C. Isoproterenol
... therefore sometimes used prophylactically in chronic treatment of asthma to prevent attacks rather than to treat the acute attack (important). Ephedrine enhances contractility and improves motor function in myasthenia gravis(is a neuromuscular disease leading to irragular muscle weakness and fatigua ...
... therefore sometimes used prophylactically in chronic treatment of asthma to prevent attacks rather than to treat the acute attack (important). Ephedrine enhances contractility and improves motor function in myasthenia gravis(is a neuromuscular disease leading to irragular muscle weakness and fatigua ...
Autonomic Nervous System Anticholinergic Drugs
... so severe (both sympathetic and parasympathetic divisions are blocked), so that patients are unable to tolerate long term treatment with them. ...
... so severe (both sympathetic and parasympathetic divisions are blocked), so that patients are unable to tolerate long term treatment with them. ...
citeline Pharma r&d annual review 2015
... equivalent figure from January 2014. [Please note that the 2014 figure was incorrectly stated as 3,107 last year due to some subsidiaries being counted as companies]. This outstrips even the 8.7% expansion seen in the previous twelve months. Some of the extraordinary increase can be ascribed to our ...
... equivalent figure from January 2014. [Please note that the 2014 figure was incorrectly stated as 3,107 last year due to some subsidiaries being counted as companies]. This outstrips even the 8.7% expansion seen in the previous twelve months. Some of the extraordinary increase can be ascribed to our ...
ANTIPSYCHOTIC DRUGS & LITHIUM
... Reduce some of the positive symptoms Hyperactivity Bizarre behavior Hallucinations and delusions Facilitate functioning in both out and inpatient environments ...
... Reduce some of the positive symptoms Hyperactivity Bizarre behavior Hallucinations and delusions Facilitate functioning in both out and inpatient environments ...
LÉČIVA OVLIVŇUJÍCÍ CHOLINERGNÍ RECEPTORY
... low dose (less than 0.5 mg) (result of central vagal stimulation + block of presynaptic M-autoreceptor inhibitory effects); as the muscarinic (M2) receptors on the SA node are blocked by higher concentrations of atropine, tachycardia results - at therapeutic doses – atropine has only mild effect on ...
... low dose (less than 0.5 mg) (result of central vagal stimulation + block of presynaptic M-autoreceptor inhibitory effects); as the muscarinic (M2) receptors on the SA node are blocked by higher concentrations of atropine, tachycardia results - at therapeutic doses – atropine has only mild effect on ...
Epidemiology and Unmet Needs in Hypertension
... hypertension.1 The prevalence of hypertension is increasing in both men and women across the age span, but more rapidly in women. Indeed, the age-adjusted prevalence of hypertension is higher in women than in men, and is also higher in black people than in members of other racial groups. If elevated ...
... hypertension.1 The prevalence of hypertension is increasing in both men and women across the age span, but more rapidly in women. Indeed, the age-adjusted prevalence of hypertension is higher in women than in men, and is also higher in black people than in members of other racial groups. If elevated ...
Urinary Incontinence Drugs
... ADRs – same as others, but less severs. Less CNS effects b/c does not cross blood brain barrier (especially solifenacin). DDis – CYP450 substrate ...
... ADRs – same as others, but less severs. Less CNS effects b/c does not cross blood brain barrier (especially solifenacin). DDis – CYP450 substrate ...
Methamphetamine, “Bath Salts,” and other Amphetamine
... from AAD toxicity [77-82]. The butyrophenones haloperidol and droperidol, and second generation agents ziprasidone and olanzapine have all been successfully used in this setting. Benzodiazepines and antipsychotics may be used alone or in combination. In the only large scale randomized study to date ...
... from AAD toxicity [77-82]. The butyrophenones haloperidol and droperidol, and second generation agents ziprasidone and olanzapine have all been successfully used in this setting. Benzodiazepines and antipsychotics may be used alone or in combination. In the only large scale randomized study to date ...
