EFFECT OF ECLIPTA ALBA ON FRUCTOSE INDUCED HYPERTENSION IN ALBINO...
... Methods- Hypertension was induced in male wistar albino rats by providing fructose (66%) in their diet for 15 days. Ethanolic extract of Eclipta alba (EEEA) leaves was administered in 100,200&400 mg/kg doses P.O.to different groups of rats for 7days starting from day 16th of fructose administration. ...
... Methods- Hypertension was induced in male wistar albino rats by providing fructose (66%) in their diet for 15 days. Ethanolic extract of Eclipta alba (EEEA) leaves was administered in 100,200&400 mg/kg doses P.O.to different groups of rats for 7days starting from day 16th of fructose administration. ...
Determinants of Neonatal Cardiac Output
... – D causes 10% decrease LV output secondary to drop in LV stroke volume; E increases LV output by 10% due to increase in LVS – Conclusion: “Epinephrine has better effect on contractility” ...
... – D causes 10% decrease LV output secondary to drop in LV stroke volume; E increases LV output by 10% due to increase in LVS – Conclusion: “Epinephrine has better effect on contractility” ...
product monograph - aralez pharmaceuticals
... Impaired Renal or Hepatic Function: ß-blocking agents should be used with caution in patients with impaired hepatic or renal function. Poor renal function has only minor effects on pindolol clearance, but poor hepatic function may cause blood levels of pindolol to increase substantially. In patients ...
... Impaired Renal or Hepatic Function: ß-blocking agents should be used with caution in patients with impaired hepatic or renal function. Poor renal function has only minor effects on pindolol clearance, but poor hepatic function may cause blood levels of pindolol to increase substantially. In patients ...
Management of Hypertension
... Ernst ME, Carter BC, Goerdt CJ, Steffensmeier JJG, Bryles Phillips B, Zimmerman MB, Bergus GR. Comparative antihypertensive effects of hydrochlorothiazide and chlorthalidone on ambulatory and office blood pressure. Hypertension. 2006; 47: 352–358. Major outcomes in high-risk hypertensive patients ra ...
... Ernst ME, Carter BC, Goerdt CJ, Steffensmeier JJG, Bryles Phillips B, Zimmerman MB, Bergus GR. Comparative antihypertensive effects of hydrochlorothiazide and chlorthalidone on ambulatory and office blood pressure. Hypertension. 2006; 47: 352–358. Major outcomes in high-risk hypertensive patients ra ...
Early treatment of psychosis
... • Partial agonist at D2 receptor • Intrinsic activity depends on synaptic levels of DA • Affinity for muscarinic, α1-adrenergic, serotonin and histamine receptors • Good oral absorption, 3-5 hr to peak plasma concentration, long elimination half life • Few extrapyramidal side effects ...
... • Partial agonist at D2 receptor • Intrinsic activity depends on synaptic levels of DA • Affinity for muscarinic, α1-adrenergic, serotonin and histamine receptors • Good oral absorption, 3-5 hr to peak plasma concentration, long elimination half life • Few extrapyramidal side effects ...
heart failure pharma team girls - Copy
... - used in acute (emergency) L.H.F (left heart failure) mainly in patients with impaired renal blood flow (it causes renal vasodilatation) *Dobtamine: - Selective 1 agonist used in acute L.H.F - Both of them are given intravenously - Adverse effect for both: - Tachycardia B/c sympathetic activity. ...
... - used in acute (emergency) L.H.F (left heart failure) mainly in patients with impaired renal blood flow (it causes renal vasodilatation) *Dobtamine: - Selective 1 agonist used in acute L.H.F - Both of them are given intravenously - Adverse effect for both: - Tachycardia B/c sympathetic activity. ...
IVG. Well-established Second Messengers Ca++
... Relationship Between Drug Dose and Clinical Response When faced with a patient who needs treatment: *variety of possible drugs which one will drug will produce a maximal benefit? what kind of dosing regimen is required? The prescriber must understand: *how drug-receptor interactions underlie the rel ...
... Relationship Between Drug Dose and Clinical Response When faced with a patient who needs treatment: *variety of possible drugs which one will drug will produce a maximal benefit? what kind of dosing regimen is required? The prescriber must understand: *how drug-receptor interactions underlie the rel ...
SEDATIVE/HYPNOTICS (Antianxiety Drugs)
... long half lives and elimination half lives (from 10 to > 100 hrs). All BDZs cross the placenta detectable in breast milk may exert depressant effects on the CNS of the lactating infant. ...
