Using natural variation to unravel the dynamic regulation of plant
... velop molecular markers was published (Botstein 1980). Molecular markers enabled us to genetically characterise individuals and to distinguish them from each other based on differences between their DNA sequences (Semagn 2006). In 2000 the first plant genome was sequenced of the model species Arabid ...
... velop molecular markers was published (Botstein 1980). Molecular markers enabled us to genetically characterise individuals and to distinguish them from each other based on differences between their DNA sequences (Semagn 2006). In 2000 the first plant genome was sequenced of the model species Arabid ...
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... hypoactivity for a variety of stimuli, including one’s own and others’ faces, as well as non-face objects. This suggests a model of distorted visual processing in which details are not contextualized or integrated into a whole percept. This may be associated with patients’ propensity to focus on det ...
... hypoactivity for a variety of stimuli, including one’s own and others’ faces, as well as non-face objects. This suggests a model of distorted visual processing in which details are not contextualized or integrated into a whole percept. This may be associated with patients’ propensity to focus on det ...
Acute and chronic effects of cannabinoids on human brain: gene-environment interactions
... Acute and chronic effects of cannabinoids on human brain: gene-environment interactions related to psychiatric disorders Albert Batalla Cases ...
... Acute and chronic effects of cannabinoids on human brain: gene-environment interactions related to psychiatric disorders Albert Batalla Cases ...
Thalamocortical neuron loss and localized astrocytosis in the Cln3
... More recently, Cln3 knock-in mice (Cln3 Dex7/8 ) have been generated which accurately reproduce the 1.02-kb deletion in the Cln3 gene that is seen in over 85% of JNCL alleles (International Batten Disease Consortium, 1995), and also exhibit an NCL-like phenotype (Cotman et al., 2002). This phenotype ...
... More recently, Cln3 knock-in mice (Cln3 Dex7/8 ) have been generated which accurately reproduce the 1.02-kb deletion in the Cln3 gene that is seen in over 85% of JNCL alleles (International Batten Disease Consortium, 1995), and also exhibit an NCL-like phenotype (Cotman et al., 2002). This phenotype ...
- TestbankU
... 37. The strength of the brain’s response to a weak or strong stimulus is a result of _____ a) how many and how fast neurons fire. b) the all or none rule. c) how many millivolts the neuron has. d) whether action potential occurs. Answer: a The all or none rule states that neurons either fire or don ...
... 37. The strength of the brain’s response to a weak or strong stimulus is a result of _____ a) how many and how fast neurons fire. b) the all or none rule. c) how many millivolts the neuron has. d) whether action potential occurs. Answer: a The all or none rule states that neurons either fire or don ...
PDF - Journal of Neuroscience
... Correspondence should be addressed to Dr. E. Masliah, Department of Neurosciences, University of California, 9500 Gilman Drive, La Jolla, CA 92093-0624. E-mail: [email protected]. ...
... Correspondence should be addressed to Dr. E. Masliah, Department of Neurosciences, University of California, 9500 Gilman Drive, La Jolla, CA 92093-0624. E-mail: [email protected]. ...
1 CURRICULUM VITAE Xiong MM, Ph.D. Office Address
... 37. Ma J, Xiong M, You M, Lozano G, Amos CI. (2014). Genome-wide association tests of inversions with application to psoriasis. Hum Genet. 133(8):967-74. PMC4281304 38. Guo S, Wang YL, Li Y, Jin L, Xiong M, Ji QH, Wang J. (2014). Significant SNPs have limited prediction ability for thyroid cancer. C ...
... 37. Ma J, Xiong M, You M, Lozano G, Amos CI. (2014). Genome-wide association tests of inversions with application to psoriasis. Hum Genet. 133(8):967-74. PMC4281304 38. Guo S, Wang YL, Li Y, Jin L, Xiong M, Ji QH, Wang J. (2014). Significant SNPs have limited prediction ability for thyroid cancer. C ...
the role of zinc in the pathogenesis and treatment of central nervous
... This metal is a component of many structural as well as regulatory and catalytic proteins. The precise regulation of zinc homeostasis is essential for central nervous system and for the whole organism. Zinc plays a significant role in the brain development and in the proper brain function at every s ...
... This metal is a component of many structural as well as regulatory and catalytic proteins. The precise regulation of zinc homeostasis is essential for central nervous system and for the whole organism. Zinc plays a significant role in the brain development and in the proper brain function at every s ...
The role of repulsive guidance molecules in the
... During the development of the nervous system, outgrowing axons often have to travel long distances to reach their target neurons. In this process, outgrowing neurites tipped with motile growth cones rely on guidance cues present in their local environment. These cues are detected by specific recepto ...
