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PI-9 siRNA (h): sc-40949 - Santa Cruz Biotechnology
PI-9 siRNA (h): sc-40949 - Santa Cruz Biotechnology

... endothelial cells and epithelial cells. PI-9 is exported from nuclei via a leptomycin B-sensitive pathway, suggesting that the nucleocytoplasmic distribution of PI-9 involves a nonconventional nuclear import pathway and the export factor CRM1. Estrogen rapidly and strongly induces PI-9, which is an ...
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§ 58-10-90

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Essential roles of the Fas-Fas ligand pathway in the development of
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... predominantly in activated T lymphocytes and natural killer cells (2). FasL is one of the major effector molecules of cytotoxic T lymphocytes such as CD8+ T cells and CD4+ T-helper 1–type T cells (3–5). In the immune system, Fas and FasL are involved in downregulation of immune reactions (6–8). Malf ...
Introduction to the cytoskeleton
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... microtubule is free in the cytoplasm. We should also know about MAPs, microtubule associated preoteins. MAPs are important in the regulation of microtubules, since they stabilize microtubules enhancing growth, suppressing the frequency of catastrophes, resulting in a longer and less dynamic microtub ...
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Apoptosis



Apoptosis (/ˌæpəˈtoʊsɪs/; from Ancient Greek ἀπό apo, ""by, from, of, since, than"" and πτῶσις ptōsis, ""fall"") is the process of programmed cell death that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal DNA fragmentation, and global mRNA decay.In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism's lifecycle. For example, the separation of fingers and toes in a developing human embryo occurs because cells between the digits undergo apoptosis. Unlike necrosis, apoptosis produces cell fragments called apoptotic bodies that phagocytic cells are able to engulf and quickly remove before the contents of the cell can spill out onto surrounding cells and cause damage.Between 50 and 70 billion cells die each day due to apoptosis in the average human adult. For an average child between the ages of 8 and 14, approximately 20 billion to 30 billion cells die a day.Research in and around apoptosis has increased substantially since the early 1990s. In addition to its importance as a biological phenomenon, defective apoptotic processes have been implicated in a wide variety of diseases. Excessive apoptosis causes atrophy, whereas an insufficient amount results in uncontrolled cell proliferation, such as cancer.Some factors like Fas receptor, caspases (C-cysteine rich, asp- aspartic acid moiety containing, ase – proteases) etc. promote apoptosis, while members of Bcl-2 inhibit apoptosis.
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