforts are the cytokines, which include both pro-inflammatory and anti-inflammatory molecules. IL-1, IL-6, and TNF-α are the primary cytokines involved in the innate imm ...
Hepatitis AE - Jacobi Medical Center
... A 34 y/o nurse reports a needle stick injury. After drawing blood from a pt, the nurse inadvertently stuck the needle into his own finger. The source pt is known to be HBsAg +. The nurse was vaccinated against HBV when he was hired 3 yrs ago. He completed the series of three injections but has never ...
... A 34 y/o nurse reports a needle stick injury. After drawing blood from a pt, the nurse inadvertently stuck the needle into his own finger. The source pt is known to be HBsAg +. The nurse was vaccinated against HBV when he was hired 3 yrs ago. He completed the series of three injections but has never ...
Slowing of wound healing by psychological stress
... interleukin-8, and tumour necrosis factor (TNF) help to protect against infection, prepare injured tissue for repair, and enhance phagocyte recruitment and activation.1 Furthermore, cytokines released by the recruited cells regulate the ability of fibroblasts and epithelial cells to remodel damaged ...
... interleukin-8, and tumour necrosis factor (TNF) help to protect against infection, prepare injured tissue for repair, and enhance phagocyte recruitment and activation.1 Furthermore, cytokines released by the recruited cells regulate the ability of fibroblasts and epithelial cells to remodel damaged ...
The evolution of costly acquired immune memory
... do assume that immunity can be lost at rate c. Analysis of these population dynamics shows that this model yields straightforward SIR-type behavior, with a forward bifurcation at R0 ¼ b^S=ðb þ a þ cÞ ¼ 1 (where ^S is the disease-free equilibrium) with one unique endemic equilibrium for R0 > 1. We no ...
... do assume that immunity can be lost at rate c. Analysis of these population dynamics shows that this model yields straightforward SIR-type behavior, with a forward bifurcation at R0 ¼ b^S=ðb þ a þ cÞ ¼ 1 (where ^S is the disease-free equilibrium) with one unique endemic equilibrium for R0 > 1. We no ...
immune system - Bio-Inspired Artificial Intelligence
... receptors (TCRs). When activated they are in charge of: – Killing cells that display antigens they recognize – Activating the elements that work in the “analog” modality – Become memory T-cells Companion slides for the book Bio-Inspired Artificial Intelligence: Theories, Methods, and Technologies by ...
... receptors (TCRs). When activated they are in charge of: – Killing cells that display antigens they recognize – Activating the elements that work in the “analog” modality – Become memory T-cells Companion slides for the book Bio-Inspired Artificial Intelligence: Theories, Methods, and Technologies by ...
Vaccination
Vaccination is the administration of antigenic material (a vaccine) to stimulate an individual's immune system to develop adaptive immunity to a pathogen. Vaccines can prevent or ameliorate morbidity from infection. When a sufficiently large percentage of a population has been vaccinated, this results in herd immunity. The effectiveness of vaccination has been widely studied and verified; for example, the influenza vaccine, the HPV vaccine, and the chicken pox vaccine. Vaccination is the most effective method of preventing infectious diseases; widespread immunity due to vaccination is largely responsible for the worldwide eradication of smallpox and the restriction of diseases such as polio, measles, and tetanus from much of the world. The World Health Organization (WHO) reports that licensed vaccines are currently available to prevent or contribute to the prevention and control of twenty-five infections.The active agent of a vaccine may be intact but inactivated (non-infective) or attenuated (with reduced infectivity) forms of the causative pathogens, or purified components of the pathogen that have been found to be highly immunogenic (e.g., outer coat proteins of a virus). Toxoids are produced for immunization against toxin-based diseases, such as the modification of tetanospasmin toxin of tetanus to remove its toxic effect but retain its immunogenic effect.Smallpox was most likely the first disease people tried to prevent by inoculating themselves and was the first disease for which a vaccine was produced. The smallpox vaccine was discovered in 1796 by the British physician Edward Jenner, although at least six people had used the same principles years earlier. Louis Pasteur furthered the concept through his work in microbiology. The immunization was called vaccination because it was derived from a virus affecting cows (Latin: vacca—cow). Smallpox was a contagious and deadly disease, causing the deaths of 20–60% of infected adults and over 80% of infected children. When smallpox was finally eradicated in 1979, it had already killed an estimated 300–500 million people in the 20th century.In common speech, 'vaccination' and 'immunization' have a similar meaning. This distinguishes it from inoculation, which uses unweakened live pathogens, although in common usage either can refer to an immunization. Vaccination efforts have been met with some controversy on scientific, ethical, political, medical safety, and religious grounds. In rare cases, vaccinations can injure people and, in the United States, they may receive compensation for those injuries under the National Vaccine Injury Compensation Program. Early success and compulsion brought widespread acceptance, and mass vaccination campaigns have greatly reduced the incidence of many diseases in numerous geographic regions.