The Role of the Innate and Adaptive Immune Responses in
... munization should lead to the appearance of anti-Acanthamoeba antibodies in the tears and resistance to Acanthamoeba keratitis. This hypothesis was confirmed in both the pig and Chinese hamster models of Acanthamoeba keratitis2, 35. Oral immunization with Acanthamoeba antigens conjugated with the mu ...
... munization should lead to the appearance of anti-Acanthamoeba antibodies in the tears and resistance to Acanthamoeba keratitis. This hypothesis was confirmed in both the pig and Chinese hamster models of Acanthamoeba keratitis2, 35. Oral immunization with Acanthamoeba antigens conjugated with the mu ...
Mortality and causes of death in South Africa
... Users may apply or process this data, provided Statistics South Africa (Stats SA) is acknowledged as the original source of the data; that it is specified that the application and/or analysis is the result of the user's independent processing of the data; and that neither the basic data nor any repr ...
... Users may apply or process this data, provided Statistics South Africa (Stats SA) is acknowledged as the original source of the data; that it is specified that the application and/or analysis is the result of the user's independent processing of the data; and that neither the basic data nor any repr ...
Pathogenesis of PSC
... Pathogenesis of PSC Hypotheses/considerations Strong association with IBD partic UC but the paradox: • PSC can occur many years before development of UC • PSC can occur many years after colectomy • Clinical activities of colitis and PSC not related unlike other EIM’s ie Skin,eyes, seronegative arth ...
... Pathogenesis of PSC Hypotheses/considerations Strong association with IBD partic UC but the paradox: • PSC can occur many years before development of UC • PSC can occur many years after colectomy • Clinical activities of colitis and PSC not related unlike other EIM’s ie Skin,eyes, seronegative arth ...
Tubules composed of non-structural protein
... Newcastle and Marek's disease in poultry (Brown, 1992). Vaccines will play an even more critical role in the future as the rapid increase in urbanisation and farming are resulting in the crowding of people and animals, thereby ensuring the rapid spread of infection not only between individuals of th ...
... Newcastle and Marek's disease in poultry (Brown, 1992). Vaccines will play an even more critical role in the future as the rapid increase in urbanisation and farming are resulting in the crowding of people and animals, thereby ensuring the rapid spread of infection not only between individuals of th ...
Insoluble and soluble immune complexes activate neutrophils by
... cytotoxic processes are activated and delivered within intracellular phagolysosomes to effect killing, and few, if any, of these toxic molecules are released. These neutrophil derived reactive oxidants (O2−, H2O2, 1O2, cOH, and HOCl) and granule enzymes (for example, myeloperoxidase, metalloproteina ...
... cytotoxic processes are activated and delivered within intracellular phagolysosomes to effect killing, and few, if any, of these toxic molecules are released. These neutrophil derived reactive oxidants (O2−, H2O2, 1O2, cOH, and HOCl) and granule enzymes (for example, myeloperoxidase, metalloproteina ...
Immunity to Intracellular Salmonella Depends on Surface
... the control antigen GFP-His6 using the same protocol. We determined immune responses to these antigens in genetically resistant, convalescent mice that had survived infection with virulent Salmonella enterica serovar Typhimurium. We detected antigen-specific CD4 T cells in spleen using a sensitive C ...
... the control antigen GFP-His6 using the same protocol. We determined immune responses to these antigens in genetically resistant, convalescent mice that had survived infection with virulent Salmonella enterica serovar Typhimurium. We detected antigen-specific CD4 T cells in spleen using a sensitive C ...
Diapositiva 1
... Interferon-γ Release Assays for Diagnosis ofTuberculosis Infection and Disease in Children. Pediatrics. 2014;134:e1763-73. Interferon-Gamma Release Assay Sensitivity in Children Younger Than 5 Years is Insufficient to Replace the Use of Tuberculin Skin Test in Western Countries Pediatr Infect Dis J. ...