... During the development of the nervous system, outgrowing axons often have to travel long distances to reach their target neurons. In this process, outgrowing neurites tipped with motile growth cones rely on guidance cues present in their local environment. These cues are detected by specific recepto ...
HCN channels are a novel therapeutic target for cognitive
... syndrome.7 This suggests that NF1 might also have a Rasindependent function in neurons. Ras-independent targets hold substantial therapeutic potential, as Ras itself is difficult to target, and drugs that interfere with downstream Ras signaling have poor tissue specificity and undesirable side effects ...
... syndrome.7 This suggests that NF1 might also have a Rasindependent function in neurons. Ras-independent targets hold substantial therapeutic potential, as Ras itself is difficult to target, and drugs that interfere with downstream Ras signaling have poor tissue specificity and undesirable side effects ...
Peptides that regulate food intake: orexin gene expression is increased during states of hypertriglyceridemia
... late-onset obesity, indicating that the orexins may have additional effects beyond the stimulation of food intake. Indeed, other studies indicate that orexin peptides can increase metabolic rate and sympathetic nervous system (SNS) activity (3, 19, 49, 51) and have variable effects on lipid utilizat ...
... late-onset obesity, indicating that the orexins may have additional effects beyond the stimulation of food intake. Indeed, other studies indicate that orexin peptides can increase metabolic rate and sympathetic nervous system (SNS) activity (3, 19, 49, 51) and have variable effects on lipid utilizat ...
... occurs in 8 to 12% of school age children worldwide; the majority (60%-85%) continues to meet criteria for the disorder during their teenage years. Volumetric studies in children with Attention-Deficit/Hyperactivity Disorder (ADHD) have consistently found global reductions of total brain volume with ...
Are there three subdivisions in the primate subthalamic nucleus? Max C. Keuken
... ordered by the number of subdivisions reported and the localization of the subdivisions within the STN. The subdivisions are represented on three schematic slices of the STN in rostrocaudal direction. This was done because individual studies could not be registered in one common anatomical space. No ...
... ordered by the number of subdivisions reported and the localization of the subdivisions within the STN. The subdivisions are represented on three schematic slices of the STN in rostrocaudal direction. This was done because individual studies could not be registered in one common anatomical space. No ...
Neurofilaments and Orthograde Transport Are Reduced in Ventral
... 1988; Johnson et al., 1990; Strong, 1994), NF inclusions typically form in the perikarya and processes of neurons, and these inclusions contain highly phosphorylated NFH and NFM (Tu et al., 1997a,b). The major functions of NFs are to provide mechanical support, especially in large myelinated axons, ...
... 1988; Johnson et al., 1990; Strong, 1994), NF inclusions typically form in the perikarya and processes of neurons, and these inclusions contain highly phosphorylated NFH and NFM (Tu et al., 1997a,b). The major functions of NFs are to provide mechanical support, especially in large myelinated axons, ...
CloudMap: A Cloud-Based Pipeline for Analysis of Mutant
... genome sequences. Available on the Galaxy web platform, CloudMap requires no software installation when run on the cloud, but it can also be run locally or via Amazon’s Elastic Compute Cloud (EC2) service. CloudMap uses a series of predefined workflows to pinpoint sequence variations in animal genomes ...
... genome sequences. Available on the Galaxy web platform, CloudMap requires no software installation when run on the cloud, but it can also be run locally or via Amazon’s Elastic Compute Cloud (EC2) service. CloudMap uses a series of predefined workflows to pinpoint sequence variations in animal genomes ...
Genetic and Functional Modularity of Hox Activities in the
... be further modulated through the actions of ancillary transcription factors that typically bind in proximity to Hox targets [24,25]. In this mode of action, a Hox protein may not depend as much on DNA site selection for specificity, but rather on how it interacts with factors it engages at a target ...
... be further modulated through the actions of ancillary transcription factors that typically bind in proximity to Hox targets [24,25]. In this mode of action, a Hox protein may not depend as much on DNA site selection for specificity, but rather on how it interacts with factors it engages at a target ...
Versican Expression During Embryonic Development in the Mouse
... [40]. Severe developmental abnormalities have not been noted in either Adamts-1 or Adamts-5 knockout mice, although Adamts-1-/-mice are smaller than wild type mice with reduced fertility and renal changes and a mild increase in cardiac valve size in late embryonic development in Adamts-5-/- mice has ...
... [40]. Severe developmental abnormalities have not been noted in either Adamts-1 or Adamts-5 knockout mice, although Adamts-1-/-mice are smaller than wild type mice with reduced fertility and renal changes and a mild increase in cardiac valve size in late embryonic development in Adamts-5-/- mice has ...
