03. Cell Mediated Immunityx
... • Production of co-stimulatory protein depends on activation of the toll like receptor on antigen presenting cell • Foreign antigens such as bacterial proteins induce B7 protein where as self proteins do not ...
... • Production of co-stimulatory protein depends on activation of the toll like receptor on antigen presenting cell • Foreign antigens such as bacterial proteins induce B7 protein where as self proteins do not ...
Purification of Antibodies
... o Of the major classes of human IgG, for example, three (IgG1, 2, and 4) bind with high affinity and one (IgG3) binds very weakly, if at all. o Similarly, mouse IgG2a binds with high affinity, IgG2b and IgG3 bind tolerably well, and IgG1 binds poorly (Ey et al. 1978). These differences are generally ...
... o Of the major classes of human IgG, for example, three (IgG1, 2, and 4) bind with high affinity and one (IgG3) binds very weakly, if at all. o Similarly, mouse IgG2a binds with high affinity, IgG2b and IgG3 bind tolerably well, and IgG1 binds poorly (Ey et al. 1978). These differences are generally ...
e. None of the above
... e. Are interchain and intrachain disulfide bridges 33. In Kohler and Milstein's paper describing the first production of a hybridoma cell line secreting antibody with a predetermined specificity (in this case, anti-sRBC antibody), they use a modified radial diffusion assay to determine the isotype o ...
... e. Are interchain and intrachain disulfide bridges 33. In Kohler and Milstein's paper describing the first production of a hybridoma cell line secreting antibody with a predetermined specificity (in this case, anti-sRBC antibody), they use a modified radial diffusion assay to determine the isotype o ...
ABO/D Blood Groups
... An unknown rbc suspension is added to known antisera. The left hand of the slide contains anti-A which reacts with the unknown cell. The right hand side contains anti-B which does not react with the cell. ...
... An unknown rbc suspension is added to known antisera. The left hand of the slide contains anti-A which reacts with the unknown cell. The right hand side contains anti-B which does not react with the cell. ...
Immunity & Abnormal Responses
... • Variable region--- binds to antigen • Constant region --- attaches to macrophage – 5 different types of “constant regions” » MADGE = all monomers, but M = pentamer & A = dimer – The constant regions have no effect on the specificity of the antibody ...
... • Variable region--- binds to antigen • Constant region --- attaches to macrophage – 5 different types of “constant regions” » MADGE = all monomers, but M = pentamer & A = dimer – The constant regions have no effect on the specificity of the antibody ...
Vaccination
... Key words: Vaccine, Antigen, Antibody, B Cells, Memory T Cells, Immunity Discuss the use of antibiotics and vaccines in the treatment and prevention of bacterial diseases. In your answer be sure to include: a) what is in a vaccine A vaccine contains dead, or weakened microbes or parts of microbes b) ...
... Key words: Vaccine, Antigen, Antibody, B Cells, Memory T Cells, Immunity Discuss the use of antibiotics and vaccines in the treatment and prevention of bacterial diseases. In your answer be sure to include: a) what is in a vaccine A vaccine contains dead, or weakened microbes or parts of microbes b) ...
Auto-immune diseases – 19/03/03
... inactivation of other potential autoreactive cells. If the no. of these cells decreases, then auto-immunity can occur. Some antigen specific CD4+ T cells can suppress antigen specific proliferation of other T cells prevent autoimmune colitis (mouse model). 4) Viruses: interfere with immunological ...
... inactivation of other potential autoreactive cells. If the no. of these cells decreases, then auto-immunity can occur. Some antigen specific CD4+ T cells can suppress antigen specific proliferation of other T cells prevent autoimmune colitis (mouse model). 4) Viruses: interfere with immunological ...
Isotype switching Diversification of Igs after B cells encounter antigens
... Very common Induce IgG and all other isotypes Much stronger immune response ...
... Very common Induce IgG and all other isotypes Much stronger immune response ...
Presentation
... adapted to their host (their goal is to grow and be transmitted to others, not to kill) ...
... adapted to their host (their goal is to grow and be transmitted to others, not to kill) ...
投影片 1
... -Production of T cell receptor that coat the surfaces of cytotoxic T cells -The cytotoxic T cells recognize and kill infected cells of the host organism -Responsible for protecting mammals from viral infection ...
... -Production of T cell receptor that coat the surfaces of cytotoxic T cells -The cytotoxic T cells recognize and kill infected cells of the host organism -Responsible for protecting mammals from viral infection ...
Slide 1
... • Antigens: foreign proteins, usually part of virus or bacteria • Antibodies: Proteins made by immune cells that “recognize” or bind with particular antigens. Original diversity of antibodyproducing cells depends on recombination of genetic sequences during cell development • Macrophages: phagocytic ...
... • Antigens: foreign proteins, usually part of virus or bacteria • Antibodies: Proteins made by immune cells that “recognize” or bind with particular antigens. Original diversity of antibodyproducing cells depends on recombination of genetic sequences during cell development • Macrophages: phagocytic ...