... Interferon-γ Release Assays for Diagnosis ofTuberculosis Infection and Disease in Children. Pediatrics. 2014;134:e1763-73. Interferon-Gamma Release Assay Sensitivity in Children Younger Than 5 Years is Insufficient to Replace the Use of Tuberculin Skin Test in Western Countries Pediatr Infect Dis J. ...
host susceptibility to rotavirus infection and
... increased secretion, hence diarrhea. These series of events lead to intestinal tract infection, also referred to as acute gastroenteritis. The rotavirus infections cause approximately 500 000 annual deaths worldwide, 85 % of which occur in low and middle income countries. Based on a recent report of ...
... increased secretion, hence diarrhea. These series of events lead to intestinal tract infection, also referred to as acute gastroenteritis. The rotavirus infections cause approximately 500 000 annual deaths worldwide, 85 % of which occur in low and middle income countries. Based on a recent report of ...
CURRICULUM VITAE William Schaffner, MD
... CDC Honor Award: “For adding substantially to the body of scientific and public health knowledge regarding avian influenza”, Asian Avian Influenza Response Team, National Center for Infectious Diseases, Co-awardee. ...
... CDC Honor Award: “For adding substantially to the body of scientific and public health knowledge regarding avian influenza”, Asian Avian Influenza Response Team, National Center for Infectious Diseases, Co-awardee. ...
Antigen-Specific Antibody Glycosylation Is Regulated via
... such as antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP) and complement-dependent cytotoxicity (CDC), in protection against [1], and control of HIV [2], influenza [3], Ebola virus [4], and bacterial infections [5]. Earlier work suggests that potent, lo ...
... such as antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP) and complement-dependent cytotoxicity (CDC), in protection against [1], and control of HIV [2], influenza [3], Ebola virus [4], and bacterial infections [5]. Earlier work suggests that potent, lo ...
ADCC_Final Layout.qxd - Autoimmune Disease Research Center
... the population – 14 to 22 million persons. The social and financial burdens imposed by these chronic, debilitating diseases include poor quality of life, high health care costs, and substantial loss of productivity. The past two decades of research on the immune system have yielded a wealth of new i ...
... the population – 14 to 22 million persons. The social and financial burdens imposed by these chronic, debilitating diseases include poor quality of life, high health care costs, and substantial loss of productivity. The past two decades of research on the immune system have yielded a wealth of new i ...
Proceedings - Animal Nutrition Conference of Canada
... Kristina Dumont, and Frédéric Guay – Université Laval ………………………………………..…………………………. 225 Effects of Dietary Fusarium Mycotoxins and Matched Feeding on Broiler Performance, Feeding Behavior and Duodenum Morphology Anhao Wang, Karen Schwean‐Lardner, and Natacha Hogan – University of Saskatchewan ……… ...
... Kristina Dumont, and Frédéric Guay – Université Laval ………………………………………..…………………………. 225 Effects of Dietary Fusarium Mycotoxins and Matched Feeding on Broiler Performance, Feeding Behavior and Duodenum Morphology Anhao Wang, Karen Schwean‐Lardner, and Natacha Hogan – University of Saskatchewan ……… ...
Mathematical and Statistical Analyses of the Spread of Dengue
... Although the vaccines against dengue are still under development,[49,50] equation (4) allows us to roughly estimate the required coverage. Since it has been suggested that secondary infection with a heterologous strain is a risk factor for DHF,[51,52] tetravalent vaccines, which ...
... Although the vaccines against dengue are still under development,[49,50] equation (4) allows us to roughly estimate the required coverage. Since it has been suggested that secondary infection with a heterologous strain is a risk factor for DHF,[51,52] tetravalent vaccines, which ...
Avian Influenza
... avian influenza hpai is a rapidly spreading viral disease that can infect many types of birds avian influenza is contagious, egg farms hit hard as bird flu affects millions of hens - avian flu viruses have affected over 33 million turkeys chickens and ducks in the united states with iowa s farmers p ...
... avian influenza hpai is a rapidly spreading viral disease that can infect many types of birds avian influenza is contagious, egg farms hit hard as bird flu affects millions of hens - avian flu viruses have affected over 33 million turkeys chickens and ducks in the united states with iowa s farmers p ...