Subregions of the human superior frontal gyrus and their connections
... critical nodes of the cognitive control network and the default mode network (DMN). The SFGdl was connected with the middle and inferior frontal gyri, which are involved in the cognitive execution network. The SFGp was connected with the precentral gyrus, caudate, thalamus, and frontal operculum, wh ...
... critical nodes of the cognitive control network and the default mode network (DMN). The SFGdl was connected with the middle and inferior frontal gyri, which are involved in the cognitive execution network. The SFGp was connected with the precentral gyrus, caudate, thalamus, and frontal operculum, wh ...
A review of MRI findings in schizophrenia
... setting the stage for the development of the symptoms of schizophrenia. Or there may be additional factors, such as stress or neurotoxicity, that occur during adolescence or early adulthood and are necessary for the development of schizophrenia, and may be associated with neurodegenerative changes. ...
... setting the stage for the development of the symptoms of schizophrenia. Or there may be additional factors, such as stress or neurotoxicity, that occur during adolescence or early adulthood and are necessary for the development of schizophrenia, and may be associated with neurodegenerative changes. ...
Dopaminergic and Glutamatergic Dysfunctions
... hypodopaminergia that may cause striatal hyperdopaminergia. Together, these observations led to the hypothesis that a deficit in dopamine transmission at D1 receptors in the prefrontal cortex might be implicated in the cognitive impairments and negative symptoms of schizophrenia [7, 29], whereas the ...
... hypodopaminergia that may cause striatal hyperdopaminergia. Together, these observations led to the hypothesis that a deficit in dopamine transmission at D1 receptors in the prefrontal cortex might be implicated in the cognitive impairments and negative symptoms of schizophrenia [7, 29], whereas the ...
Natural variation in Arabidopsis thaliana: from
... Simon Chan. This method allows the facile production of doubled haploid plants from recombinant F2 populations (Ravi and Chan, 2010). Even after five or six generations of inbreeding, which is customary for RILs, a few percent of the genome remains heterozygous. This turns out to have its own benef ...
... Simon Chan. This method allows the facile production of doubled haploid plants from recombinant F2 populations (Ravi and Chan, 2010). Even after five or six generations of inbreeding, which is customary for RILs, a few percent of the genome remains heterozygous. This turns out to have its own benef ...
Fear conditioning, synaptic plasticity and the amygdala
... BDNF–TrkB signaling has been shown to be necessary for various aspects of fear conditioning and extinction in all three of the regions implicated in PTSD: the amygdala, the hippocampus and the PFC [61–73]. In the amygdala, BDNF transcription is increased during the consolidation period 2 hours after ...
... BDNF–TrkB signaling has been shown to be necessary for various aspects of fear conditioning and extinction in all three of the regions implicated in PTSD: the amygdala, the hippocampus and the PFC [61–73]. In the amygdala, BDNF transcription is increased during the consolidation period 2 hours after ...
Brassica napus DS-3, encoding a DELLA protein, negatively
... containing Brrga1-d were similar to wild-type hybrids (Muangprom et al. 2006). Dwarf mutant ndf-1 is also GA insensitive. The dwarf phenotype is controlled by a single semidominant gene which possibly encodes the GA receptor GID1 (Li et al. 2011b). bnaC.dwf is also a GAinsensitive mutant, but its dw ...
... containing Brrga1-d were similar to wild-type hybrids (Muangprom et al. 2006). Dwarf mutant ndf-1 is also GA insensitive. The dwarf phenotype is controlled by a single semidominant gene which possibly encodes the GA receptor GID1 (Li et al. 2011b). bnaC.dwf is also a GAinsensitive mutant, but its dw ...
Formation of a full complement of cranial proprioceptors requires
... Neurotrophins are a family of trophic factors essential for the survival and differentiation of neurons. This family includes nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3), and neurotrophin-4 (NT4). NT3 is essential for the development of proprioception in ...
... Neurotrophins are a family of trophic factors essential for the survival and differentiation of neurons. This family includes nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3), and neurotrophin-4 (NT4). NT3 is essential for the development of proprioception in ...
Behavioral consequences of abnormal cortical development
... long-lasting influences on the behavior of the animal. What happens when an injury interferes with the normal developmental program of the cerebral cortex? In humans, alterations in cortical morphology that result from abnormal cortical development are associated with developmental disabilities rang ...
... long-lasting influences on the behavior of the animal. What happens when an injury interferes with the normal developmental program of the cerebral cortex? In humans, alterations in cortical morphology that result from abnormal cortical development are associated with developmental disabilities rang ...