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CTL - Molecular Immunology
... uptake, degradation, complex formation and presentation • Exogenous antigen processing uses invariant chain and HLA-DM • Endogenous antigen processing uses proteasomes and peptide transporters in antigen processing • Pathogens can evade immunity by disrupting antigen processing ...
... uptake, degradation, complex formation and presentation • Exogenous antigen processing uses invariant chain and HLA-DM • Endogenous antigen processing uses proteasomes and peptide transporters in antigen processing • Pathogens can evade immunity by disrupting antigen processing ...
Immunology 03 MED
... The final credit is conducted in a written form - one-choice test. All lessons have to be completed before the final credit. ...
... The final credit is conducted in a written form - one-choice test. All lessons have to be completed before the final credit. ...
Peptide trafficking and translocation across membranes in
... Assembly and disassembly of the peptide-loading complex at the ER membrane. De novo synthesized MHC I heavy chain (hc) initially assembles with the chaperones and ER-resident lectin calnexin. After association with b2m, calnexin is replaced by its soluble counterpart calreticulin. This MHC I subcomp ...
... Assembly and disassembly of the peptide-loading complex at the ER membrane. De novo synthesized MHC I heavy chain (hc) initially assembles with the chaperones and ER-resident lectin calnexin. After association with b2m, calnexin is replaced by its soluble counterpart calreticulin. This MHC I subcomp ...
1.0MB
... innate immune system to produce signals required for an adaptive immune response Adjuvants potentiate T cell immunity by: 1. Enhancing expansion of antigen specific T cells 2. Altering antigen presentation (upregulation of costimulation). 3. Influencing differentiation of T cell subsets. ...
... innate immune system to produce signals required for an adaptive immune response Adjuvants potentiate T cell immunity by: 1. Enhancing expansion of antigen specific T cells 2. Altering antigen presentation (upregulation of costimulation). 3. Influencing differentiation of T cell subsets. ...
Chapter 43 Presentation
... activated by antigens, they are stimulated to divide many times. 2 clones of daughter cells are created. 1 is short lived, antibody secreting cell. The other is a memory cell that is long lived and bears receptors for the same antigen. travismulthaupt.com ...
... activated by antigens, they are stimulated to divide many times. 2 clones of daughter cells are created. 1 is short lived, antibody secreting cell. The other is a memory cell that is long lived and bears receptors for the same antigen. travismulthaupt.com ...
01-Introduction to Immunology 1st lecture
... that exist prior to exposure to Ag. • Epitope (antigenic determinant): the portion of of Ag that is recognized and bound by an Ab or T cell receptor. • Pathogen: a disease causing organism ...
... that exist prior to exposure to Ag. • Epitope (antigenic determinant): the portion of of Ag that is recognized and bound by an Ab or T cell receptor. • Pathogen: a disease causing organism ...
MHC I molecule(!) - immunology.unideb.hu
... HLA-A, -B, -C, HLA-E, TAPs, B2M, proteasome subunits, … • CIITA enhanceosomes bind to the promoter regions of the MHC II presentation pathway’s genes: HLA-DR, -DP, -DQ, -DM, -DO, Invariant chain (Ii) and could influence the MHC I genes also in some professional APC-s. ...
... HLA-A, -B, -C, HLA-E, TAPs, B2M, proteasome subunits, … • CIITA enhanceosomes bind to the promoter regions of the MHC II presentation pathway’s genes: HLA-DR, -DP, -DQ, -DM, -DO, Invariant chain (Ii) and could influence the MHC I genes also in some professional APC-s. ...
Chapter 15 Adaptive, Specific Immunity and Immunization
... prevents injury to the host during responses to foreign antigens to self The two features that best distinguish adaptive and innate immunity are specificity and ...
... prevents injury to the host during responses to foreign antigens to self The two features that best distinguish adaptive and innate immunity are specificity and ...
IMMUNOSUPPRESSANTS.
... considerably higher risks of infection and cancer. •Immunosupressive drugs have one meaning: drugs that lowers body’s normal immune response. ...
... considerably higher risks of infection and cancer. •Immunosupressive drugs have one meaning: drugs that lowers body’s normal immune response. ...
RESPON IMUN TERHADAP INFEKSI
... Each produces a different receptor in the cell membrane Each receptor is composed of 1 molecule each of two different proteins Each receptor binds a specific antigen but has only one binding site Receptor only recognizes antigens which are "presented" to it within another membrane protein of the MHC ...
... Each produces a different receptor in the cell membrane Each receptor is composed of 1 molecule each of two different proteins Each receptor binds a specific antigen but has only one binding site Receptor only recognizes antigens which are "presented" to it within another membrane protein of the MHC ...
Lecture PPT - Carol Lee Lab
... (degradation products from within the cell) to T cells. The receptor of T cells can only recognize antigen fragments that are complexed with MHC proteins. ...