... long half lives and elimination half lives (from 10 to > 100 hrs). All BDZs cross the placenta detectable in breast milk may exert depressant effects on the CNS of the lactating infant. ...
presentation source
... Stop dopamine antagonist Give dopamine agonist such as bromocriptine (used for inhibiting lactation in women not wishing to breast feed). Unwanted effects are dose-dependent eg nausea, vomiting, hypotension, stroke, confusion, dyskinetic movements. Give stilboestrol to potentiate the negative ...
... Stop dopamine antagonist Give dopamine agonist such as bromocriptine (used for inhibiting lactation in women not wishing to breast feed). Unwanted effects are dose-dependent eg nausea, vomiting, hypotension, stroke, confusion, dyskinetic movements. Give stilboestrol to potentiate the negative ...
Lectures 8 and 9
... Sometimes known as ‘off-target toxicity’. Screen against other systems – similar targets will be done early on in the project. Before nomination to preclinical studies, the compound will be tested in many other assays to look for activity. ...
... Sometimes known as ‘off-target toxicity’. Screen against other systems – similar targets will be done early on in the project. Before nomination to preclinical studies, the compound will be tested in many other assays to look for activity. ...
Recent advances in the management of resistant hypertension
... studies demonstrating that Mineralocorticoid receptor antagonists provide significant antihypertensive benefit when added to existing multidrug ...
... studies demonstrating that Mineralocorticoid receptor antagonists provide significant antihypertensive benefit when added to existing multidrug ...
1 Lecture Pharmacology Dr. nahlah Pharmacology of the Autonomic
... Is an ester of carbamic acid Has both muscarinic and nicotinic actions. It is poor substrate for AChE. It is biotransformed by other esterases, but at a much slower rate. Therapeutic uses: Because of its high potency, receptor nonselectivity, and relatively long duration of action, carbacholis rarel ...
... Is an ester of carbamic acid Has both muscarinic and nicotinic actions. It is poor substrate for AChE. It is biotransformed by other esterases, but at a much slower rate. Therapeutic uses: Because of its high potency, receptor nonselectivity, and relatively long duration of action, carbacholis rarel ...
PHARMACOLOGY AND PHARMACEUTICAL INDUSTRY
... ischaemic injury, atherosclerosis and thrombosis. Cadiac Arrythmias: Several models have been employed to define the role of adrenergic and cholinergic mechanisms. The ventricle has poor cholinergic innervation. Still the acetylcholine level falls further after vagotomy in all the species studied. T ...
... ischaemic injury, atherosclerosis and thrombosis. Cadiac Arrythmias: Several models have been employed to define the role of adrenergic and cholinergic mechanisms. The ventricle has poor cholinergic innervation. Still the acetylcholine level falls further after vagotomy in all the species studied. T ...
electrical signals control the cardiac activity
... During diastole, in ischemic tissue, the membrane potential does not return to normal resting levels but remains partially depolarized and class Ib drugs remain bound (higher affinity, longer time constant for unblocking that at less negative resting potentials). Therefore, these drugs are more effe ...
... During diastole, in ischemic tissue, the membrane potential does not return to normal resting levels but remains partially depolarized and class Ib drugs remain bound (higher affinity, longer time constant for unblocking that at less negative resting potentials). Therefore, these drugs are more effe ...
IRTRA Combination Tablets LD/HD
... Irbesartan is a long-acting ARB originally created by Sanofi (Headquarters: France) with a long half-life in blood and a 24-hour-lasting blood pressure-lowering effect, having high anti-hypertensive effect in mild to severe hypertension. Based on the large-scale clinical trials, IDNT and IRMA2, whic ...
... Irbesartan is a long-acting ARB originally created by Sanofi (Headquarters: France) with a long half-life in blood and a 24-hour-lasting blood pressure-lowering effect, having high anti-hypertensive effect in mild to severe hypertension. Based on the large-scale clinical trials, IDNT and IRMA2, whic ...
Parasympathetic nervous system
... low dose (less than 0.5 mg) (result of central vagal stimulation + block of presynaptic M-autoreceptor inhibitory effects); as the muscarinic (M2) receptors on the SA node are blocked by higher concentrations of atropine, tachycardia results - at therapeutic doses – atropine has only mild effect on ...
... low dose (less than 0.5 mg) (result of central vagal stimulation + block of presynaptic M-autoreceptor inhibitory effects); as the muscarinic (M2) receptors on the SA node are blocked by higher concentrations of atropine, tachycardia results - at therapeutic doses – atropine has only mild effect on ...
Racemic beta-blockers - Krause und Pachernegg
... beta-adrenoceptor antagonists All beta-blockers that are currently used in research as well as in clinical practice are structurally related to the beta-agonists epinephrine and norepinephrine. As a common feature, these catecholamines and all beta-blockers possess an asymmetric carbon atom. Effects ...
