hTERT Inhibition Triggers Epstein–Barr Virus Lytic Cycle and
... and several histone deacetylase inhibitors (9–12). EBVcarrying tumor cells may also be killed by prodrugs, such as ganciclovir or radiolabeled nucleoside analogs, which are activated by EBV lytic proteins, such as the viral thymidine kinase (9, 13, 14). Notably, combined treatment with arginine buty ...
... and several histone deacetylase inhibitors (9–12). EBVcarrying tumor cells may also be killed by prodrugs, such as ganciclovir or radiolabeled nucleoside analogs, which are activated by EBV lytic proteins, such as the viral thymidine kinase (9, 13, 14). Notably, combined treatment with arginine buty ...
Expression of the papillomavirus E2 protein in HeLa cells leads to
... genotoxic agents (Butz et al., 1995). Since E2 could repress E6 expression, we next investigated whether this resulted in stabilization of p53. The activity of p53 was assayed via co-transfected p53-responsive CAT reporter plasmids. As shown in Figure 2A, expression of fulllength BPV-1 E2 resulted i ...
... genotoxic agents (Butz et al., 1995). Since E2 could repress E6 expression, we next investigated whether this resulted in stabilization of p53. The activity of p53 was assayed via co-transfected p53-responsive CAT reporter plasmids. As shown in Figure 2A, expression of fulllength BPV-1 E2 resulted i ...
7-3 Cell Boundaries - River Dell Regional School District
... End Show Copyright Pearson Prentice Hall ...
... End Show Copyright Pearson Prentice Hall ...
vilnius university
... Their long-term proliferative capacity in culture makes this system convenient for ex vivo gene transfer. Genetically engineered myogenic cells with improved survival properties would be a mean to improve transplanted cells survival rates in the damaged heart tissues. There were performed primary tr ...
... Their long-term proliferative capacity in culture makes this system convenient for ex vivo gene transfer. Genetically engineered myogenic cells with improved survival properties would be a mean to improve transplanted cells survival rates in the damaged heart tissues. There were performed primary tr ...
NF-κB
... • NF-κB pathway is a central signaling pathway for inflammatory and immune responses, and aberrant NFκB signaling is implicated multiple disorders, such as cancer and autoimmune, chronic inflammatory and metabolic diseases.NF-κB is regulated by various posttranslational modifications, including phos ...
... • NF-κB pathway is a central signaling pathway for inflammatory and immune responses, and aberrant NFκB signaling is implicated multiple disorders, such as cancer and autoimmune, chronic inflammatory and metabolic diseases.NF-κB is regulated by various posttranslational modifications, including phos ...
Detection of apoptosis in patients with coronary artery disease Aleksander Szymanowski
... The atherosclerotic process and its consequences are considered driven by an imbalance between pro- and anti-inflammatory actions. One contributing factor in this scenario is an altered regulation of apoptosis, which affects both immune, vascular and myocardial cells. The general aim of this thesis ...
... The atherosclerotic process and its consequences are considered driven by an imbalance between pro- and anti-inflammatory actions. One contributing factor in this scenario is an altered regulation of apoptosis, which affects both immune, vascular and myocardial cells. The general aim of this thesis ...
The Cytoplasm of a Cell and the Courtyard of a Siheyuan
... allows different cellular compartments support and “communicate” with each other, assuring that the cell obtains what it needs and is in its optimal condition (Gorlich and Kutay, 1999). Third, the cytoplasm is the public mutual area that all organelles have access to and it contains many cell-essent ...
... allows different cellular compartments support and “communicate” with each other, assuring that the cell obtains what it needs and is in its optimal condition (Gorlich and Kutay, 1999). Third, the cytoplasm is the public mutual area that all organelles have access to and it contains many cell-essent ...
Truncated products of the vestigial proliferation gene
... The Vg product plays a key role in cell proliferation of the wing disc integrating developmental cues by its two enhancers, the `boundary' and the `quadrant' enhancers. Ectopic expression of vg in all imaginal discs leads to ectopic proliferation of wing tissue.8 All vg mutants characterized so far ...
... The Vg product plays a key role in cell proliferation of the wing disc integrating developmental cues by its two enhancers, the `boundary' and the `quadrant' enhancers. Ectopic expression of vg in all imaginal discs leads to ectopic proliferation of wing tissue.8 All vg mutants characterized so far ...
Mitochondrion and Chloroplast Regulation of Plant Programmed
... localised in the OMM, so they can interact, bind and inhibit the pro-apoptotic Bcl-2 members to prevent mitochondrial membrane permeabilisation (MMP) and the release of pro-apoptotic molecules from the mitochondria into the cytosol. The proapoptotic function of BH3-only molecules is completed in two ...
... localised in the OMM, so they can interact, bind and inhibit the pro-apoptotic Bcl-2 members to prevent mitochondrial membrane permeabilisation (MMP) and the release of pro-apoptotic molecules from the mitochondria into the cytosol. The proapoptotic function of BH3-only molecules is completed in two ...