... (degradation products from within the cell) to T cells. The receptor of T cells can only recognize antigen fragments that are complexed with MHC proteins. ...
10_21_tcelld~1
... accompany the thymic differentiation of T cells: – entering thymocytes are TCR, CD3, CD4, and CD8-negative – as thymocytes mature, and undergo rearrangement of their TCR genes to generate a functional TCR, they begin to express CD3, CD4, and CD8 – mature T cells ready to go to the periphery are TCR/ ...
... accompany the thymic differentiation of T cells: – entering thymocytes are TCR, CD3, CD4, and CD8-negative – as thymocytes mature, and undergo rearrangement of their TCR genes to generate a functional TCR, they begin to express CD3, CD4, and CD8 – mature T cells ready to go to the periphery are TCR/ ...
Immunity Textbook
... endocytosis. Dendritic cells contain receptors that recognize non-self antigens that trigger endocytosis when activated. Reticular Cells Reticular cells (sometimes called fibroblastic reticular cells) are antigen presenting cells located in lymphatic organs. These cells are known to help regulate T- ...
... endocytosis. Dendritic cells contain receptors that recognize non-self antigens that trigger endocytosis when activated. Reticular Cells Reticular cells (sometimes called fibroblastic reticular cells) are antigen presenting cells located in lymphatic organs. These cells are known to help regulate T- ...
T cells - immunology.unideb.hu
... One single T-cell receptor can recognize a given MHC – peptide complex The TCR-specific peptide is recognized only when its presented with an MHC on which the TCR had been selected during its development in the thymus If the peptide binds to another MHC molecule no T-cell recognition occurs (by this ...
... One single T-cell receptor can recognize a given MHC – peptide complex The TCR-specific peptide is recognized only when its presented with an MHC on which the TCR had been selected during its development in the thymus If the peptide binds to another MHC molecule no T-cell recognition occurs (by this ...
gd T cells
... phospholipid Ag, 3-formyl-1-butyl pyrophosphate, found on M. tuberculosis and other bacteria and parasites (similat to pattern recognition receptor?) - This specificity for frequently encountered pathogens led to speculation that gd cells may function as an arm of the innate immune response, allowin ...
... phospholipid Ag, 3-formyl-1-butyl pyrophosphate, found on M. tuberculosis and other bacteria and parasites (similat to pattern recognition receptor?) - This specificity for frequently encountered pathogens led to speculation that gd cells may function as an arm of the innate immune response, allowin ...
Lecture 15 – Effector Functions of Humoral Immunity:
... D and J are joined first. Then V. The variable region is then spliced to the constant region (which is also variable—determines which Ig in B cells. Not as important in T cells). If for any reason rearrangement is unable to generate a functional BcR or TcR, the cell dies. (see previous bullet). Once ...
... D and J are joined first. Then V. The variable region is then spliced to the constant region (which is also variable—determines which Ig in B cells. Not as important in T cells). If for any reason rearrangement is unable to generate a functional BcR or TcR, the cell dies. (see previous bullet). Once ...
Chapter 3. Antigens
... Fcγ receptors enhance phagocytosis of foreign cells/particles coated with IgG Antibody made in response to foreign cells (cells/viral particles/bacteria etc) will bind to those cells. Macrophages (and neutrophils) possess receptors for the Fc region of IgG. Binding of macrophage Fc receptors to anti ...
... Fcγ receptors enhance phagocytosis of foreign cells/particles coated with IgG Antibody made in response to foreign cells (cells/viral particles/bacteria etc) will bind to those cells. Macrophages (and neutrophils) possess receptors for the Fc region of IgG. Binding of macrophage Fc receptors to anti ...
Uchanska-Ziegler, B., Loll, B., Fabian, H., Hee, CS, Saenger, W
... may contribute to the susceptibility, as in Rheumatoid Arthritis or Multiple Sclerosis (MS) (Anaya, 2010). Some diseases with a suspected autoimmune etiology, however, are clearly associated with HLA class I, and not with class II loci. The first one for which such an association was discovered, and ...
... may contribute to the susceptibility, as in Rheumatoid Arthritis or Multiple Sclerosis (MS) (Anaya, 2010). Some diseases with a suspected autoimmune etiology, however, are clearly associated with HLA class I, and not with class II loci. The first one for which such an association was discovered, and ...
Read More - Division of Rheumatology
... is expressed on B cells and monocytes and early myeloid forms, but not resting T cells. His studies on the expression of HLA-Dr during early hematopoetic differentiation are classic examples of the acquisition and loss of differentiation antigens with developmental stage. Several aspects of the expr ...
... is expressed on B cells and monocytes and early myeloid forms, but not resting T cells. His studies on the expression of HLA-Dr during early hematopoetic differentiation are classic examples of the acquisition and loss of differentiation antigens with developmental stage. Several aspects of the expr ...