Introduction to Medicinal Chemistry
... structural requirements for the drug. Thus, affinity represents kinetic constants that relate to the drug and the receptor. The drug elicits a pharmacological response after its interaction with the receptor. A given drug may act on more than one receptor differing both in function and in binding ch ...
... structural requirements for the drug. Thus, affinity represents kinetic constants that relate to the drug and the receptor. The drug elicits a pharmacological response after its interaction with the receptor. A given drug may act on more than one receptor differing both in function and in binding ch ...
Baclofen: Interaction with GABA Receptor Leading to CNS Depression
... ability to cause CNS depression. Baclofen acts on GABAB receptors both in the brain and spinal cord. This undesirable activation of GABAB receptors in the brain can cause clinically significant sedative effects.1 Currently, baclofen is being administered intrathecally to produce a localized effect i ...
... ability to cause CNS depression. Baclofen acts on GABAB receptors both in the brain and spinal cord. This undesirable activation of GABAB receptors in the brain can cause clinically significant sedative effects.1 Currently, baclofen is being administered intrathecally to produce a localized effect i ...
1 Evaluation of Dual-Activity Opioid
... understanding that tolerance and hyperalgesia caused by opioids can be greatly reduced. This discovery eventually led to the creation of dual ligands with both opioid agonist and NPFF antagonist activity. These dual ligands have been shown to prevent tolerance and opioid-induced hyperalgesia while m ...
... understanding that tolerance and hyperalgesia caused by opioids can be greatly reduced. This discovery eventually led to the creation of dual ligands with both opioid agonist and NPFF antagonist activity. These dual ligands have been shown to prevent tolerance and opioid-induced hyperalgesia while m ...
Twisting arms to angiotensin receptor blockers/antagonists: the turn
... for ARBs, prescription of this class of drugs has increased to very high levels. It is calculated that about 200 million individuals are treated with ARBs on our planet and that this class covers 25% prescription of antihypertensive agents. Even though this may be due to intensive marketing activit ...
... for ARBs, prescription of this class of drugs has increased to very high levels. It is calculated that about 200 million individuals are treated with ARBs on our planet and that this class covers 25% prescription of antihypertensive agents. Even though this may be due to intensive marketing activit ...
ACSM outline - Geriatric Assessment Tool Kit
... Weaker diuretic than the other 2 types, but does not deplete Potassium ↓ Afterload (arterial), ↓ Preload (venous) For: Dysrhythmia (not used as much as in the past) Sodium channel blockers: decreases cardiac membrane excitability For: Dysrhythmia Prolongs cardiac re-polarization, preventing too-rapi ...
... Weaker diuretic than the other 2 types, but does not deplete Potassium ↓ Afterload (arterial), ↓ Preload (venous) For: Dysrhythmia (not used as much as in the past) Sodium channel blockers: decreases cardiac membrane excitability For: Dysrhythmia Prolongs cardiac re-polarization, preventing too-rapi ...
DRUGS ACTING ON NMJ NMJ
... - But effect very short lived(∼ 5 minutes) - Effects wears off when suxamethonium degraded by, butyrylcholinesterase - in the liver pseudocholinesterase - in plasma - Cholinesterase Inhibitors can not reverse the paralysis but worsens it. ...
... - But effect very short lived(∼ 5 minutes) - Effects wears off when suxamethonium degraded by, butyrylcholinesterase - in the liver pseudocholinesterase - in plasma - Cholinesterase Inhibitors can not reverse the paralysis but worsens it. ...
Pharmacology Ch 10 132-142 Adrenergic Pharmacology
... -Studies agents that act on pathways mediated by endogenous catecholamines norepinephrine, epinephrine, and opamine -sympathetic nervous system is a major source of catecholamine production and release -effects include: increasing rate and force of cardiac contraction, modifying peripheral resistanc ...
... -Studies agents that act on pathways mediated by endogenous catecholamines norepinephrine, epinephrine, and opamine -sympathetic nervous system is a major source of catecholamine production and release -effects include: increasing rate and force of cardiac contraction, modifying peripheral resistanc ...