Interaction with PI3-kinase contributes to the cytotoxic activity ofApoptin S Maddika
... Our data further suggest that the PI3-K pathway is involved in localization of apoptin. Inhibition of the PI3-K pathway using wortmannin or RNA interference retained apoptin in the cytoplasm and led to its nuclear exclusion, hence impairing cell death. PI3-K has been mainly implicated in lipid signa ...
... Our data further suggest that the PI3-K pathway is involved in localization of apoptin. Inhibition of the PI3-K pathway using wortmannin or RNA interference retained apoptin in the cytoplasm and led to its nuclear exclusion, hence impairing cell death. PI3-K has been mainly implicated in lipid signa ...
Regulatory role of rpL3 in cell response to nucleolar stress induced
... this aim, Calu-6 and HCT 116 p53-/- cells were transiently cotransfected with the full-length p21 promoter luciferase reporter plasmid and siRNA specific for rpL3 (rpL3-siRNA) or scrambled siRNA (Src-siRNA). Then, cells were treated with 5nM of Act D for 24 h or untreated and analyzed by western blot ...
... this aim, Calu-6 and HCT 116 p53-/- cells were transiently cotransfected with the full-length p21 promoter luciferase reporter plasmid and siRNA specific for rpL3 (rpL3-siRNA) or scrambled siRNA (Src-siRNA). Then, cells were treated with 5nM of Act D for 24 h or untreated and analyzed by western blot ...
(a) (i) the three features correctly labelled on cheek cell
... (nerve) impulse sent along nerve fibre to brain each for 1 mark ...
... (nerve) impulse sent along nerve fibre to brain each for 1 mark ...
The Journal of Experimental Medicine
... report that in contrast to many other tumor entities, the CD95 system on HRS cells is rather up-regulated than down-regulated. This is evident from CD95 overexpression in HRS cell lines and from the immunohistochemical analysis of CD95, FADD, and c-FLIP on 59 cases of cHL. Upon CD95 stimulation, a s ...
... report that in contrast to many other tumor entities, the CD95 system on HRS cells is rather up-regulated than down-regulated. This is evident from CD95 overexpression in HRS cell lines and from the immunohistochemical analysis of CD95, FADD, and c-FLIP on 59 cases of cHL. Upon CD95 stimulation, a s ...
Apoptosis-inducing factor is involved in the regulation of caspase
... induces neuronal cell death through a rapid Apaf1-dependent pathway in wild-type neurons, and through a delayed pathway in Apaf1-deficient neurons. These two cell death pathways could be further distinguished on the basis of caspase involvement and cellular morphology. In wild-type neurons, camptoth ...
... induces neuronal cell death through a rapid Apaf1-dependent pathway in wild-type neurons, and through a delayed pathway in Apaf1-deficient neurons. These two cell death pathways could be further distinguished on the basis of caspase involvement and cellular morphology. In wild-type neurons, camptoth ...
Comparison of cytotoxicity and wound healing effect of
... Helsinki. Primary cultures of human corneal epithelium were obtained using human donor corneas that had been discarded before transplantation due to low endothelial cell counts as previously described [13]. Briefly, under aseptic conditions and using the dissecting microscope, donor corneoscleral ri ...
... Helsinki. Primary cultures of human corneal epithelium were obtained using human donor corneas that had been discarded before transplantation due to low endothelial cell counts as previously described [13]. Briefly, under aseptic conditions and using the dissecting microscope, donor corneoscleral ri ...
Dominant negative connexin26 mutation R75W causing severe
... in human cancers [29,30]. In this study, we demonstrate that a dominant-negative mutation of Gjb2 induced retention in the mouse GER during the early postnatal stages of cochlear development. We propose the existence of an underlying mechanism to explain the disruption of the cyto-architecture in th ...
... in human cancers [29,30]. In this study, we demonstrate that a dominant-negative mutation of Gjb2 induced retention in the mouse GER during the early postnatal stages of cochlear development. We propose the existence of an underlying mechanism to explain the disruption of the cyto-architecture in th ...
HODGKIN LYMPHOMA
... RS variants) which is the malignant cells but the other surrounding white blood cells in the affected lymph node are reactive cells ( polyclonal) not neoplastic cells. ...
... RS variants) which is the malignant cells but the other surrounding white blood cells in the affected lymph node are reactive cells ( polyclonal) not neoplastic cells. ...
ID helix-loop-helix proteins - Journal of Cell Science
... Evan, 1995; Massari and Murre, 2000). In metazoa, HLH proteins function in the coordinate regulation of gene expression, orchestrating cell cycle control, cell lineage commitment and cell differentiation. An essential role has been established for a number of HLH proteins in the development of haemo ...
... Evan, 1995; Massari and Murre, 2000). In metazoa, HLH proteins function in the coordinate regulation of gene expression, orchestrating cell cycle control, cell lineage commitment and cell differentiation. An essential role has been established for a number of HLH proteins in the development of haemo ...
PDF
... appears to be sufficient for tumorigenesis, which indicates that Rb might not have anti-apoptotic activity in all tissues and that its role in apoptosis might therefore be tissue-specific (reviewed by Sherr and McCormick, 2002). The genetic analysis of the role of mammalian Rb in apoptosis has been ...