Cells
... 1. What kinds of factors determine the specificity of immune response? 2. How could lymphocytes be activated? 3. Describe the biological effects of humoral and cellular immune response. 4. Try to explain the relationship between the innate immunity and adaptive immunity. ...
... 1. What kinds of factors determine the specificity of immune response? 2. How could lymphocytes be activated? 3. Describe the biological effects of humoral and cellular immune response. 4. Try to explain the relationship between the innate immunity and adaptive immunity. ...
basicprinciplesofimmunesystem
... Subpopulation of T cells : Helper T cells (TH) & Cytotoxic T cells (TC) discriminated based on their protein marker on the cell surface CD4 marker for TH CD8 marker for TC After contact with antigen TH cells develop into effector capable of cytokine (lymphokine) secretion activate B cells, TC ...
... Subpopulation of T cells : Helper T cells (TH) & Cytotoxic T cells (TC) discriminated based on their protein marker on the cell surface CD4 marker for TH CD8 marker for TC After contact with antigen TH cells develop into effector capable of cytokine (lymphokine) secretion activate B cells, TC ...
Chapter 12 - UBC Physics
... The T cell repertoire is the set of all the V regions expressed by T cells, together with the frequency of each of the V regions. T cell V regions are enormously diverse, but the repertoire is not random; not all protein antigens are recognized by T cells with equal frequency. T cell receptors prefe ...
... The T cell repertoire is the set of all the V regions expressed by T cells, together with the frequency of each of the V regions. T cell V regions are enormously diverse, but the repertoire is not random; not all protein antigens are recognized by T cells with equal frequency. T cell receptors prefe ...
021709.M1-Immuno.TransplantationSelfStudy
... • Syngeneic grafts (where the donor and recipient are genetically identical) will not be rejected • If donor/recipient HLA antigens are not identical, T cells will react against foreign HLA molecules • HLA matching reduces the chance of acute rejection – HLA-identical siblings are optimal – Post-tra ...
... • Syngeneic grafts (where the donor and recipient are genetically identical) will not be rejected • If donor/recipient HLA antigens are not identical, T cells will react against foreign HLA molecules • HLA matching reduces the chance of acute rejection – HLA-identical siblings are optimal – Post-tra ...
CD4+ Cell
... 14 residues are included for the MBP peptide (P-3 Asn to P11 Arg). P1 Val and P4 Phe occupy the hydrophobic P1 and P4 pockets, respectively, and serve as primary anchor residues of the MBP peptide. (C) View of the large P4 pocket of HLA-DR2 occupied by P4 Phe of the MBP peptide. Gln 70 is positioned ...
... 14 residues are included for the MBP peptide (P-3 Asn to P11 Arg). P1 Val and P4 Phe occupy the hydrophobic P1 and P4 pockets, respectively, and serve as primary anchor residues of the MBP peptide. (C) View of the large P4 pocket of HLA-DR2 occupied by P4 Phe of the MBP peptide. Gln 70 is positioned ...
Major histocompatibility complex
The major histocompatibility complex (MHC) is a set of cell surface molecules encoded by a large gene family which controls a major part of the immune system in all vertebrates. The major function of major histocompatibility complexes is to bind to peptide fragments derived from pathogens and display them on the cell surface for recognition by the appropriate T-cells. MHC molecules mediate interactions of leukocytes, also called white blood cells (WBCs), which are immune cells, with other leukocytes or with body cells. The MHC determines compatibility of donors for organ transplant, as well as one's susceptibility to an autoimmune disease via crossreacting immunization. In humans, the MHC is also called the human leukocyte antigen (HLA).In a cell, protein molecules of the host's own phenotype or of other biologic entities are continually synthesized and degraded. Each MHC molecule on the cell surface displays a molecular fraction of a protein, called epitope. The presented antigen can be either 'self' or 'nonself', thus preventing an organism`s immune system targeting its own cells. In its entirety, the MHC population is like a meter indicating the balance of proteins within the cell.The MHC gene family is divided into three subgroups: class I, class II, and class III. Class I MHC molecules have β2 subunits so can only be recognised by CD8 co-receptors. Class II MHC molecules have no β2 subunits so can be recognised by CD4 co-receptors. In this way MHC molecules chaperones which type of lymphocytes may bind to the given antigen with high affinity, since different lymphocytes express different TCR co-receptors. Diversity of antigen presentation, mediated by MHC classes I and II, is attained in at least three ways: (1) an organism's MHC repertoire is polygenic (via multiple, interacting genes); (2) MHC expression is codominant (from both sets of inherited alleles); (3) MHC gene variants are highly polymorphic (diversely varying from organism to organism within a species). Major histocompatibility complex and sexual selection has been observed in male mice making mate choices of females with different MHCs and thus demonstrating sexual selection.