... beta-adrenoceptor antagonists All beta-blockers that are currently used in research as well as in clinical practice are structurally related to the beta-agonists epinephrine and norepinephrine. As a common feature, these catecholamines and all beta-blockers possess an asymmetric carbon atom. Effects ...
3% annual mortality rate
... levels such as beta-blockers, & do not provoke angina or peripheral edema such as calciumantagonists. Nitrates have beneficial CV effects, which are complementary to the effects of other CV drugs. Nitrates are cost-effective. ...
... levels such as beta-blockers, & do not provoke angina or peripheral edema such as calciumantagonists. Nitrates have beneficial CV effects, which are complementary to the effects of other CV drugs. Nitrates are cost-effective. ...
5HT1F- and 5HT7-Receptor Agonists for the Treatment of Migraines
... studies agreed [2], 5-HT infusion aborted spontaneous or reserpine -induced attacks in reports by Kimball [3] and Anthony [4]. The subsequent discovery of sumatriptan almost 20 year ago [5] fuelled the research in migraines but also in the field of serotonin and its receptors. Although 5-HT exerts i ...
... studies agreed [2], 5-HT infusion aborted spontaneous or reserpine -induced attacks in reports by Kimball [3] and Anthony [4]. The subsequent discovery of sumatriptan almost 20 year ago [5] fuelled the research in migraines but also in the field of serotonin and its receptors. Although 5-HT exerts i ...
Structural analysis of histamine receptors and its application in drug
... Homology models of hH1R and hH4R were built by MODELLER. As a template, we used the crystal structure of bovine rhodopsin determined in 2000 (PDB ID: 1F88). The models were validated by the available mutagenesis data from literature and by a set of structural validation programs (PROCHECK, WHATIF, P ...
... Homology models of hH1R and hH4R were built by MODELLER. As a template, we used the crystal structure of bovine rhodopsin determined in 2000 (PDB ID: 1F88). The models were validated by the available mutagenesis data from literature and by a set of structural validation programs (PROCHECK, WHATIF, P ...
Herbs and Alternative Therapies in the Hypertension Clinic
... effects including inhibition of platelet activity and increased levels of antioxidant enzymes. There are probably several active ingredients in garlic preparations. Not surprisingly, several studies have been done to examine its utility in treating hypertension and hyperlipidemia. In its evidence re ...
... effects including inhibition of platelet activity and increased levels of antioxidant enzymes. There are probably several active ingredients in garlic preparations. Not surprisingly, several studies have been done to examine its utility in treating hypertension and hyperlipidemia. In its evidence re ...
2- H1 and H2 Receptors
... and are used in the treatment of asthma. 3-Histamine receptor antagonists, receptor blockers. H1 receptor antagonists The term antihistamine refers primarily to the classic H1-receptor blockers. The H1-receptor blockers can be divided into first- and second generation drugs. The older first-generati ...
... and are used in the treatment of asthma. 3-Histamine receptor antagonists, receptor blockers. H1 receptor antagonists The term antihistamine refers primarily to the classic H1-receptor blockers. The H1-receptor blockers can be divided into first- and second generation drugs. The older first-generati ...
Elicited Behavior and Classical Conditioning
... • Binding to a portion of the receptor other than the agonist binding site • Disturbing the cell membrane supporting the receptor • By interfering with the intracellular processes that were initiated by the agonist-receptor association. – In general, the shape of the dose-response curve will be dist ...
... • Binding to a portion of the receptor other than the agonist binding site • Disturbing the cell membrane supporting the receptor • By interfering with the intracellular processes that were initiated by the agonist-receptor association. – In general, the shape of the dose-response curve will be dist ...
Midterm review - February 26, 2004
... gentamicin). Requirements for minimum concentration (Cmin) for biological activity mean you have to keep levels above a threshold (gentamicin). Renal clearance declines in renal failure, and for renally excreted drugs a patient could accumulate toxic levels. Basic strategies in renal failure patient ...
... gentamicin). Requirements for minimum concentration (Cmin) for biological activity mean you have to keep levels above a threshold (gentamicin). Renal clearance declines in renal failure, and for renally excreted drugs a patient could accumulate toxic levels. Basic strategies in renal failure patient ...
Drugs for respiratory system
... Routes of administration: • Systemic administration: including oral and injection. More severe toxicity. Reserved for patients who require urgent treatment. ...
... Routes of administration: • Systemic administration: including oral and injection. More severe toxicity. Reserved for patients who require urgent treatment. ...