... appears to be sufficient for tumorigenesis, which indicates that Rb might not have anti-apoptotic activity in all tissues and that its role in apoptosis might therefore be tissue-specific (reviewed by Sherr and McCormick, 2002). The genetic analysis of the role of mammalian Rb in apoptosis has been ...
CHAPTER 1 PATHOGENESIS OF GOUSIEKTE 1.1
... Calcineurin dephosphorylates nuclear factor of activated T-cell, which then enters into the nucleus and promotes transcription (Frey et al., 2000). Recently identified proteins residing at the Z-lines include myotilin, S100A1 Ca2+-binding protein and myomaxin (Cox et al., 2008). Myotilin, a thin fil ...
... Calcineurin dephosphorylates nuclear factor of activated T-cell, which then enters into the nucleus and promotes transcription (Frey et al., 2000). Recently identified proteins residing at the Z-lines include myotilin, S100A1 Ca2+-binding protein and myomaxin (Cox et al., 2008). Myotilin, a thin fil ...
7-3 Cell Boundaries - River Dell Regional School District
... End Show Copyright Pearson Prentice Hall ...
... End Show Copyright Pearson Prentice Hall ...
The Significance of Low bcl-2 Expression by CD45RO T Cells in No
... way in which activated T cells may be selected for survival. It has been shown that T lymphocytosis, especially within the CD8 + subset, is induced by acute viral infections and these cells are activated and enter the proliferative cycle in vivo (13-15). However, CD4 § and CD8 + cell numbers rapidly ...
... way in which activated T cells may be selected for survival. It has been shown that T lymphocytosis, especially within the CD8 + subset, is induced by acute viral infections and these cells are activated and enter the proliferative cycle in vivo (13-15). However, CD4 § and CD8 + cell numbers rapidly ...
Heterochromatin silencing at p53 target genes by a small viral protein.
... • p53 induction and phosphorylation is tantamount to p53 activity, which is the premise for several cancer therapies. • Identified, E4-ORF3, directing SUV39H1/2 H3K9me3 heterochromatin assembly at p53 target promoters to silence p53 activated transcription in response to genotoxic and oncogenic stre ...
... • p53 induction and phosphorylation is tantamount to p53 activity, which is the premise for several cancer therapies. • Identified, E4-ORF3, directing SUV39H1/2 H3K9me3 heterochromatin assembly at p53 target promoters to silence p53 activated transcription in response to genotoxic and oncogenic stre ...
Regulation of Microtubule Stability and Mitotic
... progression in prometaphase (31.5 ⴞ 6.9 min) and metaphase (126.8 ⴞ 73.8 min), as compared with control injected cells (prometaphase, 21.5 ⴞ 3.3 min; metaphase, 18.9 ⴞ 4.5 min; P < 0.01). Cells injected with the antibody to survivin displayed short mitotic spindles severely depleted of microtubules ...
... progression in prometaphase (31.5 ⴞ 6.9 min) and metaphase (126.8 ⴞ 73.8 min), as compared with control injected cells (prometaphase, 21.5 ⴞ 3.3 min; metaphase, 18.9 ⴞ 4.5 min; P < 0.01). Cells injected with the antibody to survivin displayed short mitotic spindles severely depleted of microtubules ...
SB 2.0 poster
... Yeast cells react to pheromone on a wide range of timescales, from a response time on the order of seconds by the signaling cascade component of the pheromone response pathway, to the actual mating program, which can take several hours to complete. The pheromone response also produces a wide variety ...
... Yeast cells react to pheromone on a wide range of timescales, from a response time on the order of seconds by the signaling cascade component of the pheromone response pathway, to the actual mating program, which can take several hours to complete. The pheromone response also produces a wide variety ...
Apoptosis
Apoptosis (/ˌæpəˈtoʊsɪs/; from Ancient Greek ἀπό apo, ""by, from, of, since, than"" and πτῶσις ptōsis, ""fall"") is the process of programmed cell death that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal DNA fragmentation, and global mRNA decay.In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism's lifecycle. For example, the separation of fingers and toes in a developing human embryo occurs because cells between the digits undergo apoptosis. Unlike necrosis, apoptosis produces cell fragments called apoptotic bodies that phagocytic cells are able to engulf and quickly remove before the contents of the cell can spill out onto surrounding cells and cause damage.Between 50 and 70 billion cells die each day due to apoptosis in the average human adult. For an average child between the ages of 8 and 14, approximately 20 billion to 30 billion cells die a day.Research in and around apoptosis has increased substantially since the early 1990s. In addition to its importance as a biological phenomenon, defective apoptotic processes have been implicated in a wide variety of diseases. Excessive apoptosis causes atrophy, whereas an insufficient amount results in uncontrolled cell proliferation, such as cancer.Some factors like Fas receptor, caspases (C-cysteine rich, asp- aspartic acid moiety containing, ase – proteases) etc. promote apoptosis, while members of Bcl-2 inhibit apoptosis.