Pfizer Partnering Brochure
... approach to the development of new medicines for patients with rare diseases. We have a track record of creating innovative strategic partnerships with academic institutions, patient advocacy groups, and commercial enterprises to accelerate the development of novel therapeutics across the entire spe ...
... approach to the development of new medicines for patients with rare diseases. We have a track record of creating innovative strategic partnerships with academic institutions, patient advocacy groups, and commercial enterprises to accelerate the development of novel therapeutics across the entire spe ...
In immunology, an adjuvant is an agent that may stimulate the
... on the unique ability of an antibody to bind with high specificity to one or a very limited group of molecules. A molecule that binds to an antibody is called an antigen. Immunoassays can be carried out for either member of an antigen/antibody pair. For antigen analytes, an antibody that specificall ...
... on the unique ability of an antibody to bind with high specificity to one or a very limited group of molecules. A molecule that binds to an antibody is called an antigen. Immunoassays can be carried out for either member of an antigen/antibody pair. For antigen analytes, an antibody that specificall ...
Capra Colostrum
... milk, providing the two most important components for overall health—immune and growth factors. It has shown to be easily tolerated even by those with the most compromised immune systems, including victims of chemical sensitivities. Colostrum from Vitomega BV comes from goats that are never fed synt ...
... milk, providing the two most important components for overall health—immune and growth factors. It has shown to be easily tolerated even by those with the most compromised immune systems, including victims of chemical sensitivities. Colostrum from Vitomega BV comes from goats that are never fed synt ...
Chapter 16 Cholinesterase Inhibitors
... Major cause of morbidity and mortality worldwide 36,000 deaths/year in the United States Caused by influenza viruses, which are highly variable and undergo constant evolution ...
... Major cause of morbidity and mortality worldwide 36,000 deaths/year in the United States Caused by influenza viruses, which are highly variable and undergo constant evolution ...
Chapter 16 Cholinesterase Inhibitors
... Major cause of morbidity and mortality worldwide 36,000 deaths/year in the United States Caused by influenza viruses, which are highly variable and undergo constant evolution ...
... Major cause of morbidity and mortality worldwide 36,000 deaths/year in the United States Caused by influenza viruses, which are highly variable and undergo constant evolution ...
Medical Virology of Hepatitis B: how it began and where we are now
... Infection with hepatitis B virus (HBV) may lead to acute or chronic hepatitis. HBV infections were previously much more frequent but there are still 240 million chronic HBV carriers today and ca. 620,000 die per year from the late sequelae liver cirrhosis or hepatocellular carcinoma. Hepatitis B was ...
... Infection with hepatitis B virus (HBV) may lead to acute or chronic hepatitis. HBV infections were previously much more frequent but there are still 240 million chronic HBV carriers today and ca. 620,000 die per year from the late sequelae liver cirrhosis or hepatocellular carcinoma. Hepatitis B was ...
VENEZUELAN EQUINE ENCEPHALITIS VIRUS REPLICON
... This process would not have been possible without the contributions of numerous individuals, all of whom have made this such a meaningful part of my life. I first need to thank my advisor, Bob Johnston for the opportunity to work in such a stimulating environment. I am appreciative of his giving me ...
... This process would not have been possible without the contributions of numerous individuals, all of whom have made this such a meaningful part of my life. I first need to thank my advisor, Bob Johnston for the opportunity to work in such a stimulating environment. I am appreciative of his giving me ...
Artificial Immune Systems
... 3 Engineering Artificial Immune Systems [de Castro & Timmis 2002a] have proposed a flexible and generic layered approach to the development of immune inspired engineering solutions, shown in Figure 1. This framework identifies the main design decisions that need to be addressed in the deployment of ...
... 3 Engineering Artificial Immune Systems [de Castro & Timmis 2002a] have proposed a flexible and generic layered approach to the development of immune inspired engineering solutions, shown in Figure 1. This framework identifies the main design decisions that need to be addressed in the deployment of ...