QuinTMP_Lowy
... are an increasingly important family of antibiotics because they can be administered orally and parenterally, they are active against a broad spectrum of bacteria including a number of common nosocomial pathogens, and they have limited toxicity. Chemical Structure: Quinolones have a bicyclic aromati ...
... are an increasingly important family of antibiotics because they can be administered orally and parenterally, they are active against a broad spectrum of bacteria including a number of common nosocomial pathogens, and they have limited toxicity. Chemical Structure: Quinolones have a bicyclic aromati ...
Physicochemical properties of drug action
... structural requirements for the drug. Thus, affinity represents kinetic constants that relate to the drug and the receptor. The drug elicits a pharmacological response after its interaction with the receptor. A given drug may act on more than one receptor differing both in function and in binding ch ...
... structural requirements for the drug. Thus, affinity represents kinetic constants that relate to the drug and the receptor. The drug elicits a pharmacological response after its interaction with the receptor. A given drug may act on more than one receptor differing both in function and in binding ch ...
lec.11-426
... Considerable variation is possible in the tertiary amino group with retention of neuroleptic activity. The basic nitrogen could be a part of a six membered ring, (piperidine, 1,2,3,6-tetrahydropyridyl, or piperazinyl). Replacement of the sixmembered basic heterocycle by larger or smaller or uncycliz ...
... Considerable variation is possible in the tertiary amino group with retention of neuroleptic activity. The basic nitrogen could be a part of a six membered ring, (piperidine, 1,2,3,6-tetrahydropyridyl, or piperazinyl). Replacement of the sixmembered basic heterocycle by larger or smaller or uncycliz ...
Anglická výuka
... costs to individuals, families, carers and society stopping medication is the most powerful predictor of relapse ...
... costs to individuals, families, carers and society stopping medication is the most powerful predictor of relapse ...
Pulmonary Hypertension
... fatigue present at rest; discomfort increased by any physical activity ...
... fatigue present at rest; discomfort increased by any physical activity ...
Respiratory Drug Agents
... state of wheezing and respiratory failure. Labs: CBC: leukocytosis, metabolic acidosis, hypoxemia, and airway obstruction. ...
... state of wheezing and respiratory failure. Labs: CBC: leukocytosis, metabolic acidosis, hypoxemia, and airway obstruction. ...
AEMT-Pharmacology-ver-2-4-2013
... 5. Hyperkalemia – with insulin may shift K+ back to the intracellular space ...
... 5. Hyperkalemia – with insulin may shift K+ back to the intracellular space ...
2 receptor
... JH, a 63-year-old architect, complains of urinary symptoms to his family physician. He has hypertension and the last 8 years, he has been adequately managed with a thiazide diuretic and an angiotensin-converting enzyme inhibitor. During the same period, JH developed the signs of benign prostatic hyp ...
... JH, a 63-year-old architect, complains of urinary symptoms to his family physician. He has hypertension and the last 8 years, he has been adequately managed with a thiazide diuretic and an angiotensin-converting enzyme inhibitor. During the same period, JH developed the signs of benign prostatic hyp ...
Heart Failure
... • Monitor hearing (loop diuretics) • Limit unprotected sun exposure • Monitor electrolytes ...
... • Monitor hearing (loop diuretics) • Limit unprotected sun exposure • Monitor electrolytes ...
Cardiovascular system pharmacology
... - pharmacological effects of digitalis:- the most important property of cardiac glycosides is their positive inotropic effect , that is , their ability to ↑ the force of myocardial contraction .The result is ↑ed cardiac work at reduced metabolic cost. - digitalis also have effects on electrophysical ...
... - pharmacological effects of digitalis:- the most important property of cardiac glycosides is their positive inotropic effect , that is , their ability to ↑ the force of myocardial contraction .The result is ↑ed cardiac work at reduced metabolic cost. - digitalis also have effects on electrophysical ...