Autophagy Delivers Viral Antigens for MHC Class II Presentation
... To address the general relevance and the efficacy of this novel MHC class II pathway, we quantified autophagy in MHC class II-positive human cells and demonstrated constitutive autophagosome formation in epithelial, B and dendritic cells. The autophagosome marker Atg8/LC3 strongly overlapped with m ...
... To address the general relevance and the efficacy of this novel MHC class II pathway, we quantified autophagy in MHC class II-positive human cells and demonstrated constitutive autophagosome formation in epithelial, B and dendritic cells. The autophagosome marker Atg8/LC3 strongly overlapped with m ...
29 - California State University, Stanislaus
... strongly anti-self Positive selection – selects T cells with a weak response to self-antigens, which thus become both immunocompetent and self-tolerant ...
... strongly anti-self Positive selection – selects T cells with a weak response to self-antigens, which thus become both immunocompetent and self-tolerant ...
6- review article Tolou.indd
... initial events result in cytokine-dependent proliferation, differentiation and maturation of functional subsets of T-cells and B-cells that secrete immunoglobulin (1, 20, 21). These cytokines not only serve as ligands for cellular receptors that generate and regulate the immune response, but they ma ...
... initial events result in cytokine-dependent proliferation, differentiation and maturation of functional subsets of T-cells and B-cells that secrete immunoglobulin (1, 20, 21). These cytokines not only serve as ligands for cellular receptors that generate and regulate the immune response, but they ma ...
Decision-making critical amino acids: role in designing peptide
... Apart from the cytokines, other factors may also selectively control the development of Th1 and Th2 cells. It has been reported that p–MHC interactions also specifically influence the differentiation of naı̈ve CD4 T cell to either Th1 or Th2 cells (Kumar et al. 1995). Nevertheless, there is a strong ...
... Apart from the cytokines, other factors may also selectively control the development of Th1 and Th2 cells. It has been reported that p–MHC interactions also specifically influence the differentiation of naı̈ve CD4 T cell to either Th1 or Th2 cells (Kumar et al. 1995). Nevertheless, there is a strong ...
Immune Epitope Database assays
... Homo sapiens Source Species Scarification Epitope ELISPOT Cytokine Release-IFN-g HLA-A*0201 ...
... Homo sapiens Source Species Scarification Epitope ELISPOT Cytokine Release-IFN-g HLA-A*0201 ...
Human Monoclonal Antibody Reactivity With
... cells that secrete specific antibody. Developing B cells acquire a vast repertoire of immunoglobulin receptors with different antigenic specificities including those for self-epitopes on normal tissue proteins. The latter are considered predominant selective forces for the primary repertoire (13, 14 ...
... cells that secrete specific antibody. Developing B cells acquire a vast repertoire of immunoglobulin receptors with different antigenic specificities including those for self-epitopes on normal tissue proteins. The latter are considered predominant selective forces for the primary repertoire (13, 14 ...
Immune selection in neoplasia: towards a microevolutionary model
... immune response has evolved to be activated by recognition of pathogen-associated molecular patterns (PAMPs) within an inflammatory context (Janeway et al, 1996). It is difficult to envisage how an adaptive anti-tumour immune response would be initiated. The majority of human tumours do not express ...
... immune response has evolved to be activated by recognition of pathogen-associated molecular patterns (PAMPs) within an inflammatory context (Janeway et al, 1996). It is difficult to envisage how an adaptive anti-tumour immune response would be initiated. The majority of human tumours do not express ...
the_large_1 - Salk Institute
... One example of such an infectious agent is the vertically transmitted mouse mammary tumor virus which uses this time-window in mice to be treated as an NTBR-antigen. ...
... One example of such an infectious agent is the vertically transmitted mouse mammary tumor virus which uses this time-window in mice to be treated as an NTBR-antigen. ...
Chapter 16
... can depend sharply on initial conditions. There is also a higher level, non-linear selection process of the HIV species present within populations of people (as opposed to selection within individuals). Both HIV and the centre-pole change with time in each individual during these selection processes ...
... can depend sharply on initial conditions. There is also a higher level, non-linear selection process of the HIV species present within populations of people (as opposed to selection within individuals). Both HIV and the centre-pole change with time in each individual during these selection processes ...
Chapter 16
... can depend sharply on initial conditions. There is also a higher level, non-linear selection process of the HIV species present within populations of people (as opposed to selection within individuals). Both HIV and the centre-pole change with time in each individual during these selection processes ...
... can depend sharply on initial conditions. There is also a higher level, non-linear selection process of the HIV species present within populations of people (as opposed to selection within individuals). Both HIV and the centre-pole change with time in each individual during these selection processes ...