Document
... • each B cell expresses identical copies of an antibody that is specific for single epitope • when a B cell divides, the chromosomes in its progeny cells bear the selected allelic genes, and these genes do not undergo any further V/J or V/D/J rearrangements • immunoglobulins produced by given B cell ...
... • each B cell expresses identical copies of an antibody that is specific for single epitope • when a B cell divides, the chromosomes in its progeny cells bear the selected allelic genes, and these genes do not undergo any further V/J or V/D/J rearrangements • immunoglobulins produced by given B cell ...
Inadequate flow of oxygen into the respiratory system due to
... bacteria, viruses, and other foreign substances harmful to the body. ...
... bacteria, viruses, and other foreign substances harmful to the body. ...
Innate Immunity (part II) and Antigen Recognition by Adaptive
... – Defense against extracellular microbes and viruses by soluble binding molecules linked to effector functions – B cells also make a membrane-bound form of immunoglobulin that serves as their antigen receptor ...
... – Defense against extracellular microbes and viruses by soluble binding molecules linked to effector functions – B cells also make a membrane-bound form of immunoglobulin that serves as their antigen receptor ...
1 - jfriel
... pp. 356-357 Define antigen (immunogen). What are antigens made of and where are they found? **pp.350-351 What is the MHC? Since MHC shape is coded for ...
... pp. 356-357 Define antigen (immunogen). What are antigens made of and where are they found? **pp.350-351 What is the MHC? Since MHC shape is coded for ...
File
... cytokines which increase blood flow resulting in specific white blood cells accumulating at the site of infection or tissue damage. • Clonal selection theory. • Lymphocytes have a single type of membrane receptor specific for one antigen. • Antigen binding leads to repeated lymphocyte division resul ...
... cytokines which increase blood flow resulting in specific white blood cells accumulating at the site of infection or tissue damage. • Clonal selection theory. • Lymphocytes have a single type of membrane receptor specific for one antigen. • Antigen binding leads to repeated lymphocyte division resul ...
Antibody Structure and B Cell Diversity
... Amino acid sequence differences concentrated Flanked by less variable framework regions Three hypervariable regions in each V domain Hypervariable regions also called * Complementarity-determining regions (CDR) ...
... Amino acid sequence differences concentrated Flanked by less variable framework regions Three hypervariable regions in each V domain Hypervariable regions also called * Complementarity-determining regions (CDR) ...
Lecture 5 - Andrew.cmu.edu
... Lecture 9 - Antibody Structure & Protein-small Molecule Binding. Disulfide bonds: These are covalent bonds between cysteine residues, they crosslink the otherwise linear polypeptide chains. They increase the stability of proteins and are often found on proteins that function Cysteine outside of cell ...
... Lecture 9 - Antibody Structure & Protein-small Molecule Binding. Disulfide bonds: These are covalent bonds between cysteine residues, they crosslink the otherwise linear polypeptide chains. They increase the stability of proteins and are often found on proteins that function Cysteine outside of cell ...
Chapter 18: Applications of Immunology
... The Precipitin Ring Test The presence of specific antigen or antibodies in a test sample (e.g., blood serum) can be revealed by layering a solution of one on top of the other: • at the interface between antigen & antibody, the two will mix due to diffusion • within this region of mixing a “zone of ...
... The Precipitin Ring Test The presence of specific antigen or antibodies in a test sample (e.g., blood serum) can be revealed by layering a solution of one on top of the other: • at the interface between antigen & antibody, the two will mix due to diffusion • within this region of mixing a “zone of ...
CYTOKINE AND LYMPHOCYTE SUBSETS SMALL GROUPS
... quite benign attenuated tuberculosis vaccine suggests that there was clustering of a genetic defect causing a unique immunodeficiency state characterized by susceptibility to mycobacterial illness. ...
... quite benign attenuated tuberculosis vaccine suggests that there was clustering of a genetic defect causing a unique immunodeficiency state characterized by susceptibility to mycobacterial illness. ...
Disorders of the Immune System and Vaccination
... in the lab. – Pasteur saw this happen while working with Fowl Cholera in the lab. The longer he kept a particular culture in the lab and regrew it, the less virulent it became. Essentially, organisms will not hang onto genes, or extra genetic material that they don’t need. So if they don’t need viru ...
... in the lab. – Pasteur saw this happen while working with Fowl Cholera in the lab. The longer he kept a particular culture in the lab and regrew it, the less virulent it became. Essentially, organisms will not hang onto genes, or extra genetic material that they don’t need. So if they don’t need viru ...
Cell Mediated Immunity 2016-20172016-10-24 08
... • Production of IL-2 and its receptor – IL-2 is also know as T cell growth factor – Proliferation of antigen specific T cells – Effector and regulatory cells are produced along with “memory” cells – IL-2 also stimulates CD8 cytotoxic cells • Production of Interferons – Enhances anti-microbial activi ...
... • Production of IL-2 and its receptor – IL-2 is also know as T cell growth factor – Proliferation of antigen specific T cells – Effector and regulatory cells are produced along with “memory” cells – IL-2 also stimulates CD8 cytotoxic cells • Production of Interferons – Enhances anti-microbial activi ...