Curriculum Vitae
... 42. Oseroff C, Peters B, Pasquetto V, Moutaftsi M, Sidney J, Panchanathan V, Tscharke DC, Maillere B, Grey H, Sette A. Dissociation between epitope hierarchy and immunoprevalence in CD8 responses to vaccinia virus western reserve. J Immunol. 2008 Jun 1;180(11):7193. PMCID: PMC2533852 43. Sette A, M ...
... 42. Oseroff C, Peters B, Pasquetto V, Moutaftsi M, Sidney J, Panchanathan V, Tscharke DC, Maillere B, Grey H, Sette A. Dissociation between epitope hierarchy and immunoprevalence in CD8 responses to vaccinia virus western reserve. J Immunol. 2008 Jun 1;180(11):7193. PMCID: PMC2533852 43. Sette A, M ...
The Definition and Measurement of Dangerous Research Alex Greninger CISSM
... anyone potentially exposed to a biological agent to get a true sense of the number of infected cases. Given that deaths due to an infectious agent are easier to monitor than overall infections, it is likely that most lethality statistics are biased upwards in those data derived from humans. B. Defin ...
... anyone potentially exposed to a biological agent to get a true sense of the number of infected cases. Given that deaths due to an infectious agent are easier to monitor than overall infections, it is likely that most lethality statistics are biased upwards in those data derived from humans. B. Defin ...
1. NAME OF THE MEDICINAL PRODUCT PPD Tuberculin
... PPD may be temporarily depressed by certain live virus vaccines (measles, mumps, rubella, oral polio, yellow fever, and varicella (5; 22). Therefore, if a tuberculin test is to be performed it should be administered either before, or simultaneously at separate sites with the injection of measles, mu ...
... PPD may be temporarily depressed by certain live virus vaccines (measles, mumps, rubella, oral polio, yellow fever, and varicella (5; 22). Therefore, if a tuberculin test is to be performed it should be administered either before, or simultaneously at separate sites with the injection of measles, mu ...
Vaccination
Vaccination is the administration of antigenic material (a vaccine) to stimulate an individual's immune system to develop adaptive immunity to a pathogen. Vaccines can prevent or ameliorate morbidity from infection. When a sufficiently large percentage of a population has been vaccinated, this results in herd immunity. The effectiveness of vaccination has been widely studied and verified; for example, the influenza vaccine, the HPV vaccine, and the chicken pox vaccine. Vaccination is the most effective method of preventing infectious diseases; widespread immunity due to vaccination is largely responsible for the worldwide eradication of smallpox and the restriction of diseases such as polio, measles, and tetanus from much of the world. The World Health Organization (WHO) reports that licensed vaccines are currently available to prevent or contribute to the prevention and control of twenty-five infections.The active agent of a vaccine may be intact but inactivated (non-infective) or attenuated (with reduced infectivity) forms of the causative pathogens, or purified components of the pathogen that have been found to be highly immunogenic (e.g., outer coat proteins of a virus). Toxoids are produced for immunization against toxin-based diseases, such as the modification of tetanospasmin toxin of tetanus to remove its toxic effect but retain its immunogenic effect.Smallpox was most likely the first disease people tried to prevent by inoculating themselves and was the first disease for which a vaccine was produced. The smallpox vaccine was discovered in 1796 by the British physician Edward Jenner, although at least six people had used the same principles years earlier. Louis Pasteur furthered the concept through his work in microbiology. The immunization was called vaccination because it was derived from a virus affecting cows (Latin: vacca—cow). Smallpox was a contagious and deadly disease, causing the deaths of 20–60% of infected adults and over 80% of infected children. When smallpox was finally eradicated in 1979, it had already killed an estimated 300–500 million people in the 20th century.In common speech, 'vaccination' and 'immunization' have a similar meaning. This distinguishes it from inoculation, which uses unweakened live pathogens, although in common usage either can refer to an immunization. Vaccination efforts have been met with some controversy on scientific, ethical, political, medical safety, and religious grounds. In rare cases, vaccinations can injure people and, in the United States, they may receive compensation for those injuries under the National Vaccine Injury Compensation Program. Early success and compulsion brought widespread acceptance, and mass vaccination campaigns have greatly reduced the incidence of many diseases in numerous geographic regions.