Organ-specific Autoimmune Disease: A Deficiency of
... The inheritance of susceptibility to organ-specific autoimmunity is extraordinarily complex. Particular haplotypes of the major histocompatibility complex, such as HLA-DR3-DQB1*0201, are strongly associated with human susceptibility to multiple organ-specific autoimmune disorders (3). HLA-type never ...
... The inheritance of susceptibility to organ-specific autoimmunity is extraordinarily complex. Particular haplotypes of the major histocompatibility complex, such as HLA-DR3-DQB1*0201, are strongly associated with human susceptibility to multiple organ-specific autoimmune disorders (3). HLA-type never ...
Understanding Immunity by Tracing Thymocyte Development
... AAI Curriculum Unit: Understanding Immunity By Tracing T-cell Development Appendix I: 50 Sets of 400 Randomly Generated Tri-Peptides 1. mdn yqf ntg hyy nhm ctq nff ege svs cef smi vhn syy tsq tps ink tlq tng nlv kgl aqc nqq rqy gsa ccw fsg grg lww vgs qll fmv tyy wdg iss slk ppr tgs eds yck tpw k ...
... AAI Curriculum Unit: Understanding Immunity By Tracing T-cell Development Appendix I: 50 Sets of 400 Randomly Generated Tri-Peptides 1. mdn yqf ntg hyy nhm ctq nff ege svs cef smi vhn syy tsq tps ink tlq tng nlv kgl aqc nqq rqy gsa ccw fsg grg lww vgs qll fmv tyy wdg iss slk ppr tgs eds yck tpw k ...
Tail Class I Molecules through Their Cytoplasmic Surface Display of
... PstI/XhoI sites upstream of the internal ribosomal entry site (IRES) in the lentiviral expression vector pLV-IRES-GFP (29). All were engineered to contain an N-terminal FLAG-tag. The EBV BILF1wt sequence was subcloned from pcDNA5-FLAG-BILF1, and the EBV BILF1-K122A sequence was subcloned from pcDNA3 ...
... PstI/XhoI sites upstream of the internal ribosomal entry site (IRES) in the lentiviral expression vector pLV-IRES-GFP (29). All were engineered to contain an N-terminal FLAG-tag. The EBV BILF1wt sequence was subcloned from pcDNA5-FLAG-BILF1, and the EBV BILF1-K122A sequence was subcloned from pcDNA3 ...
on MHC & Leukemia Associations in Humans
... Despite the obvious effect modification by sex, and recessive nature of most MHC associations in childhood leukemia, old habits are maintained and most studies only compare all cases with all controls, and using only one genetic model. ...
... Despite the obvious effect modification by sex, and recessive nature of most MHC associations in childhood leukemia, old habits are maintained and most studies only compare all cases with all controls, and using only one genetic model. ...
Myosin Heavy Chain Expression in the Red
... Spatial and temporal variations in MHC expression do occur in fish, however. Fish genomes, like those of other vertebrates, encode multiple myosin genes (Schiaffino and Reggiani, ’96); for example, as many as 28 MHC genes are present in carp (Gerlach et al., ’90). Expression of individual myosin iso ...
... Spatial and temporal variations in MHC expression do occur in fish, however. Fish genomes, like those of other vertebrates, encode multiple myosin genes (Schiaffino and Reggiani, ’96); for example, as many as 28 MHC genes are present in carp (Gerlach et al., ’90). Expression of individual myosin iso ...
Antigen-Antibody Interaction
... The generalization of an antibodies specificity is referred to as cross-reactivity. It is the capability of an antibody to react with other antigens. There are two primary examples of cross-reactivity: 1) Other antigens possess the same antigenic determinant, thus antibodies raised for the determina ...
... The generalization of an antibodies specificity is referred to as cross-reactivity. It is the capability of an antibody to react with other antigens. There are two primary examples of cross-reactivity: 1) Other antigens possess the same antigenic determinant, thus antibodies raised for the determina ...
Immune Profiling by High Throughput Sequencing of B and T Cell
... Killer T cells, marked by the surface expression of CD8, recognize short peptides (~8-10 amino acids) presented on the surface of cells by human leukocyte antigen (HLA) Class I molecules(1). Helper T cells, marked by the surface expression of CD4, recognize longer peptides (~12-16 nucleotides) prese ...
... Killer T cells, marked by the surface expression of CD8, recognize short peptides (~8-10 amino acids) presented on the surface of cells by human leukocyte antigen (HLA) Class I molecules(1). Helper T cells, marked by the surface expression of CD4, recognize longer peptides (~12-16 nucleotides) prese ...
Table 1. Strategies and mechanisms of survival of Leishmania
... Induction of cytokines inhibiting/deactivating APC (e.g. IL-10, TGF-) Suppression or lack of induction of activating cytokines (e.g. IL-12, IL-17) ...
... Induction of cytokines inhibiting/deactivating APC (e.g. IL-10, TGF-) Suppression or lack of induction of activating cytokines (e.g. IL-12, IL-17) ...
chapter 2 antigen/antibody interactions
... we inject this material into a mouse (line 3), we see that antibodies to BSA are elicited (as we would expect), but also find antibodies which will bind specifically to the DNP groups on BSA; we can further demonstrate that these anti-DNP antibodies will also bind free DNP (or DNP coupled to any oth ...
... we inject this material into a mouse (line 3), we see that antibodies to BSA are elicited (as we would expect), but also find antibodies which will bind specifically to the DNP groups on BSA; we can further demonstrate that these anti-DNP antibodies will also bind free DNP (or DNP coupled to any oth ...
In Silico method for identification of MHC class I
... searches with exon3 and exon4 of human MR1 in the same mammalian genomes as we used for the CD1 searches. For sloth, rabbit, and dolphin no MR1 BLAST hits were found. However, we noted that the sloth and dolphin genomes are among the genomes with the smallest N50 value, which is an indicator of ho ...
... searches with exon3 and exon4 of human MR1 in the same mammalian genomes as we used for the CD1 searches. For sloth, rabbit, and dolphin no MR1 BLAST hits were found. However, we noted that the sloth and dolphin genomes are among the genomes with the smallest N50 value, which is an indicator of ho ...
Immunology 5: B lymphocytes
... TCRs can only recognise processed antigen (peptide) which is bound to major histocompatibility complex (MHC) proteins on the cell surface ...
... TCRs can only recognise processed antigen (peptide) which is bound to major histocompatibility complex (MHC) proteins on the cell surface ...
Molecular Studies of T Cell Recognition and Cross
... Intracellular pathogens are recognized by a specialized subset of lymphocytes known as CD8+ T cells. Pathogen recognition by CD8+ T cells occurs through binding of T cell receptors (TCR) to processed antigens in complex with major histocompatibility complex (MHC) class I proteins. TCR engagement of ...
... Intracellular pathogens are recognized by a specialized subset of lymphocytes known as CD8+ T cells. Pathogen recognition by CD8+ T cells occurs through binding of T cell receptors (TCR) to processed antigens in complex with major histocompatibility complex (MHC) class I proteins. TCR engagement of ...
WRL2903.tmp
... Anti-foreign and anti-anti-self in allo-antisera Lymphocytes can be used as experimental antigens. Immunizations with foreign lymphocytes have played a central role in the development of immunogenetics. MHC molecules are important antigens on lymphocyte surfaces. When a mouse is immunized with lymph ...
... Anti-foreign and anti-anti-self in allo-antisera Lymphocytes can be used as experimental antigens. Immunizations with foreign lymphocytes have played a central role in the development of immunogenetics. MHC molecules are important antigens on lymphocyte surfaces. When a mouse is immunized with lymph ...
Immunity
... a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and "antigen presentation". • The MHC molecules control the immune response through recognition of "self" and "nonself" and, consequently, serve as targets in transplantation rejection. ...
... a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and "antigen presentation". • The MHC molecules control the immune response through recognition of "self" and "nonself" and, consequently, serve as targets in transplantation rejection. ...
Major histocompatibility complex
The major histocompatibility complex (MHC) is a set of cell surface molecules encoded by a large gene family which controls a major part of the immune system in all vertebrates. The major function of major histocompatibility complexes is to bind to peptide fragments derived from pathogens and display them on the cell surface for recognition by the appropriate T-cells. MHC molecules mediate interactions of leukocytes, also called white blood cells (WBCs), which are immune cells, with other leukocytes or with body cells. The MHC determines compatibility of donors for organ transplant, as well as one's susceptibility to an autoimmune disease via crossreacting immunization. In humans, the MHC is also called the human leukocyte antigen (HLA).In a cell, protein molecules of the host's own phenotype or of other biologic entities are continually synthesized and degraded. Each MHC molecule on the cell surface displays a molecular fraction of a protein, called epitope. The presented antigen can be either 'self' or 'nonself', thus preventing an organism`s immune system targeting its own cells. In its entirety, the MHC population is like a meter indicating the balance of proteins within the cell.The MHC gene family is divided into three subgroups: class I, class II, and class III. Class I MHC molecules have β2 subunits so can only be recognised by CD8 co-receptors. Class II MHC molecules have no β2 subunits so can be recognised by CD4 co-receptors. In this way MHC molecules chaperones which type of lymphocytes may bind to the given antigen with high affinity, since different lymphocytes express different TCR co-receptors. Diversity of antigen presentation, mediated by MHC classes I and II, is attained in at least three ways: (1) an organism's MHC repertoire is polygenic (via multiple, interacting genes); (2) MHC expression is codominant (from both sets of inherited alleles); (3) MHC gene variants are highly polymorphic (diversely varying from organism to organism within a species). Major histocompatibility complex and sexual selection has been observed in male mice making mate choices of females with different MHCs and thus demonstrating sexual selection.